FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9569, 741 aa 1>>>pF1KB9569 741 - 741 aa - 741 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.6424+/-0.000552; mu= -13.0018+/- 0.035 mean_var=470.2909+/-96.908, 0's: 0 Z-trim(120.0): 86 B-trim: 1374 in 1/57 Lambda= 0.059141 statistics sampled from 34598 (34697) to 34598 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.407), width: 16 Scan time: 15.430 The best scores are: opt bits E(85289) XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 4458 395.5 4e-109 NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 4458 395.6 4e-109 NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 4458 395.6 4.1e-109 XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 4458 395.6 4.1e-109 XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 3861 344.6 8e-94 NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 3584 321.0 1.1e-86 XP_016856997 (OMIM: 164175) PREDICTED: POU domain, ( 381) 2131 196.8 1.4e-49 XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701) 1344 129.8 3.7e-29 XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29 XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29 XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29 XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29 XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711) 1344 129.8 3.7e-29 XP_016882373 (OMIM: 164176) PREDICTED: POU domain, ( 723) 1344 129.8 3.7e-29 XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723) 1344 129.8 3.7e-29 XP_016882380 (OMIM: 164176) PREDICTED: POU domain, ( 707) 1317 127.5 1.8e-28 XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600) 1308 126.7 2.7e-28 XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602) 1276 124.0 1.8e-27 XP_016882384 (OMIM: 164176) PREDICTED: POU domain, ( 602) 1276 124.0 1.8e-27 XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624) 1275 123.9 2e-27 XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 1249 121.6 8.3e-27 NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 1240 120.8 1.3e-26 XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 1239 120.8 1.4e-26 NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 1232 120.1 2e-26 XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 1115 110.2 2.4e-23 XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 1108 109.6 3.8e-23 NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 1079 107.1 1.7e-22 XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 1072 106.5 2.7e-22 NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 1020 102.0 5e-21 XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 1000 100.3 1.7e-20 XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 1000 100.3 1.7e-20 XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 1000 100.3 1.7e-20 XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 1000 100.3 1.7e-20 XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 1000 100.3 1.7e-20 NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 1000 100.3 1.8e-20 NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 1000 100.3 1.8e-20 XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 970 97.7 8.9e-20 NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 692 74.0 1.2e-12 NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 685 73.4 2.2e-12 NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 684 73.4 2.5e-12 NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 672 72.3 4.8e-12 NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 570 63.5 1.7e-09 NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265) 551 61.8 4.1e-09 NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 553 62.1 4.6e-09 NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 504 58.1 1.3e-07 NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 460 54.2 1.2e-06 NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 450 53.3 1.9e-06 NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 443 52.8 3.5e-06 NP_001167002 (OMIM: 164177) POU domain, class 5, t ( 190) 425 50.9 5.5e-06 NP_976034 (OMIM: 164177) POU domain, class 5, tran ( 190) 425 50.9 5.5e-06 >>XP_011507956 (OMIM: 164175) PREDICTED: POU domain, cla (743 aa) initn: 4458 init1: 4458 opt: 4458 Z-score: 2080.2 bits: 395.5 E(85289): 4e-109 Smith-Waterman score: 4458; 100.0% identity (100.0% similar) in 723 aa overlap (19-741:21-743) 10 20 30 40 50 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS :::::::::::::::::::::::::::::::::::::::: XP_011 MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB9 SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB9 SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB9 FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ 670 680 690 700 710 720 720 730 740 pF1KB9 NSLFTVASASGAASTTTTASKAQ ::::::::::::::::::::::: XP_011 NSLFTVASASGAASTTTTASKAQ 730 740 >>NP_001185712 (OMIM: 164175) POU domain, class 2, trans (755 aa) initn: 4458 init1: 4458 opt: 4458 Z-score: 2080.1 bits: 395.6 E(85289): 4e-109 Smith-Waterman score: 4458; 100.0% identity (100.0% similar) in 723 aa overlap (19-741:33-755) 10 20 30 40 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH :::::::::::::::::::::::::::::: NP_001 DCSDYVLDSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH 670 680 690 700 710 720 710 720 730 740 pF1KB9 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ ::::::::::::::::::::::::::::::::: NP_001 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ 730 740 750 >>NP_002688 (OMIM: 164175) POU domain, class 2, transcri (766 aa) initn: 4458 init1: 4458 opt: 4458 Z-score: 2080.0 bits: 395.6 E(85289): 4.1e-109 Smith-Waterman score: 4458; 100.0% identity (100.0% similar) in 723 aa overlap (19-741:44-766) 10 20 30 40 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH :::::::::::::::::::::::::::::: NP_002 AAAAAAADSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL 320 330 340 350 360 370 350 360 370 380 390 400 pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT 380 390 400 410 420 430 410 420 430 440 450 460 pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS 440 450 460 470 480 490 470 480 490 500 510 520 pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA 500 510 520 530 540 550 530 540 550 560 570 580 pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA 560 570 580 590 600 610 590 600 610 620 630 640 pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI 620 630 640 650 660 670 650 660 670 680 690 700 pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH 680 690 700 710 720 730 710 720 730 740 pF1KB9 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ ::::::::::::::::::::::::::::::::: NP_002 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ 740 750 760 >>XP_011507955 (OMIM: 164175) PREDICTED: POU domain, cla (769 aa) initn: 4458 init1: 4458 opt: 4458 Z-score: 2080.0 bits: 395.6 E(85289): 4.1e-109 Smith-Waterman score: 4458; 100.0% identity (100.0% similar) in 723 aa overlap (19-741:47-769) 10 20 30 40 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH :::::::::::::::::::::::::::::: XP_011 AAAADWKNSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL 320 330 340 350 360 370 350 360 370 380 390 400 pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT 380 390 400 410 420 430 410 420 430 440 450 460 pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS 440 450 460 470 480 490 470 480 490 500 510 520 pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA 500 510 520 530 540 550 530 540 550 560 570 580 pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA 560 570 580 590 600 610 590 600 610 620 630 640 pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI 620 630 640 650 660 670 650 660 670 680 690 700 pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH 680 690 700 710 720 730 710 720 730 740 pF1KB9 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ ::::::::::::::::::::::::::::::::: XP_011 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ 740 750 760 >>XP_011507957 (OMIM: 164175) PREDICTED: POU domain, cla (671 aa) initn: 4152 init1: 3861 opt: 3861 Z-score: 1805.5 bits: 344.6 E(85289): 8e-94 Smith-Waterman score: 3861; 99.5% identity (99.7% similar) in 625 aa overlap (19-643:47-671) 10 20 30 40 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH :::::::::::::::::::::::::::::: XP_011 AAAADWKNSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL 320 330 340 350 360 370 350 360 370 380 390 400 pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT 380 390 400 410 420 430 410 420 430 440 450 460 pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS 440 450 460 470 480 490 470 480 490 500 510 520 pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA 500 510 520 530 540 550 530 540 550 560 570 580 pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA 560 570 580 590 600 610 590 600 610 620 630 640 pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI ::::::::::::::::::::::::::::::::::::::::::::::::::.: : XP_011 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQVLLRG 620 630 640 650 660 670 650 660 670 680 690 700 pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH >>NP_001185715 (OMIM: 164175) POU domain, class 2, trans (703 aa) initn: 3507 init1: 3507 opt: 3584 Z-score: 1677.5 bits: 321.0 E(85289): 1.1e-86 Smith-Waterman score: 3940; 91.3% identity (91.3% similar) in 723 aa overlap (19-741:44-703) 10 20 30 40 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH :::::::::::::::::::::::::::::: NP_001 AAAAAAADSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI : NP_001 G----------------------------------------------------------- 170 180 190 200 210 220 pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ----DLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ 140 150 160 170 180 190 230 240 250 260 270 280 pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ 200 210 220 230 240 250 290 300 310 320 330 340 pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL 260 270 280 290 300 310 350 360 370 380 390 400 pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT 320 330 340 350 360 370 410 420 430 440 450 460 pF1KB9 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTS 380 390 400 410 420 430 470 480 490 500 510 520 pF1KB9 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAATTLTVSPVLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSA 440 450 460 470 480 490 530 540 550 560 570 580 pF1KB9 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLA 500 510 520 530 540 550 590 600 610 620 630 640 pF1KB9 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPI 560 570 580 590 600 610 650 660 670 680 690 700 pF1KB9 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLH 620 630 640 650 660 670 710 720 730 740 pF1KB9 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ ::::::::::::::::::::::::::::::::: NP_001 ATSTSAESIQNSLFTVASASGAASTTTTASKAQ 680 690 700 >>XP_016856997 (OMIM: 164175) PREDICTED: POU domain, cla (381 aa) initn: 2131 init1: 2131 opt: 2131 Z-score: 1011.0 bits: 196.8 E(85289): 1.4e-49 Smith-Waterman score: 2131; 100.0% identity (100.0% similar) in 334 aa overlap (19-352:47-380) 10 20 30 40 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGH :::::::::::::::::::::::::::::: XP_016 AAAADWKNSRMNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGH 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB9 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQIT 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB9 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPI 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB9 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQ 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB9 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQ 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB9 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWL 320 330 340 350 360 370 350 360 370 380 390 400 pF1KB9 NDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEIT :::: XP_016 NDAEP 380 >>XP_016882381 (OMIM: 164176) PREDICTED: POU domain, cla (701 aa) initn: 1441 init1: 556 opt: 1344 Z-score: 644.6 bits: 129.8 E(85289): 3.7e-29 Smith-Waterman score: 1700; 48.5% identity (66.2% similar) in 748 aa overlap (50-741:42-701) 20 30 40 50 60 70 pF1KB9 QTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS-LQAAAQSLNVQSKSNEESGD :: :: .... . ... :... ::: XP_016 RMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPSTKIKAEDPSGD 20 30 40 50 60 70 80 90 100 110 120 130 pF1KB9 SQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLT-LTPAQQQLLLQQAQAQAQLLAAAVQQ : :. : .: .::.::::.:.:..::: : :::::::::::::: :::::::: XP_016 SA-PAAPLPPQPAQPHLPQAQLMLTGSQLAGLTALMPAQQQLLLQQAQAQ--LLAAAVQQ 80 90 100 110 120 140 150 160 pF1KB9 HSASQQHSAAGATISASAAT------------------------------PMTQIP---- ::. .::.:. .:::.. : .: : XP_016 SSAAAAANAAAAAAAASASSSTSSSSSSSASSSTSQPPASSGGGDLPPPQPASQPPGTPQ 130 140 150 160 170 180 170 180 190 200 210 pF1KB9 --LSQPIQI-AQDLQQLQQLQQQNLNLQQFVLVHPTTNLQP-AQFIISQTPQGQQGLLQA ::::::. :::.::: :::: .::: : .::: :::.. :. :.: ::: . XP_016 LTLSQPIQLTAQDIQQLLQLQQ-------LVLV-PGHHLQPPAQFLLPQAQQSQPGLLPT 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB9 QNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSL-E ::. :::::.:. :: ::: : .: .: : : . :: :: .. :: : XP_016 PNLF-QLPQQTQGALLTSQPRAGLPTQAVT--RPTLPDPHLSHPQP---PKCLEPPSHPE 250 