FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9552, 466 aa 1>>>pF1KB9552 466 - 466 aa - 466 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5501+/-0.000312; mu= -0.6491+/- 0.020 mean_var=232.4800+/-47.078, 0's: 0 Z-trim(123.7): 144 B-trim: 43 in 1/60 Lambda= 0.084117 statistics sampled from 43717 (43898) to 43717 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.803), E-opt: 0.2 (0.515), width: 16 Scan time: 10.400 The best scores are: opt bits E(85289) NP_008872 (OMIM: 602229,609136,611584,613266) tran ( 466) 3261 408.2 2.4e-113 NP_000337 (OMIM: 114290,608160,616425) transcripti ( 509) 1350 176.3 1.7e-43 NP_055402 (OMIM: 605923) transcription factor SOX- ( 446) 869 117.9 5.6e-26 NP_071899 (OMIM: 610928,613674) transcription fact ( 414) 436 65.4 3.5e-10 NP_008874 (OMIM: 601947) transcription factor SOX- ( 315) 422 63.6 9.1e-10 NP_060889 (OMIM: 137940,601618,607823) transcripti ( 384) 414 62.7 2.1e-09 NP_003097 (OMIM: 184429,189960,206900) transcripti ( 317) 412 62.4 2.1e-09 NP_009015 (OMIM: 604974) transcription factor SOX- ( 276) 410 62.1 2.2e-09 NP_008873 (OMIM: 601297) protein SOX-15 [Homo sapi ( 233) 408 61.8 2.3e-09 NP_005625 (OMIM: 300123,312000,313430) transcripti ( 446) 407 61.9 4.2e-09 NP_113627 (OMIM: 612202) transcription factor SOX- ( 388) 405 61.6 4.5e-09 NP_003098 (OMIM: 184430) transcription factor SOX- ( 474) 405 61.6 5.3e-09 NP_005977 (OMIM: 602148) transcription factor SOX- ( 391) 400 61.0 6.9e-09 NP_004180 (OMIM: 604747) transcription factor SOX- ( 240) 391 59.7 9.9e-09 NP_003099 (OMIM: 600898,615866) transcription fact ( 441) 381 58.7 3.7e-08 NP_821078 (OMIM: 604975,616803) transcription fact ( 377) 343 54.0 8.1e-07 XP_011519144 (OMIM: 604975,616803) PREDICTED: tran ( 415) 343 54.1 8.7e-07 NP_001248343 (OMIM: 604975,616803) transcription f ( 642) 343 54.2 1.2e-06 XP_016875389 (OMIM: 604975,616803) PREDICTED: tran ( 715) 343 54.2 1.4e-06 XP_016875387 (OMIM: 604975,616803) PREDICTED: tran ( 715) 343 54.2 1.4e-06 XP_016875390 (OMIM: 604975,616803) PREDICTED: tran ( 715) 343 54.2 1.4e-06 XP_016875388 (OMIM: 604975,616803) PREDICTED: tran ( 715) 343 54.2 1.4e-06 XP_016875386 (OMIM: 604975,616803) PREDICTED: tran ( 716) 343 54.2 1.4e-06 NP_001317714 (OMIM: 604975,616803) transcription f ( 728) 343 54.2 1.4e-06 XP_011519140 (OMIM: 604975,616803) PREDICTED: tran ( 729) 343 54.2 1.4e-06 XP_016875385 (OMIM: 604975,616803) PREDICTED: tran ( 750) 343 54.2 1.4e-06 NP_694534 (OMIM: 604975,616803) transcription fact ( 750) 343 54.2 1.4e-06 XP_016875380 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 XP_016875381 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 XP_016875383 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 XP_011519137 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 XP_016875379 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 XP_011519139 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 XP_016875382 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 XP_011519136 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 XP_016875384 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 54.2 1.4e-06 NP_001248344 (OMIM: 604975,616803) transcription f ( 753) 343 54.2 1.4e-06 XP_011519135 (OMIM: 604975,616803) PREDICTED: tran ( 754) 343 54.2 1.4e-06 NP_008871 (OMIM: 604975,616803) transcription fact ( 763) 343 54.2 1.4e-06 XP_011519134 (OMIM: 604975,616803) PREDICTED: tran ( 764) 343 54.2 1.4e-06 XP_016875378 (OMIM: 