FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8984, 386 aa 1>>>pF1KB8984 386 - 386 aa - 386 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1102+/-0.00033; mu= 19.3745+/- 0.021 mean_var=105.8553+/-23.688, 0's: 0 Z-trim(117.9): 235 B-trim: 3204 in 2/49 Lambda= 0.124657 statistics sampled from 29910 (30261) to 29910 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.355), width: 16 Scan time: 8.220 The best scores are: opt bits E(85289) NP_000951 (OMIM: 600022) prostacyclin receptor [Ho ( 386) 2622 482.1 9.5e-136 XP_005259150 (OMIM: 600022) PREDICTED: prostacycli ( 342) 1720 319.8 6e-87 XP_005259152 (OMIM: 600022) PREDICTED: prostacycli ( 257) 1711 318.1 1.5e-86 NP_000947 (OMIM: 176804,208550) prostaglandin E2 r ( 358) 787 152.1 2e-36 NP_001268398 (OMIM: 604687,607277) prostaglandin D ( 296) 535 106.6 7.8e-23 NP_000944 (OMIM: 604687,607277) prostaglandin D2 r ( 359) 533 106.4 1.1e-22 XP_005267948 (OMIM: 604687,607277) PREDICTED: pros ( 359) 533 106.4 1.1e-22 XP_016865148 (OMIM: 601586) PREDICTED: prostagland ( 313) 499 100.2 7.1e-21 XP_016865147 (OMIM: 601586) PREDICTED: prostagland ( 325) 499 100.2 7.3e-21 XP_016865146 (OMIM: 601586) PREDICTED: prostagland ( 326) 499 100.2 7.3e-21 XP_016865145 (OMIM: 601586) PREDICTED: prostagland ( 350) 499 100.2 7.7e-21 NP_000949 (OMIM: 601586) prostaglandin E2 receptor ( 488) 499 100.4 9.5e-21 NP_001051 (OMIM: 188070,614009) thromboxane A2 rec ( 343) 465 94.1 5.2e-19 XP_011526516 (OMIM: 188070,614009) PREDICTED: thro ( 343) 465 94.1 5.2e-19 NP_963998 (OMIM: 188070,614009) thromboxane A2 rec ( 407) 465 94.2 5.9e-19 NP_000950 (OMIM: 600563) prostaglandin F2-alpha re ( 359) 406 83.5 8.4e-16 NP_942010 (OMIM: 176806) prostaglandin E2 receptor ( 365) 372 77.4 5.9e-14 NP_942009 (OMIM: 176806) prostaglandin E2 receptor ( 374) 372 77.4 6e-14 NP_942008 (OMIM: 176806) prostaglandin E2 receptor ( 388) 372 77.5 6.2e-14 NP_942012 (OMIM: 176806) prostaglandin E2 receptor ( 390) 372 77.5 6.2e-14 NP_942007 (OMIM: 176806) prostaglandin E2 receptor ( 390) 372 77.5 6.2e-14 NP_001119516 (OMIM: 176806) prostaglandin E2 recep ( 390) 372 77.5 6.2e-14 XP_011540112 (OMIM: 176806) PREDICTED: prostagland ( 410) 372 77.5 6.4e-14 NP_942011 (OMIM: 176806) prostaglandin E2 receptor ( 418) 372 77.5 6.4e-14 NP_000946 (OMIM: 176802) prostaglandin E2 receptor ( 402) 331 70.1 1e-11 XP_016857362 (OMIM: 600563) PREDICTED: prostagland ( 291) 293 63.1 9.7e-10 NP_001034674 (OMIM: 600563) prostaglandin F2-alpha ( 297) 293 63.1 9.8e-10 NP_003605 (OMIM: 603692) galanin receptor type 3 [ ( 368) 228 51.5 3.7e-06 NP_006574 (OMIM: 605224) visual pigment-like recep ( 337) 219 49.9 1.1e-05 NP_005281 (OMIM: 601166) G-protein coupled recepto ( 360) 216 49.4 1.6e-05 NP_543141 (OMIM: 606917) probable G-protein couple ( 368) 208 47.9 4.5e-05 NP_001269117 (OMIM: 300201) cysteinyl leukotriene ( 337) 205 47.4 6.2e-05 NP_006630 (OMIM: 300201) cysteinyl leukotriene rec ( 337) 205 47.4 6.2e-05 NP_001269116 (OMIM: 300201) cysteinyl leukotriene ( 337) 205 47.4 6.2e-05 NP_001269115 (OMIM: 300201) cysteinyl leukotriene ( 337) 205 47.4 6.2e-05 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 204 47.2 7.7e-05 XP_016875894 (OMIM: 605741) PREDICTED: G-protein c ( 361) 203 47.0 8.3e-05 NP_004942 (OMIM: 605741) G-protein coupled recepto ( 361) 203 47.0 8.3e-05 NP_062813 (OMIM: 605773) leukotriene B4 receptor 2 ( 358) 201 46.7 0.00011 NP_001158164 (OMIM: 605773) leukotriene B4 recepto ( 358) 201 46.7 0.00011 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 197 45.9 0.00017 NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] ( 354) 197 45.9 0.00017 XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 iso ( 408) 197 46.0 0.00019 NP_005152 (OMIM: 600052) apelin receptor [Homo sap ( 380) 193 45.3 0.0003 