FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9131, 579 aa 1>>>pF1KB9131 579 - 579 aa - 579 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7271+/-0.00036; mu= 13.5354+/- 0.023 mean_var=107.1560+/-21.191, 0's: 0 Z-trim(116.2): 406 B-trim: 0 in 0/58 Lambda= 0.123898 statistics sampled from 26826 (27240) to 26826 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.319), width: 16 Scan time: 10.990 The best scores are: opt bits E(85289) NP_005117 (OMIM: 602304) nuclear receptor subfamil ( 579) 3895 707.0 4.3e-203 NP_001138897 (OMIM: 602304) nuclear receptor subfa ( 504) 3413 620.8 3.3e-177 XP_006713514 (OMIM: 602304) PREDICTED: nuclear rec ( 448) 3066 558.7 1.4e-158 NP_068370 (OMIM: 602408) nuclear receptor subfamil ( 614) 1722 318.6 3.8e-86 XP_011520181 (OMIM: 600825) PREDICTED: nuclear rec ( 376) 477 95.9 2.5e-19 XP_016877956 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 477 95.9 2.5e-19 XP_011520180 (OMIM: 600825) PREDICTED: nuclear rec ( 386) 477 95.9 2.5e-19 NP_803184 (OMIM: 600409) peroxisome proliferator-a ( 361) 462 93.2 1.5e-18 XP_016866464 (OMIM: 600409) PREDICTED: peroxisome ( 365) 462 93.2 1.5e-18 XP_011532146 (OMIM: 125853,601487,601665,604367,60 ( 250) 457 92.3 2.1e-18 NP_001317544 (OMIM: 125853,601487,601665,604367,60 ( 250) 457 92.3 2.1e-18 XP_011532145 (OMIM: 125853,601487,601665,604367,60 ( 278) 457 92.3 2.3e-18 XP_011532144 (OMIM: 125853,601487,601665,604367,60 ( 445) 457 92.4 3.4e-18 NP_599023 (OMIM: 600825) nuclear receptor ROR-alph ( 523) 448 90.8 1.2e-17 XP_006724333 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 NP_005027 (OMIM: 170998) peroxisome proliferator-a ( 468) 447 90.6 1.2e-17 XP_011528544 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 XP_006724332 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 XP_011528545 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 XP_005261713 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 XP_011528543 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 NP_001001928 (OMIM: 170998) peroxisome proliferato ( 468) 447 90.6 1.2e-17 XP_005261712 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 XP_011528542 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 XP_011528541 (OMIM: 170998) PREDICTED: peroxisome ( 468) 447 90.6 1.2e-17 XP_011518110 (OMIM: 602423) PREDICTED: oxysterols ( 235) 436 88.5 2.7e-17 XP_011518109 (OMIM: 602423) PREDICTED: oxysterols ( 313) 436 88.6 3.4e-17 XP_005252773 (OMIM: 602423) PREDICTED: oxysterols ( 313) 436 88.6 3.4e-17 XP_005252772 (OMIM: 602423) PREDICTED: oxysterols ( 358) 436 88.6 3.8e-17 XP_006718179 (OMIM: 602423) PREDICTED: oxysterols ( 402) 436 88.6 4.2e-17 NP_001123574 (OMIM: 602423) oxysterols receptor LX ( 402) 436 88.6 4.2e-17 XP_005252767 (OMIM: 602423) PREDICTED: oxysterols ( 402) 436 88.6 4.2e-17 XP_006718178 (OMIM: 602423) PREDICTED: oxysterols ( 402) 436 88.6 4.2e-17 XP_016872547 (OMIM: 602423) PREDICTED: oxysterols ( 402) 436 88.6 4.2e-17 XP_005252766 (OMIM: 602423) PREDICTED: oxysterols ( 402) 436 88.6 4.2e-17 NP_005684 (OMIM: 602423) oxysterols receptor LXR-a ( 447) 436 88.6 4.6e-17 XP_005252764 (OMIM: 602423) PREDICTED: oxysterols ( 447) 436 88.6 4.6e-17 XP_005252763 (OMIM: 602423) PREDICTED: oxysterols ( 447) 436 88.6 4.6e-17 XP_006718176 (OMIM: 602423) PREDICTED: oxysterols ( 447) 436 88.6 4.6e-17 XP_005252762 (OMIM: 602423) PREDICTED: oxysterols ( 447) 436 88.6 4.6e-17 XP_011518107 (OMIM: 602423) PREDICTED: oxysterols ( 447) 436 88.6 4.6e-17 XP_006718175 (OMIM: 602423) PREDICTED: oxysterols ( 447) 436 88.6 4.6e-17 NP_001238863 (OMIM: 602423) oxysterols receptor LX ( 453) 436 88.6 4.6e-17 NP_001238864 (OMIM: 602423) oxysterols receptor LX ( 453) 436 88.6 4.6e-17 XP_005254641 (OMIM: 600825) PREDICTED: nuclear rec ( 477) 433 88.1 7e-17 XP_011520177 (OMIM: 600825) PREDICTED: nuclear rec ( 504) 433 88.1 7.3e-17 XP_016877955 (OMIM: 600825) PREDICTED: nuclear rec ( 460) 428 87.2 1.3e-16 XP_011520179 (OMIM: 600825) PREDICTED: nuclear rec ( 467) 428 87.2 1.3e-16 NP_599024 (OMIM: 600825) nuclear receptor ROR-alph ( 468) 428 87.2 1.3e-16 XP_011520176 (OMIM: 600825) PREDICTED: nuclear rec ( 525) 428 87.2 1.4e-16 >>NP_005117 (OMIM: 602304) nuclear receptor subfamily 1 (579 aa) initn: 3895 init1: 3895 opt: 3895 Z-score: 3767.2 bits: 707.0 E(85289): 4.3e-203 Smith-Waterman score: 3895; 100.0% identity (100.0% similar) in 579 aa overlap (1-579:1-579) 10 20 30 40 50 60 pF1KB9 MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 DGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLI 490 500 510 520 530 540 550 560 570 pF1KB9 MKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP ::::::::::::::::::::::::::::::::::::::: NP_005 MKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP 550 560 570 >>NP_001138897 (OMIM: 602304) nuclear receptor subfamily (504 aa) initn: 3413 init1: 3413 opt: 3413 Z-score: 3302.5 bits: 620.8 E(85289): 3.3e-177 Smith-Waterman score: 3413; 100.0% identity (100.0% similar) in 504 aa overlap (76-579:1-504) 50 60 70 80 90 100 pF1KB9 SSNSDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKV :::::::::::::::::::::::::::::: NP_001 MKTSKSSAPGMTKSHSGVTKFSGMVLLCKV 10 20 30 110 120 130 140 150 160 pF1KB9 CGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCL 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB9 SVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQE 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB9 QLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB9 RIPKNMEQYNLNHDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIPKNMEQYNLNHDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMN 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB9 FSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSNAYTQRVCDRVPIDGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEF 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB9 SMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLS 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB9 GKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSV 400 410 420 430 440 450 530 540 550 560 570 pF1KB9 EALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP 460 470 480 490 500 >>XP_006713514 (OMIM: 602304) PREDICTED: nuclear recepto (448 aa) initn: 3188 init1: 3066 opt: 3066 Z-score: 2968.0 bits: 558.7 E(85289): 1.4e-158 Smith-Waterman score: 3066; 99.8% identity (100.0% similar) in 445 aa overlap (1-445:1-445) 10 20 30 40 50 60 pF1KB9 MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MEVNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSPNSSNSDTNGNPKNGDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHAC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CGNGLSSHFPCSESQQHLNGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 DGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGFSQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG ::::::::::::::::::::::::. XP_006 KRIPGFRDLSQHDQVNLLKAGTFEIDLE 430 440 >>NP_068370 (OMIM: 602408) nuclear receptor subfamily 1 (614 aa) initn: 1836 init1: 910 opt: 1722 Z-score: 1667.6 bits: 318.6 E(85289): 3.8e-86 Smith-Waterman score: 1783; 51.1% identity (72.5% similar) in 614 aa overlap (4-577:9-611) 10 20 30 40 50 pF1KB9 MEVNAGGVIAYISSSSSA---SSPASCHSEGSENSFQSSSSSVPSS-PNSSNSDT :.::::.::.::.:. .:: : .:..:..:::: ... :. : : ... NP_068 MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSL 10 20 30 40 50 60 60 70 80 90 pF1KB9 NGNPKNGDLANIEGILKNDRIDCSMKTSKSSA--------PGM-------------TKSH . .: . ...: :..: : ..:.::. :: .:: NP_068 TQDPARS-FGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKST 70 80 90 100 110 100 110 120 130 140 150 pF1KB9 SGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMR :..::..:::::::::::::::::::::::::::::::::::::::::.:::::::::.: NP_068 SNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVR 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB9 MNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQND .::::::::::::::::::::::::::::::::::::: ::::::. . :.:.:.. . NP_068 INRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMN-LANNQLSSQCPLE 180 190 200 210 220 230 220 230 240 250 260 pF1KB9 TLVEHHEQTALPAQEQLRPKP---------QLEQENIKSSSPPSSDFAKEEVIGMVTRAH : .: : : . : : :. :. . :: . . :.::..:.::: NP_068 TSPTQHP-TPGPMGPSPPPAPVPSPLVGFSQFPQQ-LTPPRSPSPEPTVEDVISQVARAH 240 250 260 270 280 290 270 280 290 300 310 pF1KB9 KDTFMYNQEQQENSAESMQPQRGERIPKNMEQYNLNHDHCGNGLSSHFPCSESQQH---L .. : : ... .: ... ... : . ... : . ... . .:.: : NP_068 REIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLA-AQRHNEAL 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB9 NGQFKGRNIMHYPNGHAICIANGHCMNFSNAYTQRVCDRVPIDGFSQNENK---NSYLCN :: .. . :: :. : . ::. .:.: : .. :.: :: . NP_068 NGLRQAPS--SYPPTWPPGPAHHSCHQ-SNSNGHRLC---PTHVYAAPEGKAPANSPRQG 360 370 380 390 400 380 390 400 410 420 430 pF1KB9 TGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQV .. . :.:::. :. .. .::::.:::::::::.:::::::.::::::::::::: NP_068 NSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQV 410 420 430 440 450 460 440 450 460 470 480 490 pF1KB9 NLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNA .::::::::::::::::::..:..:: ::: ::...: .:: ::::..::.::::::. NP_068 TLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNS 470 480 490 500 510 520 500 510 520 530 540 550 pF1KB9 LQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLL : :..::..::::::::::::::.:: ::: :::::.::::.:..::.: :.: ::::: NP_068 LALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLL 530 540 550 560 570 580 560 570 pF1KB9 LKLPDLRSLNNMHSEELLAFKVHP :::::::.:::::::.::.:.: NP_068 LKLPDLRTLNNMHSEKLLSFRVDAQ 590 600 610 >>XP_011520181 (OMIM: 600825) PREDICTED: nuclear recepto (376 aa) initn: 339 init1: 204 opt: 477 Z-score: 468.1 bits: 95.9 E(85289): 2.5e-19 Smith-Waterman score: 494; 32.5% identity (65.7% similar) in 335 aa overlap (271-579:19-349) 250 260 270 280 290 pF1KB9 SSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAESMQPQRGERI-PK-NMEQYNLN- ::.. ...:: ..: . : :. .:. XP_011 MSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTE 10 20 30 40 300 310 320 330 340 pF1KB9 -HDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYP-------NG---HAIC---IANG-- :: .: ...: : . . . ..: .:. : :: . :: :.: XP_011 LHDDLSNYIDGHTPEGSKADSAVSSFY-LDIQPSPDQSGLDINGIKPEPICDYTPASGFF 50 60 70 80 90 100 350 360 370 380 390 pF1KB9 -HCMNFSNAYTQRVCDRVPIDGFSQNENKN-----SYLCNTGGRMHLVCPMSKSPYVDPH .: .:.:. :. . . . .. ..:: .:. .:: . .. ... . XP_011 PYC-SFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQN 110 120 130 140 150 160 400 410 420 430 440 450 pF1KB9 KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFD :. . .:. ....: :.. :::::::: :: .: :.::. :::::..::...:. :: XP_011 KQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFD 170 180 190 200 210 220 460 470 480 490 500 510 pF1KB9 AKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSAD ... :: : .:: : : ..:.: :... .:::...: ...:...:..::.: ::.::: XP_011 SQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSAD 230 240 250 260 270 280 520 530 540 550 560 570 pF1KB9 RSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAF :: ... ..: ::. . ::. ...::: : .:.:::. :. ::.: . :.:.:.:: XP_011 RSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTKLICKVSTLRALCGRHTEKLMAF 290 300 310 320 330 340 pF1KB9 K-VHP : ..: XP_011 KAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 350 360 370 >>XP_016877956 (OMIM: 600825) PREDICTED: nuclear recepto (386 aa) initn: 388 init1: 204 opt: 477 Z-score: 467.9 bits: 95.9 E(85289): 2.5e-19 Smith-Waterman score: 500; 31.4% identity (64.1% similar) in 357 aa overlap (255-579:9-359) 230 240 250 260 270 280 pF1KB9 EQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQ---ENSAESMQP : ... ..:. .: . :. ... .. : XP_016 MSRDAVKFGRMSKKQRDS-LYAEVQKHRMQQQQRDHQQ 10 20 30 290 300 310 320 330 pF1KB9 QRGERIPKNMEQYNLN-------HDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYP--- : :: : . ::.. :: .: ...: : . . . ..: .:. : XP_016 QPGEAEPLT-PTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFY-LDIQPSPDQS 40 50 60 70 80 90 340 350 360 370 pF1KB9 ----NG---HAIC---IANG---HCMNFSNAYTQRVCDRVPIDGFSQNENKN-----SYL :: . :: :.: .: .:.:. :. . . . .. ..:: .:. .:: XP_016 GLDINGIKPEPICDYTPASGFFPYC-SFTNGETSPTVSMAELEHLAQNISKSHLETCQYL 100 110 120 130 140 150 380 390 400 410 420 430 pF1KB9 CNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHD . .. ... .:. . .:. ....: :.. :::::::: :: .: :.: XP_016 REELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQND 160 170 180 190 200 210 440 450 460 470 480 490 pF1KB9 QVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKL :. :::::..::...:. ::... :: : .:: : : ..:.: :... .:::...: XP_016 QIVLLKAGSLEVVFIRMCRAFDSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSL 220 230 240 250 260 270 500 510 520 530 540 550 pF1KB9 NALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTK ...:...:..::.: ::.::::: ... ..: ::. . ::. ...::: : .:.:: XP_016 CSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTK 280 290 300 310 320 330 560 570 pF1KB9 LLLKLPDLRSLNNMHSEELLAFK-VHP :. :. ::.: . :.:.:.::: ..: XP_016 LICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 340 350 360 370 380 >>XP_011520180 (OMIM: 600825) PREDICTED: nuclear recepto (386 aa) initn: 388 init1: 204 opt: 477 Z-score: 467.9 bits: 95.9 E(85289): 2.5e-19 Smith-Waterman score: 500; 31.4% identity (64.1% similar) in 357 aa overlap (255-579:9-359) 230 240 250 260 270 280 pF1KB9 EQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQ---ENSAESMQP : ... ..:. .: . :. ... .. : XP_011 MSRDAVKFGRMSKKQRDS-LYAEVQKHRMQQQQRDHQQ 10 20 30 290 300 310 