FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9519, 373 aa 1>>>pF1KB9519 373 - 373 aa - 373 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6318+/-0.000407; mu= 20.5112+/- 0.025 mean_var=110.2677+/-29.438, 0's: 0 Z-trim(112.6): 448 B-trim: 1256 in 1/48 Lambda= 0.122138 statistics sampled from 20969 (21623) to 20969 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.254), width: 16 Scan time: 7.830 The best scores are: opt bits E(85289) NP_061842 (OMIM: 300253) probable G-protein couple ( 373) 2570 464.3 2e-130 XP_011529100 (OMIM: 300253) PREDICTED: probable G- ( 373) 2570 464.3 2e-130 XP_016867841 (OMIM: 605188) PREDICTED: probable G- ( 370) 1687 308.7 1.4e-83 NP_001139739 (OMIM: 605188) probable G-protein cou ( 370) 1687 308.7 1.4e-83 XP_005250508 (OMIM: 605188) PREDICTED: probable G- ( 370) 1687 308.7 1.4e-83 NP_061843 (OMIM: 605188) probable G-protein couple ( 370) 1687 308.7 1.4e-83 NP_001139737 (OMIM: 605188) probable G-protein cou ( 370) 1687 308.7 1.4e-83 NP_001139738 (OMIM: 605188) probable G-protein cou ( 370) 1687 308.7 1.4e-83 NP_061844 (OMIM: 605187) probable G-protein couple ( 375) 1379 254.4 3e-67 XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456) 319 67.8 5.7e-11 NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481) 319 67.8 5.9e-11 NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367) 316 67.1 7.3e-11 NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439) 308 65.8 2.1e-10 NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 304 65.0 3.1e-10 XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 304 65.0 3.1e-10 NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 304 65.0 3.1e-10 XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 304 65.0 3.1e-10 NP_000857 (OMIM: 182134) 5-hydroxytryptamine recep ( 366) 304 65.0 3.1e-10 NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 304 65.0 3.1e-10 NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 303 65.0 4e-10 NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 303 65.0 4e-10 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 302 64.7 4.1e-10 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 302 64.7 4.2e-10 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 298 64.1 7.6e-10 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 276 60.2 1.1e-08 NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 272 59.5 1.8e-08 NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 265 58.1 3.7e-08 XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 265 58.1 3.7e-08 NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 253 56.1 1.7e-07 XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 251 55.7 2e-07 NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 251 55.7 2e-07 NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 251 55.8 2.2e-07 NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 251 55.8 2.3e-07 NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 251 55.8 2.4e-07 NP_000787 (OMIM: 126451,181500,190300) D(3) dopami ( 400) 248 55.2 3.1e-07 NP_001277738 (OMIM: 126451,181500,190300) D(3) dop ( 400) 248 55.2 3.1e-07 XP_016861318 (OMIM: 126451,181500,190300) PREDICTE ( 400) 248 55.2 3.1e-07 NP_001269492 (OMIM: 126451,181500,190300) D(3) dop ( 400) 248 55.2 3.1e-07 NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 248 55.3 3.4e-07 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 243 54.1 4.9e-07 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 243 54.2 5e-07 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 243 54.2 5e-07 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 243 54.2 5.2e-07 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 244 54.5 5.2e-07 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 244 54.5 5.2e-07 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 244 54.6 5.4e-07 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 243 54.3 5.4e-07 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 243 54.3 5.5e-07 