FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9435, 216 aa 1>>>pF1KB9435 216 - 216 aa - 216 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9106+/-0.000348; mu= 15.4967+/- 0.022 mean_var=55.7462+/-11.409, 0's: 0 Z-trim(112.5): 28 B-trim: 1109 in 1/52 Lambda= 0.171778 statistics sampled from 21390 (21418) to 21390 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.251), width: 16 Scan time: 4.990 The best scores are: opt bits E(85289) NP_060691 (OMIM: 609281) MOB kinase activator 1A i ( 216) 1439 364.6 7.1e-101 NP_001304039 (OMIM: 609281) MOB kinase activator 1 ( 215) 1428 361.8 4.7e-100 NP_001304040 (OMIM: 609281) MOB kinase activator 1 ( 258) 1427 361.6 6.5e-100 NP_775739 (OMIM: 609282) MOB kinase activator 1B i ( 216) 1391 352.7 2.7e-97 XP_016864326 (OMIM: 609282) PREDICTED: MOB kinase ( 247) 1388 352.0 5.1e-97 NP_001231695 (OMIM: 609282) MOB kinase activator 1 ( 221) 1379 349.7 2.2e-96 XP_005265766 (OMIM: 609282) PREDICTED: MOB kinase ( 221) 1379 349.7 2.2e-96 XP_011530714 (OMIM: 609282) PREDICTED: MOB kinase ( 240) 1379 349.7 2.3e-96 NP_001304041 (OMIM: 609281) MOB kinase activator 1 ( 138) 922 236.3 1.8e-62 XP_011531250 (OMIM: 609281) PREDICTED: MOB kinase ( 180) 910 233.4 1.8e-61 NP_001231696 (OMIM: 609282) MOB kinase activator 1 ( 147) 894 229.4 2.3e-60 NP_001165694 (OMIM: 611969) MOB kinase activator 2 ( 268) 551 144.6 1.5e-34 NP_443731 (OMIM: 611969) MOB kinase activator 2 is ( 237) 548 143.8 2.3e-34 NP_001191023 (OMIM: 609361) MOB-like protein phoce ( 193) 190 55.0 9.8e-08 NP_955776 (OMIM: 609361) MOB-like protein phocein ( 193) 190 55.0 9.8e-08 NP_001094289 (OMIM: 609361) MOB-like protein phoce ( 204) 190 55.0 1e-07 NP_056202 (OMIM: 609361) MOB-like protein phocein ( 225) 190 55.0 1.1e-07 >>NP_060691 (OMIM: 609281) MOB kinase activator 1A isofo (216 aa) initn: 1439 init1: 1439 opt: 1439 Z-score: 1932.0 bits: 364.6 E(85289): 7.1e-101 Smith-Waterman score: 1439; 98.6% identity (99.1% similar) in 216 aa overlap (1-216:1-216) 10 20 30 40 50 60 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVN : : .::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 TVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 WVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 WVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLN 130 140 150 160 170 180 190 200 210 pF1KB9 TSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR :::::::::::::::::::::::::::::::::::: NP_060 TSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR 190 200 210 >>NP_001304039 (OMIM: 609281) MOB kinase activator 1A is (215 aa) initn: 1428 init1: 1428 opt: 1428 Z-score: 1917.3 bits: 361.8 E(85289): 4.7e-100 Smith-Waterman score: 1428; 99.1% identity (99.5% similar) in 213 aa overlap (4-216:3-215) 10 20 30 40 50 60 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVN .: :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFLFSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVN 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 TVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 WVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLN 120 130 140 150 160 170 190 200 210 pF1KB9 TSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR :::::::::::::::::::::::::::::::::::: NP_001 TSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR 180 190 200 210 >>NP_001304040 (OMIM: 609281) MOB kinase activator 1A is (258 aa) initn: 1427 init1: 1427 opt: 1427 Z-score: 1914.7 bits: 361.6 E(85289): 6.5e-100 Smith-Waterman score: 1427; 100.0% identity (100.0% similar) in 211 aa overlap (6-216:48-258) 10 20 30 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEAT :::::::::::::::::::::::::::::: NP_001 RCWPWSRIVLSSSDSAHLLALILTNFSCPRSSRSSKTFKPKKNIPEGSHQYELLKHAEAT 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB9 LGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEY 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB9 HWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRL 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB9 FRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKD 200 210 220 230 240 250 pF1KB9 R : NP_001 R >>NP_775739 (OMIM: 609282) MOB kinase activator 1B isofo (216 aa) initn: 1391 init1: 1391 opt: 1391 Z-score: 1867.7 bits: 352.7 E(85289): 2.7e-97 Smith-Waterman score: 1391; 94.4% identity (97.7% similar) in 216 aa overlap (1-216:1-216) 10 20 30 40 50 60 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVN : : ..::::::::::::::::::::::::::::::::::::.:::::::::::::.::: NP_775 MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 TVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMT ::::::::::::::::.:::: :::::::::.:::::::::::::::::::::::::::: NP_775 TVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 WVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLN :::::::::::::::::::::::::::::::::::::::::::::::: :.::::::::: NP_775 WVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLN 130 140 150 160 170 180 190 200 210 pF1KB9 TSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR ::::::::::::::::::::::::::::::: :::: NP_775 TSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR 190 200 210 >>XP_016864326 (OMIM: 609282) PREDICTED: MOB kinase acti (247 aa) initn: 1388 init1: 1388 opt: 1388 Z-score: 1862.8 bits: 352.0 E(85289): 5.1e-97 Smith-Waterman score: 1388; 94.9% identity (98.1% similar) in 