FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8932, 283 aa 1>>>pF1KB8932 283 - 283 aa - 283 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.8534+/-0.000332; mu= -2.2816+/- 0.021 mean_var=317.4752+/-64.608, 0's: 0 Z-trim(126.0): 198 B-trim: 888 in 2/60 Lambda= 0.071981 statistics sampled from 50654 (50914) to 50654 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.85), E-opt: 0.2 (0.597), width: 16 Scan time: 8.220 The best scores are: opt bits E(85289) NP_000200 (OMIM: 125853,260370,600733,606176,60639 ( 283) 2029 223.0 5e-58 XP_005249788 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 463 60.6 6.1e-09 XP_005249789 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 463 60.6 6.1e-09 XP_006715778 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 463 60.6 6.1e-09 XP_011513645 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 463 60.6 6.1e-09 XP_005249787 (OMIM: 142954) PREDICTED: homeobox pr ( 443) 463 60.6 6.1e-09 NP_705895 (OMIM: 142954) homeobox protein Hox-A3 i ( 443) 463 60.6 6.1e-09 NP_109377 (OMIM: 142954) homeobox protein Hox-A3 i ( 443) 463 60.6 6.1e-09 NP_002132 (OMIM: 142953) homeobox protein Hox-A4 [ ( 320) 394 53.3 7e-07 NP_002136 (OMIM: 142967) homeobox protein Hox-B2 [ ( 356) 393 53.2 8.1e-07 XP_005246566 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 393 53.3 9.3e-07 XP_011509368 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 393 53.3 9.3e-07 NP_008829 (OMIM: 142980) homeobox protein Hox-D3 [ ( 432) 393 53.3 9.3e-07 XP_011509367 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 393 53.3 9.3e-07 XP_005246570 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 393 53.3 9.3e-07 XP_006712540 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 393 53.3 9.3e-07 XP_005246567 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 393 53.3 9.3e-07 XP_005246568 (OMIM: 142980) PREDICTED: homeobox pr ( 432) 393 53.3 9.3e-07 NP_076920 (OMIM: 142965) homeobox protein Hox-B4 [ ( 251) 387 52.5 9.7e-07 NP_055436 (OMIM: 142981) homeobox protein Hox-D4 [ ( 255) 380 51.7 1.6e-06 NP_055435 (OMIM: 142974) homeobox protein Hox-C4 [ ( 264) 377 51.4 2.1e-06 NP_705897 (OMIM: 142974) homeobox protein Hox-C4 [ ( 264) 377 51.4 2.1e-06 NP_001317252 (OMIM: 142966) homeobox protein Hox-B ( 299) 367 50.5 4.7e-06 XP_011523023 (OMIM: 142966) PREDICTED: homeobox pr ( 430) 370 50.9 4.9e-06 XP_011523028 (OMIM: 142966) PREDICTED: homeobox pr ( 358) 367 50.5 5.3e-06 NP_001317251 (OMIM: 142966) homeobox protein Hox-B ( 358) 367 50.5 5.3e-06 NP_002137 (OMIM: 142966) homeobox protein Hox-B3 i ( 431) 367 50.6 6e-06 XP_011523021 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 367 50.6 6e-06 XP_005257334 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 367 50.6 6e-06 XP_006721917 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 367 50.6 6e-06 XP_011523012 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 367 50.6 6e-06 XP_011523022 (OMIM: 142966) PREDICTED: homeobox pr ( 431) 367 50.6 6e-06 XP_011523010 (OMIM: 142966) PREDICTED: homeobox pr ( 488) 367 50.7 6.6e-06 XP_016880051 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 367 50.7 7.4e-06 XP_011523009 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 367 50.7 7.4e-06 XP_016880052 