FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9598, 478 aa 1>>>pF1KB9598 478 - 478 aa - 478 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5893+/-0.000393; mu= 1.5717+/- 0.025 mean_var=343.5209+/-70.586, 0's: 0 Z-trim(123.4): 132 B-trim: 35 in 1/57 Lambda= 0.069199 statistics sampled from 42929 (43069) to 42929 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.505), width: 16 Scan time: 11.290 The best scores are: opt bits E(85289) NP_036315 (OMIM: 607836,611539) forkhead box prote ( 478) 3213 334.3 4.5e-91 NP_004463 (OMIM: 601091) forkhead box protein D1 [ ( 465) 882 101.6 4.9e-21 NP_004465 (OMIM: 602211) forkhead box protein D2 [ ( 495) 843 97.7 7.7e-20 NP_004464 (OMIM: 241850,602617,616534) forkhead bo ( 373) 707 84.0 7.8e-16 NP_036316 (OMIM: 611084) forkhead box protein D4-l ( 408) 700 83.4 1.3e-15 NP_954586 (OMIM: 611086) forkhead box protein D4-l ( 417) 685 81.9 3.8e-15 NP_954714 (OMIM: 611085) forkhead box protein D4-l ( 416) 683 81.7 4.4e-15 NP_997188 (OMIM: 601092) forkhead box protein D4 [ ( 439) 674 80.8 8.5e-15 NP_005242 (OMIM: 153400,602402) forkhead box prote ( 501) 620 75.5 3.9e-13 NP_036318 (OMIM: 107250,601094,610256) forkhead bo ( 319) 586 71.9 3e-12 NP_001443 (OMIM: 603250) forkhead box protein F2 [ ( 444) 575 70.9 8.1e-12 NP_075555 (OMIM: 110100,605597,608996) forkhead bo ( 376) 564 69.7 1.5e-11 NP_001444 (OMIM: 601090,601631,602482) forkhead bo ( 553) 560 69.5 2.6e-11 NP_005240 (OMIM: 164874,613454) forkhead box prote ( 489) 556 69.1 3.2e-11 NP_710141 (OMIM: 600288) hepatocyte nuclear factor ( 457) 548 68.2 5.3e-11 NP_068556 (OMIM: 600288) hepatocyte nuclear factor ( 463) 548 68.2 5.4e-11 NP_001129121 (OMIM: 612351) forkhead box protein I ( 420) 537 67.1 1.1e-10 NP_001442 (OMIM: 265380,601089) forkhead box prote ( 379) 526 66.0 2.2e-10 NP_004488 (OMIM: 602295) hepatocyte nuclear factor ( 350) 523 65.6 2.5e-10 NP_150285 (OMIM: 612788) forkhead box protein Q1 [ ( 403) 517 65.1 4.2e-10 NP_004109 (OMIM: 602939) forkhead box protein S1 [ ( 330) 514 64.7 4.5e-10 NP_005241 (OMIM: 603252) forkhead box protein L1 [ ( 345) 508 64.1 7e-10 NP_036320 (OMIM: 274600,600791,601093) forkhead bo ( 378) 492 62.6 2.3e-09 XP_016876735 (OMIM: 602294) PREDICTED: hepatocyte ( 439) 489 62.3 3.1e-09 NP_004487 (OMIM: 602294) hepatocyte nuclear factor ( 472) 489 62.4 3.2e-09 NP_001445 (OMIM: 602291) forkhead box protein J1 [ ( 421) 407 54.1 8.7e-07 NP_004505 (OMIM: 147685) forkhead box protein K2 [ ( 660) 398 53.4 2.2e-06 XP_011513493 (OMIM: 616302) PREDICTED: forkhead bo ( 570) 376 51.2 9.1e-06 NP_001032242 (OMIM: 616302) forkhead box protein K ( 733) 376 51.3 1.1e-05 XP_016856182 (OMIM: 616035) PREDICTED: forkhead bo ( 573) 367 50.3 1.7e-05 NP_001185781 (OMIM: 616035) forkhead box protein J ( 588) 367 50.3 1.7e-05 XP_006710522 (OMIM: 616035) PREDICTED: forkhead bo ( 596) 367 50.3 1.7e-05 XP_006710521 (OMIM: 616035) PREDICTED: forkhead bo ( 607) 361 49.7 2.7e-05 XP_011539328 (OMIM: 616035) PREDICTED: forkhead bo ( 622) 361 49.7 2.7e-05 NP_001185780 (OMIM: 616035) forkhead box protein J ( 622) 361 49.7 2.7e-05 NP_001185779 (OMIM: 616035) forkhead box protein J ( 622) 361 49.7 2.7e-05 NP_055762 (OMIM: 616035) forkhead box protein J3 i ( 622) 361 49.7 2.7e-05 XP_005270689 (OMIM: 616035) PREDICTED: forkhead bo ( 630) 361 49.7 2.7e-05 NP_001278210 (OMIM: 611457) forkhead box protein O ( 559) 335 47.1 0.00015 NP_658982 (OMIM: 