604975,616803) PREDICTED: tran ( 792) 343 54.3 1.5e-06 XP_016875377 (OMIM: 604975,616803) PREDICTED: tran ( 793) 343 54.3 1.5e-06 NP_001139283 (OMIM: 607257) transcription factor S ( 801) 338 53.6 2.3e-06 NP_059978 (OMIM: 607257) transcription factor SOX- ( 804) 338 53.6 2.3e-06 NP_001139291 (OMIM: 607257) transcription factor S ( 841) 338 53.7 2.3e-06 NP_201583 (OMIM: 607257) transcription factor SOX- ( 808) 323 51.8 8e-06 NP_003131 (OMIM: 400044,400045,480000) sex-determi ( 204) 309 49.7 8.6e-06 XP_005245680 (OMIM: 604748) PREDICTED: transcripti ( 621) 314 50.7 1.4e-05 NP_005677 (OMIM: 604748) transcription factor SOX- ( 622) 314 50.7 1.4e-05 XP_011532722 (OMIM: 606698) PREDICTED: transcripti ( 448) 293 48.0 6.2e-05 >>NP_008872 (OMIM: 602229,609136,611584,613266) transcri (466 aa) initn: 3261 init1: 3261 opt: 3261 Z-score: 2155.9 bits: 408.2 E(85289): 2.4e-113 Smith-Waterman score: 3261; 100.0% identity (100.0% similar) in 466 aa overlap (1-466:1-466) 10 20 30 40 50 60 pF1KB9 MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRASPGPGELGKVKKEQQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGGGSGLRASPGPGELGKVKKEQQD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 GEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 KLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 KLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 GKAAQGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGPPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 GKAAQGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGPPT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PPTTPKTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 PPTTPKTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LPPNGHPGHVSSYSAAGYGLGSALAVASGHSAWISKPPGVALPTVSPPGVDAKAQVKTET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 LPPNGHPGHVSSYSAAGYGLGSALAVASGHSAWISKPPGVALPTVSPPGVDAKAQVKTET 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 AGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHSGQASG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 AGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHSGQASG 370 380 390 400 410 420 430 440 450 460 pF1KB9 LYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP :::::::::::::::::::::::::::::::::::::::::::::: NP_008 LYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP 430 440 450 460 >>NP_000337 (OMIM: 114290,608160,616425) transcription f (509 aa) initn: 1439 init1: 805 opt: 1350 Z-score: 902.0 bits: 176.3 E(85289): 1.7e-43 Smith-Waterman score: 1624; 54.0% identity (72.2% similar) in 493 aa overlap (18-456:13-499) 10 20 30 40 50 pF1KB9 MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLGPDGGGG----GSGLRASPGPGELGKVKK :. . :: . .:... :..:. ::: . . . : NP_000 MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPK 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 EQQD--GEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVW . : :...:::::::::::::::.:::::::::::::::.::.:::::::::::::: NP_000 GEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 AQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQ ::::::::::::::::::::::::::::::::::.::::.:::::::.:::::::::::: NP_000 AQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 PRRRKNGKAAQGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSD-GNPEHPSG :::::. : .:.::: :: . . .: .:. . : : . : ::. .: . :: NP_000 PRRRKSVKNGQAEAE----EATEQTHISPNAIFKALQADSPHSSSG--MSEVHSPGEHSG 180 190 200 210 220 240 250 260 270 