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 190 44.7 0.00042 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 187 44.2 0.00061 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 187 44.2 0.00061 NP_940799 (OMIM: 601898) growth hormone secretagog ( 366) 187 44.2 0.00061 NP_473371 (OMIM: 607228) mas-related G-protein cou ( 330) 186 43.9 0.00065 NP_001290544 (OMIM: 607228) mas-related G-protein ( 330) 186 43.9 0.00065 >>NP_000951 (OMIM: 600022) prostacyclin receptor [Homo s (386 aa) initn: 2622 init1: 2622 opt: 2622 Z-score: 2558.1 bits: 482.1 E(85289): 9.5e-136 Smith-Waterman score: 2622; 100.0% identity (100.0% similar) in 386 aa overlap (1-386:1-386) 10 20 30 40 50 60 pF1KB8 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL 310 320 330 340 350 360 370 380 pF1KB8 PPTQQSSGSAVGTSSKAEASVACSLC :::::::::::::::::::::::::: NP_000 PPTQQSSGSAVGTSSKAEASVACSLC 370 380 >>XP_005259150 (OMIM: 600022) PREDICTED: prostacyclin re (342 aa) initn: 1720 init1: 1720 opt: 1720 Z-score: 1682.0 bits: 319.8 E(85289): 6e-87 Smith-Waterman score: 1720; 99.6% identity (100.0% similar) in 258 aa overlap (1-258:1-258) 10 20 30 40 50 60 pF1KB8 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF ::::::::::::::::.: XP_005 LALMTVVMAVCSLPLTMRGSVFRPVTQSQVLVLGPSIVEPDLPPTWLPSASEQAPPLPLH 250 260 270 280 290 300 >>XP_005259152 (OMIM: 600022) PREDICTED: prostacyclin re (257 aa) initn: 1711 init1: 1711 opt: 1711 Z-score: 1674.7 bits: 318.1 E(85289): 1.5e-86 Smith-Waterman score: 1711; 100.0% identity (100.0% similar) in 256 aa overlap (1-256:1-256) 10 20 30 40 50 60 pF1KB8 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF :::::::::::::::: XP_005 LALMTVVMAVCSLPLTQ 250 >>NP_000947 (OMIM: 176804,208550) prostaglandin E2 recep (358 aa) initn: 783 init1: 346 opt: 787 Z-score: 775.0 bits: 152.1 E(85289): 2e-36 Smith-Waterman score: 848; 46.1% identity (69.6% similar) in 332 aa overlap (2-309:10-332) 10 20 30 40 pF1KB8 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGIL----------SARR ...:.. .. . .:: :..:: :::.:: .::..: :: : NP_000 MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 PARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFF . : : :::: :. :::::: ..::.:...::::..:..:: . : : :::::::: NP_000 RSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRA-CTYFAFAMTFF 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 GLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLA-LPAIYAFCVLFCALPLLGLGQH .::.::.:::::.:: :...:::.: : : . :: ::.::: .:::.:::: ::. NP_000 SLATMLMLFAMALERYLSIGHPYFY-QRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQY 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 QQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQ :::::.:::.: : .:. :: :. ::..... :: :: :.: ::.:...: . NP_000 VQYCPGTWCFIRH-----GRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSR 180 190 200 210 220 230 230 240 250 260 pF1KB8 -------GSLGPRPRT-GE-----DEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDS : :: : :: .:.:::::::.::...::::::.:: :. .: NP_000 CGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTI--FAYMNETSS 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB8 SSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLAS .: :: :.:: ..: :.::::: ..: :.. .. .:: NP_000 RKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSD 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB8 GRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC NP_000 ASKQADL >>NP_001268398 (OMIM: 604687,607277) prostaglandin D2 re (296 aa) initn: 639 init1: 321 opt: 535 Z-score: 531.0 bits: 106.6 E(85289): 7.8e-23 Smith-Waterman score: 663; 43.8% identity (69.3% similar) in 274 aa overlap (5-255:8-281) 10 20 30 40 pF1KB8 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILS-------ARRPARP--SA :.: : :. . . . . ..: .:..:: ::::.:. .::: :: :. NP_001 