260 270 280 290 280 290 300 310 320 330 pF1KB9 EPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMC ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMC 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB9 KLKPLLEKWLNDAENLSSDSSLSSPSALNSP--GIEGL-SRRRKKRTSIETNIRVALEKS ::::::::::::::..: :::: ::. :.:: :..:: .::::::::::::.: ::::: XP_016 KLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKS 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB9 FLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSP :: ::::::::: .::.::.:::::::::::::::::::::: :..:. .::: XP_016 FLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINP-----CSAAPM---LPSP 420 430 440 450 460 460 470 480 490 500 510 pF1KB9 TSLVATTPSLVT-SSAATTLTVSPVLPLTSAAVTNLS-VTGT--SDTTSNNTATVISTAP . .. .: .:: ...: :: .: . :..::.:: ..:: . :... . ..:: XP_016 GKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGAAP 470 480 490 500 510 520 520 530 540 550 560 570 pF1KB9 PASSAVTSPSLSPSPSASASTSEASSASETSTTQTTSTPLSSPLGTSQVMVTASGLQTAA : .: ::..: : : : ....: :: :. .: :: XP_016 PLNSI---PSVTPPPPA---------------TTNSTNP--SPQGSH----SAIGL---- 530 540 550 580 590 600 610 620 630 pF1KB9 AAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQFAAGGALLSLNPGTLSGALSPALMSN .::::: .:.....:. : :::::::: XP_016 ----------------------SGLNPS--------TGSTMVGLSSG-----LSPALMSN 560 570 580 640 650 660 670 680 pF1KB9 STLATIQALASGGSLPITSLDATGNLVFANAG---GAPNIVTAPLFLNPQNLSLLTSNP- . :::::::::::.::.::::..::::.. :: :.:..::.::::: .: ::.. : XP_016 NPLATIQALASGGTLPLTSLDGSGNLVLGAAGAAPGSPGLVTSPLFLNHAGLPLLSTPPG 590 600 610 620 630 640 690 700 710 720 730 740 pF1KB9 VSLVSAAAASAGNS----APVASLHATSTSAESIQNSLFTVASASGAASTTTTASKAQ :.:::::::... : .: : ..:.:. : .. :.:.. :. . ..:: . XP_016 VGLVSAAAAAVAASISSKSPGLSSSSSSSSSSSSSTCSETAAQTPGGPGGPEAGSKPE 650 660 670 680 690 700 >>XP_016882378 (OMIM: 164176) PREDICTED: POU domain, cla (711 aa) initn: 1434 init1: 556 opt: 1344 Z-score: 644.5 bits: 129.8 E(85289): 3.7e-29 Smith-Waterman score: 1705; 47.4% identity (65.7% similar) in 781 aa overlap (17-741:24-711) 10 20 30 40 50 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQ :. .:: . :.. : ..: . .. .: : .. XP_016 MSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPF--SVSPTGPSTKVGILSGLH 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 LAGTSLQAAAQSLNV-QSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLT- : .. . . :. : :... :::: :. : .: .::.::::.:.:..::: XP_016 L---TFWGPGPCLSPPQIKAEDPSGDSA-PAAPLPPQPAQPHLPQAQLMLTGSQLAGLTA 60 70 80 90 100 110 120 130 140 150 pF1KB9 LTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAAT-------------- : ::::::::::::: ::::::::: ::. .::.:. .:::.. XP_016 LMPAQQQLLLQQAQA--QLLAAAVQQSSAAAAANAAAAAAAASASSSTSSSSSSSASSST 120 130 140 150 160 170 160 170 180 190 pF1KB9 ----------------PMTQIP------LSQPIQI-AQDLQQLQQLQQQNLNLQQFVLVH : .: : ::::::. :::.::: :.:::.::: XP_016 SQPPASSGGGDLPPPQPASQPPGTPQLTLSQPIQLTAQDIQQL-------LQLQQLVLV- 180 190 200 210 220 200 210 220 230 240 250 pF1KB9 PTTNLQP-AQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRT : .::: :::.. :. :.: ::: . ::. :::::.:. :: ::: : .: . :: XP_016 PGHHLQPPAQFLLPQAQQSQPGLLPTPNLF-QLPQQTQGALLTSQPRAGLPTQAV--TRP 230 240 250 260 270 280 260 270 280 290 300 310 pF1KB9 IAATPIQTLPQSQSTPKRIDTPSL-EEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG : . :: :: .. :: :::::::::::::.::::::::::::::::::::: XP_016 TLPDPHLSHPQP---PKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMG 290 300 310 320 330 320 330 340 350 360 370 pF1KB9 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSP--G ::::::::::::::::::::::::::::::::::::::::..: :::: ::. :.:: : XP_016 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLG 340 350 360 370 380 390 380 390 400 410 420 pF1KB9 IEGL-SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRR ..:: .::::::::::::.: ::::::: ::::::::: .::.::.:::::::::::::: XP_016 FDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRR 400 410 420 430 440 450 430 440 450 460 470 480 pF1KB9 QKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVT-SSAATTLTVSPVLPLTSAAVT :::::::: :..: ..::: . .. .: .:: ...: :: .: . :..:: XP_016 QKEKRINP-----CSAAP---MLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVT 460 470 480 490 500 510 490 500 510 520 530 540 pF1KB9 NLS-VTGT--SDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSASETSTTQ .:: ..:: . :... . ..::: .: ::..: : : : XP_016 TLSSAVGTLHPSRTAGGGGGGGGAAPPLNSI---PSVTPPPPA---------------TT 520 530 540 550 