FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9586, 150 aa 1>>>pF1KB9586 150 - 150 aa - 150 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4229+/-0.000278; mu= 10.5279+/- 0.018 mean_var=135.8242+/-26.635, 0's: 0 Z-trim(122.6): 36 B-trim: 0 in 0/53 Lambda= 0.110049 statistics sampled from 40839 (40879) to 40839 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.797), E-opt: 0.2 (0.479), width: 16 Scan time: 4.900 The best scores are: opt bits E(85289) NP_001797 (OMIM: 138972) CCAAT/enhancer-binding pr ( 150) 953 160.9 7.2e-40 NP_001239225 (OMIM: 138972) CCAAT/enhancer-binding ( 150) 953 160.9 7.2e-40 NP_001272808 (OMIM: 189965) CCAAT/enhancer-binding ( 147) 261 51.0 8.4e-07 NP_001272807 (OMIM: 189965) CCAAT/enhancer-binding ( 322) 261 51.3 1.5e-06 NP_005185 (OMIM: 189965) CCAAT/enhancer-binding pr ( 345) 261 51.4 1.5e-06 NP_005186 (OMIM: 116898) CCAAT/enhancer-binding pr ( 269) 240 47.9 1.3e-05 NP_001272758 (OMIM: 116897,601626) CCAAT/enhancer- ( 239) 233 46.8 2.6e-05 NP_001274364 (OMIM: 116897,601626) CCAAT/enhancer- ( 344) 233 46.9 3.3e-05 NP_004355 (OMIM: 116897,601626) CCAAT/enhancer-bin ( 358) 233 46.9 3.4e-05 NP_001274353 (OMIM: 116897,601626) CCAAT/enhancer- ( 393) 233 47.0 3.6e-05 NP_001796 (OMIM: 245480,600749) CCAAT/enhancer-bin ( 281) 228 46.0 5e-05 >>NP_001797 (OMIM: 138972) CCAAT/enhancer-binding protei (150 aa) initn: 953 init1: 953 opt: 953 Z-score: 836.8 bits: 160.9 E(85289): 7.2e-40 Smith-Waterman score: 953; 100.0% identity (100.0% similar) in 150 aa overlap (1-150:1-150) 10 20 30 40 50 60 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVAPSKQSKKSSPMDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVAPSKQSKKSSPMDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 NSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKD 70 80 90 100 110 120 130 140 150 pF1KB9 LFLEHAHNLADNVQSISTENTTADGDNAGQ :::::::::::::::::::::::::::::: NP_001 LFLEHAHNLADNVQSISTENTTADGDNAGQ 130 140 150 >>NP_001239225 (OMIM: 138972) CCAAT/enhancer-binding pro (150 aa) initn: 953 init1: 953 opt: 953 Z-score: 836.8 bits: 160.9 E(85289): 7.2e-40 Smith-Waterman score: 953; 100.0% identity (100.0% similar) in 150 aa overlap (1-150:1-150) 10 20 30 40 50 60 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVAPSKQSKKSSPMDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVAPSKQSKKSSPMDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 NSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKD 70 80 90 100 110 120 130 140 150 pF1KB9 LFLEHAHNLADNVQSISTENTTADGDNAGQ :::::::::::::::::::::::::::::: NP_001 LFLEHAHNLADNVQSISTENTTADGDNAGQ 130 140 150 >>NP_001272808 (OMIM: 189965) CCAAT/enhancer-binding pro (147 aa) initn: 253 init1: 239 opt: 261 Z-score: 243.1 bits: 51.0 E(85289): 8.4e-07 Smith-Waterman score: 261; 39.3% identity (68.0% similar) in 122 aa overlap (4-122:13-133) 10 20 30 40 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGG--GGKAVAPS .. : : .: ... : . : . : : . .: : ::: NP_001 MAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPS-PADAKAPPTACYAGAAPAPS 10 20 30 40 50 50 60 70 80 90 100 pF1KB9 K-QSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKI . .:: .. .:..::::. ::::::.::.::: :.:.. .: ..: .: :::::. :. NP_001 QVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKV 60 70 80 90 100 110 110 120 130 140 150 pF1KB9 KLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ . :..:::.:..:: NP_001 EQLSRELSTLRNLFKQLPEPLLASSGHC 120 130 140 >>NP_001272807 (OMIM: 189965) CCAAT/enhancer-binding pro (322 aa) initn: 308 init1: 239 opt: 261 Z-score: 238.8 bits: 51.3 E(85289): 1.5e-06 Smith-Waterman score: 261; 39.3% identity (68.0% similar) in 122 aa overlap (4-122:188-308) 10 20 30 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQ .. : : .: ... : . : NP_001 PADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPS-PA 160 170 180 190 200 210 40 50 60 70 80 90 pF1KB9 LVPAGPGG--GGKAVAPSK-QSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDT . : : . .: : :::. .:: .. .:..::::. ::::::.::.::: :.:.. .: NP_001 DAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLET 220 230 240 250 260 270 100 110 120 130 140 150 pF1KB9 LQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ ..: .: :::::. :.. :..:::.:..:: NP_001 QHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC 280 290 300 310 320 >>NP_005185 (OMIM: 189965) CCAAT/enhancer-binding protei (345 aa) initn: 308 init1: 239 opt: 261 Z-score: 238.4 bits: 51.4 E(85289): 1.5e-06 Smith-Waterman score: 261; 39.3% identity (68.0% similar) in 122 aa overlap (4-122:211-331) 10 20 30 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQ .. : : .: ... : . : NP_005 PADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPS-PA 190 200 210 220 230 40 50 60 70 80 90 pF1KB9 LVPAGPGG--GGKAVAPSK-QSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDT . : : . .: : :::. .:: .. .:..::::. ::::::.::.::: :.:.. .: NP_005 DAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLET 240 250 260 270 280 290 100 110 120 130 140 150 pF1KB9 LQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ ..: .: :::::. :.. :..:::.:..:: NP_005 QHKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC 300 310 320 330 340 >>NP_005186 (OMIM: 116898) CCAAT/enhancer-binding protei (269 aa) initn: 281 init1: 219 opt: 240 Z-score: 221.8 bits: 47.9 E(85289): 1.3e-05 Smith-Waterman score: 240; 41.7% identity (71.8% similar) in 103 aa overlap (25-122:151-251) 10 20 30 40 50 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAV-APSKQSK :.: : .: : : .. . . ::. . NP_005 REPDWGDGDAPGSLLPAQVAACAQTVVSLAAAG-QPTPPTSPEPPRSSPRQTPAPGPARE 130 140 150 160 170 60 70 80 90 100 pF1KB9 KSS----PMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIK ::. : ::.: ::::::::::.::.::: :.:.. :. :.. .:. :::.:. ... NP_005 KSAGKRGP-DRGSPEYRQRRERNNIAVRKSRDKAKRRNQEMQQKLVELSAENEKLHQRVE 180 190 200 210 220 230 110 120 130 140 150 pF1KB9 LLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ ::..:. :...: NP_005 QLTRDLAGLRQFFKQLPSPPFLPAAGTADCR 240 250 260 >>NP_001272758 (OMIM: 116897,601626) CCAAT/enhancer-bind (239 aa) initn: 239 init1: 208 opt: 233 Z-score: 216.4 bits: 46.8 E(85289): 2.6e-05 Smith-Waterman score: 245; 36.9% identity (69.7% similar) in 122 aa overlap (2-122:111-223) 10 20 30 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQV . . . . .:.... .. . .:: . NP_001 HLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGSALKGLGAA 90 100 110 120 130 140 40 50 60 70 80 90 pF1KB9 -PQLVPAGPGGGGKAVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDT :.: .: .:.::: ::: .:.::.::: ::::::.::.::: :.::. .: NP_001 HPDLRASGGSGAGKA-------KKS--VDKNSNEYRVRRERNNIAVRKSRDKAKQRNVET 150 160 170 180 190 100 110 120 130 140 150 pF1KB9 LQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ :.: .: .:.::. ... :..::..:. .: NP_001 QQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA 200 210 220 230 >>NP_001274364 (OMIM: 116897,601626) CCAAT/enhancer-bind (344 aa) initn: 243 init1: 208 opt: 233 Z-score: 214.4 bits: 46.9 E(85289): 3.3e-05 Smith-Waterman score: 245; 36.9% identity (69.7% similar) in 122 aa overlap (2-122:216-328) 10 20 30 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQV . . . . .:.... .. . .:: . NP_001 HLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGSALKGLGAA 190 200 210 220 230 240 40 50 60 70 80 90 pF1KB9 -PQLVPAGPGGGGKAVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDT :.: .: .:.::: ::: .:.::.::: ::::::.::.::: :.::. .: NP_001 HPDLRASGGSGAGKA-------KKS--VDKNSNEYRVRRERNNIAVRKSRDKAKQRNVET 250 260 270 280 290 100 110 120 130 140 150 pF1KB9 LQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ :.: .: .:.::. ... :..::..:. .: NP_001 QQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA 300 310 320 330 340 >>NP_004355 (OMIM: 116897,601626) CCAAT/enhancer-binding (358 aa) initn: 263 init1: 208 opt: 233 Z-score: 214.2 bits: 46.9 E(85289): 3.4e-05 Smith-Waterman score: 245; 36.9% identity (69.7% similar) in 122 aa overlap (2-122:230-342) 10 20 30 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQV . . . . .:.... .. . .:: . NP_004 HLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGSALKGLGAA 200 210 220 230 240 250 40 50 60 70 80 90 pF1KB9 -PQLVPAGPGGGGKAVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDT :.: .: .:.::: ::: .:.::.::: ::::::.::.::: :.::. .: NP_004 HPDLRASGGSGAGKA-------KKS--VDKNSNEYRVRRERNNIAVRKSRDKAKQRNVET 260 270 280 290 300 310 100 110 120 130 140 150 pF1KB9 LQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ :.: .: .:.::. ... :..::..:. .: NP_004 QQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA 320 330 340 350 >>NP_001274353 (OMIM: 116897,601626) CCAAT/enhancer-bind (393 aa) initn: 243 init1: 208 opt: 233 Z-score: 213.7 bits: 47.0 E(85289): 3.6e-05 Smith-Waterman score: 245; 36.9% identity (69.7% similar) in 122 aa overlap (2-122:265-377) 10 20 30 pF1KB9 MSKISQQNSTPGVNGISVIHTQAHASGLQQV . . . . .:.... .. . .:: . NP_001 HLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHPAPALGAAGLPGPGSALKGLGAA 240 250 260 270 280 290 40 50 60 70 80 90 pF1KB9 -PQLVPAGPGGGGKAVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDT :.: .: .:.::: ::: .:.::.::: ::::::.::.::: :.::. .: NP_001 HPDLRASGGSGAGKA-------KKS--VDKNSNEYRVRRERNNIAVRKSRDKAKQRNVET 300 310 320 330 340 100 110 120 130 140 150 pF1KB9 LQRVNQLKEENERLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ :.: .: .:.::. ... :..::..:. .: NP_001 QQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA 350 360 370 380 390 150 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:30:45 2016 done: Fri Nov 4 17:30:46 2016 Total Scan time: 4.900 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]