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 FAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARG-GPALCDAFAFAMTFFGLASM : .:: ::..::::: .:::.:..:::.: :: :: . .::.:::: :.::::.: NP_001 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB8 LILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPG : :.:::.: :.:.::..: . : . :. :.. :: . :::::..:.:. ::::: NP_001 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB8 SWCFLRMRWAQPGGAA--FSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLG .:::..: . . .. .:. :..:.:::: : ::: .. .: :.:. .:: : NP_001 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT 190 200 210 220 230 240 230 240 250 260 270 pF1KB8 -----PRPRTGE------DEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGD :: : .:.:::.:::::::....::::. NP_001 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIAFVPGVPAKTPGSR 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 LLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPR >>NP_000944 (OMIM: 604687,607277) prostaglandin D2 recep (359 aa) initn: 746 init1: 321 opt: 533 Z-score: 528.1 bits: 106.4 E(85289): 1.1e-22 Smith-Waterman score: 767; 42.8% identity (67.1% similar) in 325 aa overlap (5-301:8-332) 10 20 30 40 pF1KB8 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILS-------ARRPARP--SA :.: : :. . . . . ..: .:..:: ::::.:. .::: :: :. NP_000 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 FAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARG-GPALCDAFAFAMTFFGLASM : .:: ::..::::: .:::.:..:::.: :: :: . .::.:::: :.::::.: NP_000 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB8 LILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPG : :.:::.: :.:.::..: . : . :. :.. :: . :::::..:.:. ::::: NP_000 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB8 SWCFLRMRWAQPGGAA--FSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLG .:::..: . . .. .:. :..:.:::: : ::: .. .: :.:. .:: : NP_000 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT 190 200 210 220 230 240 230 240 250 260 pF1KB8 -----PRPRTGE------DEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAP-----DSS :: : .:.:::.:::::::....::::. : . : .: NP_000 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB8 SEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASG : :: :.:: . :.:::.::.::. ::. NP_000 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL 310 320 330 340 350 330 340 350 360 370 380 pF1KB8 RRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC >>XP_005267948 (OMIM: 604687,607277) PREDICTED: prostagl (359 aa) initn: 746 init1: 321 opt: 533 Z-score: 528.1 bits: 106.4 E(85289): 1.1e-22 Smith-Waterman score: 767; 42.8% identity (67.1% similar) in 325 aa overlap (5-301:8-332) 10 20 30 40 pF1KB8 MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILS-------ARRPARP--SA :.: : :. . . . . ..: .:..:: ::::.:. .::: :: :. XP_005 MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 FAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARG-GPALCDAFAFAMTFFGLASM : .:: ::..::::: .:::.:..:::.: :: :: . .::.:::: :.::::.: XP_005 FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB8 LILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPG : :.:::.: :.:.::..: . : . :. :.. :: . :::::..:.:. ::::: XP_005 LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB8 SWCFLRMRWAQPGGAA--FSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLG .:::..: . . .. .:. :..:.:::: : ::: .. .: :.:. .:: : XP_005 TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT 190 200 210 220 230 240 230 240 250 260 pF1KB8 -----PRPRTGE------DEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAP-----DSS :: : .:.:::.:::::::....::::. : . : .: XP_005 RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB8 SEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASG : :: :.:: . :.:::.::.::. ::. XP_005 EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL 310 320 330 340 350 330 340 350 360 370 380 pF1KB8 RRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC >>XP_016865148 (OMIM: 601586) PREDICTED: prostaglandin E (313 aa) initn: 532 init1: 358 opt: 499 Z-score: 495.7 bits: 100.2 E(85289): 7.1e-21 Smith-Waterman score: 499; 42.2% identity (67.3% similar) in 211 aa overlap (17-225:20-224) 10 20 30 40 50 pF1KB8 MADSCRNLTYVRGSVGPAT-STLMFVAGVVGNGLALGIL-SARRPARPSAFAVLVTG :.: ..::. ::::: .:. .: ..:. . ..: .:: : XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 LAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAV ::.:::::: ..::.....: . : :: ::. .: . ::.:... :. ::.: XP_016 LAVTDLLGTLLVSPVTIATYMK-----GQWPGGQPLCEYSTFILLFFSLSGLSIICAMSV 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMR :: ::..: :.:.. : : :.: :.:: ::::::: .:::. . : .:::. XP_016 ERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 WAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEV . ::.: :::. ..:. : ::: : .: ::.:: :. ::: XP_016 TNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRT-SLGTEQHHAAAAA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 DHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILF XP_016 SVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVAINPI 240 250 260 270 280 290 >>XP_016865147 (OMIM: 601586) PREDICTED: prostaglandin E (325 aa) initn: 532 init1: 358 opt: 499 Z-score: 495.5 bits: 100.2 E(85289): 7.3e-21 Smith-Waterman score: 499; 42.2% identity (67.3% similar) in 211 aa overlap (17-225:20-224) 10 20 30 40 50 pF1KB8 MADSCRNLTYVRGSVGPAT-STLMFVAGVVGNGLALGIL-SARRPARPSAFAVLVTG :.: ..::. ::::: .:. .: ..:. . ..: .:: : XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 LAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAV ::.:::::: ..::.....: . : :: ::. .: . ::.:... :. ::.: XP_016 LAVTDLLGTLLVSPVTIATYMK-----GQWPGGQPLCEYSTFILLFFSLSGLSIICAMSV 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMR :: ::..: :.:.. : : :.: :.:: ::::::: .:::. . : .:::. XP_016 ERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 WAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEV . ::.: :::. ..:. : ::: : .: ::.:: :. ::: XP_016 TNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRT-SLGTEQHHAAAAA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 DHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILF XP_016 SVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVANWKW 240 250 260 270 280 290 >>XP_016865146 (OMIM: 601586) PREDICTED: prostaglandin E (326 aa) initn: 532 init1: 358 opt: 499 Z-score: 495.5 bits: 100.2 E(85289): 7.3e-21 Smith-Waterman score: 499; 42.2% identity (67.3% similar) in 211 aa overlap (17-225:20-224) 10 20 30 40 50 pF1KB8 MADSCRNLTYVRGSVGPAT-STLMFVAGVVGNGLALGIL-SARRPARPSAFAVLVTG :.: ..::. ::::: .:. .: ..:. . ..: .:: : XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 LAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAV ::.:::::: ..::.....: . : :: ::. .: . ::.:... :. ::.: XP_016 LAVTDLLGTLLVSPVTIATYMK-----GQWPGGQPLCEYSTFILLFFSLSGLSIICAMSV 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMR :: ::..: :.:.. : : :.: :.:: ::::::: .:::. . : .:::. XP_016 ERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 WAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEV . ::.: :::. ..:. : ::: : .: ::.:: :. ::: XP_016 TNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRT-SLGTEQHHAAAAA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 DHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILF XP_016 SVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVFPKLQ 240 250 260 270 280 290 386 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:51:24 2016 done: Fri Nov 4 16:51:25 2016 Total Scan time: 8.220 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]