FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8897, 224 aa 1>>>pF1KB8897 224 - 224 aa - 224 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7534+/-0.000747; mu= 9.7909+/- 0.046 mean_var=155.9547+/-31.794, 0's: 0 Z-trim(115.1): 156 B-trim: 0 in 0/52 Lambda= 0.102701 statistics sampled from 15465 (15635) to 15465 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.814), E-opt: 0.2 (0.48), width: 16 Scan time: 2.510 The best scores are: opt bits E(32554) CCDS11531.1 HOXB6 gene_id:3216|Hs108|chr17 ( 224) 1567 242.8 1.3e-64 CCDS8871.1 HOXC6 gene_id:3223|Hs108|chr12 ( 235) 632 104.3 6.9e-23 CCDS5407.1 HOXA6 gene_id:3203|Hs108|chr7 ( 233) 589 97.9 5.6e-21 CCDS41792.1 HOXC6 gene_id:3223|Hs108|chr12 ( 153) 497 84.1 5.3e-17 CCDS2269.1 HOXD4 gene_id:3233|Hs108|chr2 ( 255) 484 82.4 2.9e-16 CCDS5406.1 HOXA5 gene_id:3202|Hs108|chr7 ( 270) 480 81.8 4.5e-16 CCDS8873.1 HOXC4 gene_id:3221|Hs108|chr12 ( 264) 474 80.9 8.3e-16 CCDS11532.1 HOXB7 gene_id:3217|Hs108|chr17 ( 217) 472 80.6 8.9e-16 CCDS11530.1 HOXB5 gene_id:3215|Hs108|chr17 ( 269) 460 78.9 3.5e-15 CCDS11529.1 HOXB4 gene_id:3214|Hs108|chr17 ( 251) 457 78.4 4.6e-15 CCDS8870.1 HOXC8 gene_id:3224|Hs108|chr12 ( 242) 452 77.6 7.5e-15 CCDS11533.1 HOXB8 gene_id:3218|Hs108|chr17 ( 243) 439 75.7 2.8e-14 CCDS5408.1 HOXA7 gene_id:3204|Hs108|chr7 ( 230) 436 75.3 3.7e-14 CCDS5405.1 HOXA4 gene_id:3201|Hs108|chr7 ( 320) 437 75.5 4.2e-14 CCDS8872.1 HOXC5 gene_id:3222|Hs108|chr12 ( 222) 422 73.2 1.5e-13 CCDS2268.1 HOXD8 gene_id:3234|Hs108|chr2 ( 290) 396 69.4 2.7e-12 CCDS56148.1 HOXD8 gene_id:3234|Hs108|chr2 ( 289) 394 69.1 3.3e-12 CCDS56149.1 HOXD8 gene_id:3234|Hs108|chr2 ( 106) 365 64.4 3.2e-11 >>CCDS11531.1 HOXB6 gene_id:3216|Hs108|chr17 (224 aa) initn: 1567 init1: 1567 opt: 1567 Z-score: 1273.4 bits: 242.8 E(32554): 1.3e-64 Smith-Waterman score: 1567; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224) 10 20 30 40 50 60 pF1KB8 MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGETEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGETEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 QKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 QKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIA 130 140 150 160 170 180 190 200 210 220 pF1KB8 HALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE :::::::::::::::::::::::::::::::::::::::::::: CCDS11 HALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE 190 200 210 220 >>CCDS8871.1 HOXC6 gene_id:3223|Hs108|chr12 (235 aa) initn: 607 init1: 486 opt: 632 Z-score: 524.4 bits: 104.3 E(32554): 6.9e-23 Smith-Waterman score: 635; 48.3% identity (72.7% similar) in 238 aa overlap (1-224:1-229) 10 20 30 40 50 60 pF1KB8 MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYP :.:::.: .. ::.::. : .. : :..: ::.::. . :: . .:.. ..: : : CCDS88 MNSYFTNPSLSCHLAGGQD-VLPNVALNSTAY-DPVRHF-STYGAAVAQNRIYSTPFYSP 10 20 30 40 50 70 80 90 100 110 pF1KB8 PAGGGYGRA-APCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQD-KSVFGET . .. . .: ::: . .::.::. ::. .. : ... ::: .: :.: CCDS88 QENVVFSSSRGPYDYG-SNSFYQEKD---MLSNCRQNTLGHN--TQTSIAQDFSSEQGRT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 --EEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRR ..:: : .::::::::: .. ..: . ::::: :.::::::::::::.::::::::: CCDS88 APQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRR 120 130 140 150 160 170 180 190 200 210 220 pF1KB8 IEIAHALCLTERQIKIWFQNRRMKWKKESKLLS----------ASQLSAEEEEEKQAE ::::.::::::::::::::::::::::::.: : :..:...::.....: CCDS88 IEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEE 180 190 200 210 220 230 CCDS88 KQKE >>CCDS5407.1 HOXA6 gene_id:3203|Hs108|chr7 (233 aa) initn: 780 init1: 551 opt: 589 Z-score: 490.0 bits: 97.9 E(32554): 5.6e-21 Smith-Waterman score: 815; 57.2% identity (75.8% similar) in 236 aa overlap (1-224:1-233) 10 20 30 40 50 60 pF1KB8 MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYP ::::::: ::: .: :::.:::::::::..:: : :: .:: :: . :: ... .: CCDS54 MSSYFVNPTFPGSLPSGQDSFLGQLPLYQAGY-DALRPFPASYGASSLPDKTYTSPCFYQ 10 20 30 40 50 70 80 90 100 pF1KB8 PAGG--GYGRAAPCDYGPAPAFYREKE-SACALSGADEQ-PP-----FHPEPR-KSDCA- ... . .::. .:: : :: .:. :. . ::. .: : : :: . : : . CCDS54 QSNSVLACNRASY-EYG-ASCFYSDKDLSGASPSGSGKQRGPGDYLHFSPEQQYKPDSSS 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 -QDKSVFGETEEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYN : :.. : ..: ..:::::::::::: .. .: :::::::::::::::::::::.: CCDS54 GQGKALHDEGADRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHFN 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 RYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE ::::::::::::.:::::::::::::::::::::::.::....: :.:. : : .: CCDS54 RYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSGEDSEAKAGE 180 190 200 210 220 230 >>CCDS41792.1 HOXC6 gene_id:3223|Hs108|chr12 (153 aa) initn: 531 init1: 486 opt: 497 Z-score: 418.7 bits: 84.1 E(32554): 5.3e-17 Smith-Waterman score: 500; 60.9% identity (81.2% similar) in 133 aa overlap (105-224:15-147) 80 90 100 110 120 130 pF1KB8 GPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQD-KSVFGET--EEQKCSTPVYPWM ... ::: .: :.: ..:: : .:::: CCDS41 MLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQKASIQIYPWM 10 20 30 40 140 150 160 170 180 190 pF1KB8 QRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIK ::::: .. ..: . ::::: :.::::::::::::.:::::::::::::.:::::::::: CCDS41 QRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIK 50 60 70 80 90 100 200 210 220 pF1KB8 IWFQNRRMKWKKESKLLS----------ASQLSAEEEEEKQAE ::::::::::::::.: : :..:...::.....: CCDS41 IWFQNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE 110 120 130 140 150 >>CCDS2269.1 HOXD4 gene_id:3233|Hs108|chr2 (255 aa) initn: 440 init1: 371 opt: 484 Z-score: 405.5 bits: 82.4 E(32554): 2.9e-16 Smith-Waterman score: 484; 44.7% identity (58.0% similar) in 226 aa overlap (1-207:3-215) 10 20 30 40 pF1KB8 MSSYFVNST-----FPVTLASGQESFLGQL--PLYSSGY--AD--PLRHYPAP-YGPG ::::.::: :: : ..::. :..: :: : :: : .: CCDS22 MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 PGQDKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEP--- : .: . .: : : : ..: . ::. : : :: : : CCDS22 PFGGSGPGPGSALPARGHGQEPGGPGGHYAAPG------EPCP---APPAPPPAPLPGAR 70 80 90 100 110 110 120 130 140 150 pF1KB8 --RKSDCAQDKSVFGETEEQKCSTPVYPWMQRM--NSCNSSSFGPSGRRGRQTYTRYQTL .:: : : : . .: . :::::... :: : . : .:.: .::: :.: CCDS22 AYSQSDPKQPPS--GTALKQP--AVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVL 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 ELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEE :::::::.::::::::::::::.:::.:::::::::::::::::. :: CCDS22 ELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSS 170 180 190 200 210 220 220 pF1KB8 EKQAE CCDS22 SSSCSSSVAPSQHLQPMAKDHHTDLTTL 230 240 250 >>CCDS5406.1 HOXA5 gene_id:3202|Hs108|chr7 (270 aa) initn: 528 init1: 448 opt: 480 Z-score: 402.0 bits: 81.8 E(32554): 4.5e-16 Smith-Waterman score: 482; 45.5% identity (67.4% similar) in 187 aa overlap (30-215:95-264) 10 20 30 40 50 pF1KB8 MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYP-APYGPGPGQDKGFATSSY : ::: : . .:.::.:. . .. CCDS54 GSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPL---PCSAVAPSPGSDSHHGGKNS 70 80 90 100 110 120 60 70 80 90 100 110 pF1KB8 YPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGET ..: : : : . .:.. . :::.:. : : ... .. : . CCDS54 LSNSSG-----ASADAGST--HISSREGVGTASGAEEDAPASSE--QASAQSEPSPAPPA 130 140 150 160 170 120 130 140 150 160 170 pF1KB8 EEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIE . : .::::.... ... :: :.:.: .::::::::::::::.::::::::::: CCDS54 QPQ-----IYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIE 180 190 200 210 220 180 190 200 210 220 pF1KB8 IAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE :::::::.:::::::::::::::::..:: : :. .: CCDS54 IAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP 230 240 250 260 270 >>CCDS8873.1 HOXC4 gene_id:3221|Hs108|chr12 (264 aa) initn: 388 init1: 356 opt: 474 Z-score: 397.3 bits: 80.9 E(32554): 8.3e-16 Smith-Waterman score: 474; 41.1% identity (61.5% similar) in 231 aa overlap (1-215:8-225) 10 20 30 40 pF1KB8 MSSYFVNSTFPVTLASGQESFLGQL-PLY-----SSGYADPLRH-YPAPYGPG :.: ... :: .:.:.. . : : ::. .. :: : : CCDS88 MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPP-PPR 10 20 30 40 50 50 60 70 80 90 pF1KB8 PGQ-DKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKE---SACA---LSGADEQPPF :. .. .. .: : :.. : .::: : ... : : : ::::. .: CCDS88 PSYPERQYSCTSLQGP-GNSRG------HGPAQAGHHHPEKSQSLCEPAPLSGASASPS- 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB8 HPEPRKSDCAQDKSVFGETEEQKCSTPVYPWMQRMN--SCNSSSFGPSGRRGRQTYTRYQ : : :.: . .: . :::::.... . : . : .:.: .::: : CCDS88 -PAP--PACSQPAPDHPSSAASK-QPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQ 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 TLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEE .:::::::::::::::::::::::.:::.:::::::::::::::::. .: ... :: CCDS88 VLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPP 170 180 190 200 210 220 220 pF1KB8 EEEKQAE CCDS88 AGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL 230 240 250 260 >>CCDS11532.1 HOXB7 gene_id:3217|Hs108|chr17 (217 aa) initn: 498 init1: 393 opt: 472 Z-score: 396.7 bits: 80.6 E(32554): 8.9e-16 Smith-Waterman score: 506; 45.1% identity (63.4% similar) in 235 aa overlap (1-222:1-216) 10 20 30 40 50 pF1KB8 MSS-YFVNSTFPVTLASGQESFLGQLPLYSS-GYA-DPLRHYPAPYGPGPGQDKGFATSS ::: :..:. : ::.. : .: .: ..: .: : :. :: : : . . . .. CCDS11 MSSLYYANTLFSKYPASSSVFATGAFPEQTSCAFASNPQR--PG-YGAGSGASFAASMQG 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 YYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGE :: .:: :..: : : : . :. . : ::. . .. : :.. . CCDS11 LYPGGGGMAGQSAA---GVYAAGYGLEPSSFNMHCA----PFE-QNLSGVCPGDSAKAAG 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 TEEQKCST-------PVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRY ..::. : .::::. : : . .::::::::::::::::::::::: CCDS11 AKEQRDSDLAAESNFRIYPWMR--------SSGTDRKRGRQTYTRYQTLELEKEFHYNRY 110 120 130 140 150 160 180 190 200 210 220 pF1KB8 LTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLL---SASQLSAEEEEEKQAE :::::::::::.::::::::::::::::::::::.: ...: :: :::.. CCDS11 LTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTAGPGTTGQDRAEAEEEEEE 170 180 190 200 210 >>CCDS11530.1 HOXB5 gene_id:3215|Hs108|chr17 (269 aa) initn: 507 init1: 411 opt: 460 Z-score: 386.0 bits: 78.9 E(32554): 3.5e-15 Smith-Waterman score: 461; 45.5% identity (63.5% similar) in 189 aa overlap (45-215:77-263) 20 30 40 50 60 pF1KB8 ASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGF--ATSS-------YYPPAGGG :.:.:. : :.:: : ..: CCDS11 YNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQEPRFRQAASSCSLSSPESLPCTNGD 50 60 70 80 90 100 70 80 90 100 110 pF1KB8 YGRAAPCDYGPAP--------AFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGE : : .:. : . : . : : : .: : . :: . . CCDS11 SHGAKPSASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLAR-AQPEPMATS 110 120 130 140 150 160 120 130 140 150 160 170 pF1KB8 TEEQKCSTP-VYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRR : . .:: ..:::.... .. . ::.:.:.: .::::::::::::::.::::::::: CCDS11 TAAPEGQTPQIFPWMRKLHISHDMT-GPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRR 170 180 190 200 210 220 180 190 200 210 220 pF1KB8 IEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEEKQAE :::::::::.:::::::::::::::::..:: : : .: CCDS11 IEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP 230 240 250 260 >>CCDS11529.1 HOXB4 gene_id:3214|Hs108|chr17 (251 aa) initn: 417 init1: 361 opt: 457 Z-score: 383.9 bits: 78.4 E(32554): 4.6e-15 Smith-Waterman score: 475; 43.1% identity (60.2% similar) in 211 aa overlap (2-207:26-223) 10 20 30 pF1KB8 MSSYFVNSTFPVTLASGQESFLGQLPLYSSGY--AD :.:. .. : :.::. . : . : : CCDS11 MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAAC 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 PLRHYPAPYGPGPGQDKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGAD ...: : ::: :: : . :: :: :. : . : ... CCDS11 TVQRYAACRDPGPPPPPPPPPP---PPPPPGLSPRAPAP-PPAGALLPEPGQRC--EAVS 70 80 90 100 110 100 110 120 130 140 150 pF1KB8 EQPPFHPEPRKSDCAQDKSVFGETEEQKCSTPV-YPWMQRMN--SCNSSSFGPSGRRGRQ .:: : : :::. . .. :. :: ::::.... . : . : .:.: CCDS11 SSPP--PPP----CAQNP-LHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRT 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 TYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSAS .::: :.::::::::::::::::::.::::::::.:::::::::::::::::. :: CCDS11 AYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTK 170 180 190 200 210 220 220 pF1KB8 QLSAEEEEEKQAE CCDS11 IRSGGAAGSAGGPPGRPNGGPRAL 230 240 250 224 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:24:38 2016 done: Fri Nov 4 16:24:39 2016 Total Scan time: 2.510 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]