FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9295, 203 aa 1>>>pF1KB9295 203 - 203 aa - 203 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7368+/-0.000345; mu= 2.7257+/- 0.022 mean_var=164.1464+/-32.584, 0's: 0 Z-trim(121.0): 32 B-trim: 1229 in 1/54 Lambda= 0.100106 statistics sampled from 36856 (36891) to 36856 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.78), E-opt: 0.2 (0.433), width: 16 Scan time: 5.990 The best scores are: opt bits E(85289) NP_057157 (OMIM: 616643) hepatoma-derived growth f ( 203) 1376 209.8 2.5e-54 XP_006720617 (OMIM: 616643) PREDICTED: hepatoma-de ( 212) 1371 209.1 4.3e-54 NP_004485 (OMIM: 600339) hepatoma-derived growth f ( 240) 624 101.2 1.4e-21 NP_001304827 (OMIM: 603620) PC4 and SFRS1-interact ( 329) 613 99.7 5.4e-21 NP_066967 (OMIM: 603620) PC4 and SFRS1-interacting ( 333) 613 99.7 5.5e-21 NP_001304829 (OMIM: 603620) PC4 and SFRS1-interact ( 324) 612 99.6 5.9e-21 NP_150091 (OMIM: 603620) PC4 and SFRS1-interacting ( 530) 613 99.9 7.8e-21 NP_001121689 (OMIM: 603620) PC4 and SFRS1-interact ( 530) 613 99.9 7.8e-21 NP_001119522 (OMIM: 600339) hepatoma-derived growt ( 256) 470 79.0 7.4e-15 NP_001119523 (OMIM: 600339) hepatoma-derived growt ( 233) 465 78.2 1.1e-14 NP_001306115 (OMIM: 600339) hepatoma-derived growt ( 263) 453 76.5 4.1e-14 XP_011507755 (OMIM: 600339) PREDICTED: hepatoma-de ( 208) 444 75.2 8.5e-14 XP_011507756 (OMIM: 600339) PREDICTED: hepatoma-de ( 208) 444 75.2 8.5e-14 XP_011507757 (OMIM: 600339) PREDICTED: hepatoma-de ( 208) 444 75.2 8.5e-14 NP_001306117 (OMIM: 600339) hepatoma-derived growt ( 208) 444 75.2 8.5e-14 NP_001306116 (OMIM: 600339) hepatoma-derived growt ( 208) 444 75.2 8.5e-14 NP_001295025 (OMIM: 610660) putative oxidoreductas ( 547) 228 44.3 0.00044 XP_016879276 (OMIM: 610660) PREDICTED: putative ox ( 552) 228 44.3 0.00044 NP_115958 (OMIM: 610660) putative oxidoreductase G ( 553) 228 44.3 0.00044 NP_001311027 (OMIM: 610660) putative oxidoreductas ( 558) 228 44.3 0.00045 XP_016879275 (OMIM: 610660) PREDICTED: putative ox ( 574) 228 44.3 0.00046 XP_011521018 (OMIM: 610660) PREDICTED: putative ox ( 548) 199 40.1 0.008 >>NP_057157 (OMIM: 616643) hepatoma-derived growth facto (203 aa) initn: 1376 init1: 1376 opt: 1376 Z-score: 1096.3 bits: 209.8 E(85289): 2.5e-54 Smith-Waterman score: 1376; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS 130 140 150 160 170 180 190 200 pF1KB9 EGGDAGNDTRNTTSDLQKTSEGT ::::::::::::::::::::::: NP_057 EGGDAGNDTRNTTSDLQKTSEGT 190 200 >>XP_006720617 (OMIM: 616643) PREDICTED: hepatoma-derive (212 aa) initn: 1371 init1: 1371 opt: 1371 Z-score: 1092.2 bits: 209.1 E(85289): 4.3e-54 Smith-Waterman score: 1371; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202) 10 20 30 40 50 60 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS 130 140 150 160 170 180 190 200 pF1KB9 EGGDAGNDTRNTTSDLQKTSEGT :::::::::::::::::::::: XP_006 EGGDAGNDTRNTTSDLQKTSEGKMLWTIIEID 190 200 210 >>NP_004485 (OMIM: 600339) hepatoma-derived growth facto (240 aa) initn: 636 init1: 576 opt: 624 Z-score: 508.4 bits: 101.2 E(85289): 1.4e-21 Smith-Waterman score: 661; 51.5% identity (69.6% similar) in 227 aa overlap (1-203:1-225) 10 20 30 40 50 pF1KB9 MARP-RPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGP :.: : .::: ::::::::::::::::::::.::.::: :::: .::::::::::::: NP_004 MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 KDLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSE--------TE ::::::.: :.:::: ::::::.:::::::::: :: .:::. :..: : .: NP_004 KDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAE 70 80 90 100 110 120 120 130 140 150 160 pF1KB9 