FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8919, 264 aa 1>>>pF1KB8919 264 - 264 aa - 264 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3941+/-0.00083; mu= 6.1050+/- 0.051 mean_var=293.6398+/-59.611, 0's: 0 Z-trim(117.7): 131 B-trim: 1047 in 1/55 Lambda= 0.074846 statistics sampled from 18359 (18511) to 18359 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.843), E-opt: 0.2 (0.569), width: 16 Scan time: 2.830 The best scores are: opt bits E(32554) CCDS8873.1 HOXC4 gene_id:3221|Hs108|chr12 ( 264) 1873 214.3 7.2e-56 CCDS11529.1 HOXB4 gene_id:3214|Hs108|chr17 ( 251) 925 111.9 4.5e-25 CCDS2269.1 HOXD4 gene_id:3233|Hs108|chr2 ( 255) 909 110.2 1.5e-24 CCDS5405.1 HOXA4 gene_id:3201|Hs108|chr7 ( 320) 705 88.3 7.5e-18 CCDS5406.1 HOXA5 gene_id:3202|Hs108|chr7 ( 270) 529 69.2 3.5e-12 CCDS11530.1 HOXB5 gene_id:3215|Hs108|chr17 ( 269) 497 65.7 3.9e-11 >>CCDS8873.1 HOXC4 gene_id:3221|Hs108|chr12 (264 aa) initn: 1873 init1: 1873 opt: 1873 Z-score: 1116.6 bits: 214.3 E(32554): 7.2e-56 Smith-Waterman score: 1873; 100.0% identity (100.0% similar) in 264 aa overlap (1-264:1-264) 10 20 30 40 50 60 pF1KB8 MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 SYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 APDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 APDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 LTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATP 190 200 210 220 230 240 250 260 pF1KB8 GTSEDHSQSATPPEQQRAEDITRL :::::::::::::::::::::::: CCDS88 GTSEDHSQSATPPEQQRAEDITRL 250 260 >>CCDS11529.1 HOXB4 gene_id:3214|Hs108|chr17 (251 aa) initn: 1092 init1: 704 opt: 925 Z-score: 563.6 bits: 111.9 E(32554): 4.5e-25 Smith-Waterman score: 953; 59.9% identity (71.8% similar) in 252 aa overlap (1-231:1-237) 10 20 30 40 pF1KB8 MIMSSYLMDSNYIDPKFPPCEEYSQNSYIP-EHSPEYY--GRTRESGFQHHH-------- : :::.:..:::.::::::::::::..:.: .::: :: :. :::.:: . CCDS11 MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAAC 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 --------QELYPPPPPRPSYPERQYSCTSLQGPGNS-RGHGPAQAGHHHPEKSQSLCEP .. ::::: : : :: : :. .: :: :: .: :: CCDS11 TVQRYAACRDPGPPPPPPPPPPPPP-------PPGLSPRAPAPPPAGALLPEPGQR-CE- 70 80 90 100 110 110 120 130 140 150 pF1KB8 APLSGASASPSPAPPACSQ-PAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRS ..: :: :: :.: : :: .: :.:.:::::.:.::::::::: ::::::: CCDS11 ------AVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRS 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 RTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPN :::::::::::::::::::::::::::.::::.:::::::::::::::::::::::.::: CCDS11 RTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPN 170 180 190 200 210 220 220 230 240 250 260 pF1KB8 TKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL ::.::. ::.: CCDS11 TKIRSGGAAGSAGGPPGRPNGGPRAL 230 240 250 >>CCDS2269.1 HOXD4 gene_id:3233|Hs108|chr2 (255 aa) initn: 828 init1: 597 opt: 909 Z-score: 554.2 bits: 110.2 E(32554): 1.5e-24 Smith-Waterman score: 909; 55.1% identity (73.5% similar) in 272 aa overlap (1-264:1-255) 10 20 30 40 50 pF1KB8 MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPP-PPR :.::::...:.:.:::::::::: :..:. :.. .::: .: : .. :: :: CCDS22 MVMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYG----GGAQG--ADFQPPGLYPR 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 PSYPERQYSCTSLQGPGNS---RGHG--PAQAGHHHPEKSQSLCEPAPLSGASASPSPAP :.. :. .. : :::.. :::: :. : :. .. : ::: . : : :. CCDS22 PDFGEQPFG-GSGPGPGSALPARGHGQEPGGPGGHYAAPGEP-C-PAPPAPPPA-PLPGA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 PACSQPAPDHP-SSAASKQP-IVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELE : :: : .: :..: ::: .:::::::.::..:::::.:::::::::::::::::::: CCDS22 RAYSQSDPKQPPSGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 KEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAP ::::.::::::::::::::.:::::::::::::::::::::::.::::: ::. CCDS22 KEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSS------- 