280 290 pF1KB9 QSHGPPTPPTTPKTELQSGKADPKRDGRSMGEGGK-PHIDFGNVDIGEISHEVMSNMETF ::.:::::::::::..: :::: ::.:: . :::. : ::: .:::::.: .:.::.::: NP_000 QSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETF 230 240 250 260 270 280 300 310 320 330 340 pF1KB9 DVAELDQYLPPNGHPG----HVSSYSAAGYGLGSALAV-ASGHSAWISK----PPGVALP :: :.::::::::::: : . ...::..:. :. ::. .:.:: :: : NP_000 DVNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQP 290 300 310 320 330 340 350 360 370 pF1KB9 TVSPPGVDAKAQVKTE-----TAGPQ---------------------------GPPHYTD .::. .: : .. .: :: .: ::.. NP_000 PQAPPAPQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSE 350 360 370 380 390 400 380 390 400 410 420 pF1KB9 QP--STSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHS-GQASGLYSAFSYM : : .::::. ..::::. ..: :.: :.::.::: :. ::.:. ::..::::.:.:: NP_000 QQQHSPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYM 410 420 430 440 450 460 430 440 450 460 pF1KB9 GPSQRPLYTAISDPS--PSGPQSHSPTHWEQPVYTTLSRP .:.:::.:: :.: : :: ::.::: ::: NP_000 NPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP 470 480 490 500 >>NP_055402 (OMIM: 605923) transcription factor SOX-8 [H (446 aa) initn: 1010 init1: 579 opt: 869 Z-score: 587.3 bits: 117.9 E(85289): 5.6e-26 Smith-Waterman score: 1281; 50.2% identity (68.1% similar) in 474 aa overlap (10-466:2-446) 10 20 30 40 50 pF1KB9 MAEEQDLSEVELSPVGSEEPRCLSPGSAPSLG--PDGGGGGSGLRA-SPGPGELG-KVKK ...: . :. : : :.: :.. :. . . : : : :. : : NP_055 MLDMSEARSQPP-CSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGG 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 EQQD-GEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNG--ASKSKPHVKRPMNAFMV . : .:: :..::.:::.::::::.::::.::::::: .: : :.::::::::::::: NP_055 ARGDPAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 WAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKY ::::::::::::::::::::::::::::::::.::.::::.:::::::.::::::::::: NP_055 WAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 QPRRRKNGKAAQGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSG ::::::..:: :... .: :: : . : ::. . : :. :. : .: NP_055 QPRRRKSAKA--GHSDSDSG-AELGPHPGGGAVYKA------EAGLGDGHHHGD--H-TG 180 190 200 210 240 250 260 270 280 290 pF1KB9 QSHGPPTPPTTPKTELQSGKADP--KRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMET :.:::::::::::::::.. : : : .:: ..:. .:::.::::.:.: :::..:.. NP_055 QTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDA 220 230 240 250 260 270 300 310 320 330 340 pF1KB9 FDVAELDQYLPPNGHPGHVSSYSAAGYGLGSALAVASGHSAWISK--PPGVALPTVSPPG ::: :.::::: .: :. : . :.: :.. .: : : . : :: . : NP_055 FDVHEFDQYLPLGG-PAP----PEPGQAYGGAYFHAGASPVWAHKSAPSASASPTETGP- 280 290 300 310 320 330 350 360 370 380 390 400 pF1KB9 VDAKAQVKTETAGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQF-----DYSD . ..::: :. : :: ::: : : : : .:: :. : ::.: NP_055 --PRPHIKTEQ--PS-PGHYGDQPRGSP-DYGSCS--GQSSATPAAPAGPFAGSQGDYGD 340 350 360 370 380 410 420 430 440 450 460 pF1KB9 HQPSGPYYGHSGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPT-HWEQPVYTTL : :. : .. : : :::. . .: .:: . . . . . : .:::: ::.::::::: NP_055 LQASSYYGAYPGYAPGLYQYPCFHSP-RRPYASPLLN-GLALPPAHSPTSHWDQPVYTTL 390 400 410 420 430 440 pF1KB9 SRP .:: NP_055 TRP >>NP_071899 (OMIM: 610928,613674) transcription factor S (414 aa) initn: 451 init1: 410 opt: 436 Z-score: 303.8 bits: 65.4 E(85289): 3.5e-10 Smith-Waterman score: 466; 35.4% identity (55.4% similar) in 325 aa overlap (91-410:55-330) 70 80 90 100 110 120 pF1KB9 GEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARR :. . : .:.. ...::::::::::. :. NP_071 AGLGPCPWAESLSPIGDMKVKGEAPANSGAPAGAAGRAKGESRIRRPMNAFMVWAKDERK 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB9 KLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKN .::.: : :::::::: ::: :. :. ..::::.:::::::.:: .:::.:::.:::::. NP_071 RLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQ 90 100 110 120 130 140 190 200 210 220 230 pF1KB9 GKAAQGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDG-NPEHP-SGQSHGP : . . :: . : : :: : : : : :: . . : .: :: NP_071 VKRLK---RVEGGFLH--GLAEPQA----AALG---PEGGRVAMDGLGLQFPEQGFPAGP 150 160 170 180 190 240 250 260 270 280 290 pF1KB9 PTPPTTPKTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELD : : :. ..:. :: .:.: : .: : . : :.. :: NP_071 PLLP--PH---MGGHY---RDCQSLGA---PPLD------GY-------PLPTPDTSPLD 200 210 220 300 310 320 330 340 350 pF1KB9 QYLPPNGHPGHVSSYSAAGYGLGSALAVASGHSAWISKPPGVALPTVSPPGVDAKAQVKT : : .. :: . :. :... : .: : : ::. . .. NP_071 GVDPD---P----AFFAAPMP-GDCPAAGTYSYAQVSDYAG---PP-EPPAGPMHPRLGP 230 240 250 260 270 360 370 380 390 400 410 pF1KB9 ETAGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYS---DHQPSGPYYGHS : :::. : ::. .. : ... : :.. .:: ... .:.: :: NP_071 EPAGPS-IPGLLAPPSALHVYYGAMGSPGAGGGRGFQMQPQHQHQHQHQHHPPGPGQPSP 280 290 300 310 320 330 420 430 440 450 460 pF1KB9 GQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP NP_071 PPEALPCRDGTDPSQPAELLGEVDRTEFEQYLHFVCKPEMGLPYQGHDSGVNLPDSHGAI 340 350 360 370 380 390 >>NP_008874 (OMIM: 601947) transcription factor SOX-12 [ (315 aa) initn: 463 init1: 414 opt: 422 Z-score: 296.3 bits: 63.6 E(85289): 9.1e-10 Smith-Waterman score: 446; 33.2% identity (57.2% similar) in 271 aa overlap (103-369:39-285) 80 90 100 110 120 130 pF1KB9 REAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNA :.::::::::::.: :::. ::.: .::: NP_008 AKRDGGPPPPGPGPAEEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNA 10 20 30 40 50 60 140 150 160 170 180 190 pF1KB9 ELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAECPG :.:: ::. :.::..:.: ::..::::::..: :.:::::.::....: :... . :: NP_008 EISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPG 70 80 90 100 110 120 200 210 220 230 240 250 pF1KB9 GEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQSG : .:: . .. . .: ::.:. . :.: .: . .: :: NP_008 G---SGGGSRLKP---GPQL----PGRGGRRAAGGPL--GGGAAAPEDDDEDDDEELLEV 130 140 150 160 170 260 270 280 290 300 310 pF1KB9 KADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQYLPPNGHPGHVSS . . :: . . . : . :. . . : .: . : . . . NP_008 RL-VETPGRELWR----MVPAGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEE 180 190 200 210 220 230 320 330 340 350 360 pF1KB9 YSAAGYGLGSALAVASGHSA--WISK-PPGVALPTVSPPGVDAKAQVKT-ETAGPQGPPH ::. : .::::. . ..:. ::: : :.: .: . . :.: : NP_008 EEAAAAEEGEEETVASGEESLGFLSRLPPG-------PAGLDCSALDRDPDLQPPSGTSH 240 250 260 270 280 370 380 390 400 410 420 pF1KB9 YTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHSGQASGLYSAFSYM . NP_008 FEFPDYCTPEVTEMIAGDWRPSSIADLVFTY 290 300 310 >>NP_060889 (OMIM: 137940,601618,607823) transcription f (384 aa) initn: 446 init1: 386 opt: 414 Z-score: 289.9 bits: 62.7 E(85289): 2.1e-09 Smith-Waterman score: 414; 45.5% identity (63.6% similar) in 154 aa overlap (104-254:85-228) 80 90 100 110 120 130 pF1KB9 EAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAE ..::::::::::. :..::.: : :::: NP_060 QRSPPRSPEPGRYGLSPAGRGERQAADESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAV 60 70 80 90 100 110 140 150 160 170 180 190 pF1KB9 LSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAE---C ::: ::: :. :: ..::::.:::::::.:: .:::.:::.:::.:... :. NP_060 LSKMLGKAWKELNAAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKARRLEPGLLL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KB9 PGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQ :: : . : ::. .. : :. . :: : ::: .: :. NP_060 PGLAPPQPPPEPFPAASGSARAFRELPPLGAEF-DG---------LGLPTPERSPLDGLE 180 190 200 210 220 260 270 280 290 300 310 pF1KB9 SGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQYLPPNGHPGHV :.: NP_060 PGEAAFFPPPAAPEDCALRPFRAPYAPTELSRDPGGCYGAPLAEALRTAPPAAPLAGLYY 230 240 250 260 270 280 >>NP_003097 (OMIM: 184429,189960,206900) transcription f (317 aa) initn: 544 init1: 396 opt: 412 Z-score: 289.7 bits: 62.4 E(85289): 2.1e-09 Smith-Waterman score: 457; 32.0% identity (58.4% similar) in 303 aa overlap (96-391:32-307) 70 80 90 100 110 120 pF1KB9 DKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKP-HVKRPMNAFMVWAQAARRKLAD : .:..: .:::::::::::... :::.:. NP_003 YNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQ 10 20 30 40 50 60 130 140 150 160 170 180 pF1KB9 QYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAA . :..::.:.:: :: :.::.:..:::::.::.::: : :.::::::.:::. . NP_003 ENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMK 70 80 90 100 110 120 190 200 210 220 230 240 pF1KB9 QGEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGPPTPPTT . . ::: ::.. .. .: : : : . . : .: :.: NP_003 KDKYTLPGGLLAPGGNSMASGVGVGAGL-----GAGVNQRMDSYAHMNGWSNGS------ 130 140 150 160 170 250 260 270 280 290 300 pF1KB9 PKTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQYLPPN . .:. . :.. : . ..:. . :.. .... :.. .:. : NP_003 -YSMMQDQLGYPQHPGLN-AHGAAQMQPMHRYDVSALQYNSMTSSQTY----------MN 180 190 200 210 310 320 330 340 350 pF1KB9 GHPGHVSSYS---AAGYGLGSALAVASGHSAWISKPPGVALPTVS-PP--GVDAKAQVKT : : . ::: . :..::: .:...... :.:: :. . : : . : . ... NP_003 GSPTYSMSYSQQGTPGMALGSMGSVVKSEAS--SSPPVVTSSSHSRAPCQAGDLRDMISM 220 230 240 250 260 270 360 370 380 390 400 410 pF1KB9 ETAGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHSGQA : . : :: ... : : :.: NP_003 YLPGAEVPE--PAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM 280 290 300 310 420 430 440 450 460 pF1KB9 SGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP >>NP_009015 (OMIM: 604974) transcription factor SOX-21 [ (276 aa) initn: 416 init1: 393 opt: 410 Z-score: 289.3 bits: 62.1 E(85289): 2.2e-09 Smith-Waterman score: 442; 34.2% identity (58.4% similar) in 281 aa overlap (100-368:2-268) 70 80 90 100 110 120 pF1KB9 VCIREAVSQVLSGYDWTLVPMPVRVNGASKSKP--HVKRPMNAFMVWAQAARRKLADQYP ::: ::::::::::::..: :::.:.. : NP_009 MSKPVDHVKRPMNAFMVWSRAQRRKMAQENP 10 20 30 130 140 150 160 170 180 pF1KB9 HLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGE ..::.:.:: :: :.::.::.:::::.::.::: .: :.::::::.:::. . . . NP_009 KMHNSEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDK 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB9 AECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEG-SPMSD-GNPEHPSGQSHGPPTPPTTP : . : . : . :.. : : : : : .:::. .. . . . : NP_009 FAFPVPYGLGGVADAEHPALKAGAGLHAGAGGGLVPESLLANPEKAAAAAAAAAARVFFP 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB9 KTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQYLPPNG .. .. : . . .:.: .. .:.: :. :. . : : : : NP_009 QSAAAAAAAA------AAAAAGSP---YSLLDLGSKMAEISSSSSGLPYASSLGY-PTAG 