FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9425, 737 aa 1>>>pF1KB9425 737 - 737 aa - 737 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.8460+/-0.000606; mu= -23.4663+/- 0.036 mean_var=687.0537+/-148.603, 0's: 0 Z-trim(115.9): 1655 B-trim: 0 in 0/55 Lambda= 0.048930 statistics sampled from 24475 (26709) to 24475 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.313), width: 16 Scan time: 12.380 The best scores are: opt bits E(85289) XP_005264485 (OMIM: 176975) PREDICTED: protein kin ( 737) 5079 375.3 4.9e-103 NP_005391 (OMIM: 176975) protein kinase C epsilon ( 737) 5079 375.3 4.9e-103 XP_011531280 (OMIM: 176975) PREDICTED: protein kin ( 623) 4277 318.6 4.8e-86 XP_016859977 (OMIM: 176975) PREDICTED: protein kin ( 623) 4277 318.6 4.8e-86 XP_016859976 (OMIM: 176975) PREDICTED: protein kin ( 623) 4277 318.6 4.8e-86 XP_011531277 (OMIM: 176975) PREDICTED: protein kin ( 641) 4277 318.6 4.9e-86 XP_011531273 (OMIM: 176975) PREDICTED: protein kin ( 641) 4277 318.6 4.9e-86 XP_016859975 (OMIM: 176975) PREDICTED: protein kin ( 641) 4277 318.6 4.9e-86 XP_011531283 (OMIM: 176975) PREDICTED: protein kin ( 587) 4056 303.0 2.3e-81 XP_016859978 (OMIM: 176975) PREDICTED: protein kin ( 587) 4056 303.0 2.3e-81 XP_016859979 (OMIM: 176975) PREDICTED: protein kin ( 587) 4056 303.0 2.3e-81 XP_011531282 (OMIM: 176975) PREDICTED: protein kin ( 587) 4056 303.0 2.3e-81 XP_016859980 (OMIM: 176975) PREDICTED: protein kin ( 587) 4056 303.0 2.3e-81 XP_011531284 (OMIM: 176975) PREDICTED: protein kin ( 497) 3400 256.6 1.8e-67 XP_005264488 (OMIM: 176975) PREDICTED: protein kin ( 496) 3313 250.4 1.3e-65 XP_016859981 (OMIM: 176975) PREDICTED: protein kin ( 481) 3310 250.2 1.4e-65 XP_006712113 (OMIM: 176975) PREDICTED: protein kin ( 460) 3110 236.1 2.5e-61 XP_011531285 (OMIM: 176975) PREDICTED: protein kin ( 436) 2812 215.0 5.1e-55 XP_016876947 (OMIM: 601367,605437) PREDICTED: prot ( 522) 1747 139.9 2.5e-32 XP_011535257 (OMIM: 601367,605437) PREDICTED: prot ( 603) 1747 140.0 2.7e-32 XP_011535256 (OMIM: 601367,605437) PREDICTED: prot ( 604) 1747 140.0 2.7e-32 NP_006246 (OMIM: 601367,605437) protein kinase C e ( 683) 1747 140.1 3e-32 XP_016880329 (OMIM: 176960) PREDICTED: protein kin ( 586) 1535 125.0 8.6e-28 XP_016880328 (OMIM: 176960) PREDICTED: protein kin ( 586) 1535 125.0 8.6e-28 XP_016880327 (OMIM: 176960) PREDICTED: protein kin ( 586) 1535 125.0 8.6e-28 XP_016880326 (OMIM: 176960) PREDICTED: protein kin ( 621) 1535 125.0 8.9e-28 NP_002728 (OMIM: 176960) protein kinase C alpha ty ( 672) 1536 125.1 9e-28 NP_997700 (OMIM: 176970) protein kinase C beta typ ( 671) 1534 125.0 9.9e-28 NP_002729 (OMIM: 176970) protein kinase C beta typ ( 673) 1526 124.4 1.5e-27 XP_016876948 (OMIM: 601367,605437) PREDICTED: prot ( 444) 1444 118.5 6.1e-26 XP_016880325 (OMIM: 176960) PREDICTED: protein kin ( 645) 1422 117.1 2.3e-25 NP_002730 (OMIM: 176980,605361) protein kinase C g ( 697) 1366 113.2 3.8e-24 NP_001303258 (OMIM: 176980,605361) protein kinase ( 710) 1366 113.2 3.8e-24 XP_016862344 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1351 112.1 7.7e-24 XP_016862345 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1351 112.1 7.7e-24 NP_006245 (OMIM: 176977,615559) protein kinase C d ( 676) 1351 112.1 7.7e-24 NP_997704 (OMIM: 176977,615559) protein kinase C d ( 676) 1351 112.1 7.7e-24 NP_001303256 (OMIM: 176977,615559) protein kinase ( 676) 1351 112.1 7.7e-24 XP_006713322 (OMIM: 176977,615559) PREDICTED: prot ( 676) 1351 112.1 7.7e-24 XP_006713320 (OMIM: 176977,615559) PREDICTED: prot ( 692) 1351 112.1 7.8e-24 XP_016871900 (OMIM: 600448) PREDICTED: protein kin ( 581) 1317 109.6 3.7e-23 NP_001310195 (OMIM: 600448) protein kinase C theta ( 581) 1317 109.6 3.7e-23 NP_001269574 (OMIM: 600448) protein kinase C theta ( 581) 1317 109.6 3.7e-23 NP_001269573 (OMIM: 600448) protein kinase C theta ( 670) 1317 109.7 4e-23 NP_006248 (OMIM: 600448) protein kinase C theta ty ( 706) 1317 109.7 4.2e-23 XP_016871899 (OMIM: 600448) PREDICTED: protein kin ( 706) 1317 109.7 4.2e-23 NP_001310194 (OMIM: 600448) protein kinase C theta ( 706) 1317 109.7 4.2e-23 XP_006717528 (OMIM: 600448) PREDICTED: protein kin ( 706) 1317 109.7 4.2e-23 XP_005252553 (OMIM: 600448) PREDICTED: protein kin ( 740) 1317 109.7 4.3e-23 XP_016857290 (OMIM: 176982) PREDICTED: protein kin ( 405) 1271 106.2 2.7e-22 >>XP_005264485 (OMIM: 176975) PREDICTED: protein kinase (737 aa) initn: 5079 init1: 5079 opt: 5079 Z-score: 1970.8 bits: 375.3 E(85289): 4.9e-103 Smith-Waterman score: 5079; 100.0% identity (100.0% similar) in 737 aa overlap (1-737:1-737) 10 20 30 40 50 60 pF1KB9 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI 670 680 690 700 710 720 730 pF1KB9 NQEEFKGFSYFGEDLMP ::::::::::::::::: XP_005 NQEEFKGFSYFGEDLMP 730 >>NP_005391 (OMIM: 176975) protein kinase C epsilon type (737 aa) initn: 5079 init1: 5079 opt: 5079 Z-score: 1970.8 bits: 375.3 E(85289): 4.9e-103 Smith-Waterman score: 5079; 100.0% identity (100.0% similar) in 737 aa overlap (1-737:1-737) 10 20 30 40 50 60 pF1KB9 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI 670 680 690 700 710 720 730 pF1KB9 NQEEFKGFSYFGEDLMP ::::::::::::::::: NP_005 NQEEFKGFSYFGEDLMP 730 >>XP_011531280 (OMIM: 176975) PREDICTED: protein kinase (623 aa) initn: 4277 init1: 4277 opt: 4277 Z-score: 1665.7 bits: 318.6 E(85289): 4.8e-86 Smith-Waterman score: 4277; 100.0% identity (100.0% similar) in 621 aa overlap (117-737:3-623) 90 100 110 120 130 140 pF1KB9 APIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERV :::::::::::::::::::::::::::::: XP_011 MQIDLEPEGRVYVIIDLSGSSGEAPKDNEERV 10 20 30 150 160 170 180 190 200 pF1KB9 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB9 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB9 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB9 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB9 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ 280 290 300 310 320 330 450 460 470 480 490 500 pF1KB9 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 340 350 360 370 380 390 510 520 530 540 550 560 pF1KB9 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT 400 410 420 430 440 450 570 580 590 600 610 620 pF1KB9 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY 460 470 480 490 500 510 630 640 650 660 670 680 pF1KB9 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK 520 530 540 550 560 570 690 700 710 720 730 pF1KB9 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP 580 590 600 610 620 >>XP_016859977 (OMIM: 176975) PREDICTED: protein kinase (623 aa) initn: 4277 init1: 4277 opt: 4277 Z-score: 1665.7 bits: 318.6 E(85289): 4.8e-86 Smith-Waterman score: 4277; 100.0% identity (100.0% similar) in 621 aa overlap (117-737:3-623) 90 100 110 120 130 140 pF1KB9 APIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERV :::::::::::::::::::::::::::::: XP_016 MQIDLEPEGRVYVIIDLSGSSGEAPKDNEERV 10 20 30 150 160 170 180 190 200 pF1KB9 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB9 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB9 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB9 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB9 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ 280 290 300 310 320 330 450 460 470 480 490 500 pF1KB9 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 340 350 360 370 380 390 510 520 530 540 550 560 pF1KB9 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT 400 410 420 430 440 450 570 580 590 600 610 620 pF1KB9 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY 460 470 480 490 500 510 630 640 650 660 670 680 pF1KB9 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK 520 530 540 550 560 570 690 700 710 720 730 pF1KB9 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP 580 590 600 610 620 >>XP_016859976 (OMIM: 176975) PREDICTED: protein kinase (623 aa) initn: 4277 init1: 4277 opt: 4277 Z-score: 1665.7 bits: 318.6 E(85289): 4.8e-86 Smith-Waterman score: 4277; 100.0% identity (100.0% similar) in 621 aa overlap (117-737:3-623) 90 100 110 120 130 140 pF1KB9 APIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERV :::::::::::::::::::::::::::::: XP_016 MQIDLEPEGRVYVIIDLSGSSGEAPKDNEERV 10 20 30 150 160 170 180 190 200 pF1KB9 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB9 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB9 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB9 