FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9116, 772 aa 1>>>pF1KB9116 772 - 772 aa - 772 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.2333+/-0.0011; mu= -2.1809+/- 0.064 mean_var=364.0412+/-85.066, 0's: 0 Z-trim(111.3): 296 B-trim: 770 in 1/53 Lambda= 0.067220 statistics sampled from 11939 (12291) to 11939 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.378), width: 16 Scan time: 3.480 The best scores are: opt bits E(32554) CCDS62283.1 TLK2 gene_id:11011|Hs108|chr17 ( 772) 5124 512.0 1.5e-144 CCDS82182.1 TLK2 gene_id:11011|Hs108|chr17 ( 601) 2553 262.5 1.4e-69 CCDS45753.1 TLK2 gene_id:11011|Hs108|chr17 ( 718) 2553 262.6 1.6e-69 CCDS11633.1 TLK2 gene_id:11011|Hs108|chr17 ( 750) 2553 262.6 1.7e-69 CCDS46448.1 TLK1 gene_id:9874|Hs108|chr2 ( 670) 2298 237.8 4.3e-62 CCDS46447.1 TLK1 gene_id:9874|Hs108|chr2 ( 718) 2298 237.9 4.5e-62 CCDS2241.1 TLK1 gene_id:9874|Hs108|chr2 ( 766) 2298 237.9 4.7e-62 >>CCDS62283.1 TLK2 gene_id:11011|Hs108|chr17 (772 aa) initn: 5124 init1: 5124 opt: 5124 Z-score: 2708.6 bits: 512.0 E(32554): 1.5e-144 Smith-Waterman score: 5124; 100.0% identity (100.0% similar) in 772 aa overlap (1-772:1-772) 10 20 30 40 50 60 pF1KB9 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 KQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR 670 680 690 700 710 720 730 740 750 760 770 pF1KB9 CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN :::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS62 CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 730 740 750 760 770 >>CCDS82182.1 TLK2 gene_id:11011|Hs108|chr17 (601 aa) initn: 2529 init1: 2529 opt: 2553 Z-score: 1362.5 bits: 262.5 E(32554): 1.4e-69 Smith-Waterman score: 3944; 96.5% identity (96.5% similar) in 623 aa overlap (150-772:1-601) 120 130 140 150 160 170 pF1KB9 LPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQ :::::::::::::::::::::::::::::: CCDS82 MSVMLAKPRLDTEQLAQRGAGLCFTFVSAQ 10 20 30 180 190 200 210 220 230 pF1KB9 QNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 QNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLL 40 50 60 70 80 90 240 250 260 270 280 290 pF1KB9 RANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 RANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHF 100 110 120 130 140 150 300 310 320 330 340 350 pF1KB9 TTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 TTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNE 160 170 180 190 200 210 360 370 380 390 400 410 pF1KB9 QKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKE ::::::::::::::: ::::::::::::::::::::::: CCDS82 QKQRKSKTNGAENET----------------------LTLAEYHEQEEIFKLRLGHLKKE 220 230 240 420 430 440 450 460 470 pF1KB9 EAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 EAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKA 250 260 270 280 290 300 480 490 500 510 520 530 pF1KB9 FDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 FDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDS 310 320 330 340 350 360 540 550 560 570 580 590 pF1KB9 FCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 FCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNIL 370 380 390 400 410 420 600 610 620 630 640 650 pF1KB9 LVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKIS 430 440 450 460 470 480 660 670 680 690 700 710 pF1KB9 NKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 NKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIR 490 500 510 520 530 540 720 730 740 750 760 770 pF1KB9 RCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 RCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 550 560 570 580 590 600 >>CCDS45753.1 TLK2 gene_id:11011|Hs108|chr17 (718 aa) initn: 3103 init1: 2529 opt: 2553 Z-score: 1361.5 bits: 262.6 E(32554): 1.6e-69 Smith-Waterman score: 4633; 93.0% identity (93.0% similar) in 772 aa overlap (1-772:1-718) 10 20 30 40 50 60 pF1KB9 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL ::::::::::::::::::::::::::::: CCDS45 RNRKRKAEPYETSQGKGTPRGHKISDYFE------------------------------- 70 80 130 140 150 160 170 180 pF1KB9 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 -RRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB9 