160 170 180 190 200 310 320 330 340 350 pF1KB9 HPGHVSSYSAAGYGLGSALAVASGHSAWISKP--PGVALP---TVSP-PGVDAK-AQVKT .... .:. . ..: :.:.::. .: :: .: .. : ::.. : . NP_009 ----AGAFHGAAAAAAAAAAAAGGHTHSHPSPGNPGYMIPCNCSAWPSPGLQPPLAYILL 210 220 230 240 250 360 370 380 390 400 410 pF1KB9 ETAG-PQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHSGQ : :: :. NP_009 PGMGKPQLDPYPAAYAAAL 260 270 >>NP_008873 (OMIM: 601297) protein SOX-15 [Homo sapiens] (233 aa) initn: 431 init1: 377 opt: 408 Z-score: 289.1 bits: 61.8 E(85289): 2.3e-09 Smith-Waterman score: 408; 41.8% identity (71.2% similar) in 153 aa overlap (104-248:49-196) 80 90 100 110 120 130 pF1KB9 EAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAE :::::::::::..: ::..:.: :..::.: NP_008 ATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSE 20 30 40 50 60 70 140 150 160 170 180 190 pF1KB9 LSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGG .:: :: :.::.:..::::.:::.::: .: .:.:::::.:::. ....: : ..: : NP_008 ISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAKSSGA-GPSRCGQG 80 90 100 110 120 130 200 210 220 230 240 pF1KB9 EAE--QGGT---AAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGP---PTPPTTP ... .:: . . : . .: :. .. . :. :.:: :.: . : NP_008 RGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGS----YGSSHCKLEAPSPCSLP 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB9 KTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQYLPPNG ... NP_008 QSDPRLQGELLPTYTHYLPPGSPTPYNPPLAGAPMPLTHL 200 210 220 230 >>NP_005625 (OMIM: 300123,312000,313430) transcription f (446 aa) initn: 434 init1: 377 opt: 407 Z-score: 284.3 bits: 61.9 E(85289): 4.2e-09 Smith-Waterman score: 430; 30.2% identity (55.9% similar) in 338 aa overlap (96-420:131-439) 70 80 90 100 110 120 pF1KB9 DKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAARRKLADQ :.. .. .:::::::::::... :::.: . NP_005 AAPGGAGKSSANAAGGANSGGGSSGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALE 110 120 130 140 150 160 130 140 150 160 170 180 pF1KB9 YPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGKAAQ :..::.:.:: :: :.::....:::::.::.::: : :..:::::.:::. . . NP_005 NPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKK 170 180 190 200 210 220 190 200 210 220 230 240 pF1KB9 GEAECPGGEAEQGGTAAIQAHYKSAHLDHRHPGEGSPMSDGNPEHPSGQSHGPPTPPTTP . :.: :..:: : .: : :. .. . : .: ..: . NP_005 DKYSLPSGLLPPGAAAAAAAAAAAAAAASSPVGVGQRLD--TYTHVNGWANGAYS----- 230 240 250 260 270 250 260 270 280 290 300 pF1KB9 KTELQSGKADPKRDGRSMGEGGKPHIDFGNVDIGEISHEVMSNMETFDVAELDQYLP--P .. : : :.: ::. : .. :. .:.: : :: : : NP_005 LVQEQLGYAQPP----SMSSPPPP--------------PALPPMHRYDMAGL-QYSPMMP 280 290 300 310 310 320 330 340 350 pF1KB9 NGHPGHVSSYSAA----GYGLGSALAVASGHSAWISKPPGVALPTVSPPGVDAKAQ---V : .... .:: ::: . :.:.. .:. ..: .: ... ... . : NP_005 PGAQSYMNVAAAAAAASGYGGMAPSATAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVV 320 330 340 350 360 370 360 370 380 390 400 410 pF1KB9 KTETAGPQGPPHYTDQPSTSQIA----YTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYY :.: ..: :: ... . . .. . :. :: :.: . : : : : NP_005 KSEPSSP--PPAIASHSQRACLGDLRDMISMYLPPGGDAADAAS-PLPGGRLHGVHQHYQ 380 390 400 410 420 430 420 430 440 450 460 pF1KB9 GHSGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPVYTTLSRP : . ..: NP_005 GAGTAVNGTVPLTHI 440 466 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:06:28 2016 done: Sat Nov 5 02:06:29 2016 Total Scan time: 10.400 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]