FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9584, 270 aa 1>>>pF1KB9584 270 - 270 aa - 270 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8436+/-0.000366; mu= 0.9166+/- 0.023 mean_var=268.7335+/-54.966, 0's: 0 Z-trim(122.7): 19 B-trim: 0 in 0/52 Lambda= 0.078237 statistics sampled from 41353 (41376) to 41353 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.795), E-opt: 0.2 (0.485), width: 16 Scan time: 6.920 The best scores are: opt bits E(85289) NP_001161860 (OMIM: 602937,614431,614433) cbp/p300 ( 270) 1944 231.8 1.1e-60 NP_006070 (OMIM: 602937,614431,614433) cbp/p300-in ( 270) 1944 231.8 1.1e-60 NP_001161861 (OMIM: 602937,614431,614433) cbp/p300 ( 275) 1944 231.8 1.1e-60 NP_001138359 (OMIM: 300149) cbp/p300-interacting t ( 193) 258 41.3 0.0016 NP_004134 (OMIM: 300149) cbp/p300-interacting tran ( 193) 258 41.3 0.0016 NP_001138358 (OMIM: 300149) cbp/p300-interacting t ( 193) 258 41.3 0.0016 XP_011529260 (OMIM: 300149) PREDICTED: cbp/p300-in ( 219) 258 41.4 0.0018 NP_001138357 (OMIM: 300149) cbp/p300-interacting t ( 219) 258 41.4 0.0018 >>NP_001161860 (OMIM: 602937,614431,614433) cbp/p300-int (270 aa) initn: 1944 init1: 1944 opt: 1944 Z-score: 1210.7 bits: 231.8 E(85289): 1.1e-60 Smith-Waterman score: 1944; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270) 10 20 30 40 50 60 pF1KB9 MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 NQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSSTPGGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSSTPGGSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 SSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRI 190 200 210 220 230 240 250 260 270 pF1KB9 KELPELWLGQNEFDFMTDFVCKQQPSRVSC :::::::::::::::::::::::::::::: NP_001 KELPELWLGQNEFDFMTDFVCKQQPSRVSC 250 260 270 >>NP_006070 (OMIM: 602937,614431,614433) cbp/p300-intera (270 aa) initn: 1944 init1: 1944 opt: 1944 Z-score: 1210.7 bits: 231.8 E(85289): 1.1e-60 Smith-Waterman score: 1944; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270) 10 20 30 40 50 60 pF1KB9 MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 NQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSSTPGGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSSTPGGSG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 SSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRI 190 200 210 220 230 240 250 260 270 pF1KB9 KELPELWLGQNEFDFMTDFVCKQQPSRVSC :::::::::::::::::::::::::::::: NP_006 KELPELWLGQNEFDFMTDFVCKQQPSRVSC 250 260 270 >>NP_001161861 (OMIM: 602937,614431,614433) cbp/p300-int (275 aa) initn: 1944 init1: 1944 opt: 1944 Z-score: 1210.6 bits: 231.8 E(85289): 1.1e-60 Smith-Waterman score: 1944; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:6-275) 10 20 30 40 50 pF1KB9 MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSGLEMADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 IHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 LQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSST 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 PGGSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGGSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEM 190 200 210 220 230 240 240 250 260 270 pF1KB9 GLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC ::::::::::::::::::::::::::::::::::: NP_001 GLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC 250 260 270 >>NP_001138359 (OMIM: 300149) cbp/p300-interacting trans (193 aa) initn: 308 init1: 248 opt: 258 Z-score: 184.1 bits: 41.3 E(85289): 0.0016 Smith-Waterman score: 310; 36.0% identity (59.3% similar) in 172 aa overlap (89-259:48-189) 60 70 80 90 100 110 pF1KB9 GAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQK :.. :... : :..:.:. . . NP_001 AKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPP 20 30 40 50 60 70 120 130 140 150 160 170 pF1KB9 LNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSG-GSSTPGGSGGSSTPG . :: :: : : . .. :.. : ...: ...::: :: NP_001 TKPPSFNLHPAP--HLLASM-------------HLQKLNSQYQGMAAATPG------QPG 80 90 100 110 180 190 200 210 220 230 pF1KB9 GSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGL .: .. :.. .:. : : :.. :. :: .::.: .:::::::::.:.:: NP_001 EAGPLQNWDFGAQAGGAESLS---PSAGAQSPA------IIDSDPVDEEVLMSLVVELGL 120 130 140 150 160 240 250 260 270 pF1KB9 DRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC :: .:::::::::::::: .:: NP_001 DRANELPELWLGQNEFDFTADFPSSC 170 180 190 >>NP_004134 (OMIM: 300149) cbp/p300-interacting transact (193 aa) initn: 308 init1: 248 opt: 258 Z-score: 184.1 bits: 41.3 E(85289): 0.0016 Smith-Waterman score: 310; 36.0% identity (59.3% similar) in 172 aa overlap (89-259:48-189) 60 70 80 90 100 110 pF1KB9 GAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQK :.. :... : :..:.:. . . NP_004 AKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPP 20 30 40 50 60 70 120 130 140 150 160 170 pF1KB9 LNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSG-GSSTPGGSGGSSTPG . :: :: : : . .. :.. : ...: ...::: :: NP_004 TKPPSFNLHPAP--HLLASM-------------HLQKLNSQYQGMAAATPG------QPG 80 90 100 110 180 190 200 210 220 230 pF1KB9 GSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGL .: .. :.. .:. : : :.. :. :: .::.: .:::::::::.:.:: NP_004 EAGPLQNWDFGAQAGGAESLS---PSAGAQSPA------IIDSDPVDEEVLMSLVVELGL 120 130 140 150 160 240 250 260 270 pF1KB9 DRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC :: .:::::::::::::: .:: NP_004 DRANELPELWLGQNEFDFTADFPSSC 170 180 190 >>NP_001138358 (OMIM: 300149) cbp/p300-interacting trans (193 aa) initn: 308 init1: 248 opt: 258 Z-score: 184.1 bits: 41.3 E(85289): 0.0016 Smith-Waterman score: 310; 36.0% identity (59.3% similar) in 172 aa overlap (89-259:48-189) 60 70 80 90 100 110 pF1KB9 GAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQK :.. :... : :..:.:. . . NP_001 AKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPP 20 30 40 50 60 70 120 130 140 150 160 170 pF1KB9 LNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSG-GSSTPGGSGGSSTPG . :: :: : : . .. :.. : ...: ...::: :: NP_001 TKPPSFNLHPAP--HLLASM-------------HLQKLNSQYQGMAAATPG------QPG 80 90 100 110 180 190 200 210 220 230 pF1KB9 GSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGL .: .. :.. .:. : : :.. :. :: .::.: .:::::::::.:.:: NP_001 EAGPLQNWDFGAQAGGAESLS---PSAGAQSPA------IIDSDPVDEEVLMSLVVELGL 120 130 140 150 160 240 250 260 270 pF1KB9 DRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC :: .:::::::::::::: .:: NP_001 DRANELPELWLGQNEFDFTADFPSSC 170 180 190 >>XP_011529260 (OMIM: 300149) PREDICTED: cbp/p300-intera (219 aa) initn: 308 init1: 248 opt: 258 Z-score: 183.4 bits: 41.4 E(85289): 0.0018 Smith-Waterman score: 310; 36.0% identity (59.3% similar) in 172 aa overlap (89-259:74-215) 60 70 80 90 100 110 pF1KB9 GAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQK :.. :... : :..:.:. . . XP_011 AKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 LNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSG-GSSTPGGSGGSSTPG . :: :: : : . .. :.. : ...: ...::: :: XP_011 TKPPSFNLHPAP--HLLASM-------------HLQKLNSQYQGMAAATPG------QPG 110 120 130 140 180 190 200 210 220 230 pF1KB9 GSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGL .: .. :.. .:. : : :.. :. :: .::.: .:::::::::.:.:: XP_011 EAGPLQNWDFGAQAGGAESLS---PSAGAQSPA------IIDSDPVDEEVLMSLVVELGL 150 160 170 180 190 240 250 260 270 pF1KB9 DRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC :: .:::::::::::::: .:: XP_011 DRANELPELWLGQNEFDFTADFPSSC 200 210 >>NP_001138357 (OMIM: 300149) cbp/p300-interacting trans (219 aa) initn: 308 init1: 248 opt: 258 Z-score: 183.4 bits: 41.4 E(85289): 0.0018 Smith-Waterman score: 310; 36.0% identity (59.3% similar) in 172 aa overlap (89-259:74-215) 60 70 80 90 100 110 pF1KB9 GAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQK :.. :... : :..:.:. . . NP_001 AKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 LNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSG-GSSTPGGSGGSSTPG . :: :: : : . .. :.. : ...: ...::: :: NP_001 TKPPSFNLHPAP--HLLASM-------------HLQKLNSQYQGMAAATPG------QPG 110 120 130 140 180 190 200 210 220 230 pF1KB9 GSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGL .: .. :.. .:. : : :.. :. :: .::.: .:::::::::.:.:: NP_001 EAGPLQNWDFGAQAGGAESLS---PSAGAQSPA------IIDSDPVDEEVLMSLVVELGL 150 160 170 180 190 240 250 260 270 pF1KB9 DRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC :: .:::::::::::::: .:: NP_001 DRANELPELWLGQNEFDFTADFPSSC 200 210 270 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:29:40 2016 done: Fri Nov 4 17:29:41 2016 Total Scan time: 6.920 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]