320 330 pF1KB9 QRGERIPKNMEQYNLN-------HDHCGNGLSSHFPCSESQQHLNGQFKGRNIMHYP--- : :: : . ::.. :: .: ...: : . . . ..: .:. : XP_011 QPGEAEPLT-PTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFY-LDIQPSPDQS 40 50 60 70 80 90 340 350 360 370 pF1KB9 ----NG---HAIC---IANG---HCMNFSNAYTQRVCDRVPIDGFSQNENKN-----SYL :: . :: :.: .: .:.:. :. . . . .. ..:: .:. .:: XP_011 GLDINGIKPEPICDYTPASGFFPYC-SFTNGETSPTVSMAELEHLAQNISKSHLETCQYL 100 110 120 130 140 150 380 390 400 410 420 430 pF1KB9 CNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHD . .. ... .:. . .:. ....: :.. :::::::: :: .: :.: XP_011 REELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQND 160 170 180 190 200 210 440 450 460 470 480 490 pF1KB9 QVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKL :. :::::..::...:. ::... :: : .:: : : ..:.: :... .:::...: XP_011 QIVLLKAGSLEVVFIRMCRAFDSQNNTVYF-DGKYASPDVFKSLGCEDFISFVFEFGKSL 220 230 240 250 260 270 500 510 520 530 540 550 pF1KB9 NALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTK ...:...:..::.: ::.::::: ... ..: ::. . ::. ...::: : .:.:: XP_011 CSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNH-REDGILTK 280 290 300 310 320 330 560 570 pF1KB9 LLLKLPDLRSLNNMHSEELLAFK-VHP :. :. ::.: . :.:.:.::: ..: XP_011 LICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG 340 350 360 370 380 >>NP_803184 (OMIM: 600409) peroxisome proliferator-activ (361 aa) initn: 589 init1: 228 opt: 462 Z-score: 453.9 bits: 93.2 E(85289): 1.5e-18 Smith-Waterman score: 462; 45.8% identity (73.6% similar) in 144 aa overlap (79-212:46-187) 50 60 70 80 90 100 pF1KB9 SDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPG--MTKSHSGVTKFS--GMVLLCK :.::.: . . . : : .. . :. NP_803 EKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECR 20 30 40 50 60 70 110 120 130 140 150 160 pF1KB9 VCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKC :::: ::::::::::::::::::::.:.....:.:: .. :.:.. :::.:: :::.:: NP_803 VCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERS--CKIQKKNRNKCQYCRFQKC 80 90 100 110 120 130 170 180 190 200 210 pF1KB9 LSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQNDTLVEHHEQ :..:::..:.::::.:. ::.... . . ...: : :: :. : : NP_803 LALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMT 140 150 160 170 180 190 220 230 240 250 260 270 pF1KB9 TALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAES NP_803 KKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTT 200 210 220 230 240 250 >-- initn: 211 init1: 124 opt: 196 Z-score: 196.9 bits: 45.7 E(85289): 0.00031 Smith-Waterman score: 196; 34.1% identity (69.1% similar) in 123 aa overlap (394-512:237-357) 370 380 390 400 410 420 pF1KB9 SQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHK--SGHEIWEEFSMSFTPAVKEVVEFAK :.: : : .. . . . . .:.:..:::: NP_803 HTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVH-VFYRCQCTTVETVRELTEFAK 210 220 230 240 250 260 430 440 450 460 470 pF1KB9 RIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGA-- ::.: .: .:::.::: :. :.... .::. . :. :: . . :.:. NP_803 SIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGF-VTREFLRSLRKPF 270 280 290 300 310 320 480 490 500 510 520 530 pF1KB9 GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTL .:... :::. :.:::.:.: ...:: :.... NP_803 SDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGGE 330 340 350 360 540 550 560 570 pF1KB9 IMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP >>XP_016866464 (OMIM: 600409) PREDICTED: peroxisome prol (365 aa) initn: 589 init1: 228 opt: 462 Z-score: 453.8 bits: 93.2 E(85289): 1.5e-18 Smith-Waterman score: 462; 45.8% identity (73.6% similar) in 144 aa overlap (79-212:46-187) 50 60 70 80 90 100 pF1KB9 SDTNGNPKNGDLANIEGILKNDRIDCSMKTSKSSAPG--MTKSHSGVTKFS--GMVLLCK :.::.: . . . : : .. . :. XP_016 EKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECR 20 30 40 50 60 70 110 120 130 140 150 160 pF1KB9 VCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKC :::: ::::::::::::::::::::.:.....:.:: .. :.:.. :::.:: :::.:: XP_016 VCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERS--CKIQKKNRNKCQYCRFQKC 80 90 100 110 120 130 170 180 190 200 210 pF1KB9 LSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ------FSGHLQNDTLVEHHEQ :..:::..:.::::.:. ::.... . . ...: : :: :. : : XP_016 LALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMT 140 150 160 170 180 190 220 230 240 250 260 270 pF1KB9 TALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQEQQENSAES XP_016 KKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTT 200 210 220 230 240 250 >-- initn: 211 init1: 124 opt: 196 Z-score: 196.8 bits: 45.7 E(85289): 0.00032 Smith-Waterman score: 196; 34.1% identity (69.1% similar) in 123 aa overlap (394-512:237-357) 370 380 390 400 410 420 pF1KB9 SQNENKNSYLCNTGGRMHLVCPMSKSPYVDPHK--SGHEIWEEFSMSFTPAVKEVVEFAK :.: : : .. . . . . .:.:..:::: XP_016 HTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVH-VFYRCQCTTVETVRELTEFAK 210 220 230 240 250 260 430 440 450 460 470 pF1KB9 RIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGA-- ::.: .: .:::.::: :. :.... .::. . :. :: . . :.:. XP_016 SIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGF-VTREFLRSLRKPF 270 280 290 300 310 320 480 490 500 510 520 530 pF1KB9 GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTL .:... :::. :.:::.:.: ...:: :.... XP_016 SDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGAAAEDG 330 340 350 360 540 550 560 570 pF1KB9 IMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFKVHP >>XP_011532146 (OMIM: 125853,601487,601665,604367,609338 (250 aa) initn: 456 init1: 238 opt: 457 Z-score: 451.4 bits: 92.3 E(85289): 2.1e-18 Smith-Waterman score: 457; 40.1% identity (68.7% similar) in 182 aa overlap (25-198:28-204) 10 20 30 40 50 pF1KB9 MEVNAGGVIAYISSSSSASSPASCHSEGSE-NSFQSSSSSVPSSPNSSNSD-TNGNP ::.. . . : . . : :.:. . : .: XP_011 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP 10 20 30 40 50 60 60 70 80 90 100 pF1KB9 KNGDLANIEGILKNDRIDCSMKTSKSSAPGMTKSHSGVTKF------SGMVLLCKVCGDV .:. . :: .. . ..:. .: : .... . .: : :.. :.:::: XP_011 V---VADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDK 70 80 90 100 110 110 120 130 140 150 160 pF1KB9 ASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGM ::::::::::::::::::::.:. .. : .: . :: : . .::.:: :::.:::.::: XP_011 ASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQYCRFQKCLAVGM 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB9 SRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQFSGHLQNDTLVEHHEQTALPAQEQLRP :..:.::::.:. ::...: :..: . . XP_011 SHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARA 180 190 200 210 220 230 579 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:03:45 2016 done: Thu Nov 3 23:03:46 2016 Total Scan time: 10.990 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]