FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9339, 1264 aa 1>>>pF1KB9339 1264 - 1264 aa - 1264 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.8457+/-0.00103; mu= -1.6815+/- 0.062 mean_var=278.2838+/-56.325, 0's: 0 Z-trim(113.0): 61 B-trim: 408 in 1/53 Lambda= 0.076883 statistics sampled from 13616 (13676) to 13616 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.42), width: 16 Scan time: 6.010 The best scores are: opt bits E(32554) CCDS78450.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1094) 4267 487.5 7.7e-137 CCDS48048.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1095) 4143 473.8 1.1e-132 CCDS48047.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1077) 4138 473.2 1.5e-132 CCDS45320.1 RASGRF1 gene_id:5923|Hs108|chr15 (1257) 531 73.2 4.8e-12 CCDS10309.1 RASGRF1 gene_id:5923|Hs108|chr15 (1273) 529 73.0 5.7e-12 CCDS42065.1 RASGRF1 gene_id:5923|Hs108|chr15 ( 489) 510 70.6 1.1e-11 >>CCDS78450.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1094 aa) initn: 4267 init1: 4267 opt: 4267 Z-score: 2570.1 bits: 487.5 E(32554): 7.7e-137 Smith-Waterman score: 6940; 86.6% identity (86.6% similar) in 1264 aa overlap (1-1264:1-1094) 10 20 30 40 50 60 pF1KB9 MSGGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MSGGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 PEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 NLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 NLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 PALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 ESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 ESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 PQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 AASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 AASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 FVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 FVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 KLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLQASCAASSFSSVSHCVQQTKVAFTP ::::::::::::::::::::::::::::::::::: CCDS78 KLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQL------------------------- 610 620 630 670 680 690 700 710 720 pF1KB9 EDGSAAQGLSVSVSNSFLSRHGSLPVPSYKSVFRSYSQDFVPHHQASVPPFLPPTSSSSP CCDS78 ------------------------------------------------------------ 730 740 750 760 770 780 pF1KB9 HFPPAHQSQSSDLAVPTMAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASE CCDS78 ------------------------------------------------------------ 790 800 810 820 830 840 pF1KB9 EAGEGEYVNLYSSGQSSEELAPSRGEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSP ::::::::::::::::::::::::::::::::::: CCDS78 -------------------------EPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSP 640 650 660 670 850 860 870 880 890 900 pF1KB9 DALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 DALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLV 680 690 700 710 720 730 910 920 930 940 950 960 pF1KB9 LYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVE 740 750 760 770 780 790 970 980 990 1000 1010 1020 pF1KB9 LTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARP 800 810 820 830 840 850 1030 1040 1050 1060 1070 1080 pF1KB9 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWV 860 870 880 890 900 910 1090 1100 1110 1120 1130 1140 pF1KB9 RSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 RSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG 920 930 940 950 960 970 1150 1160 1170 1180 1190 1200 pF1KB9 LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRW 980 990 1000 1010 1020 1030 1210 1220 1230 1240 1250 1260 pF1KB9 QQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 QQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDR 1040 1050 1060 1070 1080 1090 pF1KB9 EEKT :::: CCDS78 EEKT >>CCDS48048.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1095 aa) initn: 4143 init1: 4143 opt: 4143 Z-score: 2495.8 bits: 473.8 E(32554): 1.1e-132 Smith-Waterman score: 6816; 86.3% identity (86.3% similar) in 1246 aa overlap (19-1264:20-1095) 10 20 30 40 50 pF1KB9 MSGGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVK : ::::::::::::::::::::::::::::::::::::::: CCDS48 MGNAIEKQKPLKRSHLYPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 IPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 IPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 ALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 ALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 ANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 ANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 SPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 SPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 PPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 GESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 GESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQ 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 IPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 IPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 SAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 SAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB9 EFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 EFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQK 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB9 NKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLQASCAASSFSSVSHCVQQTKVAFT :::::::::::::::::::::::::::::::::::: CCDS48 NKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQL------------------------ 610 620 630 660 670 680 690 700 710 pF1KB9 PEDGSAAQGLSVSVSNSFLSRHGSLPVPSYKSVFRSYSQDFVPHHQASVPPFLPPTSSSS CCDS48 ------------------------------------------------------------ 720 730 740 750 760 770 pF1KB9 PHFPPAHQSQSSDLAVPTMAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENAS CCDS48 ------------------------------------------------------------ 780 790 800 810 820 830 pF1KB9 EEAGEGEYVNLYSSGQSSEELAPSRGEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKS :::::::::::::::::::::::::::::::::: CCDS48 --------------------------EPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKS 640 650 660 670 840 850 860 870 880 890 pF1KB9 PDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDL 680 690 700 710 720 730 900 910 920 930 940 950 pF1KB9 VLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 VLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLV 740 750 760 770 780 790 960 970 980 990 1000 1010 pF1KB9 ELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 ELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAAR 800 810 820 830 840 850 1020 1030 1040 1050 1060 1070 pF1KB9 PGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYW 860 870 880 890 900 910 1080 1090 1100 1110 1120 1130 pF1KB9 VRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 VRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSE 920 930 940 950 960 970 1140 1150 1160 1170 1180 1190 pF1KB9 GLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 GLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKR 980 990 1000 1010 1020 1030 1200 1210 1220 1230 1240 1250 pF1KB9 WQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 WQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTD 1040 1050 1060 1070 1080 1090 1260 pF1KB9 REEKT ::::: CCDS48 REEKT >>CCDS48047.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1077 aa) initn: 4138 init1: 4138 opt: 4138 Z-score: 2492.9 bits: 473.2 E(32554): 1.5e-132 Smith-Waterman score: 6811; 86.3% identity (86.3% similar) in 1244 aa overlap (21-1264:4-1077) 10 20 30 40 50 60 pF1KB9 MSGGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKI :::::::::::::::::::::::::::::::::::::::: CCDS48 MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKI 10 20 30 40 70 80 90 100 110 120 pF1KB9 PEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB9 LRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 LRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLA 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB9 NLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 NLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSS 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB9 PASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPP 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB9 PALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB9 ESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 ESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQI 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB9 PQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRS 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB9 AASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 AASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVE 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB9 FVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 FVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKN 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB9 KLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLQASCAASSFSSVSHCVQQTKVAFTP ::::::::::::::::::::::::::::::::::: CCDS48 KLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQL------------------------- 590 600 610 670 680 690 700 710 720 pF1KB9 EDGSAAQGLSVSVSNSFLSRHGSLPVPSYKSVFRSYSQDFVPHHQASVPPFLPPTSSSSP