FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9213, 839 aa 1>>>pF1KB9213 839 - 839 aa - 839 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8654+/-0.000426; mu= 8.0129+/- 0.026 mean_var=117.7577+/-23.693, 0's: 0 Z-trim(113.4): 24 B-trim: 129 in 2/53 Lambda= 0.118190 statistics sampled from 22667 (22691) to 22667 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.266), width: 16 Scan time: 13.240 The best scores are: opt bits E(85289) XP_011524081 (OMIM: 604908) PREDICTED: serine/thre ( 891) 5443 939.9 0 XP_016881594 (OMIM: 604908) PREDICTED: serine/thre ( 949) 4223 731.9 3.3e-210 XP_016881595 (OMIM: 604908) PREDICTED: serine/thre ( 861) 4214 730.3 8.8e-210 XP_016881596 (OMIM: 604908) PREDICTED: serine/thre ( 861) 4214 730.3 8.8e-210 NP_005125 (OMIM: 604908) serine/threonine-protein ( 933) 4214 730.3 9.5e-210 NP_001035847 (OMIM: 604908) serine/threonine-prote ( 950) 4214 730.3 9.6e-210 XP_011524078 (OMIM: 604908) PREDICTED: serine/thre ( 985) 4214 730.3 1e-209 XP_011524077 (OMIM: 604908) PREDICTED: serine/thre (1002) 4214 730.3 1e-209 NP_055040 (OMIM: 605983,616362) serine/threonine-p ( 589) 179 42.3 0.008 XP_016882418 (OMIM: 605983,616362) PREDICTED: seri ( 410) 176 41.7 0.0082 NP_001171034 (OMIM: 211980,603113) serine/threonin ( 474) 176 41.7 0.0093 >>XP_011524081 (OMIM: 604908) PREDICTED: serine/threonin (891 aa) initn: 5443 init1: 5443 opt: 5443 Z-score: 5019.5 bits: 939.9 E(85289): 0 Smith-Waterman score: 5443; 100.0% identity (100.0% similar) in 836 aa overlap (4-839:56-891) 10 20 30 pF1KB9 MADLSLLQEDLQEDADGFGVDDYSSESDVIIIP :::::::::::::::::::::::::::::: XP_011 GGEAALPPRGGGTPAPTTSEPPPAPDRRRHLSLLQEDLQEDADGFGVDDYSSESDVIIIP 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB9 SALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISR 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB9 LADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQA 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB9 ALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAVRQAAFQSLGPFISTFAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAVRQAAFQSLGPFISTFAN 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB9 PSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTME 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB9 DHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQD 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB9 SALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATR 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB9 KELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDELDINELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDELDINELP 450 460 470 480 490 500 460 470 480 490 500 510 pF1KB9 NCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQ 510 520 530 540 550 560 520 530 540 550 560 570 pF1KB9 YLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLA 570 580 590 600 610 620 580 590 600 610 620 630 pF1KB9 FSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQL 630 640 650 660 670 680 640 650 660 670 680 690 pF1KB9 QEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKL 690 700 710 720 730 740 700 710 720 730 740 750 pF1KB9 VSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAV 750 760 770 780 790 800 760 770 780 790 800 810 pF1KB9 HLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSD 810 820 830 840 850 860 820 830 pF1KB9 VKYFASIHPASTKISEDAMSTASSTY :::::::::::::::::::::::::: XP_011 VKYFASIHPASTKISEDAMSTASSTY 870 880 890 >>XP_016881594 (OMIM: 604908) PREDICTED: serine/threonin (949 aa) initn: 4223 init1: 4223 opt: 4223 Z-score: 3894.8 bits: 731.9 E(85289): 3.3e-210 Smith-Waterman score: 5168; 93.3% identity (93.3% similar) in 871 aa overlap (27-839:79-949) 10 20 30 40 50 pF1KB9 MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAA :::::::::::::::::::::::::::::: XP_016 APDRRRHLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAA 50 60 70 80 90 100 60 70 80 90 100 110 pF1KB9 SENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALF 110 120 130 140 150 160 120 130 140 150 160 170 pF1KB9 CQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPV 170 180 190 200 210 220 180 190 pF1KB9 LIELTAPDSNDDVKTEAVA----------------------------------------- ::::::::::::::::::: XP_016 LIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAAN 230 