274600,600791,601093) forkhead bo ( 283) 317 44.9 0.00034 NP_003914 (OMIM: 603621) forkhead box protein H1 [ ( 365) 309 44.3 0.0007 XP_011519236 (OMIM: 602341) PREDICTED: forkhead bo ( 433) 299 43.4 0.0016 NP_001230018 (OMIM: 602341) forkhead box protein M ( 747) 287 42.4 0.0052 NP_973732 (OMIM: 602341) forkhead box protein M1 i ( 748) 287 42.4 0.0052 NP_001230017 (OMIM: 602341) forkhead box protein M ( 748) 286 42.3 0.0055 XP_011519233 (OMIM: 602341) PREDICTED: forkhead bo ( 749) 286 42.3 0.0055 XP_016859447 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 279 41.4 0.0062 NP_002149 (OMIM: 143089) forkhead box protein N2 [ ( 431) 279 41.4 0.0062 XP_006712065 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 279 41.4 0.0062 XP_005264339 (OMIM: 143089) PREDICTED: forkhead bo ( 431) 279 41.4 0.0062 >>NP_036315 (OMIM: 607836,611539) forkhead box protein D (478 aa) initn: 3213 init1: 3213 opt: 3213 Z-score: 1756.1 bits: 334.3 E(85289): 4.5e-91 Smith-Waterman score: 3213; 100.0% identity (100.0% similar) in 478 aa overlap (1-478:1-478) 10 20 30 40 50 60 pF1KB9 MTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGPPELRLDEADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGPPELRLDEADE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 VPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GAGSGSAGGLAPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 GAGSGSAGGLAPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYRE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 KFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 QQEHLREQTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QQEHLREQTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 LQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 AGTTASLIKSEPSARPSFSIENIIGGGPAAPGGSAVGAGVAGGTGGSGGGSTAQSFLRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AGTTASLIKSEPSARPSFSIENIIGGGPAAPGGSAVGAGVAGGTGGSGGGSTAQSFLRPP 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 GTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 GTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ 430 440 450 460 470 >>NP_004463 (OMIM: 601091) forkhead box protein D1 [Homo (465 aa) initn: 766 init1: 766 opt: 882 Z-score: 498.6 bits: 101.6 E(85289): 4.9e-21 Smith-Waterman score: 1047; 45.7% identity (61.1% similar) in 486 aa overlap (1-447:1-446) 10 20 30 40 50 pF1KB9 MTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGP----PELRLD :::: :: :: ::..::::::::.: .:.. : . .:: : : NP_004 MTLS--TEMSDASG----LAEETDIDVVGEGEDEEDEEEEDDDEGGGGGPRLAVPAQRRR 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 EADEVPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGAS . . . .. . : :.:. : :: :: : . :: :: ::.. NP_004 RRRSYAGEDELEDLEEEEDDDDILLAPPAGGSPAPPG---PAPAAGAGAGGGGG--GGGA 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 GGGPGAGSGSAGGLAPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFP ::: .::::. :: ::::::::::::::::::::.:.:::: ::::::.::: NP_004 GGGGSAGSGA---------KNPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFP 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB9 YYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKR :::::::::::::::::::::::::::::::::::::::::::.: :::::::::::::: NP_004 YYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKR 170 180 190 200 210 220 240 250 260 270 pF1KB9 FKRHQ--QEHLREQTALMMQSFGAYSLAA--AAGAA---------------GPYGRPYGL :::. . .:.... :: . :. ::.:: :::: ::: NP_004 