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB9 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB9 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB9 KQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEE :::::::::::::: :::::::::::::::::::::::: CCDS45 KQRKSKTNGAENET----------------------LTLAEYHEQEEIFKLRLGHLKKEE 330 340 350 360 430 440 450 460 470 480 pF1KB9 AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF 370 380 390 400 410 420 490 500 510 520 530 540 pF1KB9 DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF 430 440 450 460 470 480 550 560 570 580 590 600 pF1KB9 CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL 490 500 510 520 530 540 610 620 630 640 650 660 pF1KB9 VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISN 550 560 570 580 590 600 670 680 690 700 710 720 pF1KB9 KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR 610 620 630 640 650 660 730 740 750 760 770 pF1KB9 CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN :::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 670 680 690 700 710 >>CCDS11633.1 TLK2 gene_id:11011|Hs108|chr17 (750 aa) initn: 2529 init1: 2529 opt: 2553 Z-score: 1361.3 bits: 262.6 E(32554): 1.7e-69 Smith-Waterman score: 4930; 97.2% identity (97.2% similar) in 772 aa overlap (1-772:1-750) 10 20 30 40 50 60 pF1KB9 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 RNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 TVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEE :::::::::::::: :::::::::::::::::::::::: CCDS11 KQRKSKTNGAENET----------------------LTLAEYHEQEEIFKLRLGHLKKEE 370 380 390 430 440 450 460 470 480 pF1KB9 AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB9 DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSF 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB9 CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 CTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB9 VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISN 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB9 KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 KVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR 640 650 660 670 680 690 730 740 750 760 770 pF1KB9 CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN :::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN 700 710 720 730 740 750 >>CCDS46448.1 TLK1 gene_id:9874|Hs108|chr2 (670 aa) initn: 3202 init1: 1487 opt: 2298 Z-score: 1228.2 bits: 237.8 E(32554): 4.3e-62 Smith-Waterman score: 3253; 71.6% identity (82.6% similar) in 725 aa overlap (51-769:14-666) 30 40 50 60 70 pF1KB9 TGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ-RNRKRKAEPY-ETSQGKGT .::::::... :.:::::: :.::::. CCDS46 MAVLFLYDLKTTGKTPEKKQSESSRGRKRKAENQNESSQGKSI 10 20 30 40 80 90 100 110 120 130 pF1KB9 P-RGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAK ::::::::::. ::. :.:: :..::. :: ::.: :. : .: CCDS46 GGRGHKISDYFEYQGGN--GSSPVRGIPPAIRS-PQNSHSHSTPSSSVRP---------- 50 60 70 80 90 140 150 160 170 180 190 pF1KB9 EATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSS :::: :. . .: . CCDS46 -------------------------------------------NSPSPTALAFGDHPIVQ 100 200 210 220 230 240 250 pF1KB9 QKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLE ::.:. . :.:::. :..:::..: .::::::::::::::::::::::::::::.:: CCDS46 PKQLSF--KIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLE 110 120 130 140 150 160 260 270 280 290 300 310 pF1KB9 KYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYA :::::::.:..:::::::::: :::.. :.::::::::::::::::::::::::::::.: CCDS46 KYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFA 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB9 FQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAENET ::::.:::: .:.:::.::::::.:::::::. . ::: ...: ::::.:. :::::. CCDS46 FQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEND- 230 240 250 260 270 280 380 390 400 410 420 430 pF1KB9 PSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVR : .. . : : :::::::::::::::::::::::::::::::::::::: CCDS46 P-----FVRPNLPQL-------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVR 290 300 