CCDS48 ------------------------------------------------------------ 730 740 750 760 770 780 pF1KB9 HFPPAHQSQSSDLAVPTMAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASE CCDS48 ------------------------------------------------------------ 790 800 810 820 830 840 pF1KB9 EAGEGEYVNLYSSGQSSEELAPSRGEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSP ::::::::::::::::::::::::::::::::::: CCDS48 -------------------------EPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSP 620 630 640 650 850 860 870 880 890 900 pF1KB9 DALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 DALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLV 660 670 680 690 700 710 910 920 930 940 950 960 pF1KB9 LYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 LYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVE 720 730 740 750 760 770 970 980 990 1000 1010 1020 pF1KB9 LTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 LTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARP 780 790 800 810 820 830 1030 1040 1050 1060 1070 1080 pF1KB9 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWV 840 850 860 870 880 890 1090 1100 1110 1120 1130 1140 pF1KB9 RSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 RSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEG 900 910 920 930 940 950 1150 1160 1170 1180 1190 1200 pF1KB9 LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRW 960 970 980 990 1000 1010 1210 1220 1230 1240 1250 1260 pF1KB9 QQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 QQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDR 1020 1030 1040 1050 1060 1070 pF1KB9 EEKT :::: CCDS48 EEKT >>CCDS45320.1 RASGRF1 gene_id:5923|Hs108|chr15 (1257 aa) initn: 386 init1: 175 opt: 531 Z-score: 329.7 bits: 73.2 E(32554): 4.8e-12 Smith-Waterman score: 542; 27.2% identity (58.3% similar) in 569 aa overlap (707-1251:722-1254) 680 690 700 710 720 730 pF1KB9 FLSRHGSLPVPSYKSVFRSYSQDFVPHHQASVPPFLPPTSSSSPHFPPAHQSQSSDLAVP : :: : :..::: . .. .: .: CCDS45 RSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPS-----RRRKLSLNIP 700 710 720 730 740 740 750 760 770 780 790 pF1KB9 TMAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASEEAGEGEYVNLYSSGQS ..: ...: :.: . .: .: : . . :. .. ..:. :: :.. CCDS45 IITGG--KALD--LAALSCNS-NGYTSMYSAMSPFSKATLDTSK---------LYVSSSF 750 760 770 780 790 800 810 820 830 840 pF1KB9 SEELAPSRGEPPAGKDGHPRDPSAVS------------GVPGKDSRDG-SERAP-KSPDA .... :..:. : :.::::.: . ..: :: .: .: ::: . CCDS45 TNKI-PDEGDTTPEK---PEDPSALSKQSSEVSMREESDIDQNQSDDGDTETSPTKSPTT 800 810 820 830 840 850 860 870 880 890 900 pF1KB9 LESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLY .:..... .:. :...:. . . .. .. . ..:. . . ... . : CCDS45 PKSVKNKNS-SEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB9 CEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDEL-C-LVE . :.. . .. :.. : . ..... :::.. .. ::: : .. CCDS45 RRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHS--QDFETNDELKCKVIG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB9 LTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARP . ::... ::. . .. .. :.: .. : :.. :. :. :.:: :.: CCDS45 FLEEVMHD-PELLTQER-KAAANIIRTLTQE--DPGDNQITLEEITQ----MAEGVKAEP 970 980 990 1000 1010 1030 1040 1050 1060 1070 pF1KB9 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSY ... . :::::::::: .: :: : . : : ...:..: . . :.:::..: CCDS45 --FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISN 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KB9 WVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--W--- . : :. .: . : . :.. . : :.:.:. : : :... . : ::. : CCDS45 LIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKV 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KB9 QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DG .:::. . . :..: . :. : ::.. .:::.::::. : ::.:.. :.:.: :: CCDS45 SKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDG 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KB9 KVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRN ::::: . .:. .: :::. : .... . ... : : . ::.:.: ::.:.:. CCDS45 LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKL 1200 1210 1220 1230 1240 1250 1260 pF1KB9 ITRRKTDREEKT CCDS45 PT >>CCDS10309.1 RASGRF1 gene_id:5923|Hs108|chr15 (1273 aa) initn: 386 init1: 175 opt: 529 Z-score: 328.4 bits: 73.0 E(32554): 5.7e-12 Smith-Waterman score: 542; 27.2% identity (58.3% similar) in 569 aa overlap (707-1251:738-1270) 680 690 700 710 720 730 pF1KB9 FLSRHGSLPVPSYKSVFRSYSQDFVPHHQASVPPFLPPTSSSSPHFPPAHQSQSSDLAVP : :: : :..::: . .. .: .: CCDS10 RSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPS-----RRRKLSLNIP 710 720 730 740 