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 367 50.7 7.4e-06 XP_016880047 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 367 50.7 7.4e-06 XP_016880049 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 367 50.7 7.4e-06 XP_016880046 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 367 50.7 7.4e-06 XP_016880050 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 367 50.7 7.4e-06 XP_016880048 (OMIM: 142966) PREDICTED: homeobox pr ( 578) 367 50.7 7.4e-06 NP_663632 (OMIM: 616542) GS homeobox 1 [Homo sapie ( 264) 355 49.2 1e-05 NP_061826 (OMIM: 142973) homeobox protein Hox-C5 [ ( 222) 317 45.1 0.00014 XP_005257332 (OMIM: 142967) PREDICTED: homeobox pr ( 247) 317 45.2 0.00015 NP_062458 (OMIM: 142985) homeobox protein Hox-D8 i ( 290) 318 45.4 0.00015 NP_005506 (OMIM: 142994,176450) motor neuron and p ( 401) 320 45.7 0.00017 NP_001186675 (OMIM: 142985) homeobox protein Hox-D ( 289) 315 45.0 0.00019 NP_001795 (OMIM: 600746) homeobox protein CDX-1 [H ( 265) 312 44.7 0.00022 NP_061975 (OMIM: 142952) homeobox protein Hox-A5 [ ( 270) 311 44.6 0.00024 NP_061825 (OMIM: 142961) homeobox protein Hox-B6 [ ( 224) 309 44.3 0.00025 >>NP_000200 (OMIM: 125853,260370,600733,606176,606392) p (283 aa) initn: 2029 init1: 2029 opt: 2029 Z-score: 1162.8 bits: 223.0 E(85289): 5e-58 Smith-Waterman score: 2029; 100.0% identity (100.0% similar) in 283 aa overlap (1-283:1-283) 10 20 30 40 50 60 pF1KB8 MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 WMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 WMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPP 190 200 210 220 230 240 250 260 270 280 pF1KB8 PPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR ::::::::::::::::::::::::::::::::::::::::::: NP_000 PPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR 250 260 270 280 >>XP_005249788 (OMIM: 142954) PREDICTED: homeobox protei (443 aa) initn: 453 init1: 310 opt: 463 Z-score: 281.5 bits: 60.6 E(85289): 6.1e-09 Smith-Waterman score: 477; 35.4% identity (55.4% similar) in 316 aa overlap (2-281:27-327) 10 20 pF1KB8 MNGEEQYYAAT-------QLYKDPCAFQR----GP :...: : :. . .. :..: : XP_005 MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGG 10 20 30 40 50 60 30 40 50 60 70 pF1KB8 APEFSASPPACLYMGRQPP--PP----PP-HPFPGALGALEQGSPPDISPYEVPPLADDP :. ::: :: :: :: :: : .: .::. .: :: : : XP_005 HPKAHELSEACLRTLSAPPSQPPSLGEPPLHP-PPPQAAPPAPQPPQPAPQ--PP-APTP 70 80 90 100 110 80 90 100 110 120 130 pF1KB8 AVAHLHHHLPAQLALPHPPAG--PFP-EGAEPGVLEEPNRVQLPFPWMKSTKAHAWK--- :. : . : : :. : : ..:. .:. :. .. ::::: .. .. . XP_005 AAPP-----PPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTS 120 130 140 150 160 170 140 150 160 170 180 pF1KB8 ----GQWAGGAYAAEPEEN-KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLT :. .: . . . ::.::::: :::.:::::: ::.:. ::::::.: .:::: XP_005 SSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLT 180 190 200 210 220 230 190 200 210 220 230 pF1KB8 ERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAE----PEQDCAVTSGEELL-ALP-- ::.:::::::::::.::.. : .: :. :: . .. : ..: . :. ..: XP_005 ERQIKIWFQNRRMKYKKDQ-KGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYE 240 250 260 270 280 290 240 250 260 270 280 pF1KB8 PPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR : :: . :: . . :::. . :: . : ::. XP_005 