FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8970, 359 aa 1>>>pF1KB8970 359 - 359 aa - 359 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.4849+/-0.000367; mu= 21.7584+/- 0.023 mean_var=76.5242+/-16.178, 0's: 0 Z-trim(113.4): 95 B-trim: 0 in 0/51 Lambda= 0.146614 statistics sampled from 22594 (22699) to 22594 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.266), width: 16 Scan time: 7.510 The best scores are: opt bits E(85289) NP_000944 (OMIM: 604687,607277) prostaglandin D2 r ( 359) 2409 519.1 6e-147 XP_005267948 (OMIM: 604687,607277) PREDICTED: pros ( 359) 2409 519.1 6e-147 NP_001268398 (OMIM: 604687,607277) prostaglandin D ( 296) 1901 411.5 1.2e-114 NP_000947 (OMIM: 176804,208550) prostaglandin E2 r ( 358) 773 173.0 8.9e-43 XP_005259150 (OMIM: 600022) PREDICTED: prostacycli ( 342) 535 122.7 1.2e-27 XP_005259152 (OMIM: 600022) PREDICTED: prostacycli ( 257) 533 122.1 1.4e-27 NP_000951 (OMIM: 600022) prostacyclin receptor [Ho ( 386) 533 122.3 1.8e-27 XP_016865148 (OMIM: 601586) PREDICTED: prostagland ( 313) 405 95.1 2.2e-19 XP_016865147 (OMIM: 601586) PREDICTED: prostagland ( 325) 405 95.2 2.3e-19 XP_016865146 (OMIM: 601586) PREDICTED: prostagland ( 326) 405 95.2 2.3e-19 XP_016865145 (OMIM: 601586) PREDICTED: prostagland ( 350) 405 95.2 2.4e-19 NP_000949 (OMIM: 601586) prostaglandin E2 receptor ( 488) 405 95.4 3e-19 NP_942011 (OMIM: 176806) prostaglandin E2 receptor ( 418) 382 90.4 7.8e-18 NP_942010 (OMIM: 176806) prostaglandin E2 receptor ( 365) 376 89.1 1.7e-17 NP_942009 (OMIM: 176806) prostaglandin E2 receptor ( 374) 373 88.5 2.7e-17 NP_942008 (OMIM: 176806) prostaglandin E2 receptor ( 388) 372 88.3 3.2e-17 NP_942007 (OMIM: 176806) prostaglandin E2 receptor ( 390) 372 88.3 3.2e-17 NP_001119516 (OMIM: 176806) prostaglandin E2 recep ( 390) 372 88.3 3.2e-17 NP_942012 (OMIM: 176806) prostaglandin E2 receptor ( 390) 372 88.3 3.2e-17 XP_011540112 (OMIM: 176806) PREDICTED: prostagland ( 410) 372 88.3 3.3e-17 XP_011526516 (OMIM: 188070,614009) PREDICTED: thro ( 343) 306 74.2 4.7e-13 NP_001051 (OMIM: 188070,614009) thromboxane A2 rec ( 343) 306 74.2 4.7e-13 NP_963998 (OMIM: 188070,614009) thromboxane A2 rec ( 407) 306 74.3 5.3e-13 NP_000946 (OMIM: 176802) prostaglandin E2 receptor ( 402) 250 62.5 1.9e-09 XP_016857362 (OMIM: 600563) PREDICTED: prostagland ( 291) 229 57.9 3.4e-08 NP_001034674 (OMIM: 600563) prostaglandin F2-alpha ( 297) 229 57.9 3.4e-08 NP_000950 (OMIM: 600563) prostaglandin F2-alpha re ( 359) 229 58.0 3.9e-08 NP_001025186 (OMIM: 606665) melanopsin isoform 2 [ ( 489) 190 49.9 1.4e-05 XP_016872444 (OMIM: 606665) PREDICTED: melanopsin ( 539) 190 49.9 1.5e-05 XP_016872446 (OMIM: 606665) PREDICTED: melanopsin ( 405) 177 47.0 8.6e-05 NP_473362 (OMIM: 300393,300943) probable G-protein ( 508) 167 45.0 0.00043 NP_703143 (OMIM: 604847) G-protein coupled recepto ( 337) 164 44.2 0.00051 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 161 43.7 0.001 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 161 43.8 0.0011 NP_543009 (OMIM: 606921) G-protein coupled recepto ( 363) 151 41.5 0.0036 NP_000667 (OMIM: 600446) adenosine receptor A2b [H ( 332) 150 41.2 0.004 XP_011527129 (OMIM: 162651) PREDICTED: neurotensin ( 336) 148 40.8 0.0053 >>NP_000944 (OMIM: 604687,607277) prostaglandin D2 recep (359 aa) initn: 2409 init1: 2409 opt: 2409 Z-score: 2759.1 bits: 519.1 E(85289): 6e-147 Smith-Waterman score: 2409; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359) 10 20 30 40 50 60 pF1KB8 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL 310 320 330 340 350 >>XP_005267948 (OMIM: 604687,607277) PREDICTED: prostagl (359 aa) initn: 2409 init1: 2409 opt: 2409 Z-score: 2759.1 bits: 