FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9478, 1211 aa 1>>>pF1KB9478 1211 - 1211 aa - 1211 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 17.9673+/-0.00045; mu= -39.1890+/- 0.028 mean_var=615.4764+/-126.348, 0's: 0 Z-trim(124.5): 127 B-trim: 0 in 0/62 Lambda= 0.051697 statistics sampled from 46040 (46193) to 46040 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.542), width: 16 Scan time: 19.700 The best scores are: opt bits E(85289) NP_001300888 (OMIM: 159557) AF4/FMR2 family member (1211) 8058 616.6 3e-175 NP_005926 (OMIM: 159557) AF4/FMR2 family member 1 (1210) 8039 615.2 8.1e-175 XP_005263068 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1216) 8030 614.5 1.3e-174 XP_011530275 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1218) 8030 614.5 1.3e-174 NP_001160165 (OMIM: 159557) AF4/FMR2 family member (1218) 8030 614.5 1.3e-174 XP_005263064 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1218) 8030 614.5 1.3e-174 XP_005263066 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1217) 8011 613.1 3.4e-174 XP_005263070 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1057) 6994 537.2 2.1e-151 XP_016863704 (OMIM: 159557) PREDICTED: AF4/FMR2 fa ( 849) 5604 433.5 2.7e-120 NP_001300889 (OMIM: 159557) AF4/FMR2 family member ( 849) 5604 433.5 2.7e-120 XP_016863705 (OMIM: 159557) PREDICTED: AF4/FMR2 fa ( 849) 5604 433.5 2.7e-120 XP_006714650 (OMIM: 604417,616368) PREDICTED: AF4/ (1134) 1609 135.6 1.8e-30 XP_005272020 (OMIM: 604417,616368) PREDICTED: AF4/ (1163) 1581 133.5 7.7e-30 NP_055238 (OMIM: 604417,616368) AF4/FMR2 family me (1163) 1581 133.5 7.7e-30 XP_005272021 (OMIM: 604417,616368) PREDICTED: AF4/ ( 785) 1546 130.9 3.3e-29 XP_011509475 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1251) 1318 113.9 6.6e-24 NP_001020279 (OMIM: 601464) AF4/FMR2 family member (1251) 1318 113.9 6.6e-24 XP_011509476 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1251) 1318 113.9 6.6e-24 XP_011509472 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1303) 1318 113.9 6.9e-24 XP_011509471 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1250) 1317 113.8 6.9e-24 NP_002276 (OMIM: 601464) AF4/FMR2 family member 3 (1226) 1313 113.5 8.4e-24 XP_005264000 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1226) 1313 113.5 8.4e-24 XP_011509477 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1226) 1313 113.5 8.4e-24 XP_011509478 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1226) 1313 113.5 8.4e-24 XP_011509479 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1226) 1313 113.5 8.4e-24 XP_011509474 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1235) 1095 97.3 6.6e-19 XP_011509481 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 864) 1082 96.3 9.3e-19 XP_016859576 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 861) 1076 95.8 1.3e-18 XP_016859575 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 862) 1076 95.8 1.3e-18 XP_011509480 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 865) 1076 95.8 1.3e-18 XP_016859574 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 894) 1076 95.8 1.3e-18 XP_005264002 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 895) 1076 95.8 1.3e-18 XP_011509473 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1235) 1027 92.2 2.2e-17 NP_002016 (OMIM: 300806,309548) AF4/FMR2 family me (1311) 780 73.8 8.3e-12 NP_001162593 (OMIM: 300806,309548) AF4/FMR2 family (1276) 772 73.2 1.2e-11 NP_001164099 (OMIM: 300806,309548) AF4/FMR2 family ( 952) 761 72.3 1.6e-11 NP_001162596 (OMIM: 300806,309548) AF4/FMR2 family (1272) 751 71.6 3.6e-11 NP_001162595 (OMIM: 300806,309548) AF4/FMR2 family (1276) 751 71.6 3.6e-11 NP_001162594 (OMIM: 300806,309548) AF4/FMR2 family (1301) 751 71.6 3.7e-11 NP_001121182 (OMIM: 208250,604283) proteoglycan 4 (1270) 436 48.1 0.00042 XP_016855492 (OMIM: 208250,604283) PREDICTED: prot (1270) 436 48.1 0.00042 XP_016855491 (OMIM: 208250,604283) PREDICTED: prot (1311) 436 48.1 0.00044 NP_001121181 (OMIM: 208250,604283) proteoglycan 4 (1311) 436 48.1 0.00044 NP_001290161 (OMIM: 208250,604283) proteoglycan 4 (1361) 436 48.1 0.00045 >>NP_001300888 (OMIM: 159557) AF4/FMR2 family member 1 i (1211 aa) initn: 8058 init1: 8058 opt: 8058 Z-score: 3267.2 bits: 616.6 E(85289): 3e-175 Smith-Waterman score: 8058; 100.0% identity (100.0% similar) in 1211 aa overlap (1-1211:1-1211) 10 20 30 40 50 60 pF1KB9 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 CPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 DQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 SMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 SDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 GTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 PAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB9 TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB9 SRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB9 SSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB9 SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFD 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB9 KQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB9 ETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKH 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB9 FESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB9 NMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQG 1150 1160 1170 1180 1190 1200 1210 pF1KB9 FQQLQELTKTP ::::::::::: NP_001 FQQLQELTKTP 1210 >>NP_005926 (OMIM: 159557) AF4/FMR2 family member 1 isof (1210 aa) initn: 7624 init1: 7338 opt: 8039 Z-score: 3259.6 bits: 615.2 E(85289): 8.1e-175 Smith-Waterman score: 8039; 99.9% identity (99.9% similar) in 1211 aa overlap (1-1211:1-1210) 10 20 30 40 50 60 pF1KB9 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 CPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 DQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 SMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 SDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 GTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 PAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB9 TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB9 SRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB9 SSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB9 SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFD 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB9 KQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB9 ETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKH 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB9 FESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQ :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_005 FESSSKVAQAPSPCIA-STGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQ 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KB9 NMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQG 1140 1150 1160 1170 1180 1190 1210 pF1KB9 FQQLQELTKTP ::::::::::: NP_005 FQQLQELTKTP 1200 1210 >>XP_005263068 (OMIM: 159557) PREDICTED: AF4/FMR2 family (1216 aa) initn: 8029 init1: 8029 opt: 8030 Z-score: 3255.9 bits: 614.5 E(85289): 1.3e-174 Smith-Waterman score: 8030; 99.7% identity (99.8% similar) in 1211 aa overlap (1-1211:6-1216) 10 20 30 40 50 pF1KB9 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSS : . :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPSNAMFLMHSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 RIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 IHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 KGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 NSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVR 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 PMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHC 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 VEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 QQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 DSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRST 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB9 EPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB9 QRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB9 SNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB9 GSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQ 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB9 PPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKS 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB9 QSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQD 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB9 PPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKP 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB9 QVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSA 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KB9 YSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSR 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KB9 TLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATIST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATIST 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KB9 PVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVH 1150 1160 1170 1180 1190 1200 1200 1210 pF1KB9 YTRQGFQQLQELTKTP :::::::::::::::: XP_005 YTRQGFQQLQELTKTP 1210 >>XP_011530275 (OMIM: 159557) PREDICTED: AF4/FMR2 family (1218 aa) initn: 8030 init1: 8030 opt: 8030 Z-score: 3255.9 bits: 614.5 E(85289): 1.3e-174 Smith-Waterman score: 8030; 99.9% identity (100.0% similar) in 1207 aa overlap (5-1211:12-1218) 10 20 30 40 50 pF1KB9 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL .:::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB9 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB9 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB9 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB9 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB9 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB9 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB9 