PQSPPPFSKPPQGTYG-----LPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPH 300 310 320 330 340 XP_005 AHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLG 350 360 370 380 390 400 >>XP_005249789 (OMIM: 142954) PREDICTED: homeobox protei (443 aa) initn: 453 init1: 310 opt: 463 Z-score: 281.5 bits: 60.6 E(85289): 6.1e-09 Smith-Waterman score: 477; 35.4% identity (55.4% similar) in 316 aa overlap (2-281:27-327) 10 20 pF1KB8 MNGEEQYYAAT-------QLYKDPCAFQR----GP :...: : :. . .. :..: : XP_005 MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGG 10 20 30 40 50 60 30 40 50 60 70 pF1KB8 APEFSASPPACLYMGRQPP--PP----PP-HPFPGALGALEQGSPPDISPYEVPPLADDP :. ::: :: :: :: :: : .: .::. .: :: : : XP_005 HPKAHELSEACLRTLSAPPSQPPSLGEPPLHP-PPPQAAPPAPQPPQPAPQ--PP-APTP 70 80 90 100 110 80 90 100 110 120 130 pF1KB8 AVAHLHHHLPAQLALPHPPAG--PFP-EGAEPGVLEEPNRVQLPFPWMKSTKAHAWK--- :. : . : : :. : : ..:. .:. :. .. ::::: .. .. . XP_005 AAPP-----PPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTS 120 130 140 150 160 170 140 150 160 170 180 pF1KB8 ----GQWAGGAYAAEPEEN-KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLT :. .: . . . ::.::::: :::.:::::: ::.:. ::::::.: .:::: XP_005 SSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLT 180 190 200 210 220 230 190 200 210 220 230 pF1KB8 ERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAE----PEQDCAVTSGEELL-ALP-- ::.:::::::::::.::.. : .: :. :: . .. : ..: . :. ..: XP_005 ERQIKIWFQNRRMKYKKDQ-KGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYE 240 250 260 270 280 290 240 250 260 270 280 pF1KB8 PPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR : :: . :: . . :::. . :: . : ::. XP_005 PQSPPPFSKPPQGTYG-----LPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPH 300 310 320 330 340 XP_005 AHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLG 350 360 370 380 390 400 >>XP_006715778 (OMIM: 142954) PREDICTED: homeobox protei (443 aa) initn: 453 init1: 310 opt: 463 Z-score: 281.5 bits: 60.6 E(85289): 6.1e-09 Smith-Waterman score: 477; 35.4% identity (55.4% similar) in 316 aa overlap (2-281:27-327) 10 20 pF1KB8 MNGEEQYYAAT-------QLYKDPCAFQR----GP :...: : :. . .. :..: : XP_006 MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGG 10 20 30 40 50 60 30 40 50 60 70 pF1KB8 APEFSASPPACLYMGRQPP--PP----PP-HPFPGALGALEQGSPPDISPYEVPPLADDP :. ::: :: :: :: :: : .: .::. .: :: : : XP_006 HPKAHELSEACLRTLSAPPSQPPSLGEPPLHP-PPPQAAPPAPQPPQPAPQ--PP-APTP 70 80 90 100 110 80 90 100 110 120 130 pF1KB8 AVAHLHHHLPAQLALPHPPAG--PFP-EGAEPGVLEEPNRVQLPFPWMKSTKAHAWK--- :. : . : : :. : : ..:. .:. :. .. ::::: .. .. . XP_006 AAPP-----PPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTS 120 130 140 150 160 170 140 150 160 170 180 pF1KB8 ----GQWAGGAYAAEPEEN-KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLT :. .: . . . ::.::::: :::.:::::: ::.:. ::::::.: .:::: XP_006 SSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLT 180 190 200 210 220 230 190 200 210 220 230 pF1KB8 ERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAE----PEQDCAVTSGEELL-ALP-- ::.:::::::::::.::.. : .: :. :: . .. : ..: . :. ..: XP_006 ERQIKIWFQNRRMKYKKDQ-KGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYE 240 250 260 270 280 290 240 250 260 270 280 pF1KB8 PPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR : :: . :: . . :::. . :: . : ::. XP_006 PQSPPPFSKPPQGTYG-----LPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPH 300 310 320 330 340 XP_006 AHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLG 350 360 370 380 390 400 >>XP_011513645 (OMIM: 142954) PREDICTED: homeobox protei (443 aa) initn: 453 init1: 310 opt: 463 Z-score: 281.5 bits: 60.6 E(85289): 6.1e-09 Smith-Waterman score: 477; 35.4% identity (55.4% similar) in 316 aa overlap (2-281:27-327) 10 20 pF1KB8 MNGEEQYYAAT-------QLYKDPCAFQR----GP :...: : :. . .. :..: : XP_011 MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGG 10 20 30 40 50 60 30 40 50 60 70 pF1KB8 APEFSASPPACLYMGRQPP--PP----PP-HPFPGALGALEQGSPPDISPYEVPPLADDP :. ::: :: :: :: :: : .: .::. .: :: : : XP_011 HPKAHELSEACLRTLSAPPSQPPSLGEPPLHP-PPPQAAPPAPQPPQPAPQ--PP-APTP 70 80 90 100 110 80 90 100 110 120 130 pF1KB8 AVAHLHHHLPAQLALPHPPAG--PFP-EGAEPGVLEEPNRVQLPFPWMKSTKAHAWK--- :. : . : : :. : : ..:. .:. :. .. ::::: .. .. . XP_011 AAPP-----PPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTS 120 130 140 150 160 170 140 150 160 170 180 pF1KB8 ----GQWAGGAYAAEPEEN-KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLT :. .: . . . ::.::::: :::.:::::: ::.:. ::::::.: .:::: XP_011 SSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLT 180 190 200 210 220 230 190 200 210 220 230 pF1KB8 ERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAE----PEQDCAVTSGEELL-ALP-- ::.:::::::::::.::.. : .: :. :: . .. : ..: . :. ..: XP_011 ERQIKIWFQNRRMKYKKDQ-KGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYE 240 250 260 270 280 290 240 250 260 270 280 pF1KB8 PPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR : :: . :: . . :::. . :: . : ::. XP_011 PQSPPPFSKPPQGTYG-----LPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPH 300 310 320 330 340 XP_011 AHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLG 350 360 370 380 390 400 >>XP_005249787 (OMIM: 142954) PREDICTED: homeobox protei (443 aa) initn: 453 init1: 310 opt: 463 Z-score: 281.5 bits: 60.6 E(85289): 6.1e-09 Smith-Waterman score: 477; 35.4% identity (55.4% similar) in 316 aa overlap (2-281:27-327) 10 20 pF1KB8 MNGEEQYYAAT-------QLYKDPCAFQR----GP :...: : :. . .. :..: : XP_005 MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGG 10 20 30 40 50 60 30 40 50 60 70 pF1KB8 APEFSASPPACLYMGRQPP--PP----PP-HPFPGALGALEQGSPPDISPYEVPPLADDP :. ::: :: :: :: :: : .: .::. .: :: : : XP_005 HPKAHELSEACLRTLSAPPSQPPSLGEPPLHP-PPPQAAPPAPQPPQPAPQ--PP-APTP 70 80 90 100 110 80 90 100 110 120 130 pF1KB8 AVAHLHHHLPAQLALPHPPAG--PFP-EGAEPGVLEEPNRVQLPFPWMKSTKAHAWK--- :. : . : : :. : : ..:. .:. :. .. ::::: .. .. . XP_005 AAPP-----PPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTS 120 130 140 150 160 170 140 150 160 170 180 pF1KB8 ----GQWAGGAYAAEPEEN-KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLT :. .: . . . ::.::::: :::.:::::: ::.:. ::::::.: .:::: XP_005 SSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLT 180 190 200 210 220 230 190 200 210 220 230 pF1KB8 ERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAE----PEQDCAVTSGEELL-ALP-- ::.:::::::::::.::.. : .: :. :: . .. : ..: . :. ..: XP_005 ERQIKIWFQNRRMKYKKDQ-KGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYE 240 250 260 270 280 290 240 250 260 270 