FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8891, 211 aa 1>>>pF1KB8891 211 - 211 aa - 211 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3430+/-0.000594; mu= 15.2572+/- 0.036 mean_var=83.6250+/-16.374, 0's: 0 Z-trim(113.6): 22 B-trim: 0 in 0/52 Lambda= 0.140251 statistics sampled from 14217 (14238) to 14217 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.793), E-opt: 0.2 (0.437), width: 16 Scan time: 2.330 The best scores are: opt bits E(32554) CCDS3922.1 GDNF gene_id:2668|Hs108|chr5 ( 211) 1441 300.2 6.3e-82 CCDS54845.1 GDNF gene_id:2668|Hs108|chr5 ( 228) 1441 300.2 6.7e-82 CCDS3923.1 GDNF gene_id:2668|Hs108|chr5 ( 185) 1097 230.5 5.2e-61 CCDS54846.1 GDNF gene_id:2668|Hs108|chr5 ( 202) 1097 230.5 5.5e-61 CCDS75237.1 GDNF gene_id:2668|Hs108|chr5 ( 159) 1089 228.8 1.4e-60 CCDS12151.1 NRTN gene_id:4902|Hs108|chr19 ( 197) 336 76.6 1.2e-14 >>CCDS3922.1 GDNF gene_id:2668|Hs108|chr5 (211 aa) initn: 1441 init1: 1441 opt: 1441 Z-score: 1584.3 bits: 300.2 E(32554): 6.3e-82 Smith-Waterman score: 1441; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211) 10 20 30 40 50 60 pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR 130 140 150 160 170 180 190 200 210 pF1KB8 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI ::::::::::::::::::::::::::::::: CCDS39 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 190 200 210 >>CCDS54845.1 GDNF gene_id:2668|Hs108|chr5 (228 aa) initn: 1441 init1: 1441 opt: 1441 Z-score: 1583.8 bits: 300.2 E(32554): 6.7e-82 Smith-Waterman score: 1441; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:18-228) 10 20 30 40 pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRA ::::::::::::::::::::::::::::::::::::::::::: CCDS54 MQSLPNSNGAAAGRDFKMKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 PFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 PFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB8 RGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 RGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL 130 140 150 160 170 180 170 180 190 200 210 pF1KB8 SRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI :::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 SRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 190 200 210 220 >>CCDS3923.1 GDNF gene_id:2668|Hs108|chr5 (185 aa) initn: 1097 init1: 1097 opt: 1097 Z-score: 1208.9 bits: 230.5 E(32554): 5.2e-61 Smith-Waterman score: 1197; 87.2% identity (87.7% similar) in 211 aa overlap (1-211:1-185) 10 20 30 40 50 60 pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQ :::::::::::::::::::::::: .::::::::: CCDS39 MKLWDVVAVCLVLLHTASAFPLPA--------------------------ANMPEDYPDQ 10 20 30 70 80 90 100 110 120 pF1KB8 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 FDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS39 TAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCR 100 110 120 130 140 150 190 200 210 pF1KB8 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI ::::::::::::::::::::::::::::::: CCDS39 PIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 160 170 180 >>CCDS54846.1 GDNF gene_id:2668|Hs108|chr5 (202 aa) initn: 1097 init1: 1097 opt: 1097 Z-score: 1208.4 bits: 230.5 E(32554): 5.5e-61 Smith-Waterman score: 1197; 87.2% identity (87.7% similar) in 211 aa overlap (1-211:18-202) 10 20 30 40 pF1KB8 MKLWDVVAVCLVLLHTASAFPLPAGKRPPEAPAEDRSLGRRRA :::::::::::::::::::::::: CCDS54 MQSLPNSNGAAAGRDFKMKLWDVVAVCLVLLHTASAFPLPA------------------- 10 20 30 40 50 60 70 80 90 100 pF1KB8 PFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENS .:::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 -------ANMPEDYPDQFDDVMDFIQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENS 50 60 70 80 90 110 120 130 140 150 160 pF1KB8 RGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 RGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL 100 110 120 130 140 150 170 180 190 200 210 pF1KB8 SRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI :::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 SRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 160 170 180 190 200 >>CCDS75237.1 GDNF gene_id:2668|Hs108|chr5 (159 aa) initn: 1089 init1: 1089 opt: 1089 Z-score: 1201.0 bits: 228.8 E(32554): 1.4e-60 Smith-Waterman score: 1089; 100.0% identity (100.0% similar) in 159 aa overlap (53-211:1-159) 30 40 50 60 70 80 pF1KB8 PAGKRPPEAPAEDRSLGRRRAPFALSSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQ :::::::::::::::::::::::::::::: CCDS75 MPEDYPDQFDDVMDFIQATIKRLKRSPDKQ 10 20 30 90 100 110 120 130 140 pF1KB8 MAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 MAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIF 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 RYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 RYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRK 100 110 120 130 140 150 210 pF1KB8 HSAKRCGCI ::::::::: CCDS75 HSAKRCGCI >>CCDS12151.1 NRTN gene_id:4902|Hs108|chr19 (197 aa) initn: 322 init1: 156 opt: 336 Z-score: 376.3 bits: 76.6 E(32554): 1.2e-14 Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (98-211:87-197) 70 80 90 100 110 120 pF1KB8 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV :.:. :...: : : : : ... : CCDS12 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD ..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..: CCDS12 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED 120 130 140 150 160 170 190 200 210 pF1KB8 DLSFLDDNLVYHILRKHSAKRCGCI ..:::: . :: ... ::..:.:. CCDS12 EVSFLDAHSRYHTVHELSARECACV 180 190 211 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:22:26 2016 done: Fri Nov 4 16:22:26 2016 Total Scan time: 2.330 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]