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB9 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KB9 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KB9 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KB9 STPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDL 1150 1160 1170 1180 1190 1200 1200 1210 pF1KB9 VHYTRQGFQQLQELTKTP :::::::::::::::::: XP_011 VHYTRQGFQQLQELTKTP 1210 >>NP_001160165 (OMIM: 159557) AF4/FMR2 family member 1 i (1218 aa) initn: 8030 init1: 8030 opt: 8030 Z-score: 3255.9 bits: 614.5 E(85289): 1.3e-174 Smith-Waterman score: 8030; 99.9% identity (100.0% similar) in 1207 aa overlap (5-1211:12-1218) 10 20 30 40 50 pF1KB9 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL .:::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB9 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB9 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB9 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB9 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB9 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB9 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB9 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB9 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KB9 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KB9 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KB9 STPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDL 1150 1160 1170 1180 1190 1200 1200 1210 pF1KB9 VHYTRQGFQQLQELTKTP :::::::::::::::::: NP_001 VHYTRQGFQQLQELTKTP 1210 >>XP_005263064 (OMIM: 159557) PREDICTED: AF4/FMR2 family (1218 aa) initn: 8030 init1: 8030 opt: 8030 Z-score: 3255.9 bits: 614.5 E(85289): 1.3e-174 Smith-Waterman score: 8030; 99.9% identity (100.0% similar) in 1207 aa overlap (5-1211:12-1218) 10 20 30 40 50 pF1KB9 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL .:::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB9 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB9 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB9 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB9 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB9 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB9 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB9 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB9 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KB9 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KB9 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KB9 STPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDL 1150 1160 1170 1180 1190 1200 1200 1210 pF1KB9 VHYTRQGFQQLQELTKTP :::::::::::::::::: XP_005 VHYTRQGFQQLQELTKTP 1210 >>XP_005263066 (OMIM: 159557) PREDICTED: AF4/FMR2 family (1217 aa) initn: 5704 init1: 5704 opt: 8011 Z-score: 3248.2 bits: 613.1 E(85289): 3.4e-174 Smith-Waterman score: 8011; 99.8% identity (99.9% similar) in 1207 aa overlap (5-1211:12-1217) 10 20 30 40 50 pF1KB9 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL .:::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV ::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: XP_005 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVE-TYSNEV 310 320 330 340 350 360 370 380 390 400 410 pF1KB9 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB9 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB9 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB9 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB9 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB9 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB9 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB9 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG 840 850 860 870 880 890 900 910 920 930 940 950 pF1KB9 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KB9 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KB9 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KB9 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KB9 STPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDL 1140 1150 1160 1170 1180 1190 1200 1210 pF1KB9 VHYTRQGFQQLQELTKTP :::::::::::::::::: XP_005 VHYTRQGFQQLQELTKTP 1200 1210 >>XP_005263070 (OMIM: 159557) PREDICTED: AF4/FMR2 family (1057 aa) initn: 6994 init1: 6994 opt: 6994 Z-score: 2839.3 bits: 537.2 E(85289): 2.1e-151 Smith-Waterman score: 6994; 99.9% identity (100.0% similar) in 1046 aa overlap (5-1050:12-1057) 10 20 30 40 50 pF1KB9 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL .:::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESES 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPR 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB9 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB9 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRA 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB9 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB9 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRI 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB9 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB9 