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB9 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ 280 290 300 310 320 330 450 460 470 480 490 500 pF1KB9 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 340 350 360 370 380 390 510 520 530 540 550 560 pF1KB9 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT 400 410 420 430 440 450 570 580 590 600 610 620 pF1KB9 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY 460 470 480 490 500 510 630 640 650 660 670 680 pF1KB9 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK 520 530 540 550 560 570 690 700 710 720 730 pF1KB9 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP 580 590 600 610 620 >>XP_011531277 (OMIM: 176975) PREDICTED: protein kinase (641 aa) initn: 4277 init1: 4277 opt: 4277 Z-score: 1665.6 bits: 318.6 E(85289): 4.9e-86 Smith-Waterman score: 4277; 100.0% identity (100.0% similar) in 621 aa overlap (117-737:21-641) 90 100 110 120 130 140 pF1KB9 APIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERV :::::::::::::::::::::::::::::: XP_011 MESSPLTEERQRPVSSELLRIDLEPEGRVYVIIDLSGSSGEAPKDNEERV 10 20 30 40 50 150 160 170 180 190 200 pF1KB9 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC 60 70 80 90 100 110 210 220 230 240 250 260 pF1KB9 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL 120 130 140 150 160 170 270 280 290 300 310 320 pF1KB9 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG 180 190 200 210 220 230 330 340 350 360 370 380 pF1KB9 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL 240 250 260 270 280 290 390 400 410 420 430 440 pF1KB9 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ 300 310 320 330 340 350 450 460 470 480 490 500 pF1KB9 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 360 370 380 390 400 410 510 520 530 540 550 560 pF1KB9 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT 420 430 440 450 460 470 570 580 590 600 610 620 pF1KB9 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY 480 490 500 510 520 530 630 640 650 660 670 680 pF1KB9 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK 540 550 560 570 580 590 690 700 710 720 730 pF1KB9 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP 600 610 620 630 640 >>XP_011531273 (OMIM: 176975) PREDICTED: protein kinase (641 aa) initn: 4277 init1: 4277 opt: 4277 Z-score: 1665.6 bits: 318.6 E(85289): 4.9e-86 Smith-Waterman score: 4277; 100.0% identity (100.0% similar) in 621 aa overlap (117-737:21-641) 90 100 110 120 130 140 pF1KB9 APIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERV :::::::::::::::::::::::::::::: XP_011 MESSPLTEERQRPVSSELLRIDLEPEGRVYVIIDLSGSSGEAPKDNEERV 10 20 30 40 50 150 160 170 180 190 200 pF1KB9 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC 60 70 80 90 100 110 210 220 230 240 250 260 pF1KB9 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL 120 130 140 150 160 170 270 280 290 300 310 320 pF1KB9 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG 180 190 200 210 220 230 330 340 350 360 370 380 pF1KB9 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL 240 250 260 270 280 290 390 400 410 420 430 440 pF1KB9 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ 300 310 320 330 340 350 450 460 470 480 490 500 pF1KB9 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 360 370 380 390 400 410 510 520 530 540 550 560 pF1KB9 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT 420 430 440 450 460 470 570 580 590 600 610 620 pF1KB9 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY 480 490 500 510 520 530 630 640 650 660 670 680 pF1KB9 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK 540 550 560 570 580 590 690 700 710 720 730 pF1KB9 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP 600 610 620 630 640 >>XP_016859975 (OMIM: 176975) PREDICTED: protein kinase (641 aa) initn: 4277 init1: 4277 opt: 4277 Z-score: 1665.6 bits: 318.6 E(85289): 4.9e-86 Smith-Waterman score: 4277; 100.0% identity (100.0% similar) in 621 aa overlap (117-737:21-641) 90 100 110 120 130 140 pF1KB9 APIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERV :::::::::::::::::::::::::::::: XP_016 MESSPLTEERQRPVSSELLRIDLEPEGRVYVIIDLSGSSGEAPKDNEERV 10 20 30 40 50 150 160 170 180 190 200 