FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8882, 182 aa 1>>>pF1KB8882 182 - 182 aa - 182 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9036+/-0.00027; mu= 15.4589+/- 0.017 mean_var=63.1239+/-12.438, 0's: 0 Z-trim(120.0): 21 B-trim: 0 in 0/55 Lambda= 0.161427 statistics sampled from 34622 (34644) to 34622 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.406), width: 16 Scan time: 6.140 The best scores are: opt bits E(85289) NP_001532 (OMIM: 602179) heat shock protein beta-2 ( 182) 1230 294.1 8.5e-80 XP_011540910 (OMIM: 123590,608810,613763,613869,61 ( 175) 381 96.3 2.7e-20 NP_001276737 (OMIM: 123590,608810,613763,613869,61 ( 175) 381 96.3 2.7e-20 NP_001276736 (OMIM: 123590,608810,613763,613869,61 ( 175) 381 96.3 2.7e-20 NP_001876 (OMIM: 123590,608810,613763,613869,61518 ( 175) 381 96.3 2.7e-20 NP_653218 (OMIM: 610695) heat shock protein beta-6 ( 160) 349 88.8 4.5e-18 NP_000385 (OMIM: 123580,604219) alpha-crystallin A ( 173) 324 83.0 2.7e-16 NP_001531 (OMIM: 602195,606595,608634) heat shock ( 205) 309 79.6 3.5e-15 NP_001317308 (OMIM: 123590,608810,613763,613869,61 ( 108) 293 75.7 2.8e-14 XP_005261150 (OMIM: 123580,604219) PREDICTED: alph ( 136) 277 72.0 4.4e-13 NP_006299 (OMIM: 604624,613376) heat shock protein ( 150) 240 63.4 1.9e-10 NP_055180 (OMIM: 158590,608014,608673) heat shock ( 196) 206 55.6 5.6e-08 NP_055239 (OMIM: 610692) heat shock protein beta-7 ( 170) 187 51.1 1.1e-06 XP_011539552 (OMIM: 610692) PREDICTED: heat shock ( 262) 178 49.2 6.4e-06 XP_011539551 (OMIM: 610692) PREDICTED: heat shock ( 263) 174 48.2 1.2e-05 >>NP_001532 (OMIM: 602179) heat shock protein beta-2 [Ho (182 aa) initn: 1230 init1: 1230 opt: 1230 Z-score: 1553.6 bits: 294.1 E(85289): 8.5e-80 Smith-Waterman score: 1230; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KB8 MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIV 130 140 150 160 170 180 pF1KB8 EP :: NP_001 EP >>XP_011540910 (OMIM: 123590,608810,613763,613869,615184 (175 aa) initn: 358 init1: 310 opt: 381 Z-score: 485.2 bits: 96.3 E(85289): 2.7e-20 Smith-Waterman score: 381; 43.1% identity (72.3% similar) in 137 aa overlap (16-148:15-149) 10 20 30 40 50 pF1KB8 MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEIL-TPTLYHGYYVRPRA---APA . : .:::: .: ::: :: ... : : .:.:: . ::. XP_011 MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 GEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSRE . : ::.:: . .:.. :::.::.:.:. :... ...:: ..: .: :.:::.::: XP_011 WFDT--GLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISRE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 FCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEE : : : .:::::: . ..:: ::.:....:: XP_011 FHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK 120 130 140 150 160 170 180 pF1KB8 AAIVEP >>NP_001276737 (OMIM: 123590,608810,613763,613869,615184 (175 aa) initn: 358 init1: 310 opt: 381 Z-score: 485.2 bits: 96.3 E(85289): 2.7e-20 Smith-Waterman score: 381; 43.1% identity (72.3% similar) in 137 aa overlap (16-148:15-149) 10 20 30 40 50 pF1KB8 MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEIL-TPTLYHGYYVRPRA---APA . : .:::: .: ::: :: ... : : .:.:: . ::. NP_001 MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 GEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSRE . : ::.:: . .:.. :::.::.:.:. :... ...:: ..: .: :.:::.::: NP_001 WFDT--GLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISRE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 FCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEE : : : .:::::: . ..:: ::.:....:: NP_001 FHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK 120 130 140 150 160 170 180 pF1KB8 AAIVEP >>NP_001276736 (OMIM: 123590,608810,613763,613869,615184 (175 aa) initn: 358 init1: 310 opt: 381 Z-score: 485.2 bits: 96.3 E(85289): 2.7e-20 Smith-Waterman score: 381; 43.1% identity (72.3% similar) in 137 aa overlap (16-148:15-149) 10 20 30 40 50 pF1KB8 MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEIL-TPTLYHGYYVRPRA---APA . : .:::: .: ::: :: ... : : .:.:: . ::. NP_001 MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 GEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSRE . : ::.:: . .:.. :::.::.:.:. :... ...:: ..: .: :.:::.::: NP_001 WFDT--GLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISRE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 FCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEE : : : .:::::: . ..:: ::.:....:: NP_001 FHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK 120 130 140 150 160 170 180 pF1KB8 AAIVEP >>NP_001876 (OMIM: 123590,608810,613763,613869,615184) a (175 aa) initn: 358 init1: 310 opt: 381 Z-score: 485.2 bits: 96.3 E(85289): 2.7e-20 Smith-Waterman score: 381; 43.1% identity (72.3% similar) in 137 aa overlap (16-148:15-149) 10 20 30 40 50 pF1KB8 MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEIL-TPTLYHGYYVRPRA---APA . : .:::: .: ::: :: ... : : .:.:: . ::. NP_001 MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 GEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSRE . : ::.:: . .:.. :::.::.:.:. :... ...:: ..: .: :.:::.::: NP_001 WFDT--GLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISRE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 FCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEE : : : .:::::: . ..:: ::.:....:: NP_001 FHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK 120 130 140 150 160 170 180 pF1KB8 AAIVEP >>NP_653218 (OMIM: 610695) heat shock protein beta-6 [Ho (160 aa) initn: 339 init1: 253 opt: 349 Z-score: 445.5 bits: 88.8 E(85289): 4.5e-18 Smith-Waterman score: 349; 45.0% identity (71.0% similar) in 131 aa overlap (18-146:22-146) 10 20 30 40 50 pF1KB8 MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEI--LTPTLYHGYYVRPRAA .. :.:: .:::::::: :. : :: ::.: : NP_653 MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLR---A 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 PAGEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVS :. .... . :.:...:::.::.:.:..:..: . .:: ::: .: :.::::. NP_653 PS---VALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 REFCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEE ::: : : :: ::: : .::: .:.:...: NP_653 REFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK 120 130 140 150 160 180 pF1KB8 EEAAIVEP >>NP_000385 (OMIM: 123580,604219) alpha-crystallin A cha (173 aa) initn: 336 init1: 279 opt: 324 Z-score: 413.6 bits: 83.0 E(85289): 2.7e-16 Smith-Waterman score: 324; 38.0% identity (62.0% similar) in 158 aa overlap (21-178:19-170) 10 20 30 40 50 60 pF1KB8 MSGRSVPHAHPATAEYEFANPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGS :::: .: :::::. ..: : : : . NP_000 MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLL-PFLSSTISPYYRQSLFRTVL 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 RAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRT .: ::.: .. :: ::::.::.:...::.. :...:. ..: .: : ::..:::: : NP_000 DSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 YVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIV : ::..:: . .:: ::.:.. .:. ::. : : : . ::. .: NP_000 YRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAI-----PVSREEKPTSAPS 120 130 140 150 160 170 pF1KB8 EP NP_000 S >>NP_001531 (OMIM: 602195,606595,608634) heat shock prot (205 aa) initn: 351 init1: 294 opt: 309 Z-score: 393.6 bits: 79.6 E(85289): 3.5e-15 Smith-Waterman score: 341; 37.2% identity (58.9% similar) in 207 aa overlap (1-178:1-204) 10 20 30 40 50 pF1KB8 MSGRSVPHA---HPATAEYEFANP-SRLGEQRFGEGLLPEEI---LTPTLYHGYYVRPRA :. : :: . :. .. : ::: .: :: :::: : . . :: ::: NP_001 MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGY-VRPLP 10 20 30 40 50 60 70 80 90 pF1KB8 APAGEG--------SRA-------GASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNLLE : :. ::: :.::.: . .... :::.::.:::.::.: :...: NP_001 PAAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVE 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB8 VSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTEVN ....: .: :.::..:: : : :.:: ::: .: ..:: .: :..::: .: :. : NP_001 ITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMP--KLATQSN 120 130 140 150 160 170 160 170 180 pF1KB8 EVYISL-------LPAPPDPEEEEEAAIVEP :. : . : .: . .: :: NP_001 EITIPVTFESRAQLGGPEAAKSDETAAK 180 190 200 >>NP_001317308 (OMIM: 123590,608810,613763,613869,615184 (108 aa) initn: 293 init1: 293 opt: 293 Z-score: 377.5 bits: 75.7 E(85289): 2.8e-14 Smith-Waterman score: 293; 46.3% identity (81.7% similar) in 82 aa overlap (67-148:1-82) 40 50 60 70 80 90 pF1KB8 EILTPTLYHGYYVRPRAAPAGEGSRAGASELRLSEGKFQAFLDVSHFTPDEVTVRTVDNL .:: . .:.. :::.::.:.:. :... .. NP_001 MRLEKDRFSVNLDVKHFSPEELKVKVLGDV 10 20 30 100 110 120 130 140 150 pF1KB8 LEVSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHDGILNLEAPRGGRHLDTE .:: ..: .: :.:::.:::: : : .:::::: . ..:: ::.:....:: NP_001 IEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPER 40 50 60 70 80 90 160 170 180 pF1KB8 VNEVYISLLPAPPDPEEEEEAAIVEP NP_001 TIPITREEKPAVTAAPKK 100 >>XP_005261150 (OMIM: 123580,604219) PREDICTED: alpha-cr (136 aa) initn: 262 init1: 262 opt: 277 Z-score: 355.9 bits: 72.0 E(85289): 4.4e-13 Smith-Waterman score: 277; 37.5% identity (64.8% similar) in 128 aa overlap (51-178:12-133) 30 40 50 60 70 80 pF1KB8 PSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGSRAGASELRLSEGKFQAFLDV :.: : .: : ..: .. :: :::: XP_005 MPVCPGDSHRPPKALPHLVCGRRG-RQVRSDRDKFVIFLDV 10 20 30 40 90 100 110 120 130 140 pF1KB8 SHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHDG .::.:...::.. :...:. ..: .: : ::..:::: : : ::..:: . .:: :: XP_005 KHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADG 50 60 70 80 90 100 150 160 170 180 pF1KB8 ILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIVEP .:.. .:. ::. : : : . ::. .: XP_005 MLTFCGPKIQTGLDATHAERAI-----PVSREEKPTSAPSS 110 120 130 182 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:58:22 2016 done: Sat Nov 5 19:58:23 2016 Total Scan time: 6.140 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]