240 250 260 270 280 200 210 220 230 pF1KB9 -----------------VRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR ::::::::::::::::::::::::::::::::::::::::::: XP_016 FGDICSVVGQQATEEMLVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR 290 300 310 320 330 340 240 250 260 270 280 290 pF1KB9 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT 350 360 370 380 390 400 300 310 320 330 340 350 pF1KB9 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD 410 420 430 440 450 460 360 370 380 390 400 410 pF1KB9 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV 470 480 490 500 510 520 420 430 440 450 460 470 pF1KB9 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH 530 540 550 560 570 580 480 490 500 510 520 530 pF1KB9 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL 590 600 610 620 630 640 540 550 560 570 580 590 pF1KB9 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG 650 660 670 680 690 700 600 610 620 630 640 650 pF1KB9 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL 710 720 730 740 750 760 660 670 680 690 700 710 pF1KB9 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV 770 780 790 800 810 820 720 730 740 750 760 770 pF1KB9 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL 830 840 850 860 870 880 780 790 800 810 820 830 pF1KB9 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST 890 900 910 920 930 940 pF1KB9 Y : XP_016 Y >>XP_016881595 (OMIM: 604908) PREDICTED: serine/threonin (861 aa) initn: 4214 init1: 4214 opt: 4214 Z-score: 3887.2 bits: 730.3 E(85289): 8.8e-210 Smith-Waterman score: 4604; 86.9% identity (87.0% similar) in 853 aa overlap (98-839:9-861) 70 80 90 100 110 120 pF1KB9 RSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYA .::::::::::::::::::::::::::::: XP_016 MLQVRTYLTEPTVRAELMEQVPHIALFCQENRPSIPYA 10 20 30 130 140 150 160 170 180 pF1KB9 FSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSND 40 50 60 70 80 90 190 pF1KB9 DVKTEAVA---------------------------------------------------- :::::::: XP_016 DVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQ 100 110 120 130 140 150 pF1KB9 -----------------------------------------------------------V : XP_016 ATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWV 160 170 180 190 200 210 200 210 220 230 240 250 pF1KB9 RQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTP 220 230 240 250 260 270 260 270 280 290 300 310 pF1KB9 SDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKP 280 290 300 310 320 330 320 330 340 350 360 370 pF1KB9 GNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEE 340 350 360 370 380 390 380 390 400 410 420 430 pF1KB9 ESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETIS 400 410 420 430 440 450 440 450 460 470 480 490 pF1KB9 IEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDE 460 470 480 490 500 510 500 510 520 530 540 550 pF1KB9 ERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRET 520 530 540 550 560 570 560 570 580 590 600 610 pF1KB9 YETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHD 580 590 600 610 620 630 620 630 640 650 660 670 pF1KB9 FLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIAL 640 650 660 670 680 690 680 690 700 710 720 730 pF1KB9 NLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFV 700 710 720 730 740 750 740 750 760 770 780 790 pF1KB9 CQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQ 760 770 780 790 800 810 800 810 820 830 pF1KB9 EAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY ::::::::::::::::::::::::::::::::::::::::::: XP_016 EAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY 820 830 840 850 860 >>XP_016881596 (OMIM: 604908) PREDICTED: serine/threonin (861 aa) initn: 4214 init1: 4214 opt: 4214 Z-score: 3887.2 bits: 730.3 E(85289): 8.8e-210 Smith-Waterman score: 4604; 86.9% identity (87.0% similar) in 853 aa overlap (98-839:9-861) 70 80 90 100 110 120 pF1KB9 RSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYA .::::::::::::::::::::::::::::: XP_016 MLQVRTYLTEPTVRAELMEQVPHIALFCQENRPSIPYA 10 20 30 130 140 150 160 170 180 pF1KB9 FSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSND 40 50 60 70 80 90 190 pF1KB9 DVKTEAVA---------------------------------------------------- :::::::: XP_016 DVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQ 100 110 120 130 140 150 pF1KB9 -----------------------------------------------------------V : XP_016 ATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWV 160 170 180 190 200 210 200 210 220 230 240 250 pF1KB9 RQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTP 220 230 240 250 260 270 260 270 280 290 300 310 pF1KB9 SDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKP 280 290 300 310 320 330 320 330 340 350 360 370 pF1KB9 GNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEE 340 350 360 370 380 390 380 390 400 410 420 430 pF1KB9 ESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETIS 400 410 420 430 440 450 440 450 460 470 480 490 pF1KB9 IEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDE 460 470 480 490 500 510 500 510 520 530 540 550 pF1KB9 ERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRET 520 530 540 550 560 570 560 570 580 590 600 610 pF1KB9 YETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKDLDEVRIGVLKHLHD 580 590 600 610 620 630 620 630 640 650 660 670 pF1KB9 FLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIAL 640 650 660 670 680 690 680 690 700 710 720 730 pF1KB9 NLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFV 700 710 720 730 740 750 740 750 760 770 780 790 pF1KB9 CQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQ 760 770 780 790 800 810 800 810 820 830 pF1KB9 EAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY ::::::::::::::::::::::::::::::::::::::::::: XP_016 EAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASSTY 820 830 840 850 860 >>NP_005125 (OMIM: 604908) serine/threonine-protein phos (933 aa) initn: 4308 init1: 4214 opt: 4214 Z-score: 3886.7 bits: 730.3 E(85289): 9.5e-210 Smith-Waterman score: 4725; 87.3% identity (87.3% similar) in 871 aa overlap (80-839:63-933) 50 60 70 80 90 100 pF1KB9 RLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQ :::::::::::::::::::::::::::::: NP_005 RLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQ 40 50 60 70 80 90 110 120 130 140 150 160 pF1KB9 VPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDV 100 110 120 130 140 150 170 180 190 pF1KB9 ETKVCPVLIELTAPDSNDDVKTEAVA---------------------------------- :::::::::::::::::::::::::: NP_005 ETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHV 160 170 180 190 200 210 pF1KB9 ------------------------------------------------------------ NP_005 RKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRR 220 230 240 250 260 270 200 210 220 230 pF1KB9 -----------------VRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR ::::::::::::::::::::::::::::::::::::::::::: NP_005 TKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR 280 290 300 310 320 330 240 250 260 270 280 290 pF1KB9 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT 340 350 360 370 380 390 300 310 320 330 340 350 pF1KB9 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD 400 410 420 430 440 450 360 370 380 390 400 410 pF1KB9 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV 460 470 480 490 500 510 420 430 440 450 460 470 pF1KB9 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH 520 530 540 550 560 570 480 490 500 510 520 530 pF1KB9 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL 580 590 600 610 620 630 540 550 560 570 580 590 pF1KB9 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG 640 650 660 670 680 690 600 610 620 630 640 650 pF1KB9 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL 700 710 720 730 740 750 660 670 680 690 700 710 pF1KB9 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV 760 770 780 790 800 810 720 730 740 750 760 770 pF1KB9 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL 820 830 840 850 860 870 780 790 800 810 820 830 pF1KB9 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST 880 890 900 910 920 930 pF1KB9 Y : NP_005 Y >-- initn: 379 init1: 285 opt: 285 Z-score: 266.0 bits: 60.4 E(85289): 4.5e-08 Smith-Waterman score: 349; 77.2% identity (78.5% similar) in 79 aa overlap (1-79:1-62) 10 20 30 40 50 60 pF1KB9 MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENI ::::::::::::::::: .::::::::::::::::::::::::: NP_005 MADLSLLQEDLQEDADG-----------------SLDFVSQDEMLTPLGRLDKYAASENI 10 20 30 40 70 80 90 100 110 120 pF1KB9 FNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQEN ::::::::::::::::::: NP_005 FNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQEN 50 60 70 80 90 100 >>NP_001035847 (OMIM: 604908) serine/threonine-protein p (950 aa) initn: 4214 init1: 4214 opt: 4214 Z-score: 3886.5 bits: 730.3 E(85289): 9.6e-210 Smith-Waterman score: 4725; 87.3% identity (87.3% similar) in 871 aa overlap (80-839:80-950) 50 60 70 80 90 100 pF1KB9 RLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQ :::::::::::::::::::::::::::::: NP_001 RLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQ 50 60 70 80 90 100 110 120 130 140 150 160 pF1KB9 VPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDV 110 120 130 140 150 160 170 180 190 pF1KB9 ETKVCPVLIELTAPDSNDDVKTEAVA---------------------------------- :::::::::::::::::::::::::: NP_001 ETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHV 170 180 190 200 210 220 pF1KB9 ------------------------------------------------------------ NP_001 RKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRR 230 240 250 260 270 280 200 210 220 230 pF1KB9 -----------------VRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR ::::::::::::::::::::::::::::::::::::::::::: NP_001 TKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR 290 300 310 320 330 340 240 250 260 270 280 290 pF1KB9 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT 350 360 370 380 390 400 300 310 320 330 340 350 pF1KB9 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD 410 420 430 440 450 460 360 370 380 390 400 410 pF1KB9 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV 470 480 490 500 510 520 420 430 440 450 460 470 pF1KB9 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH 530 540 550 560 570 580 480 490 500 510 520 530 pF1KB9 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL 590 600 610 620 630 640 540 550 560 570 580 590 pF1KB9 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG 650 660 670 680 690 700 600 610 620 630 640 650 pF1KB9 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL 710 720 730 740 750 760 660 670 680 690 700 710 pF1KB9 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV 770 780 790 800 810 820 720 730 740 750 760 770 pF1KB9 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL 830 840 850 860 870 880 780 790 800 810 820 830 pF1KB9 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST 890 900 910 920 930 940 pF1KB9 Y : NP_001 Y 950 >-- initn: 506 init1: 506 opt: 506 Z-score: 469.5 bits: 98.1 E(85289): 2.1e-19 Smith-Waterman score: 506; 100.0% identity (100.0% similar) in 79 aa overlap (1-79:1-79) 10 20 30 40 50 60 pF1KB9 MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQEN ::::::::::::::::::: NP_001 FNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQEN 70 80 90 100 110 120 >>XP_011524078 (OMIM: 604908) PREDICTED: serine/threonin (985 aa) initn: 4288 init1: 4214 opt: 4214 Z-score: 3886.3 bits: 730.3 E(85289): 1e-209 Smith-Waterman score: 4725; 87.3% identity (87.3% similar) in 871 aa overlap (80-839:115-985) 50 60 70 80 90 100 pF1KB9 RLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQ :::::::::::::::::::::::::::::: XP_011 RLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQ 90 100 110 120 130 140 110 120 130 140 150 160 pF1KB9 VPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDV 150 160 170 180 190 200 170 180 190 pF1KB9 ETKVCPVLIELTAPDSNDDVKTEAVA---------------------------------- :::::::::::::::::::::::::: XP_011 ETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHV 210 220 230 240 250 260 pF1KB9 ------------------------------------------------------------ XP_011 RKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRR 270 280 290 300 310 320 200 210 220 230 pF1KB9 -----------------VRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR ::::::::::::::::::::::::::::::::::::::::::: XP_011 TKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR 330 340 350 360 370 380 240 250 260 270 280 290 pF1KB9 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT 390 400 410 420 430 440 300 310 320 330 340 350 pF1KB9 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD 450 460 470 480 490 500 360 370 380 390 400 410 pF1KB9 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV 510 520 530 540 550 560 420 430 440 450 460 470 pF1KB9 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH 570 580 590 600 610 620 480 490 500 510 520 530 pF1KB9 