FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9494, 840 aa 1>>>pF1KB9494 840 - 840 aa - 840 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9543+/-0.000356; mu= 17.6004+/- 0.022 mean_var=105.3666+/-23.568, 0's: 0 Z-trim(115.8): 232 B-trim: 146 in 1/49 Lambda= 0.124946 statistics sampled from 26192 (26477) to 26192 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.31), width: 16 Scan time: 13.420 The best scores are: opt bits E(85289) NP_006758 (OMIM: 600574,615670,616564) leucine-zip ( 840) 5733 1045.0 0 NP_476502 (OMIM: 611248) kelch domain-containing p ( 382) 280 61.7 7.2e-09 NP_061867 (OMIM: 609109) F-box only protein 42 [Ho ( 717) 258 58.0 1.8e-07 XP_006710761 (OMIM: 609109) PREDICTED: F-box only ( 717) 258 58.0 1.8e-07 XP_016869669 (OMIM: 605962) PREDICTED: rab9 effect ( 267) 245 55.3 4.3e-07 XP_016869671 (OMIM: 605962) PREDICTED: rab9 effect ( 267) 245 55.3 4.3e-07 XP_016869670 (OMIM: 605962) PREDICTED: rab9 effect ( 267) 245 55.3 4.3e-07 XP_005251701 (OMIM: 605962) PREDICTED: rab9 effect ( 275) 245 55.3 4.4e-07 XP_016869667 (OMIM: 605962) PREDICTED: rab9 effect ( 318) 240 54.5 9.2e-07 XP_005251699 (OMIM: 605962) PREDICTED: rab9 effect ( 326) 240 54.5 9.4e-07 NP_001007229 (OMIM: 602650) speckle-type POZ prote ( 374) 239 54.3 1.2e-06 NP_001007228 (OMIM: 602650) speckle-type POZ prote ( 374) 239 54.3 1.2e-06 NP_001007230 (OMIM: 602650) speckle-type POZ prote ( 374) 239 54.3 1.2e-06 NP_001007231 (OMIM: 602650) speckle-type POZ prote ( 374) 239 54.3 1.2e-06 NP_001007227 (OMIM: 602650) speckle-type POZ prote ( 374) 239 54.3 1.2e-06 NP_003554 (OMIM: 602650) speckle-type POZ protein ( 374) 239 54.3 1.2e-06 XP_016880693 (OMIM: 602650) PREDICTED: speckle-typ ( 374) 239 54.3 1.2e-06 XP_005257780 (OMIM: 602650) PREDICTED: speckle-typ ( 374) 239 54.3 1.2e-06 XP_005257781 (OMIM: 602650) PREDICTED: speckle-typ ( 374) 239 54.3 1.2e-06 XP_011534912 (OMIM: 611280) PREDICTED: kelch domai ( 334) 235 53.6 1.8e-06 NP_055130 (OMIM: 611280) kelch domain-containing p ( 406) 235 53.6 2.1e-06 XP_006720157 (OMIM: 611280) PREDICTED: kelch domai ( 368) 228 52.3 4.6e-06 XP_005247610 (OMIM: 611295) PREDICTED: kelch-like ( 600) 221 51.3 1.6e-05 NP_060114 (OMIM: 611295) kelch-like protein 24 [Ho ( 600) 221 51.3 1.6e-05 XP_005247609 (OMIM: 611295) PREDICTED: kelch-like ( 600) 221 51.3 1.6e-05 XP_005247611 (OMIM: 611295) PREDICTED: kelch-like ( 600) 221 51.3 1.6e-05 XP_005247613 (OMIM: 611295) PREDICTED: kelch-like ( 600) 221 51.3 1.6e-05 XP_011511240 (OMIM: 611295) PREDICTED: kelch-like ( 600) 221 51.3 1.6e-05 XP_016862149 (OMIM: 611295) PREDICTED: kelch-like ( 600) 221 51.3 1.6e-05 XP_005247612 (OMIM: 611295) PREDICTED: kelch-like ( 600) 221 51.3 1.6e-05 XP_016862148 (OMIM: 611295) PREDICTED: kelch-like ( 600) 221 51.3 1.6e-05 XP_016862147 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_016862140 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_016862139 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_016862143 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_016862145 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_016862141 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_016862142 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_016862146 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_016862144 (OMIM: 611295) PREDICTED: kelch-like ( 625) 221 51.3 1.6e-05 XP_005250290 (OMIM: 615152) PREDICTED: kelch domai ( 413) 204 48.1 0.0001 NP_055812 (OMIM: 615152) kelch domain-containing p ( 442) 204 48.1 0.00011 XP_011512584 (OMIM: 611237) PREDICTED: BTB/POZ dom ( 387) 202 47.7 0.00012 XP_016865716 (OMIM: 611237) PREDICTED: BTB/POZ dom ( 387) 202 47.7 0.00012 XP_011512583 (OMIM: 611237) PREDICTED: BTB/POZ dom ( 391) 202 47.7 0.00012 XP_011512582 (OMIM: 611237) PREDICTED: BTB/POZ dom ( 401) 202 47.7 0.00013 NP_001401 (OMIM: 604267,614976) multiple epidermal (2778) 213 50.4 0.00014 NP_001258867 (OMIM: 604267,614976) multiple epider (2845) 213 50.4 0.00014 XP_011512581 (OMIM: 611237) PREDICTED: BTB/POZ dom ( 612) 202 47.8 0.00017 NP_443125 (OMIM: 611237) BTB/POZ domain-containing ( 612) 202 47.8 0.00017 >>NP_006758 (OMIM: 600574,615670,616564) leucine-zipper- (840 aa) initn: 5733 init1: 5733 opt: 5733 Z-score: 5588.0 bits: 1045.0 E(85289): 0 Smith-Waterman score: 5733; 100.0% identity (100.0% similar) in 840 aa overlap (1-840:1-840) 10 20 30 40 50 60 pF1KB9 MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 HSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 HSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 TVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 SRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 FSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKITQARER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKITQARER 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 LAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKIKYPRKGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKIKYPRKGH 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 VEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHCLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHCLN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 FVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 GAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB9 ESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB9 DKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI 790 800 810 820 830 840 >>NP_476502 (OMIM: 611248) kelch domain-containing prote (382 aa) initn: 246 init1: 128 opt: 280 Z-score: 280.3 bits: 61.7 E(85289): 7.2e-09 Smith-Waterman score: 301; 29.5% identity (55.6% similar) in 241 aa overlap (52-278:113-336) 30 40 50 60 70 80 pF1KB9 SKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIY :.: : . : . :. :.. . .: NP_476 VLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFT-PRVSGTVPGARDGHSACVLGKIMY 90 100 110 120 130 140 90 100 110 120 130 pF1KB9 VFGG--DNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYT-- .::: ... . ::. ..:.. .: : :.: : :::.. :: :.:::: . NP_476 IFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADR 150 160 170 180 190 200 140 150 160 170 180 190 pF1KB9 -GDIYSNSNLK-NKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDG : ..::... :. .:. . : : . :: .: .:.: :. .:.::.:: NP_476 FGPFHSNNEIYCNRIRVFDTR--TEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGY-- 210 220 230 240 250 200 210 220 230 240 pF1KB9 NARLN----DMWTIGLQDRELTCWEEVAQSGEIP-P---SCCNFPVAVCRDKMFVFSGQS ::::: :.: .. .: :... .:. : : .:: . ::. .:.: : NP_476 NARLNRHFHDLWK--FNPVSFT-WKKIEPKGKGPCPRRRQCC----CIVGDKIVLFGGTS 260 270 280 290 300 310 250 260 270 280 290 300 pF1KB9 GAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTL . . .:.. :.. :.: :: NP_476 PSPEEGLGDEFDLIDHS-----DLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWELN 320 330 340 350 360 310 320 330 340 350 360 pF1KB9 PNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKKSRDVFGL NP_476 AMTTNSNISRPIVSSHG 370 380 >>NP_061867 (OMIM: 609109) F-box only protein 42 [Homo s (717 aa) initn: 334 init1: 125 opt: 258 Z-score: 255.2 bits: 58.0 E(85289): 1.8e-07 Smith-Waterman score: 258; 24.8% identity (57.3% similar) in 262 aa overlap (53-294:103-356) 30 40 50 60 70 pF1KB9 KVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWR-RLPPCDEFVGARRSKHTVVAY--KDA .:. : : ..: .:.. : ... NP_061 LVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQS 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB9 IYVFGG---DNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGY .::::: .. .. .::: :.:... : : ...:. :.:. . ::: . . .:::. NP_061 MYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGW 140 150 160 170 180 190 140 150 160 170 180 190 pF1KB9 TGDIYSNSNLKNKNDLFE--YKFATGQ-WTEWKIEGRLPVARSAHGATVYSDKLWIFAGY : : :.. . .:. . .. .. : . . . : ..:.. : .::. .:.: NP_061 TRP--SPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGS 200 210 220 230 240 250 200 210 220 230 240 250 pF1KB9 DGNARL-NDMWTIGLQDRELTCWEEVAQSGEIP-PSCCNFPVAVCRDKMFVFSGQSGAKI :. .. ::.:.. : : : . :: : : . ... .....: .: NP_061 LGSRQMSNDVWVL---DLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGG--- 260 270 280 290 300 260 270 280 290 300 pF1KB9 TNNLFQ----FEFKDKTWTRIP--TEHLLRGSPP---PPQRRYGHTMVAFDRHLYVFGGA : ::. ..... :. : .:. .:.: : : :. .:.:.. NP_061 PNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPL 310 320 330 340 350 360 310 320 330 340 350 360 pF1KB9 ADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKKSR NP_061 SPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSR 370 380 390 400 410 420 >>XP_006710761 (OMIM: 609109) PREDICTED: F-box only prot (717 aa) initn: 334 init1: 125 opt: 258 Z-score: 255.2 bits: 58.0 E(85289): 1.8e-07 Smith-Waterman score: 258; 24.8% identity (57.3% similar) in 262 aa overlap (53-294:103-356) 30 40 50 60 70 pF1KB9 KVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWR-RLPPCDEFVGARRSKHTVVAY--KDA .:. : : ..: .:.. : ... XP_006 LVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQS 80 90 100 110 120 130 80 90 100 110 120 130 pF1KB9 IYVFGG---DNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGY .::::: .. .. .::: :.:... : : ...:. :.:. . ::: . . .:::. XP_006 MYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGW 140 150 160 170 180 190 140 150 160 170 180 190 pF1KB9 TGDIYSNSNLKNKNDLFE--YKFATGQ-WTEWKIEGRLPVARSAHGATVYSDKLWIFAGY : : :.. . .:. . .. .. : . . . : ..:.. : .::. .:.: XP_006 TRP--SPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGS 200 210 220 230 240 250 200 210 220 230 240 250 pF1KB9 DGNARL-NDMWTIGLQDRELTCWEEVAQSGEIP-PSCCNFPVAVCRDKMFVFSGQSGAKI :. .. ::.:.. : : : . :: : : . ... .....: .: XP_006 LGSRQMSNDVWVL---DLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGG--- 260 270 280 290 300 260 270 280 290 300 pF1KB9 TNNLFQ----FEFKDKTWTRIP--TEHLLRGSPP---PPQRRYGHTMVAFDRHLYVFGGA : ::. ..... :. : .:. .:.: : : :. .:.:.. XP_006 PNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPL 310 320 330 340 350 360 310 320 330 340 350 360 pF1KB9 ADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKKSR XP_006 SPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSR 370 380 390 400 410 420 >>XP_016869669 (OMIM: 605962) PREDICTED: rab9 effector p (267 aa) initn: 324 init1: 171 opt: 245 Z-score: 248.2 bits: 55.3 E(85289): 4.3e-07 Smith-Waterman score: 245; 25.7% identity (55.7% similar) in 183 aa overlap (59-236:28-202) 30 40 50 60 70 80 pF1KB9 DFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVV--AYKDAIYVFGGD :: . :: : : : . ... :: XP_016 MKQLPVLEPGDKPRKATWYTLTVPGDSPCAR-VGHSCSYLPPVGNAKRGKVFIVGGA 10 20 30 40 50 90 100 110 120 130 140 pF1KB9 NGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNL : . ..:. .:. .: . : :.::.::. : :. :...:. :: .:: . . XP_016 NPNRSFSDVHTMDLDTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYD--- 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB9 KNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIG :: .. .: . . : :.. .::.:.... ...::.:. . :. :. XP_016 ----DLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYH 120 130 140 150 160 210 220 230 240 250 260 pF1KB9 LQDRELTC--WEEVAQSGEIPPSCCNFPVAV-CRDKMFVFSGQSGAKITNNLFQFEFKDK .... : .. . :.. : : .: : : XP_016 TEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMS 170 180 190 200 210 220 270 280 290 300 310 320 pF1KB9 TWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEV XP_016 HSGDSHEESQTATLLCLVFGGMNTEGEIYDDCIVTVVD 230 240 250 260 >>XP_016869671 (OMIM: 605962) PREDICTED: rab9 effector p (267 aa) initn: 324 init1: 171 opt: 245 Z-score: 248.2 bits: 55.3 E(85289): 4.3e-07 Smith-Waterman score: 245; 25.7% identity (55.7% similar) in 183 aa overlap (59-236:28-202) 30 40 50 60 70 80 pF1KB9 DFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVV--AYKDAIYVFGGD :: . :: : : : . ... :: XP_016 MKQLPVLEPGDKPRKATWYTLTVPGDSPCAR-VGHSCSYLPPVGNAKRGKVFIVGGA 10 20 30 40 50 90 100 110 120 130 140 pF1KB9 NGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNL : . ..:. .:. .: . : :.::.::. : :. :...:. :: .:: . . XP_016 NPNRSFSDVHTMDLDTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYD--- 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB9 KNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIG :: .. .: . . : :.. .::.:.... ...::.:. . :. :. XP_016 ----DLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYH 120 130 140 150 160 210 220 230 240 250 260 pF1KB9 LQDRELTC--WEEVAQSGEIPPSCCNFPVAV-CRDKMFVFSGQSGAKITNNLFQFEFKDK .... : .. . :.. : : .: : : XP_016 TEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMS 170 180 190 200 210 220 270 280 290 300 310 320 pF1KB9 TWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEV XP_016 HSGDSHEESQTATLLCLVFGGMNTEGEIYDDCIVTVVD 230 240 250 260 >>XP_016869670 (OMIM: 605962) PREDICTED: rab9 effector p (267 aa) initn: 324 init1: 171 opt: 245 Z-score: 248.2 bits: 55.3 E(85289): 4.3e-07 Smith-Waterman score: 245; 25.7% identity (55.7% similar) in 183 aa overlap (59-236:28-202) 30 40 50 60 70 80 pF1KB9 DFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVV--AYKDAIYVFGGD :: . :: : : : . ... :: XP_016 MKQLPVLEPGDKPRKATWYTLTVPGDSPCAR-VGHSCSYLPPVGNAKRGKVFIVGGA 10 20 30 40 50 90 100 110 120 130 140 pF1KB9 NGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNL : . ..:. .:. .: . : :.::.::. : :. :...:. :: .:: . . XP_016 NPNRSFSDVHTMDLDTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYD--- 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB9 KNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIG :: .. .: . . : :.. .::.:.... ...::.:. . :. :. XP_016 ----DLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYH 120 130 140 150 160 210 220 230 240 250 260 pF1KB9 LQDRELTC--WEEVAQSGEIPPSCCNFPVAV-CRDKMFVFSGQSGAKITNNLFQFEFKDK .... : .. . :.. : : .: : : XP_016 TEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMS 170 180 190 200 210 220 270 280 290 300 310 320 pF1KB9 TWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEV XP_016 HSGDSHEESQTATLLCLVFGGMNTEGEIYDDCIVTVVD 230 240 250 260 >>XP_005251701 (OMIM: 605962) PREDICTED: rab9 effector p (275 aa) initn: 324 init1: 171 opt: 245 Z-score: 248.1 bits: 55.3 E(85289): 4.4e-07 Smith-Waterman score: 245; 25.7% identity (55.7% similar) in 183 aa overlap (59-236:36-210) 30 40 50 60 70 80 pF1KB9 DFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVV--AYKDAIYVFGGD :: . :: : : : . ... :: XP_005 EDTMKQLPVLEPGDKPRKATWYTLTVPGDSPCAR-VGHSCSYLPPVGNAKRGKVFIVGGA 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB9 NGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNL : . ..:. .:. .: . : :.::.::. : :. :...:. :: .:: . . XP_005 NPNRSFSDVHTMDLDTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYD--- 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB9 KNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIG :: .. .: . . : :.. .::.:.... ...::.:. . :. :. XP_005 ----DLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYH 130 140 150 160 170 210 220 230 240 250 260 pF1KB9 LQDRELTC--WEEVAQSGEIPPSCCNFPVAV-CRDKMFVFSGQSGAKITNNLFQFEFKDK .... : .. . :.. : : .: : : XP_005 TEEQHWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKVMS 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB9 TWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEV XP_005 HSGDSHEESQTATLLCLVFGGMNTEGEIYDDCIVTVVD 240 250 260 270 >>XP_016869667 (OMIM: 605962) PREDICTED: rab9 effector p (318 aa) initn: 318 init1: 165 opt: 240 Z-score: 242.4 bits: 54.5 E(85289): 9.2e-07 Smith-Waterman score: 248; 24.2% identity (52.5% similar) in 236 aa overlap (59-289:28-244) 30 40 50 60 70 80 pF1KB9 DFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVV--AYKDAIYVFGGD :: . :: : : : . ... :: XP_016 MKQLPVLEPGDKPRKATWYTLTVPGDSPCAR-VGHSCSYLPPVGNAKRGKVFIVGGA 10 20 30 40 50 90 100 110 120 130 140 pF1KB9 NGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSS---MFVFGGYTGDIYSN : . ..:. .:. .: : :::.:.. . . . ..:::: .: XP_016 NPNRSFSDVHTMDLGKHQWDLDTCKGL--LPRYEHASFIPSCTPDRIWVFGG------AN 60 70 80 90 100 150 160 170 180 190 200 pF1KB9 SNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMW .. :.: : . : :.. . : : : .: .. . ::.: .: :. .:. XP_016 QS-GNRNCLQVLNPDTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLH 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB9 TIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDK : ..: . :... .: : .: ... ....:.:.. : ....:.. ... XP_016 CIDISDMK---WQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQ 170 180 190 200 210 220 270 280 290 300 310 320 pF1KB9 TWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEV :: . . :: :: : :.: XP_016 HWTLLKFDTLL----PPG--RLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKV 230 240 250 260 270 >>XP_005251699 (OMIM: 605962) PREDICTED: rab9 effector p (326 aa) initn: 318 init1: 165 opt: 240 Z-score: 242.2 bits: 54.5 E(85289): 9.4e-07 Smith-Waterman score: 248; 24.2% identity (52.5% similar) in 236 aa overlap (59-289:36-252) 30 40 50 60 70 80 pF1KB9 DFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVV--AYKDAIYVFGGD :: . :: : : : . ... :: XP_005 EDTMKQLPVLEPGDKPRKATWYTLTVPGDSPCAR-VGHSCSYLPPVGNAKRGKVFIVGGA 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB9 NGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSS---MFVFGGYTGDIYSN : . ..:. .:. .: : :::.:.. . . . ..:::: .: XP_005 NPNRSFSDVHTMDLGKHQWDLDTCKGL--LPRYEHASFIPSCTPDRIWVFGG------AN 70 80 90 100 110 150 160 170 180 190 200 pF1KB9 SNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMW .. :.: : . : :.. . : : : .: .. . ::.: .: :. .:. XP_005 QS-GNRNCLQVLNPDTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLH 120 130 140 150 160 170 210 220 230 240 250 260 pF1KB9 TIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDK : ..: . :... .: : .: ... ....:.:.. : ....:.. ... XP_005 CIDISDMK---WQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQ 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB9 TWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEV :: . . :: :: : :.: XP_005 HWTLLKFDTLL----PPG--RLDHSMCIIPWPVTCASEKEDSNSLTLNHEAEKEDSADKV 240 250 260 270 280 840 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 23:57:45 2016 done: Thu Nov 3 23:57:46 2016 Total Scan time: 13.420 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]