FKRQPLLPPNAAAAESLLLRGAGAAGGAGDPAAAAALFPPAPPPPPHAYGYGPYGCGYGL 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB9 HPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQL . : . :::::::::::. .:.. :: :: : ..::.: .::: . NP_004 QLPPYAPPSALFAAAAAAAAAAAF-HPHS-PP-----PPPPPHGAAAELAR--TAFGYRP 290 300 310 320 330 340 350 360 370 380 390 pF1KB9 GP-GLQLQLNSLGAAAAAAGTAGAAGTTASLIKSEPSARPSFSIENIIGG--GPAAPGGS : : : . : :.:: :: ::.. :: ::::.:::: :::: ... NP_004 HPLGAALP-GPLPASAAKAGGPGASAL----------ARSPFSIESIIGGSLGPAAAAAA 340 350 360 370 380 400 410 420 430 440 pF1KB9 AVGAGVAG-------------GTGGSGGGSTAQSFLRPPGTVQSAALMATHQPLSLSRTT :. :..:. . :.:::: .::. . : ... . . :. : .. NP_004 AAQAAAAAQASPSPSPVAAPPAPGSSGGGCAAQAAVGPAAALTRSLVAAAAAAASSVSSS 390 400 410 420 430 440 450 460 470 pF1KB9 ATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ :... . NP_004 AALGTLHQGTALSSVENFTARISNC 450 460 >>NP_004465 (OMIM: 602211) forkhead box protein D2 [Homo (495 aa) initn: 913 init1: 740 opt: 843 Z-score: 477.2 bits: 97.7 E(85289): 7.7e-20 Smith-Waterman score: 975; 42.7% identity (57.5% similar) in 485 aa overlap (10-434:12-472) 10 20 30 40 50 pF1KB9 MTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGPPELRLDEA :. :. ..:. :.:::::: :. : : . .:: : NP_004 MTLGSCCCEIMSSESSPAALSEADADIDVVGGGSGGGE-------LPARSGPRAPR---- 10 20 30 40 60 70 80 90 100 110 pF1KB9 DEVPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGPGGDV------GAPEADGCKGGVGGEE : .: ::. : .. : .. .:. :. :: : : : .. NP_004 DVLP-----HGHEPPAEEAEADLAEDEEESGGCSDGEPRALASRGAAAAAGSPGPGAAAA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 GGASGGGPGAGSGSAGGLAPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFIS ::.: ::: ::.:. .: ::::::::::::::::::::.:.:::: :::::: NP_004 RGAAGPGPGPPSGGAATRSP------LVKPPYSYIALITMAILQSPKKRLTLSEICEFIS 110 120 130 140 150 180 190 200 210 220 230 pF1KB9 NRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLR .::::::::::::::::::::::::::::::::::::::::::::::.: :::::::::: NP_004 GRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLR 160 170 180 190 200 210 240 250 260 270 pF1KB9 RRKRFKRHQ----QEHLREQTALMMQSFGAYSLAAAA-----GAAGPYGRPYGLH----- :::::::. . : . . :.... .: . .: .: : :: ::: NP_004 RRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYG 220 230 240 250 260 270 280 290 300 310 320 330 pF1KB9 ---PAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPS-----GELGRKA :. : . :: : : :::::: ..:: . :: : : : : NP_004 APPPGPAPHPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSAPAPA 280 290 300 310 320 330 340 350 360 370 pF1KB9 AAFGSQLGPG-------LQLQLNSLGAAAAAAGTAGAAGTTASL--------IKSEPSA- : :: ::: : .:. : ::. . ::::.:.: .:.. .. NP_004 PASGSGPGPGPAGLPAFLGAELGCAKAFYAASLSPPAAGTAAGLPTALLRQGLKTDAGGG 340 350 360 370 380 390 380 390 400 410 pF1KB9 ----------RPSFSIENIIG--GGPAAPGGSAVGAGVAG----GTGGSGGGSTAQSFLR ::::::..:.: :: ::: :. : : : ...: :: . . ..: NP_004 AGGGGAGAGQRPSFSIDHIMGHGGGGAAPPGA--GEGSPGPPFAAAAGPGGQAQVLAMLT 400 410 420 430 440 450 420 430 440 450 460 470 pF1KB9 PPGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ :. . :. . .: NP_004 APALAPVAGHIRLSHPGDALLSSGSRFASKVAGLSGCHF 460 470 480 490 >>NP_004464 (OMIM: 241850,602617,616534) forkhead box pr (373 aa) initn: 687 init1: 574 opt: 707 Z-score: 405.3 bits: 84.0 E(85289): 7.8e-16 Smith-Waterman score: 712; 44.1% identity (63.2% similar) in 345 aa overlap (112-434:24-342) 90 100 110 120 130 140 pF1KB9 PKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGPGAGSG-SAGGLAPSKPKNSLV : .:..: :: ..: .::: ..: . NP_004 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRG- 10 20 30 40 50 150 160 170 180 190 200 pF1KB9 KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFV ::::::::::.::: ..:...:::.:: .::..:::.::.. :::::::::.:::::. NP_004 KPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFL 60 70 80 90 100 110 210 220 230 240 250 260 pF1KB9 KIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYS ::::: : :::::::.:::..::::..:::::::::::: . : : : .. .: . NP_004 KIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSD---LSTYPAYMHDAAAAAA 120 130 140 150 160 270 280 290 300 310 pF1KB9 LAAAAGAAG-------PYGRPYGLHPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPV ::::.::. : .:: .:.:. ..:. :. :: . :: : : : NP_004 AAAAAAAAAAIFPGAVPAARPP--YPGAVYAGYAPPSLAA----PPPVYYPAASPGPCRV 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB9 --LPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSE : : :: : ::: . ::: . . : :: :...: :. : : . NP_004 FGLVPERPLSP--ELGPAPS------GPGGSCAFASAGAPATTTGYQPAGCTGA-----R 230 240 250 260 270 380 390 400 410 pF1KB9 PSARPSFSIENIIGGGPAAP--GGSAV--GAGVAGG-----TGGSGGG--STAQSFLRP- : : :: : : : .:::. .:: .: .:::.:: .:.. . : NP_004 P-ANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTS 280 290 300 310 320 420 430 440 450 460 470 pF1KB9 PGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ :: : .:: : ..: NP_004 PG--QFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM 330 340 350 360 370 >>NP_036316 (OMIM: 611084) forkhead box protein D4-like (408 aa) initn: 754 init1: 660 opt: 700 Z-score: 401.1 bits: 83.4 E(85289): 1.3e-15 Smith-Waterman score: 750; 45.2% identity (62.5% similar) in 347 aa overlap (106-410:65-405) 80 90 100 110 120 130 pF1KB9 QQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGPGAGS--GSAGGLAP- :::. . ::::. : :. : NP_036 DEDEVEDEEEEASQKFLEQSLQPGLQVARWGGVALPREHIEGGGPSDPSEFGTEFRAPPR 40 50 60 70 80 90 140 150 160 170 180 pF1KB9 ----SKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNS :. . .::::::::::::::::::.:.::::::: :::.::::::.:::::::: NP_036 SAAASEDARQPAKPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB9 IRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQE---HL :::::::::::::::::::.::::.::.::: :.::::::::::::::::::: :: NP_036 IRHNLSLNDCFVKIPREPGHPGKGTYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHL 160 170 180 190 200 210 250 260 270 280 pF1KB9 RE-------QTALMMQS----FGAYSLAAAAGAA----GPYGRPYGL-HPAAAAGAY-SH . ..:: .:: .: . .: .: :::.: :: : NP_036 PHPFPLPAAHAALHNPRPGPLLGAPALPQPVPGAYPNTAPGRRPYALLHPHPPRYLLLSA 220 230 240 250 260 270 290 300 310 320 330 340 pF1KB9 PAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPG-LQLQLNS :: :.: : . . : : . ::: :.. : : :. ...: : : ......: NP_036 PAYAGAPKKAEGAD--LATPGTLPVLQPSLGPQP-WEEGK---GLASPPGGGCISFSIES 280 290 300 310 320 350 360 370 380 390 pF1KB9 LGAAAAAAGTAGAAGTTASLIKSEPS-ARPSFSIENIIGGGPAAPGG--------SAVGA . .. .:::..: . . . . : ::: .:. . . :. :: .. :: NP_036 IMQGVRGAGTGAAQSLSPTAWSYCPLLQRPSSLSDNFAATAAASGGGLRQRLRSHQGRGA 330 340 350 360 370 380 400 410 420 430 440 450 pF1KB9 GVA-----GGTGGSGGGSTAQSFLRPPGTVQSAALMATHQPLSLSRTTATIAPILSVPLS : : :... :::: NP_036 GRAPVGRVGAAAVSGGGRGL 390 400 >>NP_954586 (OMIM: 611086) forkhead box protein D4-like (417 aa) initn: 734 init1: 666 opt: 685 Z-score: 392.9 bits: 81.9 E(85289): 3.8e-15 Smith-Waterman score: 700; 48.5% identity (61.2% similar) in 299 