214 aa overlap (3-216:34-247) 10 20 30 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHA .: .:::::::::::::::::::::::::: XP_016 SGMTTANCSFDFPGSGDPFISNPLPATSSWYYSGSRSSKTFKPKKNIPEGSHQYELLKHA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 EATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPR ::::::::::.:::::::::::::.:::::::::::::::::::.:::: :::::::::. XP_016 EATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 YEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTIL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB9 KRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLG :::::::::::::::: :.:::::::::::::::::::::::::::::::::::::::: XP_016 KRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLT 190 200 210 220 230 240 pF1KB9 SKDR :::: XP_016 SKDR >>NP_001231695 (OMIM: 609282) MOB kinase activator 1B is (221 aa) initn: 1379 init1: 1379 opt: 1379 Z-score: 1851.5 bits: 349.7 E(85289): 2.2e-96 Smith-Waterman score: 1379; 96.2% identity (98.6% similar) in 210 aa overlap (7-216:12-221) 10 20 30 40 50 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNE ::::::::::::::::::::::::::::::::::::.:::::::::::: NP_001 MEGATDVNESGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 WIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYI :.:::::::::::::::::::.:::: :::::::::.::::::::::::::::::::::: NP_001 WVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 DYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQE ::::::::::::::::::::::::::::::::::::::::::::::::::::: :.:::: NP_001 DYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQE 130 140 150 160 170 180 180 190 200 210 pF1KB9 EAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR :::::::::::::::::::::::::::::::::::: :::: NP_001 EAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR 190 200 210 220 >>XP_005265766 (OMIM: 609282) PREDICTED: MOB kinase acti (221 aa) initn: 1379 init1: 1379 opt: 1379 Z-score: 1851.5 bits: 349.7 E(85289): 2.2e-96 Smith-Waterman score: 1379; 96.2% identity (98.6% similar) in 210 aa overlap (7-216:12-221) 10 20 30 40 50 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNE ::::::::::::::::::::::::::::::::::::.:::::::::::: XP_005 MEGATDVNESGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 WIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYI :.:::::::::::::::::::.:::: :::::::::.::::::::::::::::::::::: XP_005 WVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 DYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQE ::::::::::::::::::::::::::::::::::::::::::::::::::::: :.:::: XP_005 DYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQE 130 140 150 160 170 180 180 190 200 210 pF1KB9 EAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR :::::::::::::::::::::::::::::::::::: :::: XP_005 EAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR 190 200 210 220 >>XP_011530714 (OMIM: 609282) PREDICTED: MOB kinase acti (240 aa) initn: 1379 init1: 1379 opt: 1379 Z-score: 1850.9 bits: 349.7 E(85289): 2.3e-96 Smith-Waterman score: 1379; 96.2% identity (98.6% similar) in 210 aa overlap (7-216:31-240) 10 20 30 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEATL :::::::::::::::::::::::::::::: XP_011 MTPNRVDRGAGQPRRTRWASSLAAEETRSGSRSSKTFKPKKNIPEGSHQYELLKHAEATL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 GSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYH ::::::.:::::::::::::.:::::::::::::::::::.:::: :::::::::.:::: XP_011 GSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 WADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLF 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB9 RVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR :::::::::::: :.:::::::::::::::::::::::::::::::::::::::: :::: XP_011 RVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR 190 200 210 220 230 240 >>NP_001304041 (OMIM: 609281) MOB kinase activator 1A is (138 aa) initn: 922 init1: 922 opt: 922 Z-score: 1242.5 bits: 236.3 E(85289): 1.8e-62 Smith-Waterman score: 922; 97.8% identity (98.6% similar) in 138 aa overlap (1-138:1-138) 10 20 30 40 50 60 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVN : : .::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 TVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 WVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLN :::::::::::::::::: NP_001 WVQDQLDDETLFPSKIGV 130 >>XP_011531250 (OMIM: 609281) PREDICTED: MOB kinase acti (180 aa) initn: 910 init1: 910 opt: 910 Z-score: 1224.7 bits: 233.4 E(85289): 1.8e-61 Smith-Waterman score: 910; 100.0% identity (100.0% similar) in 133 aa overlap (6-138:48-180) 10 20 30 pF1KB9 MLFYLSSRSSKTFKPKKNIPEGSHQYELLKHAEAT :::::::::::::::::::::::::::::: XP_011 RCWPWSRIVLSSSDSAHLLALILTNFSCPRSSRSSKTFKPKKNIPEGSHQYELLKHAEAT 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB9 LGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEY 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB9 HWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRL ::::::::::::::::::::::::::::::::::::::::::: XP_011 HWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGV 140 150 160 170 180 160 170 180 190 200 210 pF1KB9 FRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKD 216 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:14:33 2016 done: Sat Nov 5 02:14:34 2016 Total Scan time: 4.990 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]