Result of FASTA (omim) for
pF1KB9464
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9464, 1190 aa
1>>>pF1KB9464 1190 - 1190 aa - 1190 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.0293+/-0.000532; mu= -3.8753+/- 0.033
mean_var=377.4474+/-77.839, 0's: 0 Z-trim(119.6): 231 B-trim: 874 in 1/52
Lambda= 0.066016
statistics sampled from 33676 (33925) to 33676 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.398), width: 16
Scan time: 15.990
The best scores are: opt bits E(85289)
NP_004808 (OMIM: 607709,607748,615878) tight junct (1190) 7952 772.9 0
XP_005252371 (OMIM: 607709,607748,615878) PREDICTE (1194) 7811 759.4 2.9e-218
NP_001163887 (OMIM: 607709,607748,615878) tight ju (1221) 7804 758.8 4.7e-218
XP_016870815 (OMIM: 607709,607748,615878) PREDICTE (1213) 7800 758.4 6.1e-218
XP_011517508 (OMIM: 607709,607748,615878) PREDICTE (1167) 7776 756.1 2.9e-217
XP_011517511 (OMIM: 607709,607748,615878) PREDICTE (1167) 7776 756.1 2.9e-217
XP_011517510 (OMIM: 607709,607748,615878) PREDICTE (1167) 7776 756.1 2.9e-217
XP_011517509 (OMIM: 607709,607748,615878) PREDICTE (1167) 7776 756.1 2.9e-217
NP_963923 (OMIM: 607709,607748,615878) tight junct (1043) 6410 626.0 3.9e-178
XP_016870816 (OMIM: 607709,607748,615878) PREDICTE (1153) 6411 626.1 3.9e-178
XP_016870817 (OMIM: 607709,607748,615878) PREDICTE (1047) 6269 612.5 4.3e-174
NP_001163886 (OMIM: 607709,607748,615878) tight ju (1157) 6270 612.7 4.3e-174
NP_001163885 (OMIM: 607709,607748,615878) tight ju (1020) 6234 609.2 4.3e-173
XP_011517506 (OMIM: 607709,607748,615878) PREDICTE (1130) 6235 609.3 4.3e-173
NP_003248 (OMIM: 601009) tight junction protein ZO (1748) 1908 197.4 6.7e-49
XP_016878018 (OMIM: 601009) PREDICTED: tight junct (1755) 1908 197.4 6.7e-49
XP_016878017 (OMIM: 601009) PREDICTED: tight junct (1759) 1908 197.4 6.7e-49
NP_001317168 (OMIM: 601009) tight junction protein (1768) 1908 197.4 6.8e-49
XP_016878016 (OMIM: 601009) PREDICTED: tight junct (1783) 1908 197.4 6.8e-49
XP_016878015 (OMIM: 601009) PREDICTED: tight junct (1785) 1908 197.4 6.8e-49
XP_016878014 (OMIM: 601009) PREDICTED: tight junct (1789) 1908 197.4 6.8e-49
NP_001287954 (OMIM: 601009) tight junction protein (1835) 1908 197.4 7e-49
XP_005254674 (OMIM: 601009) PREDICTED: tight junct (1841) 1908 197.4 7e-49
XP_011520274 (OMIM: 601009) PREDICTED: tight junct (1848) 1908 197.4 7e-49
XP_016878012 (OMIM: 601009) PREDICTED: tight junct (1858) 1908 197.4 7e-49
XP_016878011 (OMIM: 601009) PREDICTED: tight junct (1865) 1908 197.4 7e-49
XP_016878010 (OMIM: 601009) PREDICTED: tight junct (1878) 1908 197.4 7.1e-49
XP_016878020 (OMIM: 601009) PREDICTED: tight junct (1452) 1902 196.8 8.7e-49
NP_783297 (OMIM: 601009) tight junction protein ZO (1668) 1886 195.3 2.8e-48
XP_016878019 (OMIM: 601009) PREDICTED: tight junct (1688) 1886 195.3 2.8e-48
NP_001287955 (OMIM: 601009) tight junction protein (1692) 1886 195.3 2.8e-48
XP_005254677 (OMIM: 601009) PREDICTED: tight junct (1761) 1886 195.3 2.9e-48
XP_005254676 (OMIM: 601009) PREDICTED: tight junct (1781) 1886 195.3 2.9e-48
XP_016878013 (OMIM: 601009) PREDICTED: tight junct (1798) 1886 195.3 2.9e-48
NP_001254489 (OMIM: 612689) tight junction protein ( 919) 1479 156.3 8.4e-37
NP_001254490 (OMIM: 612689) tight junction protein ( 928) 1479 156.3 8.4e-37
>>NP_004808 (OMIM: 607709,607748,615878) tight junction (1190 aa)
initn: 7952 init1: 7952 opt: 7952 Z-score: 4112.0 bits: 772.9 E(85289): 0
Smith-Waterman score: 7952; 99.7% identity (99.9% similar) in 1190 aa overlap (1-1190:1-1190)
10 20 30 40 50 60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_004 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
1150 1160 1170 1180 1190
>>XP_005252371 (OMIM: 607709,607748,615878) PREDICTED: t (1194 aa)
initn: 7806 init1: 7806 opt: 7811 Z-score: 4039.4 bits: 759.4 E(85289): 2.9e-218
Smith-Waterman score: 7811; 99.2% identity (99.6% similar) in 1179 aa overlap (13-1190:16-1194)
10 20 30 40 50
pF1KB9 MPVRGDRGFPPRRELSGWL-RAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPH
..: : :::::::::::::::::::::::::::::::::::::
XP_005 MKTAQALHRMWIQAVKKLRRWKGRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 FENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB9 KRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB9 RGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRD
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB9 RDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB9 PEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGT
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB9 VTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB9 EERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKE
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB9 PRYQEEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVA
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB9 GIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYR
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB9 DILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEK
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB9 GLIPNKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKF
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKF
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB9 PAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRL
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB9 NTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSS
790 800 810 820 830 840
840 850 860 870 880 890
pF1KB9 RKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDD
850 860 870 880 890 900
900 910 920 930 940 950
pF1KB9 PEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPV
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KB9 QHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYK
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KB9 SNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPK
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KB9 SVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTS
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KB9 SRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
1150 1160 1170 1180 1190
>>NP_001163887 (OMIM: 607709,607748,615878) tight juncti (1221 aa)
initn: 7803 init1: 7803 opt: 7804 Z-score: 4035.7 bits: 758.8 E(85289): 4.7e-218
Smith-Waterman score: 7804; 98.6% identity (98.9% similar) in 1190 aa overlap (9-1190:35-1221)
10 20 30
pF1KB9 MPVRGDRGFPPRRELSGW--------LRAPGMEELIWE
:: .::.: : ::::::::::
NP_001 QALHRMWIQAVKKLRRWKGRVSPSASSPLVFP---NLSSWEGEGSKTILTAPGMEELIWE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 QYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNG
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 TPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 FRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRSGYSERSRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHA
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 RTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTRDRSRGRSLERGLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYR
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB9 RGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGARHDARSRGPRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 EMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLI
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB9 NIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLS
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB9 RMGATPTPFKSTGDIAGTVVPETNKEPRYQEEPPAPQPKAAPRTFLRPSPEDEAIYGPNT
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
NP_001 RMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNT
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB9 KMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVRED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVRED
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB9 AVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEV
610 620 630 640 650 660
640 650 660 670 680 690
pF1KB9 FRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQIASVQNAQRDNAGDRADFWRMRG
:::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::
NP_001 FRVVDTLYDGKLGNWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KB9 QRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRSGVKKNLRKSREDLTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANE
730 740 750 760 770 780
760 770 780 790 800 810
pF1KB9 LPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPDWFQTAKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIV
790 800 810 820 830 840
820 830 840 850 860 870
pF1KB9 IFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGS
850 860 870 880 890 900
880 890 900 910 920 930
pF1KB9 LKDTIQHQQGEAVWVSEGKMEGMDDHPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGG
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 LKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGG
910 920 930 940 950 960
940 950 960 970 980 990
pF1KB9 AYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPA
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KB9 FKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKPEPPKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSIL
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KB9 KPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPSTPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEI
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KB9 AQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQL
1150 1160 1170 1180 1190 1200
1180 1190
pF1KB9 SEHSKRGYYGQSARYRDTEL
::::::::::::::::::::
NP_001 SEHSKRGYYGQSARYRDTEL
1210 1220
>>XP_016870815 (OMIM: 607709,607748,615878) PREDICTED: t (1213 aa)
initn: 7800 init1: 7800 opt: 7800 Z-score: 4033.7 bits: 758.4 E(85289): 6.1e-218
Smith-Waterman score: 7800; 99.7% identity (99.9% similar) in 1171 aa overlap (20-1190:43-1213)
10 20 30 40
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVS
.:::::::::::::::::::::::::::::
XP_016 PCEWDWHPGCSSRSKYSRKHRAVPVHGPRCQAPGMEELIWEQYTVTLQKDSKRGFGIAVS
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB9 GGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSG
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB9 KVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSR
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB9 SWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDF
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB9 GPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREH
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB9 PHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDI
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB9 ILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIE
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB9 SNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNRSFSPEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTV
440 450 460 470 480 490
470 480 490 500 510 520
pF1KB9 VPETNKEPRYQEEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGN
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGN
500 510 520 530 540 550
530 540 550 560 570 580
pF1KB9 DVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQ
560 570 580 590 600 610
590 600 610 620 630 640
pF1KB9 SRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVR
620 630 640 650 660 670
650 660 670 680 690 700
pF1KB9 IGNELEKGLIPNKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAV
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 IGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAV
680 690 700 710 720 730
710 720 730 740 750 760
pF1KB9 VSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEK
740 750 760 770 780 790
770 780 790 800 810 820
pF1KB9 STGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLN
800 810 820 830 840 850
830 840 850 860 870 880
pF1KB9 PTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGK
860 870 880 890 900 910
890 900 910 920 930 940
pF1KB9 MEGMDDHPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSI
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSI
920 930 940 950 960 970
950 960 970 980 990 1000
pF1KB9 TRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDF
980 990 1000 1010 1020 1030
1010 1020 1030 1040 1050 1060
pF1KB9 SKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSE
1040 1050 1060 1070 1080 1090
1070 1080 1090 1100 1110 1120
pF1KB9 EQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDP
1100 1110 1120 1130 1140 1150
1130 1140 1150 1160 1170 1180
pF1KB9 GTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTE
1160 1170 1180 1190 1200 1210
1190
pF1KB9 L
:
XP_016 L
>>XP_011517508 (OMIM: 607709,607748,615878) PREDICTED: t (1167 aa)
initn: 7776 init1: 7776 opt: 7776 Z-score: 4021.6 bits: 756.1 E(85289): 2.9e-217
Smith-Waterman score: 7776; 99.7% identity (99.9% similar) in 1167 aa overlap (24-1190:1-1167)
10 20 30 40 50 60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
:::::::::::::::::::::::::::::::::::::
XP_011 MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
10 20 30
70 80 90 100 110 120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
700 710 720 730 740 750
790 800 810 820 830 840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
760 770 780 790 800 810
850 860 870 880 890 900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
820 830 840 850 860 870
910 920 930 940 950 960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
1120 1130 1140 1150 1160
>>XP_011517511 (OMIM: 607709,607748,615878) PREDICTED: t (1167 aa)
initn: 7776 init1: 7776 opt: 7776 Z-score: 4021.6 bits: 756.1 E(85289): 2.9e-217
Smith-Waterman score: 7776; 99.7% identity (99.9% similar) in 1167 aa overlap (24-1190:1-1167)
10 20 30 40 50 60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
:::::::::::::::::::::::::::::::::::::
XP_011 MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
10 20 30
70 80 90 100 110 120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
700 710 720 730 740 750
790 800 810 820 830 840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