519.1 E(85289): 6e-147 Smith-Waterman score: 2409; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359) 10 20 30 40 50 60 pF1KB8 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL 310 320 330 340 350 >>NP_001268398 (OMIM: 604687,607277) prostaglandin D2 re (296 aa) initn: 1901 init1: 1901 opt: 1901 Z-score: 2179.4 bits: 411.5 E(85289): 1.2e-114 Smith-Waterman score: 1901; 100.0% identity (100.0% similar) in 282 aa overlap (1-282:1-282) 10 20 30 40 50 60 pF1KB8 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS :::::::::::::::::::::::::::::::::::::::::: NP_001 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIAFVPGVPAKTPGSR 250 260 270 280 290 310 320 330 340 350 pF1KB8 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL >>NP_000947 (OMIM: 176804,208550) prostaglandin E2 recep (358 aa) initn: 916 init1: 345 opt: 773 Z-score: 888.9 bits: 173.0 E(85289): 8.9e-43 Smith-Waterman score: 895; 44.1% identity (68.5% similar) in 356 aa overlap (8-357:13-350) 10 20 30 40 50 pF1KB8 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLG--WCSRRP :.. . :.: ....:.::.:.::::.::.:::: : :: NP_000 MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSA-G 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 LRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMS : :.:..:: :. ::::: ::.::::::.::.:..: .::: .. : ::: :. NP_000 RRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAP--ESRACTYFAFAMT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 FFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGK ::.:.. :.:.::::: .::.:::.::.:... : : ::. : :: ::.::.. .:. NP_000 FFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 FVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQ .:::::::::::. .: . : ::..:. ::..... ::.... :: :::: . NP_000 YVQYCPGTWCFIR----HGRTAYLQ---LYATLLLLLIVSVLACNFSVILNLIRMHRRSR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 RH---PRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAF : : : . : : : . :: :::.:::.::. :..:::: ::.. NP_000 RSRCGP-SLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNET 240 250 260 270 280 300 310 320 330 340 pF1KB8 KDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIR-PLRYRSRC .. ::: ::.::::::. ::.:::.: :.: ::.:.. . : :: .. NP_000 SSRKEK-------WDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDAT 290 300 310 320 330 340 350 pF1KB8 SNSTNMESSL ..: . .: NP_000 QTSCSTQSDASKQADL 350 >>XP_005259150 (OMIM: 600022) PREDICTED: prostacyclin re (342 aa) initn: 645 init1: 321 opt: 535 Z-score: 617.1 bits: 122.7 E(85289): 1.2e-27 Smith-Waterman score: 671; 42.7% identity (69.1% similar) in 288 aa overlap (8-295:5-267) 10 20 30 40 50 60 pF1KB8 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV :.: : :. . . . . ..: .:..:: ::::.:. .::: :: :. XP_005 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILS-------ARRPARP--SA 10 20 30 40 70 80 90 100 110 120 pF1KB8 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST : .:: ::..::::: .:::.:..:::.: :: :: . .::.:::: :.::::.: XP_005 FAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARG-GPALCDAFAFAMTFFGLASM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG : :.:::.: :.:.::..: . : . :. :.. :: . :::::..:.:. ::::: XP_005 LILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPG 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT .:::..: . . .. .:. :..:.:::: : ::: .. .: :.:. .:: : XP_005 SWCFLRMRWAQPGGAA--FSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLG 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS :: : .:.:::.:::::::....::::. .:. ..:. : . XP_005 -----PRPRTGE------DEVDHLILLALMTVVMAVCSLPLTMRG--SVFRPVTQSQVLV 230 240 250 260 270 310 320 330 340 350 pF1KB8 