FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8963, 350 aa 1>>>pF1KB8963 350 - 350 aa - 350 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5207+/-0.000472; mu= 20.9235+/- 0.029 mean_var=109.8579+/-26.458, 0's: 0 Z-trim(110.0): 708 B-trim: 864 in 1/48 Lambda= 0.122365 statistics sampled from 17505 (18319) to 17505 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.566), E-opt: 0.2 (0.215), width: 16 Scan time: 7.480 The best scores are: opt bits E(85289) NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350) 2315 420.3 3.2e-117 XP_011530304 (OMIM: 600665) PREDICTED: melatonin r ( 265) 1777 325.1 1.1e-88 NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 1392 257.3 3.7e-68 XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 1392 257.3 3.7e-68 XP_016873266 (OMIM: 125853,600804) PREDICTED: mela ( 320) 1212 225.5 1.3e-58 NP_004215 (OMIM: 300207) melatonin-related recepto ( 617) 1142 213.6 9.5e-55 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 451 91.2 3.7e-18 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 451 91.3 3.9e-18 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 451 91.3 3.9e-18 NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 451 91.3 3.9e-18 NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 451 91.3 3.9e-18 NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 451 91.3 4e-18 NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 451 91.3 4e-18 NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 451 91.3 4e-18 NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 451 91.3 4e-18 NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 451 91.3 4.1e-18 NP_001008505 (OMIM: 600018) mu-type opioid recepto ( 446) 451 91.4 4.2e-18 NP_001138751 (OMIM: 600018) mu-type opioid recepto ( 493) 451 91.4 4.4e-18 NP_001272453 (OMIM: 600018) mu-type opioid recepto ( 493) 451 91.4 4.4e-18 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 431 87.7 4.4e-17 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 417 85.3 2.5e-16 NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 416 85.1 2.7e-16 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 412 84.4 4.5e-16 NP_003848 (OMIM: 603691) galanin receptor type 2 [ ( 387) 407 83.5 8.4e-16 NP_001138753 (OMIM: 600018) mu-type opioid recepto ( 319) 401 82.3 1.6e-15 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 399 82.1 2.2e-15 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 399 82.1 2.3e-15 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 397 81.7 2.8e-15 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 397 81.7 2.8e-15 NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 394 81.2 4e-15 NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 394 81.2 4e-15 NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 394 81.2 4e-15 XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 394 81.2 4e-15 XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 394 81.2 4.1e-15 XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 394 81.2 4.1e-15 XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 394 81.2 4.1e-15 NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 394 81.2 4.2e-15 NP_001272456 (OMIM: 600018) mu-type opioid recepto ( 292) 391 80.5 5.1e-15 NP_001138752 (OMIM: 600018) mu-type opioid recepto ( 300) 391 80.5 5.2e-15 NP_001138759 (OMIM: 600018) mu-type opioid recepto ( 300) 391 80.5 5.2e-15 XP_016866395 (OMIM: 600018) PREDICTED: mu-type opi ( 300) 391 80.5 5.2e-15 NP_001272455 (OMIM: 600018) mu-type opioid recepto ( 300) 391 80.5 5.2e-15 NP_001272457 (OMIM: 600018) mu-type opioid recepto ( 314) 391 80.5 5.3e-15 XP_016866394 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 391 80.6 5.6e-15 XP_011534158 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 391 80.6 5.6e-15 XP_011534164 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 391 80.6 5.6e-15 XP_011534155 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 391 80.6 5.6e-15 XP_016866393 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 391 80.6 5.6e-15 XP_016866392 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 391 80.6 5.6e-15 XP_011534153 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 391 80.6 5.6e-15 >>NP_005949 (OMIM: 600665) melatonin receptor type 1A [H (350 aa) initn: 2315 init1: 2315 opt: 2315 Z-score: 2225.5 bits: 420.3 E(85289): 3.2e-117 Smith-Waterman score: 2315; 99.7% identity (99.7% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KB8 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAETLQYDPRIYSCTFA ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: NP_005 IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV :::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV 310 320 330 340 350 >>XP_011530304 (OMIM: 600665) PREDICTED: melatonin recep (265 aa) initn: 1777 init1: 1777 opt: 1777 Z-score: 1713.4 bits: 325.1 E(85289): 1.1e-88 Smith-Waterman score: 1777; 99.6% identity (99.6% similar) in 265 aa overlap (86-350:1-265) 60 70 80 90 100 110 pF1KB8 KKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSI :::::::::::::::::::::::::::::: XP_011 MSIFNNGWNLGYLHCQVSGFLMGLSVIGSI 10 20 30 120 130 140 150 160 170 pF1KB8 FNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAETLQYDPRIY :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: XP_011 FNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIY 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB8 SCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFR 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB8 NFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIY 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB8 GLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV 220 230 240 250 260 >>NP_005950 (OMIM: 125853,600804) melatonin receptor typ (362 aa) initn: 1396 init1: 1373 opt: 1392 Z-score: 1344.7 bits: 257.3 E(85289): 3.7e-68 Smith-Waterman score: 1392; 61.2% identity (83.0% similar) in 335 aa overlap (3-337:24-350) 10 20 30 pF1KB8 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIV : ::: :. . : :: :.: ::. ::: : . NP_005 MSENGSFANCCEAGGWAVRPGWSGAGSARPSRT-P-------RPPWVAPALSAVLIVTTA 10 20 30 40 50 40 50 60 70 80 90 pF1KB8 VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLH ::..::::::::: ::.:::::::.:.::::.::::::.:::::.:..:: .:: :: : NP_005 VDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB8 CQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAV :..:.:.::::::::.::::.::::::::::::. : ..: .. .. ::::::..:. NP_005 CKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVAL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB8 LPNLRAETLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQ :::. . .:.:::::::::: :..:. :: ::::.:::.:. .: :::::::.::::.:. NP_005 LPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARR 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB8 RVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVA ..::. . :::.:.:.:.:::::::.::::::::: :::::: .: :.:.::: :::. NP_005 KAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVT 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 SYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLM :: .::::::::::.:::::::::.::.::...: . : . :.:. . .:.: NP_005 SYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPI 300 310 320 330 340 350 340 350 pF1KB8 TNNNVVKVDSV NP_005 IGVQHQADAL 360 >>XP_011541141 (OMIM: 125853,600804) PREDICTED: melatoni (362 aa) initn: 1396 init1: 1373 opt: 1392 Z-score: 1344.7 bits: 257.3 E(85289): 3.7e-68 Smith-Waterman score: 1392; 61.2% identity (83.0% similar) in 335 aa overlap (3-337:24-350) 10 20 30 pF1KB8 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIV : ::: :. . : :: :.: ::. ::: : . XP_011 MSENGSFANCCEAGGWAVRPGWSGAGSARPSRT-P-------RPPWVAPALSAVLIVTTA 10 20 30 40 50 40 50 60 70 80 90 pF1KB8 VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLH ::..::::::::: ::.:::::::.:.::::.::::::.:::::.:..:: .:: :: : XP_011 VDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEH 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB8 CQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAV :..:.:.::::::::.::::.::::::::::::. : ..: .. .. ::::::..:. XP_011 CKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVAL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB8 LPNLRAETLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQ :::. . .:.:::::::::: :..:. :: ::::.:::.:. .: :::::::.::::.:. XP_011 LPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARR 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB8 RVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVA ..::. . :::.:.:.:.:::::::.::::::::: :::::: .: :.:.::: :::. XP_011 KAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVT 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 SYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLM :: .::::::::::.:::::::::.::.::...: . : . :.:. . .:.: XP_011 SYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPI 300 310 320 330 340 350 340 350 pF1KB8 TNNNVVKVDSV XP_011 IGVQHQADAL 360 >>XP_016873266 (OMIM: 125853,600804) PREDICTED: melatoni (320 aa) initn: 1218 init1: 1195 opt: 1212 Z-score: 1173.5 bits: 225.5 E(85289): 1.3e-58 Smith-Waterman score: 1212; 56.4% identity (81.4% similar) in 312 aa overlap (26-337:1-308) 10 20 30 40 50 60 pF1KB8 