310 320 330 440 450 460 470 480 490 pF1KB9 NLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQ ::::::::::.::::::::::::::.:::::::::::::::::::::: ::::.:::::: CCDS46 NLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQ 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB9 LNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDF :::.::::::::::::::::::::::::::::::::::::::::.::::::::::::::: CCDS46 LNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDF 400 410 420 430 440 450 560 570 580 590 600 610 pF1KB9 YLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDF ::::::::::::::::.:::::::.::::::::::::::::::::::.:::::::::::: CCDS46 YLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDF 460 470 480 490 500 510 620 630 640 650 660 670 pF1KB9 GLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQC :::::::::::. ::::.:::::::::::::::::::::::::::::::::::::::.:: CCDS46 GLSKIMDDDSYG-VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQC 520 530 540 550 560 570 680 690 700 710 720 730 pF1KB9 LYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQ ::::::::::::::::::::::::::::::: ::::. :::::::::::::::::.::.: CCDS46 LYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQ 580 590 600 610 620 630 740 750 760 770 pF1KB9 LACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN :: :::::::.:.: :... :..... ..: CCDS46 LANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 640 650 660 670 >>CCDS46447.1 TLK1 gene_id:9874|Hs108|chr2 (718 aa) initn: 3342 init1: 1487 opt: 2298 Z-score: 1227.9 bits: 237.9 E(32554): 4.5e-62 Smith-Waterman score: 3448; 70.7% identity (81.8% similar) in 786 aa overlap (2-769:1-714) 10 20 30 40 pF1KB9 MMEELHSLDPRRQELLEARFTGVGV------------SKGPLNSESSNQSLCSVGSLSDK :.::::::::::::::::::::. .:. :.::::.:. :.:::::: CCDS46 MDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDK 10 20 30 40 50 50 60 70 80 90 100 pF1KB9 EVETPEKKQNDQ-RNRKRKAEPY-ETSQGKGTP-RGHKISDYFEFAGGSAPGTSPGRSVP : :::::::... :.:::::: :.::::. ::::::::::. ::. :.:: :..: CCDS46 ESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGN--GSSPVRGIP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB9 PVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLA :. :: ::.: :. : .: CCDS46 PAIRS-PQNSHSHSTPSSSVRP-------------------------------------- 120 130 170 180 190 200 210 220 pF1KB9 QRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKN :::: :. . .: . ::.:. . :.:::. :..:::..: CCDS46 ---------------NSPSPTALAFGDHPIVQPKQLSF--KIIQTDLTMLKLAALESNKI 140 150 160 170 180 230 240 250 260 270 280 pF1KB9 SDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMAC .::::::::::::::::::::::::::::.:::::::::.:..:::::::::: :::.. CCDS46 QDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSS 190 200 210 220 230 240 290 300 310 320 330 340 pF1KB9 RDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKR :.::::::::::::::::::::::::::::.:::::.:::: .:.:::.::::::.:::: CCDS46 REKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKR 250 260 270 280 290 300 350 360 370 380 390 400 pF1KB9 KPPAMG--QAPPATNEQKQRKSKT-NGAENETPSSGNTELKDTAPALGAHSLLRLTLAEY :::. . ::: ...: ::::.:. :::::. : .. . : : :::::: CCDS46 KPPTANNSQAPSTNSEPKQRKNKAVNGAEND-PF-----VRPNLPQL-------LTLAEY 310 320 330 340 410 420 430 440 450 460 pF1KB9 HEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRY ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::.:: CCDS46 HEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERY 350 360 370 380 390 400 470 480 490 500 510 520 pF1KB9 LLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELD :::::::::::::::::::: ::::.:::::::::.:::::::::::::::::::::::: CCDS46 LLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELD 410 420 430 440 450 460 530 540 550 560 570 580 pF1KB9 HPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLN ::::::::::::::::.:::::::::::::::::::::::::::::::.:::::::.::: CCDS46 HPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLN 470 480 490 500 510 520 590 600 610 620 630 640 pF1KB9 EIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYW :::::::::::::::::::.:::::::::::::::::::::::. ::::.:::::::::: CCDS46 EIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG-VDGMDLTSQGAGTYW 