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL XP_005 LGPSIVEPDLPPTWLPSASEQAPPLPLHLGFLRGPRPAPPQWEWHRPWYPLSVCDTWSCH 280 290 300 310 320 330 >>XP_005259152 (OMIM: 600022) PREDICTED: prostacyclin re (257 aa) initn: 639 init1: 321 opt: 533 Z-score: 616.3 bits: 122.1 E(85289): 1.4e-27 Smith-Waterman score: 663; 43.8% identity (69.3% similar) in 274 aa overlap (8-281:5-255) 10 20 30 40 50 60 pF1KB8 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV :.: : :. . . . . ..: .:..:: ::::.:. .::: :: :. XP_005 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILS-------ARRPARP--SA 10 20 30 40 70 80 90 100 110 120 pF1KB8 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST : .:: ::..::::: .:::.:..:::.: :: :: . .::.:::: :.::::.: XP_005 FAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARG-GPALCDAFAFAMTFFGLASM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG : :.:::.: :.:.::..: . : . :. :.. :: . :::::..:.:. ::::: XP_005 LILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPG 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT .:::..: . . . ..:. :..:.:::: : ::: .. .: :.:. .:: : XP_005 SWCFLRMRWAQPGGA--AFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLG 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS :: : .:.:::.:::::::....::::. XP_005 -----PRPRTGE------DEVDHLILLALMTVVMAVCSLPLTQ 230 240 250 310 320 330 340 350 pF1KB8 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL >>NP_000951 (OMIM: 600022) prostacyclin receptor [Homo s (386 aa) initn: 746 init1: 321 opt: 533 Z-score: 614.2 bits: 122.3 E(85289): 1.8e-27 Smith-Waterman score: 767; 42.8% identity (67.1% similar) in 325 aa overlap (8-332:5-301) 10 20 30 40 50 60 pF1KB8 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV :.: : :. . . . . ..: .:..:: ::::.:. .::: :: :. NP_000 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILS-------ARRPARP--SA 10 20 30 40 70 80 90 100 110 120 pF1KB8 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST : .:: ::..::::: .:::.:..:::.: :: :: . .::.:::: :.::::.: NP_000 FAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARG-GPALCDAFAFAMTFFGLASM 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG : :.:::.: :.:.::..: . : . :. :.. :: . :::::..:.:. ::::: NP_000 LILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPG 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT .:::..: . . .. .:. :..:.:::: : ::: .. .: :.:. .:: : NP_000 SWCFLRMRWAQPGGAA--FSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLG 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS :: : .:.:::.:::::::....::::. : . : .: NP_000 -----PRPRTGE------DEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAP-----DSS 230 240 250 260 310 320 330 340 350 pF1KB8 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL : :: :.:: . :.:::.::.::. ::. NP_000 SEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASG 270 280 290 300 310 320 NP_000 RRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC 330 340 350 360 370 380 >>XP_016865148 (OMIM: 601586) PREDICTED: prostaglandin E (313 aa) initn: 424 init1: 218 opt: 405 Z-score: 469.0 bits: 95.1 E(85289): 2.2e-19 Smith-Waterman score: 453; 36.9% identity (67.8% similar) in 236 aa overlap (1-234:1-219) 10 20 30 40 50 pF1KB8 MKSPFYRCQNTTSVEKGNSAV-MGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPS :..: . . : .. :: : . .:.: :..:::.:. .: .: :. . . XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKS------RKEQKE--T 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSS .:: :::::.:::::: :.:::..:.: ... :. . ::. .:.. ::.::. XP_016 TFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQ-----WPG-GQPLCEYSTFILLFFSLSG 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 TLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKF-VQYC . ::..: .:...: .:: ... ::..:. .: : .. ::::: ::.:. .:: XP_016 LSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQY- 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 PGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRS : :::::. . . . .. :: .:... ..:.:::::::. . : :::...: XP_016 PDTWCFIDWTTNVTAHAA--YSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSL 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB8 CTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNR XP_016 GTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLI 230 240 250 260 270 280 >>XP_016865147 (OMIM: 601586) PREDICTED: prostaglandin E (325 aa) initn: 424 init1: 218 opt: 405 Z-score: 468.8 bits: 95.2 E(85289): 2.3e-19 Smith-Waterman score: 453; 36.9% identity (67.8% similar) in 236 aa overlap (1-234:1-219) 10 20 30 40 50 pF1KB8 MKSPFYRCQNTTSVEKGNSAV-MGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPS :..: . . : .. :: : . .:.: :..:::.:. .: .: :. . . XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKS------RKEQKE--T 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSS .:: :::::.:::::: :.:::..:.: ... :. . ::. .:.. ::.::. XP_016 TFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQ-----WPG-GQPLCEYSTFILLFFSLSG 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 TLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKF-VQYC . ::..: .:...: .:: ... ::..:. .: : .. ::::: ::.:. .:: XP_016 LSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQY- 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 PGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRS : :::::. . . . .. :: .:... ..:.:::::::. . : :::...: XP_016 PDTWCFIDWTTNVTAHAA--YSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSL 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB8 CTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNR XP_016 GTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLI 230 240 250 260 270 280 >>XP_016865146 (OMIM: 601586) PREDICTED: prostaglandin E (326 aa) initn: 424 init1: 218 opt: 405 Z-score: 468.8 bits: 95.2 E(85289): 2.3e-19 Smith-Waterman score: 456; 31.9% identity (61.6% similar) in 307 aa overlap (1-283:1-290) 10 20 30 40 50 pF1KB8 MKSPFYRCQNTTSVEKGNSAV-MGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPS :..: . . : .. :: : . .:.: :..:::.:. .: .: :. . . XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKS------RKEQKE--T 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSS .:: :::::.:::::: :.:::..:.: ... :. . ::. .:.. ::.::. XP_016 TFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQ-----WPG-GQPLCEYSTFILLFFSLSG 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 TLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKF-VQYC . ::..: .:...: .:: ... ::..:. .: : .. ::::: ::.:. .:: XP_016 LSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQY- 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB8 PGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRS : :::::. . . . .. :: .:... ..:.:::::::. . : :::...:. XP_016 PDTWCFIDWTTNVTAHAA--YSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSL 170 180 190 200 210 220 240 250 260 270 pF1KB8 CTRD-----CAEPRADGREASPQPLE-----------------ELDHLLLLALMTVLFTM :.. : . :. :. : :.. ..:: ... . XP_016 GTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLI 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB8 CSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFH ::.:... XP_016 CSIPLVFPKLQMKNLYHSATYRVAIGASIRQPVISAKFGARSQ 290 300 310 320 359 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:46:02 2016 done: Fri Nov 4 16:46:03 2016 Total Scan time: 7.510 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]