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL 630 640 650 660 670 680 540 550 560 570 580 590 pF1KB9 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG 690 700 710 720 730 740 600 610 620 630 640 650 pF1KB9 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL 750 760 770 780 790 800 660 670 680 690 700 710 pF1KB9 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV 810 820 830 840 850 860 720 730 740 750 760 770 pF1KB9 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL 870 880 890 900 910 920 780 790 800 810 820 830 pF1KB9 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST 930 940 950 960 970 980 pF1KB9 Y : XP_011 Y >-- initn: 359 init1: 285 opt: 285 Z-score: 265.6 bits: 60.4 E(85289): 4.7e-08 Smith-Waterman score: 329; 76.3% identity (77.6% similar) in 76 aa overlap (4-79:56-114) 10 20 30 pF1KB9 MADLSLLQEDLQEDADGFGVDDYSSESDVIIIP :::::::::::::: XP_011 GGEAALPPRGGGTPAPTTSEPPPAPDRRRHLSLLQEDLQEDADG---------------- 30 40 50 60 40 50 60 70 80 90 pF1KB9 SALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISR .:::::::::::::::::::::::::::::::::::::::::::: XP_011 -SLDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 LADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQA XP_011 LADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQA 130 140 150 160 170 180 >>XP_011524077 (OMIM: 604908) PREDICTED: serine/threonin (1002 aa) initn: 4214 init1: 4214 opt: 4214 Z-score: 3886.1 bits: 730.3 E(85289): 1e-209 Smith-Waterman score: 4725; 87.3% identity (87.3% similar) in 871 aa overlap (80-839:132-1002) 50 60 70 80 90 100 pF1KB9 RLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQ :::::::::::::::::::::::::::::: XP_011 RLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELMEQ 110 120 130 140 150 160 110 120 130 140 150 160 pF1KB9 VPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDV 170 180 190 200 210 220 170 180 190 pF1KB9 ETKVCPVLIELTAPDSNDDVKTEAVA---------------------------------- :::::::::::::::::::::::::: XP_011 ETKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHV 230 240 250 260 270 280 pF1KB9 ------------------------------------------------------------ XP_011 RKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRR 290 300 310 320 330 340 200 210 220 230 pF1KB9 -----------------VRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR ::::::::::::::::::::::::::::::::::::::::::: XP_011 TKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNR 350 360 370 380 390 400 240 250 260 270 280 290 pF1KB9 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCT 410 420 430 440 450 460 300 310 320 330 340 350 pF1KB9 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEIDLD 470 480 490 500 510 520 360 370 380 390 400 410 pF1KB9 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEV 530 540 550 560 570 580 420 430 440 450 460 470 pF1KB9 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLH 590 600 610 620 630 640 480 490 500 510 520 530 pF1KB9 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YIHSDSDLSNNSSFSPDEERRTKVQDVVPQALLDQYLSMTDPSRAQTVDTEIAKHCAYSL 650 660 670 680 690 700 540 550 560 570 580 590 pF1KB9 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNG 710 720 730 740 750 760 600 610 620 630 640 650 pF1KB9 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILL 770 780 790 800 810 820 660 670 680 690 700 710 pF1KB9 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELV 830 840 850 860 870 880 720 730 740 750 760 770 pF1KB9 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL 890 900 910 920 930 940 780 790 800 810 820 830 pF1KB9 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFASIHPASTKISEDAMSTASST 950 960 970 980 990 1000 pF1KB9 Y : XP_011 Y >-- initn: 486 init1: 486 opt: 486 Z-score: 450.7 bits: 94.7 E(85289): 2.3e-18 Smith-Waterman score: 486; 100.0% identity (100.0% similar) in 76 aa overlap (4-79:56-131) 10 20 30 pF1KB9 MADLSLLQEDLQEDADGFGVDDYSSESDVIIIP :::::::::::::::::::::::::::::: XP_011 GGEAALPPRGGGTPAPTTSEPPPAPDRRRHLSLLQEDLQEDADGFGVDDYSSESDVIIIP 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB9 SALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISR :::::::::::::::::::::::::::::::::::::::::::::: XP_011 SALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISR 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB9 LADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQA XP_011 LADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQA 150 160 170 180 190 200 >>NP_055040 (OMIM: 605983,616362) serine/threonine-prote (589 aa) initn: 195 init1: 113 opt: 179 Z-score: 171.7 bits: 42.3 E(85289): 0.008 Smith-Waterman score: 264; 24.8% identity (53.6% similar) in 412 aa overlap (386-780:156-546) 360 370 380 390 400 410 pF1KB9 DLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVK-A : .. :.. ::.....:: : : :. : NP_055 AHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSD-DTPMVRRA 130 140 150 160 170 180 420 430 440 450 460 pF1KB9 QVEVLSAALRASSLD-AHEETISIEKR--SDLQDELDINELPNCKIN------QED---- . :. .. :: .. : : . . :: :: . . . : .: ::: NP_055 AASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEAC-VNIAQLLPQEDLEAL 190 200 210 220 230 240 470 480 490 500 510 pF1KB9 SVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVP--QALLDQYLSMTD .: . .:.:. . ..:. .:. ... .:. ::. :.:: : :. . . . NP_055 VMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPE---ITKT-DLVPAFQNLMKDCEAEVR 250 260 270 280 290 520 530 540 550 560 570 pF1KB9 PSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHEL . .. : . : .: .. : :..: :.:: . .:. .:: : : NP_055 AAASHKVKEFCENLSADCRENVIMS---QILPCIKE----LVSDANQHVKSALASVIMGL 300 310 320 330 340 350 580 590 600 610 620 630 pF1KB9 AVILGDQLTAADLVPIFNGFLKD-LDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLV . ::: . : :.:.: . ::: :::......: ... : . . : :. NP_055 SPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELA 360 370 380 390 400 410 640 650 660 670 680 690 pF1KB9 TDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEMV : .:: : . : . :: . . . : . . .:.: ..: . . ....: NP_055 EDA--KWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLV 420 430 440 450 460 470 700 710 720 730 740 750 pF1KB9 KKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPH .:. . .: ... : :.. :.. .: : .:. . : .: . :..: NP_055 EKFGKEWAHA---TIIPKVLAMSGD-PNYLHRMTTLF-CINVLSEVC-GQDITTKHMLPT 480 490 500 510 520 760 770 780 790 800 810 pF1KB9 LLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYFA .: .:.: : ::: .::.:.. NP_055 VLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALT 530 540 550 560 570 580 >>XP_016882418 (OMIM: 605983,616362) PREDICTED: serine/t (410 aa) initn: 193 init1: 113 opt: 176 Z-score: 171.5 bits: 41.7 E(85289): 0.0082 Smith-Waterman score: 236; 24.6% identity (53.0% similar) in 353 aa overlap (441-780:35-367) 420 430 440 450 460 pF1KB9 DVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDELDINELPNCKIN------QED--- :: :: . . . : .: ::: XP_016 AAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEAC-VNIAQLLPQEDLEA 10 20 30 40 50 60 470 480 490 500 510 pF1KB9 -SVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVP--QALLDQYLSMT .: . .:.:. . ..:. .:. ... .: : .: :.:: : :. . . . XP_016 LVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGP-EITKT---DLVPAFQNLMKDCEAEV 70 80 90 100 110 520 530 540 550 560 570 pF1KB9 DPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHE . .. : . : .: .. : :..: :.:: . .:. .:: : XP_016 RAAASHKVKEFCENLSADCRENVIMS---QILPCIKE----LVSDANQHVKSALASVIMG 120 130 140 150 160 170 580 590 600 610 620 630 pF1KB9 LAVILGDQLTAADLVPIFNGFLKD-LDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFL :. ::: . : :.:.: . ::: :::......: ... : . . : : XP_016 LSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVEL 180 190 200 210 220 230 640 650 660 670 680 690 pF1KB9 VTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWISYKLVSEM . : .:: : . : . :: . . . : . . .:.: ..: . . .... XP_016 AEDA--KWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKL 240 250 260 270 280 290 700 710 720 730 740 750 pF1KB9 VKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMP :.:. . .: ... : :.. :.. .: : .:. . : .: . :..: XP_016 VEKFGKEWAH---ATIIPKVLAMSGD-PNYLHRMTTLF-CINVLSEVC-GQDITTKHMLP 300 310 320 330 340 760 770 780 790 800 810 pF1KB9 HLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEAVEQTIMALQMDRDSDVKYF .: .:.: : ::: .::.:.. XP_016 TVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEAL 350 360 370 380 390 400 839 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:06:37 2016 done: Thu Nov 3 23:06:38 2016 Total Scan time: 13.240 Total Display time: 0.270 Function used was FASTA [36.3.4 Apr, 2011]