280 pF1KB8 PPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR : :: . :: . . :::. . :: . : ::. XP_005 PQSPPPFSKPPQGTYG-----LPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPH 300 310 320 330 340 XP_005 AHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLG 350 360 370 380 390 400 >>NP_705895 (OMIM: 142954) homeobox protein Hox-A3 isofo (443 aa) initn: 453 init1: 310 opt: 463 Z-score: 281.5 bits: 60.6 E(85289): 6.1e-09 Smith-Waterman score: 477; 35.4% identity (55.4% similar) in 316 aa overlap (2-281:27-327) 10 20 pF1KB8 MNGEEQYYAAT-------QLYKDPCAFQR----GP :...: : :. . .. :..: : NP_705 MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGG 10 20 30 40 50 60 30 40 50 60 70 pF1KB8 APEFSASPPACLYMGRQPP--PP----PP-HPFPGALGALEQGSPPDISPYEVPPLADDP :. ::: :: :: :: :: : .: .::. .: :: : : NP_705 HPKAHELSEACLRTLSAPPSQPPSLGEPPLHP-PPPQAAPPAPQPPQPAPQ--PP-APTP 70 80 90 100 110 80 90 100 110 120 130 pF1KB8 AVAHLHHHLPAQLALPHPPAG--PFP-EGAEPGVLEEPNRVQLPFPWMKSTKAHAWK--- :. : . : : :. : : ..:. .:. :. .. ::::: .. .. . NP_705 AAPP-----PPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTS 120 130 140 150 160 170 140 150 160 170 180 pF1KB8 ----GQWAGGAYAAEPEEN-KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLT :. .: . . . ::.::::: :::.:::::: ::.:. ::::::.: .:::: NP_705 SSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLT 180 190 200 210 220 230 190 200 210 220 230 pF1KB8 ERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAE----PEQDCAVTSGEELL-ALP-- ::.:::::::::::.::.. : .: :. :: . .. : ..: . :. ..: NP_705 ERQIKIWFQNRRMKYKKDQ-KGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYE 240 250 260 270 280 290 240 250 260 270 280 pF1KB8 PPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR : :: . :: . . :::. . :: . : ::. NP_705 PQSPPPFSKPPQGTYG-----LPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPH 300 310 320 330 340 NP_705 AHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLG 350 360 370 380 390 400 >>NP_109377 (OMIM: 142954) homeobox protein Hox-A3 isofo (443 aa) initn: 453 init1: 310 opt: 463 Z-score: 281.5 bits: 60.6 E(85289): 6.1e-09 Smith-Waterman score: 477; 35.4% identity (55.4% similar) in 316 aa overlap (2-281:27-327) 10 20 pF1KB8 MNGEEQYYAAT-------QLYKDPCAFQR----GP :...: : :. . .. :..: : NP_109 MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGG 10 20 30 40 50 60 30 40 50 60 70 pF1KB8 APEFSASPPACLYMGRQPP--PP----PP-HPFPGALGALEQGSPPDISPYEVPPLADDP :. ::: :: :: :: :: : .: .::. .: :: : : NP_109 HPKAHELSEACLRTLSAPPSQPPSLGEPPLHP-PPPQAAPPAPQPPQPAPQ--PP-APTP 70 80 90 100 110 80 90 100 110 120 130 pF1KB8 AVAHLHHHLPAQLALPHPPAG--PFP-EGAEPGVLEEPNRVQLPFPWMKSTKAHAWK--- :. : . : : :. : : ..:. .:. :. .. ::::: .. .. . NP_109 AAPP-----PPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTS 120 130 140 150 160 170 140 150 160 170 180 pF1KB8 ----GQWAGGAYAAEPEEN-KRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLT :. .: . . . ::.::::: :::.:::::: ::.:. ::::::.: .:::: NP_109 SSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLT 180 190 200 210 220 230 190 200 210 220 230 pF1KB8 ERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAE----PEQDCAVTSGEELL-ALP-- ::.:::::::::::.::.. : .: :. :: . .. : ..: . :. ..: NP_109 ERQIKIWFQNRRMKYKKDQ-KGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYE 240 250 260 270 280 290 240 250 260 270 280 pF1KB8 PPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR : :: . :: . . :::. . :: . : ::. NP_109 PQSPPPFSKPPQGTYG-----LPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPH 300 310 320 330 340 NP_109 AHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLG 350 360 370 380 390 400 >>NP_002132 (OMIM: 142953) homeobox protein Hox-A4 [Homo (320 aa) initn: 383 init1: 290 opt: 394 Z-score: 244.5 bits: 53.3 E(85289): 7e-07 Smith-Waterman score: 415; 36.8% identity (57.7% similar) in 239 aa overlap (17-249:101-315) 10 20 30 40 pF1KB8 MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPP : ... : .: . :: . .::: NP_002 ASYYAPRTAREPAYPAAALYPAHGAADTAYPYGYRGGASP---GRPP----QPEQPPAQA 80 90 100 110 120 50 60 70 80 90 100 pF1KB8 PHPFPG--ALGALEQGSPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGA : : : .:. :: ..: ::: : : . :. : :: :. : NP_002 KGPAHGLHASHVLQPQLPPPLQPRAVPPAA--PRRCEAAPATPGVPAGGSAPACPL-LLA 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB8 EPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKE . . : .. . .::::. .. : . .. :: :: ::.:::::: :.:::::: NP_002 DKSPLGLKGKEPVVYPWMKKIHVSAVNPSYNGG----EP---KRSRTAYTRQQVLELEKE 190 200 210 220 230 170 180 190 200 210 220 pF1KB8 FLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEED----KKRGGGTAVGGGGV : ::.:..: ::.:.: : :.::..:::::::::::::.. : :....: ...: NP_002 FHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNSASASAG- 240 250 260 270 280 290 230 240 250 260 270 280 pF1KB8 AEPEQDCAVTSGEELLALPPPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQ : . : . : : : :. ..: NP_002 --PPGKAQTQSPH----LHPHPHPSTSTPVPSSI 300 310 320 >>NP_002136 (OMIM: 142967) homeobox protein Hox-B2 [Homo (356 aa) initn: 380 init1: 281 opt: 393 Z-score: 243.4 bits: 53.2 E(85289): 8.1e-07 Smith-Waterman score: 406; 34.8% identity (51.5% similar) in 264 aa overlap (45-282:44-302) 20 30 40 50 60 70 pF1KB8 KDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDISPYEVPPLA ::: :: .. .:. :. : NP_002 SQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGASTLQRPRSQKRAE 20 30 40 50 60 70 80 90 100 110 120 130 pF1KB8 DDPAVAHLHHHLPAQLALPH-PPAGPFPEGAEPGVLEEPNRVQL-PFPWMKSTKAHAWKG : ::. : :: ::: :: : ..:.. : : ... : . . NP_002 DGPALPP-----PPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASGVGS 80 90 100 110 120 140 150 160 170 180 190 pF1KB8 QWAG-GAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIK : : : .: ::::: .::::::::: ::::. ::::::.:..:.::::..: NP_002 PADGLGLPEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVK 130 140 150 160 170 180 200 210 220 230 pF1KB8 IWFQNRRMKWKKEEDKKR--GGGTAVGGG--GVAEPEQDCAVTSGE--------ELLALP .:::::::: :.. .... : : :. . .: .. :.. : : : NP_002 VWFQNRRMKHKRQTQHREPPDGEPACPGALEDICDPAEEPAASPGGPSASRAAWEACCHP 190 200 210 220 230 240 240 250 260 270 280 pF1KB8 PPPPPGGAVPPAAPVAAR-EG----------RLPPGLSASPQPSSVAPRRPQEPR : ::. :.:.: :: : :: .: : .: : . : NP_002 PEVVPGALSADPRPLAVRLEGAGASSPGCALRGAGGLEPGPLPEDVFSGRQDSPFLPDLN 250 260 270 280 290 300 NP_002 FFAADSCLQLSGGLSPSLQGSLDSPVPFSEEELDFFTSTLCAIDLQFP 310 320 330 340 350 283 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:33:26 2016 done: Fri Nov 4 16:33:28 2016 Total Scan time: 8.220 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]