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN .:... : .. ... : .: .. : . XP_016 MATVFFCFPNSSMGISMAGA----MSFIHHCVLLE 10 20 30 70 80 90 100 110 120 pF1KB8 AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG ::.:.::::.::::::.:::::.:..:: .:: :: ::..:.:.::::::::.::::. XP_016 CGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAETLQYDPRIYSCTFA ::::::::::::. : ..: .. .. ::::::..:.:::. . .:.:::::::::: XP_016 IAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFI 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM :..:. :: ::::.:::.:. .: :::::::.::::.:...::. . :::.:.:.:.:: XP_016 QTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTM 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ :::::.::::::::: :::::: .: :.:.::: :::.:: .::::::::::.:::::: XP_016 FVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQ 220 230 240 250 260 270 310 320 330 340 350 pF1KB8 NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV :::.::.::...: . : . :.:. . .:.: XP_016 NFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL 280 290 300 310 320 >>NP_004215 (OMIM: 300207) melatonin-related receptor [H (617 aa) initn: 1134 init1: 780 opt: 1142 Z-score: 1103.9 bits: 213.6 E(85289): 9.5e-55 Smith-Waterman score: 1142; 51.1% identity (79.3% similar) in 305 aa overlap (23-327:24-326) 10 20 30 40 50 pF1KB8 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLR : : . :....:::::..:: .:::.: .::::: NP_004 MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 NAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNIT :.::::::::.:::..::::::::.: .. .::.:. :.::. ::. ::::.::::::. NP_004 NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 GIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAETLQYDPRIYSCTF .:::::::::::::.:....: .:. :... :..:. :::::. :..:::: :.: : NP_004 AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 AQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVT . ..:...: .::..:..:: :::.::: :: .:. ..: . . :::.: NP_004 NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARD--PAGQNPDNQLAEVRNFLT 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 MFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLN :::.:.:::.:: :.: . . :: .: :. .::.::..:.:..:::::::::.:::::: NP_004 MFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLN 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 QNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV .:::.:: :. .. .:: .:. NP_004 ENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAV 300 310 320 330 340 350 >>NP_001471 (OMIM: 600377) galanin receptor type 1 [Homo (349 aa) initn: 285 init1: 210 opt: 451 Z-score: 447.1 bits: 91.2 E(85289): 3.7e-18 Smith-Waterman score: 451; 28.8% identity (61.1% similar) in 347 aa overlap (2-336:10-343) 10 20 30 40 50 pF1KB8 MQGNGS-ALPNASQP-VLRGDGARPSWLASALACVLIFTIVVDILGNLLVIL .::.: : : .: : : :.. ... .. :::.. .::: ::: NP_001 MELAVGNLSEGNASWPEPPAPEPGPLFGIGVEN--FVTLVVFGLIFAL--GVLGNSLVIT 10 20 30 40 50 60 70 80 90 100 pF1KB8 SVYRNK--KLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMG . :.: : :.. :.:...:..:::. .. :. : :: . :. ... NP_001 VLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFT 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 LSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAETL .:.. :::........:: : :: . ..: :.:.: : :: :..: . : . : NP_001 VSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 QYDPRIYSCTFAQSV------SSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVK . :: . :: ..::.. . :: .:.:.... ::: .. . ......: NP_001 -FHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKV---LNHLHKKLK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB8 PDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLF-VASY . . : . . .. :..:: :.:.: : : ..: : . ..: .:: .... NP_001 -NMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTP--ASFLFRITAH 240 250 260 270 280 290 300 310 320 330 340 pF1KB8 YMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARV-FFVDSSNDVADRVKWKPSPLMT .:: :: .: :::..:..:::: :.... : : ...... .:. :: NP_001 CLAYSNSSVNPIIYAFLSENFRKAYKQVF--KCHIRKDSHLSDTKESKSRIDTPPSTNCT 290 300 310 320 330 340 350 pF1KB8 NNNVVKVDSV NP_001 HV >>NP_001138757 (OMIM: 600018) mu-type opioid receptor is (389 aa) initn: 331 init1: 117 opt: 451 Z-score: 446.6 bits: 91.3 E(85289): 3.9e-18 Smith-Waterman score: 451; 25.8% identity (59.6% similar) in 329 aa overlap (23-341:65-380) 10 20 30 40 50 pF1KB8 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIV--VDILGNLLVIL :: . .:.. . ...:: : ..::.::. NP_001 SHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPS-MITAITIMALYSIVCVVGLFGNFLVMY 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB8 SVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLS . : :...: ::.. .::.:: ..: :. .. . . : .: . :.. . . NP_001 VIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB8 VIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAETLQY .. :::.. ....:: .:: .: . . .:. . :.:. : :: . : .: NP_001 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY 160 170 180 190 200 210 180 190 200 210 220 pF1KB8 DPRIYSCTFAQSVSSAY-----TIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDR .::.. : . : : : .: :..:..:. :: ...:.... :. NP_001 RQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCY---GLMILRLKS-VRMLS 220 230 240 250 260 230 240 250 260 270 280 pF1KB8 KPKLKPQDFRNFVTM-FVVFVLFAICWAPLNF--IGLAVASDPASMVPRIPEWLFVASYY : : ...: .. : .:: ..: .::.:... : :... : . . : : . NP_001 GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVS-WHFCIA-- 270 280 290 300 310 320 290 300 310 320 330 340 pF1KB8 MAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNN ..: ::::: ..:..:..::.. .:. .: ....:.. : . . : .: NP_001 LGYTNSCLNPVLYAFLDENFKRCFRE----FCIPTSSNIEQQNSTRIRQNTRDHPSTANT 330 340 350 360 370 380 350 pF1KB8 NVVKVDSV NP_001 VDRTNHQS >>NP_001008504 (OMIM: 600018) mu-type opioid receptor is (392 aa) initn: 331 init1: 117 opt: 451 Z-score: 446.6 bits: 91.3 E(85289): 3.9e-18 Smith-Waterman score: 451; 25.8% identity (59.6% similar) in 329 aa overlap (23-341:65-380) 10 20 30 40 50 pF1KB8 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIV--VDILGNLLVIL :: . .:.. . ...:: : ..::.::. NP_001 SHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPS-MITAITIMALYSIVCVVGLFGNFLVMY 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB8 SVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLS . : :...: ::.. .::.:: ..: :. .. . . : .: . :.. . . NP_001 VIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB8 VIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAETLQY .. :::.. ....:: .:: .: . . .:. . :.:. : :: . : .: NP_001 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY 160 170 180 190 200 210 180 190 200 210 220 pF1KB8 DPRIYSCTFAQSVSSAY-----TIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDR .::.. : . : : : .: :..:..:. :: ...:.... :. NP_001 RQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCY---GLMILRLKS-VRMLS 220 230 240 250 260 230 240 250 260 270 280 pF1KB8 KPKLKPQDFRNFVTM-FVVFVLFAICWAPLNF--IGLAVASDPASMVPRIPEWLFVASYY : : ...: .. : .:: ..: .::.:... : :... : . . : : . NP_001 GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVS-WHFCIA-- 270 280 290 300 310 320 290 300 310 320 330 340 pF1KB8 MAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNN ..: ::::: ..:..:..::.. .:. .: ....:.. : . . : .: NP_001 LGYTNSCLNPVLYAFLDENFKRCFRE----FCIPTSSNIEQQNSTRIRQNTRDHPSTANT 330 340 350 360 370 380 350 pF1KB8 NVVKVDSV NP_001 VDRTNHQVRSL 390 >>NP_001138755 (OMIM: 600018) mu-type opioid receptor is (397 aa) initn: 331 init1: 117 opt: 451 Z-score: 446.5 bits: 91.3 E(85289): 3.9e-18 Smith-Waterman score: 451; 25.8% identity (59.6% similar) in 329 aa overlap (23-341:65-380) 10 20 30 40 50 pF1KB8 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIV--VDILGNLLVIL :: . .:.. . ...:: : ..::.::. NP_001 SHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPS-MITAITIMALYSIVCVVGLFGNFLVMY 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB8 SVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLS . : :...: ::.. .::.:: ..: :. .. . . : .: . :.. . . NP_001 VIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYN 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB8 VIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAETLQY .. :::.. ....:: .:: .: . . .:. . :.:. : :: . : .: NP_001 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKY 160 170 180 190 200 210 180 190 200 210 220 pF1KB8 DPRIYSCTFAQSVSSAY-----TIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDR .::.. : . : : : .: :..:..:. :: ...:.... :. NP_001 RQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCY---GLMILRLKS-VRMLS 220 230 240 250 260 230 240 250 260 270 280 pF1KB8 KPKLKPQDFRNFVTM-FVVFVLFAICWAPLNF--IGLAVASDPASMVPRIPEWLFVASYY : : ...: .. : .:: ..: .::.:... : :... : . . : : . NP_001 GSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVS-WHFCIA-- 270 280 290 300 310 320 290 300 310 320 330 340 pF1KB8 MAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNN ..: ::::: ..:..:..::.. .:. .: ....:.. : . . : .: NP_001 LGYTNSCLNPVLYAFLDENFKRCFRE----FCIPTSSNIEQQNSTRIRQNTRDHPSTANT 330 340 350 360 370 380 350 pF1KB8 NVVKVDSV NP_001 VDRTNHQRERRQKSDW 390 350 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 01:38:25 2016 done: Sat Nov 5 01:38:27 2016 Total Scan time: 7.480 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]