GEG---GNTADASSEEEGDRVEEDGKGKRKNEKAGSKRKKS---YTSKKSSKQSRKSPGD :.: :: :..::.::: : : .:.::::.. ::. . : : :.... :. NP_004 GDGDKKGN-AEGSSDEEGKLVI-DEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGE 130 140 150 160 170 170 180 190 200 pF1KB9 EDDKDCKE---------EENKSSSEGGDAGNDTRNTTSDLQKTSEGT : . : :.:.. :: :.. . .. . .. :.: NP_004 EKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHE 180 190 200 210 220 230 NP_004 SL 240 >>NP_001304827 (OMIM: 603620) PC4 and SFRS1-interacting (329 aa) initn: 604 init1: 572 opt: 613 Z-score: 497.9 bits: 99.7 E(85289): 5.4e-21 Smith-Waterman score: 613; 55.6% identity (78.8% similar) in 160 aa overlap (7-166:3-155) 10 20 30 40 50 60 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK :..: :::.:::::::::::::.::.:.::::::.:: :::::::::::::::: NP_001 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPK 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA :.:::.: :.:.:: :::::::::::::.::: :::.. :: .::.. .. : . . NP_001 DIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS :.:. :. : : .:: . . . :. :.....:: ... NP_001 VSKEDTDHEE-----KASNEDV--TKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTAT 120 130 140 150 160 190 200 pF1KB9 EGGDAGNDTRNTTSDLQKTSEGT NP_001 ASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKK 170 180 190 200 210 220 >>NP_066967 (OMIM: 603620) PC4 and SFRS1-interacting pro (333 aa) initn: 604 init1: 572 opt: 613 Z-score: 497.8 bits: 99.7 E(85289): 5.5e-21 Smith-Waterman score: 613; 55.6% identity (78.8% similar) in 160 aa overlap (7-166:3-155) 10 20 30 40 50 60 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK :..: :::.:::::::::::::.::.:.::::::.:: :::::::::::::::: NP_066 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPK 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA :.:::.: :.:.:: :::::::::::::.::: :::.. :: .::.. .. : . . NP_066 DIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS :.:. :. : : .:: . . . :. :.....:: ... NP_066 VSKEDTDHEE-----KASNEDV--TKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTAT 120 130 140 150 160 190 200 pF1KB9 EGGDAGNDTRNTTSDLQKTSEGT NP_066 ASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKK 170 180 190 200 210 220 >>NP_001304829 (OMIM: 603620) PC4 and SFRS1-interacting (324 aa) initn: 604 init1: 572 opt: 612 Z-score: 497.2 bits: 99.6 E(85289): 5.9e-21 Smith-Waterman score: 612; 57.4% identity (79.4% similar) in 155 aa overlap (7-161:3-150) 10 20 30 40 50 60 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK :..: :::.:::::::::::::.::.:.::::::.:: :::::::::::::::: NP_001 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPK 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA :.:::.: :.:.:: :::::::::::::.::: :::.. :: .::.. .. : . . NP_001 DIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS :.:. :. : : .:: . . . :. :.....:: NP_001 VSKEDTDHEE-----KASNEDV--TKAVDITTPKAARRGRKRKAGVVTTATASVNLKVSP 120 130 140 150 160 190 200 pF1KB9 EGGDAGNDTRNTTSDLQKTSEGT NP_001 KRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQ 170 180 190 200 210 220 >>NP_150091 (OMIM: 603620) PC4 and SFRS1-interacting pro (530 aa) initn: 626 init1: 572 opt: 613 Z-score: 495.0 bits: 99.9 E(85289): 7.8e-21 Smith-Waterman score: 613; 55.6% identity (78.8% similar) in 160 aa overlap (7-166:3-155) 10 20 30 40 50 60 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK :..: :::.:::::::::::::.::.:.::::::.:: :::::::::::::::: NP_150 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPK 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA :.:::.: :.:.:: :::::::::::::.::: :::.. :: .::.. .. : . . NP_150 DIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS :.:. :. : : .:: . . . :. :.....:: ... NP_150 VSKEDTDHEE-----KASNEDV--TKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTAT 120 130 140 150 160 190 200 pF1KB9 EGGDAGNDTRNTTSDLQKTSEGT NP_150 ASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKK 170 180 190 200 210 220 >>NP_001121689 (OMIM: 603620) PC4 and SFRS1-interacting (530 aa) initn: 626 init1: 572 opt: 613 Z-score: 495.0 bits: 99.9 E(85289): 7.8e-21 Smith-Waterman score: 613; 55.6% identity (78.8% similar) in 160 aa overlap (7-166:3-155) 10 20 30 40 50 60 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK :..: :::.:::::::::::::.::.:.::::::.:: :::::::::::::::: NP_001 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPK 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADA :.:::.: :.:.:: :::::::::::::.::: :::.. :: .::.. .. : . . NP_001 DIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 SSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSS :.:. :. : : .:: . . . :. :.....:: ... NP_001 VSKEDTDHEE-----KASNEDV--TKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTAT 120 130 140 150 160 190 200 pF1KB9 EGGDAGNDTRNTTSDLQKTSEGT NP_001 ASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKK 170 180 190 200 210 220 >>NP_001119522 (OMIM: 600339) hepatoma-derived growth fa (256 aa) initn: 486 init1: 426 opt: 470 Z-score: 387.8 bits: 79.0 E(85289): 7.4e-15 Smith-Waterman score: 507; 47.3% identity (66.7% similar) in 201 aa overlap (26-203:43-241) 10 20 30 40 50 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETA : :::.::.::: :::: .::::::::: NP_001 LGHLLATKLKRFLLSKGGRRAQIPDVSRATPHTIDEMPEAAVKSTANKYQVFFFGTHETA 20 30 40 50 60 70 60 70 80 90 100 pF1KB9 FLGPKDLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSE------ ::::::::::.: :.:::: ::::::.:::::::::: :: .:::. :..: : NP_001 FLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEP 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB9 --TEGEG---GNTADASSEEEGDRVEEDGKGKRKNEKAGSKRKKS---YTSKKSSKQSRK .::.: :: :..::.::: : : .:.::::.. ::. . : : :.... NP_001 EAAEGDGDKKGN-AEGSSDEEGKLVI-DEPAKEKNEKGALKRRAGDLLEDSPKRPKEAEN 140 150 160 170 180 190 170 180 190 200 pF1KB9 SPGDEDDKDCKE---------EENKSSSEGGDAGNDTRNTTSDLQKTSEGT :.: . : :.:.. :: :.. . .. . .. :.: NP_001 PEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGI 200 210 220 230 240 250 NP_001 RDHESL >>NP_001119523 (OMIM: 600339) hepatoma-derived growth fa (233 aa) initn: 488 init1: 428 opt: 465 Z-score: 384.4 bits: 78.2 E(85289): 1.1e-14 Smith-Waterman score: 502; 47.5% identity (67.0% similar) in 200 aa overlap (27-203:21-218) 10 20 30 40 50 60 pF1KB9 MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPK : :::.::.::: :::: .:::::::::::::: NP_001 MEQRAGGNRVQTSTLNCAGAAVIDEMPEAAVKSTANKYQVFFFGTHETAFLGPK 10 20 30 40 50 70 80 90 100 110 pF1KB9 DLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSE--------TEG :::::.: :.:::: ::::::.:::::::::: :: .:::. :..: : .:: NP_001 DLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCVEEPEPEPEAAEG 60 70 80 90 100 110 120 130 140 150 160 pF1KB9 EG---GNTADASSEEEGDRVEEDGKGKRKNEKAGSKRKKS---YTSKKSSKQSRKSPGDE .: :: :..::.::: : : .:.::::.. ::. . : : :.... :.: NP_001 DGDKKGN-AEGSSDEEGKLVI-DEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEE 120 130 140 150 160 170 170 180 190 200 pF1KB9 DDKDCKE---------EENKSSSEGGDAGNDTRNTTSDLQKTSEGT . : :.:.. :: :.. . .. . .. :.: NP_001 KEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEEDEEEEATKEDAEAPGIRDHES 180 190 200 210 220 230 NP_001 L 203 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:17:14 2016 done: Sat Nov 5 13:17:15 2016 Total Scan time: 5.990 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]