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 244 54.6 5.5e-07 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 244 54.6 5.5e-07 >>NP_061842 (OMIM: 300253) probable G-protein coupled re (373 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2462.5 bits: 464.3 E(85289): 2e-130 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 AAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 AAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 PYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGT 310 320 330 340 350 360 370 pF1KB9 GGAPAPREPYCVM ::::::::::::: NP_061 GGAPAPREPYCVM 370 >>XP_011529100 (OMIM: 300253) PREDICTED: probable G-prot (373 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2462.5 bits: 464.3 E(85289): 2e-130 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 AAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 PYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGT 310 320 330 340 350 360 370 pF1KB9 GGAPAPREPYCVM ::::::::::::: XP_011 GGAPAPREPYCVM 370 >>XP_016867841 (OMIM: 605188) PREDICTED: probable G-prot (370 aa) initn: 1698 init1: 1293 opt: 1687 Z-score: 1621.6 bits: 308.7 E(85289): 1.4e-83 Smith-Waterman score: 1687; 62.4% identity (86.9% similar) in 375 aa overlap (1-373:1-370) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF ::: . ... ::: .:..::. ::.:. ::..:: ..:.:..:...::.::::: XP_016 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT ::::: .: .:::.:::::. ::..::.::...:.::..::..:: :::.:::::::::: XP_016 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY ::.::::::::.::.:.::: :::::.::::::::::::.:::::.:::::::: :.:: XP_016 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ :.:::.:::::.::... ::. :: ::..: . .:::::::.: :.:::::::::::.:: XP_016 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 180 190 200 210 220 230 250 260 270 280 290 pF1KB9 AAANWIAGFGRGPMPPTLLGIRQNGHAASRR-LLGMDEVKGEKQLGRMFYAITLLFLLLW :::::.::::::: ::::::::::.....:: :: .:: : ::...:::: .:.::: :: XP_016 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA-PCW .::.::::::::... .:: .:..:::::::::..::.::.. :..:..:. : : XP_016 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCR 300 310 320 330 340 350 360 370 pF1KB9 GTGGAPAPREPYCVM . :::::::. XP_016 KSR---LPREPYCVI 360 370 >>NP_001139739 (OMIM: 605188) probable G-protein coupled (370 aa) initn: 1698 init1: 1293 opt: 1687 Z-score: 1621.6 bits: 308.7 E(85289): 1.4e-83 Smith-Waterman score: 1687; 62.4% identity (86.9% similar) in 375 aa overlap (1-373:1-370) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF ::: . ... ::: .:..::. ::.:. ::..:: ..:.:..:...::.::::: NP_001 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT ::::: .: .:::.:::::. ::..::.::...:.::..::..:: :::.:::::::::: NP_001 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY ::.::::::::.::.:.::: :::::.::::::::::::.:::::.:::::::: :.:: NP_001 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ :.:::.:::::.::... ::. :: ::..: . .:::::::.: :.:::::::::::.:: NP_001 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 180 190 200 210 220 230 250 260 270 280 290 pF1KB9 AAANWIAGFGRGPMPPTLLGIRQNGHAASRR-LLGMDEVKGEKQLGRMFYAITLLFLLLW :::::.::::::: ::::::::::.....:: :: .:: : ::...:::: .:.::: :: NP_001 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA-PCW .::.::::::::... .:: .:..:::::::::..::.::.. :..:..:. : : NP_001 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCR 300 310 320 330 340 350 360 370 pF1KB9 GTGGAPAPREPYCVM . :::::::. NP_001 KSR---LPREPYCVI 360 370 >>XP_005250508 (OMIM: 605188) PREDICTED: probable G-prot (370 aa) initn: 1698 init1: 1293 opt: 1687 Z-score: 1621.6 bits: 308.7 E(85289): 1.4e-83 Smith-Waterman score: 1687; 62.4% identity (86.9% similar) in 375 aa overlap (1-373:1-370) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF ::: . ... ::: .:..::. ::.:. ::..:: ..:.:..:...::.::::: XP_005 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT ::::: .: .:::.:::::. ::..::.::...:.::..::..:: :::.:::::::::: XP_005 