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCG 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB9 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPG 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB9 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSK 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KB9 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKY ::::::::::::::::::::::::::::::::::::: XP_005 SAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVL 1030 1040 1050 1080 1090 1100 1110 1120 1130 pF1KB9 SRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATI >>XP_016863704 (OMIM: 159557) PREDICTED: AF4/FMR2 family (849 aa) initn: 5604 init1: 5604 opt: 5604 Z-score: 2280.6 bits: 433.5 E(85289): 2.7e-120 Smith-Waterman score: 5604; 100.0% identity (100.0% similar) in 849 aa overlap (363-1211:1-849) 340 350 360 370 380 390 pF1KB9 AKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDS :::::::::::::::::::::::::::::: XP_016 MTHSWPPPLTAIHTPSTAEPSKFPFPTKDS 10 20 30 400 410 420 430 440 450 pF1KB9 QHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPS 40 50 60 70 80 90 460 470 480 490 500 510 pF1KB9 APQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNK 100 110 120 130 140 150 520 530 540 550 560 570 pF1KB9 WQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPR 160 170 180 190 200 210 580 590 600 610 620 630 pF1KB9 APPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPY 220 230 240 250 260 270 640 650 660 670 680 690 pF1KB9 GSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN 280 290 300 310 320 330 700 710 720 730 740 750 pF1KB9 VEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPL 340 350 360 370 380 390 760 770 780 790 800 810 pF1KB9 RDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAK 400 410 420 430 440 450 820 830 840 850 860 870 pF1KB9 KRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSS 460 470 480 490 500 510 880 890 900 910 920 930 pF1KB9 SSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGS 520 530 540 550 560 570 940 950 960 970 980 990 pF1KB9 SGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYL 580 590 600 610 620 630 1000 1010 1020 1030 1040 1050 pF1KB9 EAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCM 640 650 660 670 680 690 1060 1070 1080 1090 1100 1110 pF1KB9 RCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPA 700 710 720 730 740 750 1120 1130 1140 1150 1160 1170 pF1KB9 SSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKE 760 770 780 790 800 810 1180 1190 1200 1210 pF1KB9 FFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP ::::::::::::::::::::::::::::::::::::::: XP_016 FFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP 820 830 840 >>NP_001300889 (OMIM: 159557) AF4/FMR2 family member 1 i (849 aa) initn: 5604 init1: 5604 opt: 5604 Z-score: 2280.6 bits: 433.5 E(85289): 2.7e-120 Smith-Waterman score: 5604; 100.0% identity (100.0% similar) in 849 aa overlap (363-1211:1-849) 340 350 360 370 380 390 pF1KB9 AKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDS :::::::::::::::::::::::::::::: NP_001 MTHSWPPPLTAIHTPSTAEPSKFPFPTKDS 10 20 30 400 410 420 430 440 450 pF1KB9 QHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPS 40 50 60 70 80 90 460 470 480 490 500 510 pF1KB9 APQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNK 100 110 120 130 140 150 520 530 540 550 560 570 pF1KB9 WQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPR 160 170 180 190 200 210 580 590 600 610 620 630 pF1KB9 APPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPY 220 230 240 250 260 270 640 650 660 670 680 690 pF1KB9 GSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN 280 290 300 310 320 330 700 710 720 730 740 750 pF1KB9 VEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPL 340 350 360 370 380 390 760 770 780 790 800 810 pF1KB9 RDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAK 400 410 420 430 440 450 820 830 840 850 860 870 pF1KB9 KRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSS 460 470 480 490 500 510 880 890 900 910 920 930 pF1KB9 SSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGS 520 530 540 550 560 570 940 950 960 970 980 990 pF1KB9 SGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYL 580 590 600 610 620 630 1000 1010 1020 1030 1040 1050 pF1KB9 EAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCM 640 650 660 670 680 690 1060 1070 1080 1090 1100 1110 pF1KB9 RCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPA 700 710 720 730 740 750 1120 1130 1140 1150 1160 1170 pF1KB9 SSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKE 760 770 780 790 800 810 1180 1190 1200 1210 pF1KB9 FFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP ::::::::::::::::::::::::::::::::::::::: NP_001 FFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP 820 830 840 1211 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:46:54 2016 done: Thu Nov 3 23:46:57 2016 Total Scan time: 19.700 Total Display time: 0.490 Function used was FASTA [36.3.4 Apr, 2011]