530 540 550 560 570 580 650 660 670 680 690 700 pF1KB9 YLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEV :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: CCDS46 YLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEV 590 600 610 620 630 640 710 720 730 740 750 760 pF1KB9 QFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIAST ::: ::::. :::::::::::::::::.::.::: :::::::.:.: :... :..... CCDS46 QFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTAS 650 660 670 680 690 700 770 pF1KB9 SGASNNSSSN ..: CCDS46 PTPPSSSIITY 710 >>CCDS2241.1 TLK1 gene_id:9874|Hs108|chr2 (766 aa) initn: 3342 init1: 1487 opt: 2298 Z-score: 1227.5 bits: 237.9 E(32554): 4.7e-62 Smith-Waterman score: 3448; 70.7% identity (81.8% similar) in 786 aa overlap (2-769:49-762) 10 20 pF1KB9 MMEELHSLDPRRQELLEARFTGVGV------ :.::::::::::::::::::::. CCDS22 LSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGST 20 30 40 50 60 70 30 40 50 60 70 pF1KB9 ------SKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQ-RNRKRKAEPY-ETSQGKG .:. :.::::.:. :.::::::: :::::::... :.:::::: :.::::. CCDS22 GSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKS 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB9 TP-RGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAA ::::::::::. ::. :.:: :..::. :: ::.: :. : .: CCDS22 IGGRGHKISDYFEYQGGN--GSSPVRGIPPAIRS-PQNSHSHSTPSSSVRP--------- 140 150 160 170 180 140 150 160 170 180 190 pF1KB9 KEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCS :::: :. . .: CCDS22 --------------------------------------------NSPSPTALAFGDHPIV 190 200 200 210 220 230 240 250 pF1KB9 SQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKML . ::.:. . :.:::. :..:::..: .::::::::::::::::::::::::::::.: CCDS22 QPKQLSF--KIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLL 210 220 230 240 250 260 260 270 280 290 300 310 pF1KB9 EKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGY ::::::::.:..:::::::::: :::.. :.::::::::::::::::::::::::::::. CCDS22 EKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGF 270 280 290 300 310 320 320 330 340 350 360 370 pF1KB9 AFQNLIKQQERINSQREEIERQRKMLAKRKPPAMG--QAPPATNEQKQRKSKT-NGAENE :::::.:::: .:.:::.::::::.:::::::. . ::: ...: ::::.:. :::::. CCDS22 AFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAEND 330 340 350 360 370 380 380 390 400 410 420 430 pF1KB9 TPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERV : .. . : : ::::::::::::::::::::::::::::::::::::: CCDS22 -PF-----VRPNLPQL-------LTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERV 390 400 410 420 440 450 460 470 480 490 pF1KB9 RNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIH :::::::::::.::::::::::::::.:::::::::::::::::::::: ::::.::::: CCDS22 RNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIH 430 440 450 460 470 480 500 510 520 530 540 550 pF1KB9 QLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLD ::::.::::::::::::::::::::::::::::::::::::::::.:::::::::::::: CCDS22 QLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLD 490 500 510 520 530 540 560 570 580 590 600 610 pF1KB9 FYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITD :::::::::::::::::.:::::::.::::::::::::::::::::::.::::::::::: CCDS22 FYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITD 550 560 570 580 590 600 620 630 640 650 660 670 pF1KB9 FGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQ ::::::::::::. ::::.:::::::::::::::::::::::::::::::::::::::.: CCDS22 FGLSKIMDDDSYG-VDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQ 610 620 630 640 650 660 680 690 700 710 720 730 pF1KB9 CLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQ :::::::::::::::::::::::::::::::: ::::. :::::::::::::::::.::. CCDS22 CLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVH 670 680 690 700 710 720 740 750 760 770 pF1KB9 QLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN ::: :::::::.:.: :... :..... ..: CCDS22 QLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY 730 740 750 760 772 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:22:53 2016 done: Sat Nov 5 23:22:53 2016 Total Scan time: 3.480 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]