pF1KB9 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTC 60 70 80 90 100 110 210 220 230 240 250 260 pF1KB9 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGL 120 130 140 150 160 170 270 280 290 300 310 320 pF1KB9 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAG 180 190 200 210 220 230 330 340 350 360 370 380 pF1KB9 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL 240 250 260 270 280 290 390 400 410 420 430 440 pF1KB9 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ 300 310 320 330 340 350 450 460 470 480 490 500 pF1KB9 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 360 370 380 390 400 410 510 520 530 540 550 560 pF1KB9 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT 420 430 440 450 460 470 570 580 590 600 610 620 pF1KB9 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY 480 490 500 510 520 530 630 640 650 660 670 680 pF1KB9 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK 540 550 560 570 580 590 690 700 710 720 730 pF1KB9 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP 600 610 620 630 640 >>XP_011531283 (OMIM: 176975) PREDICTED: protein kinase (587 aa) initn: 4056 init1: 4056 opt: 4056 Z-score: 1581.7 bits: 303.0 E(85289): 2.3e-81 Smith-Waterman score: 4056; 100.0% identity (100.0% similar) in 587 aa overlap (151-737:1-587) 130 140 150 160 170 180 pF1KB9 PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP :::::::::::::::::::::::::::::: XP_011 MRPRKRQGAVRRRVHQVNGHKFMATYLRQP 10 20 30 190 200 210 220 230 240 pF1KB9 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN 40 50 60 70 80 90 250 260 270 280 290 300 pF1KB9 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA 100 110 120 130 140 150 310 320 330 340 350 360 pF1KB9 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE 160 170 180 190 200 210 370 380 390 400 410 420 pF1KB9 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG 220 230 240 250 260 270 430 440 450 460 470 480 pF1KB9 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD 280 290 300 310 320 330 490 500 510 520 530 540 pF1KB9 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 340 350 360 370 380 390 550 560 570 580 590 600 pF1KB9 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 400 410 420 430 440 450 610 620 630 640 650 660 pF1KB9 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED 460 470 480 490 500 510 670 680 690 700 710 720 pF1KB9 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI 520 530 540 550 560 570 730 pF1KB9 NQEEFKGFSYFGEDLMP ::::::::::::::::: XP_011 NQEEFKGFSYFGEDLMP 580 >>XP_016859978 (OMIM: 176975) PREDICTED: protein kinase (587 aa) initn: 4056 init1: 4056 opt: 4056 Z-score: 1581.7 bits: 303.0 E(85289): 2.3e-81 Smith-Waterman score: 4056; 100.0% identity (100.0% similar) in 587 aa overlap (151-737:1-587) 130 140 150 160 170 180 pF1KB9 PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP :::::::::::::::::::::::::::::: XP_016 MRPRKRQGAVRRRVHQVNGHKFMATYLRQP 10 20 30 190 200 210 220 230 240 pF1KB9 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN 40 50 60 70 80 90 250 260 270 280 290 300 pF1KB9 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA 100 110 120 130 140 150 310 320 330 340 350 360 pF1KB9 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE 160 170 180 190 200 210 370 380 390 400 410 420 pF1KB9 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG 220 230 240 250 260 270 430 440 450 460 470 480 pF1KB9 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD 280 290 300 310 320 330 490 500 510 520 530 540 pF1KB9 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 340 350 360 370 380 390 550 560 570 580 590 600 pF1KB9 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 400 410 420 430 440 450 610 620 630 640 650 660 pF1KB9 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED 460 470 480 490 500 510 670 680 690 700 710 720 pF1KB9 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI 520 530 540 550 560 570 730 pF1KB9 NQEEFKGFSYFGEDLMP ::::::::::::::::: XP_016 NQEEFKGFSYFGEDLMP 580 737 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:18:41 2016 done: Thu Nov 3 23:18:43 2016 Total Scan time: 12.380 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]