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY ::.::::::::.::.:.::: :::::.::::::::::::.:::::.:::::::: :.:: XP_005 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ :.:::.:::::.::... ::. :: ::..: . .:::::::.: :.:::::::::::.:: XP_005 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 180 190 200 210 220 230 250 260 270 280 290 pF1KB9 AAANWIAGFGRGPMPPTLLGIRQNGHAASRR-LLGMDEVKGEKQLGRMFYAITLLFLLLW :::::.::::::: ::::::::::.....:: :: .:: : ::...:::: .:.::: :: XP_005 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA-PCW .::.::::::::... .:: .:..:::::::::..::.::.. :..:..:. : : XP_005 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCR 300 310 320 330 340 350 360 370 pF1KB9 GTGGAPAPREPYCVM . :::::::. XP_005 KSR---LPREPYCVI 360 370 >>NP_061843 (OMIM: 605188) probable G-protein coupled re (370 aa) initn: 1698 init1: 1293 opt: 1687 Z-score: 1621.6 bits: 308.7 E(85289): 1.4e-83 Smith-Waterman score: 1687; 62.4% identity (86.9% similar) in 375 aa overlap (1-373:1-370) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF ::: . ... ::: .:..::. ::.:. ::..:: ..:.:..:...::.::::: NP_061 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT ::::: .: .:::.:::::. ::..::.::...:.::..::..:: :::.:::::::::: NP_061 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY ::.::::::::.::.:.::: :::::.::::::::::::.:::::.:::::::: :.:: NP_061 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ :.:::.:::::.::... ::. :: ::..: . .:::::::.: :.:::::::::::.:: NP_061 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 180 190 200 210 220 230 250 260 270 280 290 pF1KB9 AAANWIAGFGRGPMPPTLLGIRQNGHAASRR-LLGMDEVKGEKQLGRMFYAITLLFLLLW :::::.::::::: ::::::::::.....:: :: .:: : ::...:::: .:.::: :: NP_061 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA-PCW .::.::::::::... .:: .:..:::::::::..::.::.. :..:..:. : : NP_061 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCR 300 310 320 330 340 350 360 370 pF1KB9 GTGGAPAPREPYCVM . :::::::. NP_061 KSR---LPREPYCVI 360 370 >>NP_001139737 (OMIM: 605188) probable G-protein coupled (370 aa) initn: 1698 init1: 1293 opt: 1687 Z-score: 1621.6 bits: 308.7 E(85289): 1.4e-83 Smith-Waterman score: 1687; 62.4% identity (86.9% similar) in 375 aa overlap (1-373:1-370) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF ::: . ... ::: .:..::. ::.:. ::..:: ..:.:..:...::.::::: NP_001 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT ::::: .: .:::.:::::. ::..::.::...:.::..::..:: :::.:::::::::: NP_001 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY ::.::::::::.::.:.::: :::::.::::::::::::.:::::.:::::::: :.:: NP_001 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ :.:::.:::::.::... ::. :: ::..: . .:::::::.: :.:::::::::::.:: NP_001 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 180 190 200 210 220 230 250 260 270 280 290 pF1KB9 AAANWIAGFGRGPMPPTLLGIRQNGHAASRR-LLGMDEVKGEKQLGRMFYAITLLFLLLW :::::.::::::: ::::::::::.....:: :: .:: : ::...:::: .:.::: :: NP_001 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA-PCW .::.::::::::... .:: .:..:::::::::..::.::.. :..:..:. : : NP_001 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCR 300 310 320 330 340 350 360 370 pF1KB9 GTGGAPAPREPYCVM . :::::::. NP_001 KSR---LPREPYCVI 360 370 >>NP_001139738 (OMIM: 605188) probable G-protein coupled (370 aa) initn: 1698 init1: 1293 opt: 1687 Z-score: 1621.6 bits: 308.7 E(85289): 1.4e-83 Smith-Waterman score: 1687; 62.4% identity (86.9% similar) in 375 aa overlap (1-373:1-370) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF ::: . ... ::: .:..::. ::.:. ::..:: ..:.:..:...::.::::: NP_001 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT ::::: .: .:::.:::::. ::..::.::...:.::..::..:: :::.:::::::::: NP_001 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY ::.::::::::.::.:.::: :::::.::::::::::::.:::::.:::::::: :.:: NP_001 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ :.:::.:::::.::... ::. :: ::..: . .:::::::.: :.:::::::::::.:: NP_001 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 