FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8914, 255 aa 1>>>pF1KB8914 255 - 255 aa - 255 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.6810+/-0.000959; mu= 1.0509+/- 0.059 mean_var=448.1703+/-92.224, 0's: 0 Z-trim(118.9): 102 B-trim: 202 in 1/54 Lambda= 0.060583 statistics sampled from 19927 (20034) to 19927 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.863), E-opt: 0.2 (0.615), width: 16 Scan time: 2.710 The best scores are: opt bits E(32554) CCDS2269.1 HOXD4 gene_id:3233|Hs108|chr2 ( 255) 1819 171.7 4.3e-43 CCDS8873.1 HOXC4 gene_id:3221|Hs108|chr12 ( 264) 903 91.7 5.5e-19 CCDS11529.1 HOXB4 gene_id:3214|Hs108|chr17 ( 251) 852 87.2 1.2e-17 CCDS5405.1 HOXA4 gene_id:3201|Hs108|chr7 ( 320) 744 77.9 9.4e-15 >>CCDS2269.1 HOXD4 gene_id:3233|Hs108|chr2 (255 aa) initn: 1819 init1: 1819 opt: 1819 Z-score: 887.2 bits: 171.7 E(32554): 4.3e-43 Smith-Waterman score: 1819; 99.6% identity (99.6% similar) in 255 aa overlap (1-255:1-255) 10 20 30 40 50 60 pF1KB8 MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGGGAQGADFQPPGLYPRPDFGEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARAYSQSDPKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PFGGSGPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPAPLPGARAYSQSDPKQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLT :: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PPSGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 RRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 RRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQH 190 200 210 220 230 240 250 pF1KB8 LQPMAKDHHTDLTTL ::::::::::::::: CCDS22 LQPMAKDHHTDLTTL 250 >>CCDS8873.1 HOXC4 gene_id:3221|Hs108|chr12 (264 aa) initn: 828 init1: 597 opt: 903 Z-score: 454.3 bits: 91.7 E(32554): 5.5e-19 Smith-Waterman score: 903; 54.4% identity (73.5% similar) in 272 aa overlap (1-255:1-264) 10 20 30 40 50 pF1KB8 MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYG----GGAQG--ADFQPPGLYPR :.::::...:.:.:::::::::: :..:. :.. .::: .: : .. :: :: CCDS88 MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPP-PPR 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 PDFGEQPFGGSG-PGPGSALPARGHGQEPGGPGGHYAAPGEP-C-PAPPAPPPA-PLPGA :.. :. .. .. :::.. :::: :. : :. .. : ::: . : : :. CCDS88 PSYPERQYSCTSLQGPGNS---RGHG--PAQAGHHHPEKSQSLCEPAPLSGASASPSPAP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 RAYSQSDPKQPPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELE : :: : .: ..: ::: .:::::::.::..:::::.:::::::::::::::::::: CCDS88 PACSQPAPDHPS-SAASKQP-IVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELE 120 130 140 150 160 170 180 190 200 210 220 pF1KB8 KEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSS------- ::::.::::::::::::::.:::::::::::::::::::::::.::::: ::. CCDS88 KEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAP 180 190 200 210 220 230 230 240 250 pF1KB8 SSSSSSSCSSSVAPSQHLQPMAKDHHTDLTTL :. :... ..: :: : ... :.: : CCDS88 STLSAATPGTSEDHSQSATPPEQQRAEDITRL 240 250 260 >>CCDS11529.1 HOXB4 gene_id:3214|Hs108|chr17 (251 aa) initn: 963 init1: 599 opt: 852 Z-score: 430.5 bits: 87.2 E(32554): 1.2e-17 Smith-Waterman score: 856; 57.7% identity (71.4% similar) in 248 aa overlap (1-229:1-237) 10 20 30 40 50 pF1KB8 MVMSSYMVNSKYVDPKFPPCEEYLQGGYL-GEQGADYYGGGAQG-ADFQPP-GLYPRPDF :.:::...::.:::::::::::: :. :: .... ::.:: . ..::: :. : CCDS11 MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAAC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 GEQPFGGS-GPGPGSALPARGHGQEPGGPGGHYAAPGEPCPAPPAPPPA----PLPGAR- : ... ::: : : : :: : :::::: : :: : CCDS11 TVQRYAACRDPGPPPPPPP----PPPPPP-----PPGLS-PRAPAPPPAGALLPEPGQRC 70 80 90 100 110 120 130 140 150 160 pF1KB8 -AYSQSDPKQP---------PPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAY : :.: : : : .: :.: ::::::.::::..:::::.::::::::::: CCDS11 EAVSSSPPPPPCAQNPLHPSPSHSACKEP-VVYPWMRKVHVSTVNPNYAGGEPKRSRTAY 120 130 140 150 160 170 180 190 200 210 220 pF1KB8 TRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGR :::::::::::::.:::::::::.::::.::::::::::::::::::::::::::::: : CCDS11 TRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIR 170 180 190 200 210 220 230 240 250 pF1KB8 SSSSSSSSSCSSSVAPSQHLQPMAKDHHTDLTTL :.....:. CCDS11 SGGAAGSAGGPPGRPNGGPRAL 230 240 250 >>CCDS5405.1 HOXA4 gene_id:3201|Hs108|chr7 (320 aa) initn: 835 init1: 633 opt: 744 Z-score: 378.4 bits: 77.9 E(32554): 9.4e-15 Smith-Waterman score: 744; 53.2% identity (66.5% similar) in 248 aa overlap (4-243:71-306) 10 20 30 pF1KB8 MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQG .::.. .: .: : : CCDS54 GYQQPPAPPTQHLPLQQPQLPHAGGGREPTASYYAPRTAREPAYPAAALYPAHGAADTAY 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB8 ADYYGGGAQGADFQPPGLYPRPDFGEQPFGGSGPGPGSALPARGHGQEPGGPGG---HYA : :::. :: :.: ::: ... ::. .: : .: .: : . . CCDS54 PYGYRGGAS------PGRPPQP---EQP-PAQAKGPAHGLHA-SHVLQPQLPPPLQPRAV 110 120 130 140 100 110 120 130 140 pF1KB8 APGEP--CPAPPAPPPAPLPG-ARAYSQSDPKQPPPGTALKQPAVVYPWMKKVHVNSVNP :. : : : :: : .: : : : . : : :.: ::::::::.::..::: CCDS54 PPAAPRRCEAAPATPGVPAGGSAPACPLLLADKSPLGLKGKEP-VVYPWMKKIHVSAVNP 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB8 NYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRM .:.:::::::::::::::::::::::::::::::::::::::::::::::.::::::::: CCDS54 SYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRM 210 220 230 240 250 260 210 220 230 240 250 pF1KB8 KWKKDHKLPNTKGRSSSSSSSSSCSSSVAPSQ--HLQPMAKDHHTDLTTL :::::::::::: :::.:.:.:. . : .: ::.: CCDS54 KWKKDHKLPNTKMRSSNSASASAGPPGKAQTQSPHLHPHPHPSTSTPVPSSI 270 280 290 300 310 320 255 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:28:36 2016 done: Fri Nov 4 16:28:37 2016 Total Scan time: 2.710 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]