760 770 780 790 800 810
850 860 870 880 890 900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
820 830 840 850 860 870
910 920 930 940 950 960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
1120 1130 1140 1150 1160
>>XP_011517510 (OMIM: 607709,607748,615878) PREDICTED: t (1167 aa)
initn: 7776 init1: 7776 opt: 7776 Z-score: 4021.6 bits: 756.1 E(85289): 2.9e-217
Smith-Waterman score: 7776; 99.7% identity (99.9% similar) in 1167 aa overlap (24-1190:1-1167)
10 20 30 40 50 60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
:::::::::::::::::::::::::::::::::::::
XP_011 MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
10 20 30
70 80 90 100 110 120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
700 710 720 730 740 750
790 800 810 820 830 840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
760 770 780 790 800 810
850 860 870 880 890 900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
820 830 840 850 860 870
910 920 930 940 950 960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
1120 1130 1140 1150 1160
>>XP_011517509 (OMIM: 607709,607748,615878) PREDICTED: t (1167 aa)
initn: 7776 init1: 7776 opt: 7776 Z-score: 4021.6 bits: 756.1 E(85289): 2.9e-217
Smith-Waterman score: 7776; 99.7% identity (99.9% similar) in 1167 aa overlap (24-1190:1-1167)
10 20 30 40 50 60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
:::::::::::::::::::::::::::::::::::::
XP_011 MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
10 20 30
70 80 90 100 110 120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
700 710 720 730 740 750
790 800 810 820 830 840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
760 770 780 790 800 810
850 860 870 880 890 900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
820 830 840 850 860 870
910 920 930 940 950 960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
1120 1130 1140 1150 1160
>>NP_963923 (OMIM: 607709,607748,615878) tight junction (1043 aa)
initn: 6391 init1: 6391 opt: 6410 Z-score: 3319.1 bits: 626.0 E(85289): 3.9e-178
Smith-Waterman score: 6664; 87.4% identity (87.6% similar) in 1190 aa overlap (1-1190:1-1043)
10 20 30 40 50 60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_963 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
NP_963 ------------------------------------------------------------
1030 1040 1050 1060 1070 1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
NP_963 ------------------------------------------------------------
1090 1100 1110 1120 1130 1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
:::::::::::::::::::::::::::::::::
NP_963 ---------------------------IEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
970 980 990
1150 1160 1170 1180 1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
1000 1010 1020 1030 1040
>>XP_016870816 (OMIM: 607709,607748,615878) PREDICTED: t (1153 aa)
initn: 6598 init1: 6392 opt: 6411 Z-score: 3319.0 bits: 626.1 E(85289): 3.9e-178
Smith-Waterman score: 7606; 96.6% identity (96.8% similar) in 1190 aa overlap (1-1190:1-1153)
10 20 30 40 50 60
pF1KB9 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPVRGDRGFPPRRELSGWLRAPGMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEPR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTEN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 EEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEKGLIP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 NKSRAEQIASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPKDAGSEKSTGVVRLNTVR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB9 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDHPEDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_016 DQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB9 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB9 SIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEPPKAKTQNKEESYDFSKSYEYKSNPS
:::::::::::::::::::::::
XP_016 -------------------------------------AKTQNKEESYDFSKSYEYKSNPS
970 980
1030 1040 1050 1060 1070 1080
pF1KB9 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAGNETPGASTKGYPPPVAAKPTFGRSILKPSTPIPPQEGEEVGESSEEQDNAPKSVLG
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KB9 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGTPQHTSSRPP
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190
pF1KB9 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPQKAPSRPYQDTRGSYGSDAEEEEYRQQLSEHSKRGYYGQSARYRDTEL
1110 1120 1130 1140 1150
1190 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 23:36:31 2016 done: Thu Nov 3 23:36:33 2016
Total Scan time: 15.990 Total Display time: 0.450
Function used was FASTA [36.3.4 Apr, 2011]