180 190 200 210 220 230 250 260 270 280 290 pF1KB9 AAANWIAGFGRGPMPPTLLGIRQNGHAASRR-LLGMDEVKGEKQLGRMFYAITLLFLLLW :::::.::::::: ::::::::::.....:: :: .:: : ::...:::: .:.::: :: NP_001 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA-PCW .::.::::::::... .:: .:..:::::::::..::.::.. :..:..:. : : NP_001 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCR 300 310 320 330 340 350 360 370 pF1KB9 GTGGAPAPREPYCVM . :::::::. NP_001 KSR---LPREPYCVI 360 370 >>NP_061844 (OMIM: 605187) probable G-protein coupled re (375 aa) initn: 970 init1: 398 opt: 1379 Z-score: 1328.3 bits: 254.4 E(85289): 3e-67 Smith-Waterman score: 1379; 54.7% identity (83.4% similar) in 362 aa overlap (1-357:1-355) 10 20 30 40 50 60 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF :::.. :: .:. . .:. .::. :.:..:::::::....::...::.::.::::. NP_061 MANAS-EP---GGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYL 10 20 30 40 50 70 80 90 100 110 pF1KB9 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFS---ALSCKIVAFMAVLFCFHAAFMLFCI :::::::::.:. .:.: :. ..:.... . . ::.::..::.:.::::::::.:. . NP_061 LLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 SVTRYMAIAHHRFYAKRMTLWTCAAV-ICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF .::::.:::::::::.:.. : :::. .: ::.:..: :::::.: : :. : . NP_061 GVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDD---EDAPCAL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 EHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPG :.: : .:::.:.:::...::: :: .::.: . .:::.:...:::.:..::::::: NP_061 EQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 ATGQAAANWIAGFGRGPMPPTLLGIRQNGHA-ASRRLLGMDEVKGEKQLGRMFYAITLLF ::::::::: ::::::: ::.:.::: : . ..:::: ..: : ::.: .::::.:::: NP_061 ATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 LLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA ::::.::.:: : ::.:. :::. ::...::..::::..::.::::.:..:. :.:.. NP_061 LLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQF 300 310 320 330 340 350 360 370 pF1KB9 PCWGTGGAPAPREPYCVM :: NP_061 PCCQSPRTTQATHPCDLKGIGL 360 370 >>XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytrypta (456 aa) initn: 238 init1: 179 opt: 319 Z-score: 317.9 bits: 67.8 E(85289): 5.7e-11 Smith-Waterman score: 326; 23.4% identity (54.3% similar) in 368 aa overlap (8-357:15-372) 10 20 30 40 50 pF1KB9 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERAL :::.. . . . . .:. ... ...::... : : :. : XP_006 MLSKITTKPETESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 HKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFM . : :::..: .:: . . .:..: .. . : . . : :. ::: :..: XP_006 QYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFST-ASIM 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 LFC-ISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFP-PVFDVGTYKFIREE .: ::: ::.:: . . . : : ..: .:...:.: :. . : .. XP_006 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNN 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 DQCIFEHRYFKANDTLG----FMLMLAVLMAA----THAVYGKLLLFEYRHRKMKPVQMV :.. .. : .: :. ::..... ::. : : : :: : . XP_006 ITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLV-----KNKPPQRL 180 190 200 210 220 230 230 240 250 260 270 pF1KB9 PAISQNWTFH---GPGATGQAAANWIAGFGRGPMPPT--LLGIRQNGHAASRRLLGM-DE .. . .:. : .. . .: .. .: . .:... ... . . .: XP_006 TWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB9 VKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKAC--AVPHRYLATAVWMSFAQAAV .. : :: .:. ::::.: :.... :. .: .. . : ::.......: XP_006 QRASKVLGIVFF----LFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGV 300 310 320 330 340 350 340 350 360 370 pF1KB9 NPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM ::.: :.:: .. . . : XP_006 NPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRN 360 370 380 390 400 410 373 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 00:12:13 2016 done: Fri Nov 4 00:12:14 2016 Total Scan time: 7.830 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]