750 760 740 750 760 770 780 790 pF1KB9 TMAGPPPSTVDGPLSASQESSFHGNTVCLPSETSFTDSSENASEEAGEGEYVNLYSSGQS ..: ...: :.: . .: .: : . . :. .. ..:. :: :.. CCDS10 IITGG--KALD--LAALSCNS-NGYTSMYSAMSPFSKATLDTSK---------LYVSSSF 770 780 790 800 800 810 820 830 840 pF1KB9 SEELAPSRGEPPAGKDGHPRDPSAVS------------GVPGKDSRDG-SERAP-KSPDA .... :..:. : :.::::.: . ..: :: .: .: ::: . CCDS10 TNKI-PDEGDTTPEK---PEDPSALSKQSSEVSMREESDIDQNQSDDGDTETSPTKSPTT 810 820 830 840 850 860 850 860 870 880 890 900 pF1KB9 LESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLY .:..... .:. :...:. . . .. .. . ..:. . . ... . : CCDS10 PKSVKNKNS-SEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKY 870 880 890 900 910 920 910 920 930 940 950 960 pF1KB9 CEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDEL-C-LVE . :.. . .. :.. : . ..... :::.. .. ::: : .. CCDS10 RRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHS--QDFETNDELKCKVIG 930 940 950 960 970 980 970 980 990 1000 1010 1020 pF1KB9 LTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARP . ::... ::. . .. .. :.: .. : :.. :. :. :.:: :.: CCDS10 FLEEVMHD-PELLTQER-KAAANIIRTLTQE--DPGDNQITLEEITQ----MAEGVKAEP 990 1000 1010 1020 1030 1030 1040 1050 1060 1070 pF1KB9 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSY ... . :::::::::: .: :: : . : : ...:..: . . :.:::..: CCDS10 --FENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISN 1040 1050 1060 1070 1080 1090 1080 1090 1100 1110 1120 1130 pF1KB9 WVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--W--- . : :. .: . : . :.. . : :.:.:. : : :... . : ::. : CCDS10 LIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKV 1100 1110 1120 1130 1140 1150 1140 1150 1160 1170 1180 1190 pF1KB9 QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DG .:::. . . :..: . :. : ::.. .:::.::::. : ::.:.. :.:.: :: CCDS10 SKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDG 1160 1170 1180 1190 1200 1210 1200 1210 1220 1230 1240 1250 pF1KB9 KVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRN ::::: . .:. .: :::. : .... . ... : : . ::.:.: ::.:.:. CCDS10 LVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKL 1220 1230 1240 1250 1260 1270 1260 pF1KB9 ITRRKTDREEKT CCDS10 PT >>CCDS42065.1 RASGRF1 gene_id:5923|Hs108|chr15 (489 aa) initn: 350 init1: 175 opt: 510 Z-score: 323.2 bits: 70.6 E(32554): 1.1e-11 Smith-Waterman score: 518; 28.0% identity (59.5% similar) in 486 aa overlap (790-1251:18-486) 760 770 780 790 800 810 pF1KB9 GNTVCLPSETSFTDSSENASEEAGEGEYVNLYSSGQSSEELAPSRGEPPAGKDGHPRDPS :: :.. .... :..:. : :.::: CCDS42 MYSAMSPFSKATLDTSKLYVSSSFTNKI-PDEGDTTPEK---PEDPS 10 20 30 40 820 830 840 850 860 pF1KB9 AVS------------GVPGKDSRDG-SERAP-KSPDALESAQSEEEVDELSLIDHNEIMS :.: . ..: :: .: .: ::: . .:..... .:. :...:. . CCDS42 ALSKQSSEVSMREESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNS-SEFPLFSYNNGVV 50 60 70 80 90 100 870 880 890 900 910 920 pF1KB9 RLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQY . .. .. . ..:. . . ... . : . :.. . .. :.. CCDS42 MTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVI 110 120 130 140 150 160 930 940 950 960 970 980 pF1KB9 RYEKFSPFADTFKKRVSKNTFFVLVRVVDEL-C-LVELTEEILKLLMELVFRLVCNGELS : . ..... :::.. .. ::: : .. . ::... ::. . .. . CCDS42 RRAATNRVLNVLRHWVSKHS--QDFETNDELKCKVIGFLEEVMHD-PELLTQER-KAAAN 170 180 190 200 210 990 1000 1010 1020 1030 1040 pF1KB9 LARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELF . :.: .. : :.. :. :. :.:: :.: ... . :::::::::: .: CCDS42 IIRTLTQE--DPGDNQITLEEITQ----MAEGVKAEP--FENHSALEIAEQLTLLDHLVF 220 230 240 250 260 270 1050 1060 1070 1080 1090 1100 pF1KB9 YKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFI :: : . : : ...:..: . . :.:::..: . : :. .: . : . :.. CCDS42 KKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWV 280 290 300 310 320 330 1110 1120 1130 1140 1150 pF1KB9 KIMKHLRKLNNFNSYLAILSALDSAPIRRLE--W---QKQTSEGLAEYCTLIDSSSSFRA . : :.:.:. : : :... . : ::. : .:::. . . :..: . :. CCDS42 AVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKN 340 350 360 370 380 390 1160 1170 1180 1190 1200 1210 pF1KB9 YRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQA : ::.. .:::.::::. : ::.:.. :.:.: :: ::::: . .:. .: :::. CCDS42 LREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQT 400 410 420 430 440 450 1220 1230 1240 1250 1260 pF1KB9 HYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT : .... . ... : : . ::.:.: ::.:.:. CCDS42 AYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKLPT 460 470 480 1264 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:09:05 2016 done: Thu Nov 3 23:09:06 2016 Total Scan time: 6.010 Total Display time: 0.250 Function used was FASTA [36.3.4 Apr, 2011]