180 190 200 210 220 240 250 260 pF1KB8 STLSAATPGTSEDHSQSATPPEQQRAEDITRL :. :... ..: :: : ... :.: : CCDS22 SSSSSSSCSSSVAPSQHLQPMAKDHHTDLTTL 230 240 250 >>CCDS5405.1 HOXA4 gene_id:3201|Hs108|chr7 (320 aa) initn: 820 init1: 659 opt: 705 Z-score: 434.0 bits: 88.3 E(32554): 7.5e-18 Smith-Waterman score: 705; 48.6% identity (62.5% similar) in 253 aa overlap (10-252:71-306) 10 20 30 pF1KB8 MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGR ..: :. : . : :. CCDS54 GYQQPPAPPTQHLPLQQPQLPHAGGGREPTASYYAPRTAREPAYPAAALYPAHGAA--DT 50 60 70 80 90 40 50 60 70 80 90 pF1KB8 TRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGP--GNSRGH------GPAQAGHHHP . :.. . : ::.: : : .:: : .: : . : CCDS54 AYPYGYRGGAS---PGRPPQPEQPPAQA-----KGPAHGLHASHVLQPQLPPPLQPRAVP 100 110 120 130 140 150 100 110 120 130 140 pF1KB8 EKSQSLCEPAPLS-GASASPSPAPPACSQPAPDH-PSSAASKQPIVYPWMKKIHVSTVNP . :: :: . :. :. : ::: :. : . .:.:.:::::::::::.::: CCDS54 PAAPRRCEAAPATPGVPAGGS--APACPLLLADKSPLGLKGKEPVVYPWMKKIHVSAVNP 160 170 180 190 200 150 160 170 180 190 200 pF1KB8 NYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRM .::::::::::::::::::::::::::.::::::::::::::.:::::::.::::::::: CCDS54 SYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRM 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB8 KWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL ::::::.:::::.::. :.: ::. :: .. .: : CCDS54 KWKKDHKLPNTKMRSSNSASA-----SAGPPGKAQTQSPHLHPHPHPSTSTPVPSSI 270 280 290 300 310 320 >>CCDS5406.1 HOXA5 gene_id:3202|Hs108|chr7 (270 aa) initn: 586 init1: 382 opt: 529 Z-score: 332.1 bits: 69.2 E(32554): 3.5e-12 Smith-Waterman score: 529; 49.2% identity (64.9% similar) in 185 aa overlap (54-231:96-267) 30 40 50 60 70 80 pF1KB8 SQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQ-GPGNSRGHG : : : : :... .::.. :: CCDS54 SGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLP--------CSAVAPSPGSDSHHG 70 80 90 100 110 90 100 110 120 130 pF1KB8 -----PAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQP-APDHPSSAASKQPIVY ..: : . .. ::.. :: . : : ..:: : :: .: CCDS54 GKNSLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIY 120 130 140 150 160 170 140 150 160 170 180 190 pF1KB8 PWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLS :::.:.:.: . : .: : ::.:::::: :.::::::::.::::::::::::::.:::: CCDS54 PWMRKLHIS--HDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLS 180 190 200 210 220 230 200 210 220 230 240 250 pF1KB8 ERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQ ::::::::::::::::::..: : : ::.: CCDS54 ERQIKIWFQNRRMKWKKDNKL---KSMSMAAAGGAFRP 240 250 260 270 260 pF1KB8 RAEDITRL >>CCDS11530.1 HOXB5 gene_id:3215|Hs108|chr17 (269 aa) initn: 452 init1: 384 opt: 497 Z-score: 313.5 bits: 65.7 E(32554): 3.9e-11 Smith-Waterman score: 520; 46.2% identity (67.2% similar) in 195 aa overlap (53-228:76-266) 30 40 50 60 70 pF1KB8 YSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGP------- .: : .: . . :: ::..: CCDS11 GYNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQEPRFRQAASSC-SLSSPESLPCTN 50 60 70 80 90 100 80 90 100 110 120 pF1KB8 GNSRGHGP-AQAGHHHPEKSQSLCEPAPLSGASASPSPAPPAC---------SQPAPDHP :.:.: : :.. . ...: . . .. :::: : : .:: : CCDS11 GDSHGAKPSASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMAT 110 120 130 140 150 160 130 140 150 160 170 180 pF1KB8 SSAA--SKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTR :.:: .. : ..:::.:.:.: ...: . ::.:::::: :.::::::::.:::::: CCDS11 STAAPEGQTPQIFPWMRKLHIS---HDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTR 170 180 190 200 210 220 190 200 210 220 230 240 pF1KB8 RRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTS ::::::::.::::::::::::::::::::::..: . .. .: : CCDS11 RRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP 230 240 250 260 250 260 pF1KB8 EDHSQSATPPEQQRAEDITRL 264 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:29:59 2016 done: Fri Nov 4 16:30:00 2016 Total Scan time: 2.830 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]