FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9540, 351 aa 1>>>pF1KB9540 351 - 351 aa - 351 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0129+/-0.00033; mu= 6.7718+/- 0.021 mean_var=180.4645+/-35.909, 0's: 0 Z-trim(121.5): 14 B-trim: 1958 in 1/55 Lambda= 0.095473 statistics sampled from 38119 (38134) to 38119 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.783), E-opt: 0.2 (0.447), width: 16 Scan time: 9.880 The best scores are: opt bits E(85289) NP_001666 (OMIM: 604064) cyclic AMP-dependent tran ( 351) 2337 333.4 4.6e-91 XP_016884296 (OMIM: 604064) PREDICTED: cyclic AMP- ( 351) 2337 333.4 4.6e-91 NP_877962 (OMIM: 604064) cyclic AMP-dependent tran ( 351) 2337 333.4 4.6e-91 NP_036200 (OMIM: 606398) cyclic AMP-dependent tran ( 282) 307 53.7 5.7e-07 NP_001180575 (OMIM: 606398) cyclic AMP-dependent t ( 282) 307 53.7 5.7e-07 XP_011524931 (OMIM: 606398) PREDICTED: cyclic AMP- ( 282) 307 53.7 5.7e-07 NP_001277675 (OMIM: 606398) cyclic AMP-dependent t ( 282) 307 53.7 5.7e-07 >>NP_001666 (OMIM: 604064) cyclic AMP-dependent transcri (351 aa) initn: 2337 init1: 2337 opt: 2337 Z-score: 1755.9 bits: 333.4 E(85289): 4.6e-91 Smith-Waterman score: 2337; 100.0% identity (100.0% similar) in 351 aa overlap (1-351:1-351) 10 20 30 40 50 60 pF1KB9 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP 310 320 330 340 350 >>XP_016884296 (OMIM: 604064) PREDICTED: cyclic AMP-depe (351 aa) initn: 2337 init1: 2337 opt: 2337 Z-score: 1755.9 bits: 333.4 E(85289): 4.6e-91 Smith-Waterman score: 2337; 100.0% identity (100.0% similar) in 351 aa overlap (1-351:1-351) 10 20 30 40 50 60 pF1KB9 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP 310 320 330 340 350 >>NP_877962 (OMIM: 604064) cyclic AMP-dependent transcri (351 aa) initn: 2337 init1: 2337 opt: 2337 Z-score: 1755.9 bits: 333.4 E(85289): 4.6e-91 Smith-Waterman score: 2337; 100.0% identity (100.0% similar) in 351 aa overlap (1-351:1-351) 10 20 30 40 50 60 pF1KB9 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP 310 320 330 340 350 >>NP_036200 (OMIM: 606398) cyclic AMP-dependent transcri (282 aa) initn: 334 init1: 273 opt: 307 Z-score: 246.1 bits: 53.7 E(85289): 5.7e-07 Smith-Waterman score: 336; 33.2% identity (51.5% similar) in 340 aa overlap (12-348:3-278) 10 20 30 40 50 60 pF1KB9 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE :.. : .:.. : : .:: : :: .. : .. .. .:. : NP_036 MSLLATLGLELDRALLPAS-GLGWLVDYGKLPP--APAPLAPYEVLGGALE 10 20 30 40 70 80 90 100 110 120 pF1KB9 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC :: .. :.:: ::: :..: . ::: .. .: : . : NP_036 ----GGLPVGGEPLAGDGFS--DWMTERVD-----FTALLPLE--PPLPPGTLPQPSPTP 50 60 70 80 90 130 140 150 160 170 pF1KB9 -DL--FAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHS :: .: :... .: . :: .: . : ::: .:.. : : : NP_036 PDLEAMASLLKKELEQMEDFFLDAPPLPPP--SPPPLPP----PPLPPAPSLPLSLP--S 100 110 120 130 140 180 190 200 210 220 230 pF1KB9 FSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPS :.: .: : : : .: .... : : : : ::. : NP_036 FDLPQPPVLDTL------DLLAIY-----CRNEA---GQEEVG--MPP---LPPPQQPPP 150 160 170 180 240 250 260 270 280 290 pF1KB9 TRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQ :: :.: .: :: : : ..: :.: :: .:::.:: :::: NP_036 P--SP----PQP------SRLAPYPHP------ATTRG---DRKQKKRDQNKSAALRYRQ 190 200 210 220 300 310 320 330 340 350 pF1KB9 KKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP .:::: ::: :::. :: .:. :::::.:. .::::.:::. :: :::... NP_036 RKRAEGEALEGECQGLEARNRELKERAESVEREIQYVKDLLIEVYKARSQRTRSC 230 240 250 260 270 280 >>NP_001180575 (OMIM: 606398) cyclic AMP-dependent trans (282 aa) initn: 334 init1: 273 opt: 307 Z-score: 246.1 bits: 53.7 E(85289): 5.7e-07 Smith-Waterman score: 336; 33.2% identity (51.5% similar) in 340 aa overlap (12-348:3-278) 10 20 30 40 50 60 pF1KB9 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE :.. : .:.. : : .:: : :: .. : .. .. .:. : NP_001 MSLLATLGLELDRALLPAS-GLGWLVDYGKLPP--APAPLAPYEVLGGALE 10 20 30 40 70 80 90 100 110 120 pF1KB9 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC :: .. :.:: ::: :..: . ::: .. .: : . : NP_001 ----GGLPVGGEPLAGDGFS--DWMTERVD-----FTALLPLE--PPLPPGTLPQPSPTP 50 60 70 80 90 130 140 150 160 170 pF1KB9 -DL--FAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHS :: .: :... .: . :: .: . : ::: .:.. : : : NP_001 PDLEAMASLLKKELEQMEDFFLDAPPLPPP--SPPPLPP----PPLPPAPSLPLSLP--S 100 110 120 130 140 180 190 200 210 220 230 pF1KB9 FSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPS :.: .: : : : .: .... : : : : ::. : NP_001 FDLPQPPVLDTL------DLLAIY-----CRNEA---GQEEVG--MPP---LPPPQQPPP 150 160 170 180 240 250 260 270 280 290 pF1KB9 TRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQ :: :.: .: :: : : ..: :.: :: .:::.:: :::: NP_001 P--SP----PQP------SRLAPYPHP------ATTRG---DRKQKKRDQNKSAALRYRQ 190 200 210 220 300 310 320 330 340 350 pF1KB9 KKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP .:::: ::: :::. :: .:. :::::.:. .::::.:::. :: :::... NP_001 RKRAEGEALEGECQGLEARNRELKERAESVEREIQYVKDLLIEVYKARSQRTRSC 230 240 250 260 270 280 >>XP_011524931 (OMIM: 606398) PREDICTED: cyclic AMP-depe (282 aa) initn: 334 init1: 273 opt: 307 Z-score: 246.1 bits: 53.7 E(85289): 5.7e-07 Smith-Waterman score: 336; 33.2% identity (51.5% similar) in 340 aa overlap (12-348:3-278) 10 20 30 40 50 60 pF1KB9 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE :.. : .:.. : : .:: : :: .. : .. .. .:. : XP_011 MSLLATLGLELDRALLPAS-GLGWLVDYGKLPP--APAPLAPYEVLGGALE 10 20 30 40 70 80 90 100 110 120 pF1KB9 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC :: .. :.:: ::: :..: . ::: .. .: : . : XP_011 ----GGLPVGGEPLAGDGFS--DWMTERVD-----FTALLPLE--PPLPPGTLPQPSPTP 50 60 70 80 90 130 140 150 160 170 pF1KB9 -DL--FAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHS :: .: :... .: . :: .: . : ::: .:.. : : : XP_011 PDLEAMASLLKKELEQMEDFFLDAPPLPPP--SPPPLPP----PPLPPAPSLPLSLP--S 100 110 120 130 140 180 190 200 210 220 230 pF1KB9 FSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPS :.: .: : : : .: .... : : : : ::. : XP_011 FDLPQPPVLDTL------DLLAIY-----CRNEA---GQEEVG--MPP---LPPPQQPPP 150 160 170 180 240 250 260 270 280 290 pF1KB9 TRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQ :: :.: .: :: : : ..: :.: :: .:::.:: :::: XP_011 P--SP----PQP------SRLAPYPHP------ATTRG---DRKQKKRDQNKSAALRYRQ 190 200 210 220 300 310 320 330 340 350 pF1KB9 KKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP .:::: ::: :::. :: .:. :::::.:. .::::.:::. :: :::... XP_011 RKRAEGEALEGECQGLEARNRELKERAESVEREIQYVKDLLIEVYKARSQRTRSC 230 240 250 260 270 280 >>NP_001277675 (OMIM: 606398) cyclic AMP-dependent trans (282 aa) initn: 334 init1: 273 opt: 307 Z-score: 246.1 bits: 53.7 E(85289): 5.7e-07 Smith-Waterman score: 336; 33.2% identity (51.5% similar) in 340 aa overlap (12-348:3-278) 10 20 30 40 50 60 pF1KB9 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE :.. : .:.. : : .:: : :: .. : .. .. .:. : NP_001 MSLLATLGLELDRALLPAS-GLGWLVDYGKLPP--APAPLAPYEVLGGALE 10 20 30 40 70 80 90 100 110 120 pF1KB9 WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC :: .. :.:: ::: :..: . ::: .. .: : . : NP_001 ----GGLPVGGEPLAGDGFS--DWMTERVD-----FTALLPLE--PPLPPGTLPQPSPTP 50 60 70 80 90 130 140 150 160 170 pF1KB9 -DL--FAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHS :: .: :... .: . :: .: . : ::: .:.. : : : NP_001 PDLEAMASLLKKELEQMEDFFLDAPPLPPP--SPPPLPP----PPLPPAPSLPLSLP--S 100 110 120 130 140 180 190 200 210 220 230 pF1KB9 FSLELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPS :.: .: : : : .: .... : : : : ::. : NP_001 FDLPQPPVLDTL------DLLAIY-----CRNEA---GQEEVG--MPP---LPPPQQPPP 150 160 170 180 240 250 260 270 280 290 pF1KB9 TRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQ :: :.: .: :: : : ..: :.: :: .:::.:: :::: NP_001 P--SP----PQP------SRLAPYPHP------ATTRG---DRKQKKRDQNKSAALRYRQ 190 200 210 220 300 310 320 330 340 350 pF1KB9 KKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP .:::: ::: :::. :: .:. :::::.:. .::::.:::. :: :::... NP_001 RKRAEGEALEGECQGLEARNRELKERAESVEREIQYVKDLLIEVYKARSQRTRSC 230 240 250 260 270 280 351 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:03:52 2016 done: Sat Nov 5 02:03:53 2016 Total Scan time: 9.880 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]