550 560 570 580 590 600 pF1KB9 TTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQ ....: :: :. .: :: .::::: XP_016 NSTNP--SPQGSH----SAIGL--------------------------SGLNPS------ 560 570 610 620 630 640 650 660 pF1KB9 FAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLVFANAG-- .:.....:. : ::::::::. :::::::::::.::.::::..::::.. :: XP_016 --TGSTMVGLSSG-----LSPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLGAAGAA 580 590 600 610 620 670 680 690 700 710 pF1KB9 -GAPNIVTAPLFLNPQNLSLLTSNP-VSLVSAAAASAGNS----APVASLHATSTSAESI :.:..::.::::: .: ::.. : :.:::::::... : .: : ..:.:. : XP_016 PGSPGLVTSPLFLNHAGLPLLSTPPGVGLVSAAAAAVAASISSKSPGLSSSSSSSSSSSS 630 640 650 660 670 680 720 730 740 pF1KB9 QNSLFTVASASGAASTTTTASKAQ .. :.:.. :. . ..:: . XP_016 STCSETAAQTPGGPGGPEAGSKPE 690 700 710 >>XP_016882376 (OMIM: 164176) PREDICTED: POU domain, cla (711 aa) initn: 1434 init1: 556 opt: 1344 Z-score: 644.5 bits: 129.8 E(85289): 3.7e-29 Smith-Waterman score: 1705; 47.4% identity (65.7% similar) in 781 aa overlap (17-741:24-711) 10 20 30 40 50 pF1KB9 MKTRMKIFVMIHFHLMNSTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQ :. .:: . :.. : ..: . .. .: : .. XP_016 MSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPF--SVSPTGPSTKVGILSGLH 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 LAGTSLQAAAQSLNV-QSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLT- : .. . . :. : :... :::: :. : .: .::.::::.:.:..::: XP_016 L---TFWGPGPCLSPPQIKAEDPSGDSA-PAAPLPPQPAQPHLPQAQLMLTGSQLAGLTA 60 70 80 90 100 110 120 130 140 150 pF1KB9 LTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAAT-------------- : ::::::::::::: ::::::::: ::. .::.:. .:::.. XP_016 LMPAQQQLLLQQAQA--QLLAAAVQQSSAAAAANAAAAAAAASASSSTSSSSSSSASSST 120 130 140 150 160 170 160 170 180 190 pF1KB9 ----------------PMTQIP------LSQPIQI-AQDLQQLQQLQQQNLNLQQFVLVH : .: : ::::::. :::.::: :.:::.::: XP_016 SQPPASSGGGDLPPPQPASQPPGTPQLTLSQPIQLTAQDIQQL-------LQLQQLVLV- 180 190 200 210 220 200 210 220 230 240 250 pF1KB9 PTTNLQP-AQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRT : .::: :::.. :. :.: ::: . ::. :::::.:. :: ::: : .: . :: XP_016 PGHHLQPPAQFLLPQAQQSQPGLLPTPNLF-QLPQQTQGALLTSQPRAGLPTQAV--TRP 230 240 250 260 270 280 260 270 280 290 300 310 pF1KB9 IAATPIQTLPQSQSTPKRIDTPSL-EEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMG : . :: :: .. :: :::::::::::::.::::::::::::::::::::: XP_016 TLPDPHLSHPQP---PKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMG 290 300 310 320 330 320 330 340 350 360 370 pF1KB9 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSP--G ::::::::::::::::::::::::::::::::::::::::..: :::: ::. :.:: : XP_016 KLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLG 340 350 360 370 380 390 380 390 400 410 420 pF1KB9 IEGL-SRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRR ..:: .::::::::::::.: ::::::: ::::::::: .::.::.:::::::::::::: XP_016 FDGLPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRR 400 410 420 430 440 450 430 440 450 460 470 480 pF1KB9 QKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVT-SSAATTLTVSPVLPLTSAAVT :::::::: :..: ..::: . .. .: .:: ...: :: .: . :..:: XP_016 QKEKRINP-----CSAAP---MLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVT 460 470 480 490 500 510 490 500 510 520 530 540 pF1KB9 NLS-VTGT--SDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSASETSTTQ .:: ..:: . :... . ..::: .: ::..: : : : XP_016 TLSSAVGTLHPSRTAGGGGGGGGAAPPLNSI---PSVTPPPPA---------------TT 520 530 540 550 550 560 570 580 590 600 pF1KB9 TTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNPSLMAPSQ ....: :: :. .: :: .::::: XP_016 NSTNP--SPQGSH----SAIGL--------------------------SGLNPS------ 560 570 610 620 630 640 650 660 pF1KB9 FAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLVFANAG-- .:.....:. : ::::::::. :::::::::::.::.::::..::::.. :: XP_016 --TGSTMVGLSSG-----LSPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLGAAGAA 580 590 600 610 620 670 680 690 700 710 pF1KB9 -GAPNIVTAPLFLNPQNLSLLTSNP-VSLVSAAAASAGNS----APVASLHATSTSAESI :.:..::.::::: .: ::.. : :.:::::::... : .: : ..:.:. : XP_016 PGSPGLVTSPLFLNHAGLPLLSTPPGVGLVSAAAAAVAASISSKSPGLSSSSSSSSSSSS 630 640 650 660 670 680 720 730 740 pF1KB9 QNSLFTVASASGAASTTTTASKAQ .. :.:.. :. . ..:: . XP_016 STCSETAAQTPGGPGGPEAGSKPE 690 700 710 741 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:22:59 2016 done: Fri Nov 4 17:23:01 2016 Total Scan time: 15.430 Total Display time: 0.190 Function used was FASTA [36.3.4 Apr, 2011]