aa overlap (38-314:18-303) 10 20 30 40 50 60 pF1KB9 SASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGPPELRLDEADEVPPAAPH .::: : : : .. .: :: . NP_954 MNLPRAERLRSTPQRSLRDSD-GED---GKIDVLGEEEDEDEVEDEE 10 20 30 40 70 80 90 100 110 120 pF1KB9 HGQPQPPHQQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGPGAGSGSA .. : .: : : : .. : :. :. . .:: : . . : : :: NP_954 EAASQQFLEQSLQ-P----GLQVARWGGVALPR-EHIEGGGGPSDPSEFGTKFRAPPRSA 50 60 70 80 90 130 140 150 160 170 180 pF1KB9 GGLAPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQN : :. . .::::::::::::::::.:.:.::::::: :::.::::::.::::::: NP_954 ---AASEDARQPAKPPYSYIALITMAILQNPHKRLTLSGICAFISGRFPYYRRKFPAWQN 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB9 SIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQE---H ::::::::::::::::::::.:::::::.::: :.::::::::::::::::::: : NP_954 SIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAH 160 170 180 190 200 210 250 260 270 280 pF1KB9 LRE-------QTALMMQSFGAYSLAAAA-----GA---AGPYGRPYGL-HPAAAAGAY-S : . ..:: : : : :: ..: :::.: :: : NP_954 LPHPFPLPAAHAALHNPRPGPLLGAPAPPQPVPGAYPNTAPGRRPYALLHPHPLRYLLLS 220 230 240 250 260 270 290 300 310 320 330 340 pF1KB9 HPAAAAAA--AAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQL :. :.: : .::: : .: .: : NP_954 APVYAGAPKKAEGAALATPAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVLCKGS 280 290 300 310 320 330 >>NP_954714 (OMIM: 611085) forkhead box protein D4-like (416 aa) initn: 724 init1: 666 opt: 683 Z-score: 391.8 bits: 81.7 E(85289): 4.4e-15 Smith-Waterman score: 693; 54.7% identity (64.9% similar) in 225 aa overlap (106-322:65-265) 80 90 100 110 120 130 pF1KB9 QQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVG-GEEGGASGGGPGAGS--GSAGGLAP :::. .: .::::. : :. : NP_954 DEDEVEDEEEEARQQFLEQSLQPGLQVARWGGVALPREHIEGGGGPSDPSEFGTKFRAPP 40 50 60 70 80 90 140 150 160 170 180 pF1KB9 -----SKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQN :. . .::::::::::::::::.:.:.::::::: :::.::::::.::::::: NP_954 RSAAASEDARQPAKPPYSYIALITMAILQNPHKRLTLSGICAFISGRFPYYRRKFPAWQN 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB9 SIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLRE ::::::::::::::::::::.:::::::.::: :.::::::::::::::::::: NP_954 SIRHNLSLNDCFVKIPREPGHPGKGNYWSLDPASQDMFDNGSFLRRRKRFKRHQL----- 160 170 180 190 200 250 260 270 280 290 300 pF1KB9 QTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAALQYPYAL . :: :. :. : : :: ::. .: : : : NP_954 ----------------TPGAHLPH--PFPLPAAHAALHNPHPGPLLGAPAPPQ-PVPGAY 210 220 230 240 250 310 320 330 340 350 360 pF1KB9 PPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASL : .:: : . : : NP_954 PNTAPGRRPYALLHPHPLRYLLLSARVYAGAPKKAEGADLATPAPFPCCSPHLVLSLGRR 260 270 280 290 300 310 >>NP_997188 (OMIM: 601092) forkhead box protein D4 [Homo (439 aa) initn: 725 init1: 656 opt: 674 Z-score: 386.6 bits: 80.8 E(85289): 8.5e-15 Smith-Waterman score: 695; 54.8% identity (64.9% similar) in 239 aa overlap (106-314:61-299) 80 90 100 110 120 130 pF1KB9 QQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVG-GEEGGASGGGPGAGS--GSAGGLAP :::. .: .::::. : :. : NP_997 GEEEDEDEEEAASQQFLEQSLQPGLQVARWGGVALPREHIEGGGGPSDPSEFGTEFRAPP 40 50 60 70 80 90 140 150 160 170 180 pF1KB9 -----SKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQN :. . .::: ::::::::::::::.:.::::::: :::.::::::.::::::: NP_997 RSAAASEDARQPAKPPSSYIALITMAILQSPHKRLTLSGICAFISDRFPYYRRKFPAWQN 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB9 SIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQE---H :::::::::::::::::::: :::::::.::: :.:::::::::::::::.::: : NP_997 SIRHNLSLNDCFVKIPREPGRPGKGNYWSLDPASQDMFDNGSFLRRRKRFQRHQPTPGAH 160 170 180 190 200 210 250 260 270 280 pF1KB9 LRE-------QTALMMQSFGAYSLAAAA-----GA---AGPYGRPYGL-HPAAAAGAY-S : . ..:: : : : :: .:: :::.: :: : NP_997 LPHPFPLPAAHAALHNPRPGPLLGAPAPPQPVPGAYPNTGPGRRPYALLHPHPPRYLLLS 220 230 240 250 260 270 290 300 310 320 330 340 pF1KB9 HPAAAAAA--AAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQL :: :.: : .: : : .: .: : NP_997 APAYAGAPKKAEGADLATPAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVSCKGS 280 290 300 310 320 330 >>NP_005242 (OMIM: 153400,602402) forkhead box protein C (501 aa) initn: 633 init1: 546 opt: 620 Z-score: 356.8 bits: 75.5 E(85289): 3.9e-13 Smith-Waterman score: 636; 41.1% identity (60.5% similar) in 309 aa overlap (101-402:27-295) 80 90 100 110 120 130 pF1KB9 PQPPHQQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGPGAGSGSAGGL : : ::... : :: ..: . . NP_005 MQARYSVSDPNALGVVPYLSEQNYYRAAGSYGGMASPMGVYSGHPEQYSAGMGRSY 10 20 30 40 50 140 150 160 170 180 pF1KB9 AP------SKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPA :: . ::. :::::::::::::::: ..:.::.::.:: .:: .:::.:::. . NP_005 APYHHHQPAAPKD-LVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQG 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB9 WQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEH ::::::::::::.::::.::. .::::.::::::.: .::.::::::::.:::... . NP_005 WQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVSK 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB9 LREQTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAALQYP .:. : . . : : :::. :: ::. : : . NP_005 EKEERAHLKE---------------P---P----PAASKGA---PATPHLADAPKEAEKK 180 190 200 210 310 320 330 340 350 360 pF1KB9 YALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGAAGTT .. : ::.:.. . : :.: :: . .::.. ::. :. NP_005 VVIKSEAA--SPALPVITKVET----------LSPESALQGSPRSAASTPAGSPD--GSL 220 230 240 250 370 380 390 400 410 420 pF1KB9 ASLIKSEPSARPSFSIENIIGGGPAAPGGS-AVGAGVAGGTGGSGGGSTAQSFLRPPGTV . :.. :.::.:::. . ::: . ::: :: NP_005 PEHHAAAPNGLPGFSVENIMTLRTSPPGGELSPGAGRAGLVVPPLALPYAAAPPAAYGQP 260 270 280 290 300 310 430 440 450 460 470 pF1KB9 QSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ NP_005 CAQGLEAGAAGGYQCSMRAMSLYTGAERPAHMCVPPALDEALSDHPSGPTSPLSALNLAA 320 330 340 350 360 370 >>NP_036318 (OMIM: 107250,601094,610256) forkhead box pr (319 aa) initn: 612 init1: 537 opt: 586 Z-score: 340.8 bits: 71.9 E(85289): 3e-12 Smith-Waterman score: 614; 42.3% identity (56.1% similar) in 319 aa overlap (58-356:5-297) 30 40 50 60 70 80 pF1KB9 VGEGDDGLEEKDSDAGCDSPAGPPELRLDEADEVPPAAPHHGQPQPPHQQPLTLPKEAAG .: :::: : : : : . : . NP_036 MAGRSDMDPPAA-FSGFPALPAVAP-SGPPPSPL 10 20 30 90 100 110 120 130 140 pF1KB9 AGAGPGGDVGAPEADGCKGGVGGEEGGASGGGPGAGSGSAG-GLAPSKPKNSLVKPPYSY ::: :: . :: .:.: : .: . . : : .: . :::::: NP_036 AGAEPGRE---PEE------------AAAGRGEAAPTPAPGPGRRRRRPLQRG-KPPYSY 40 50 60 70 150 160 170 180 190 200 pF1KB9 IALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREP ::::.::. ..: ..:::..: .::..:: .::.. :::::::::.:::::::.:::: NP_036 IALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREP 80 90 100 110 120 130 210 220 230 240 250 260 pF1KB9 GNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSLAAAAG ::::::::::::: . ::::::::::::::::: . . : : : : NP_036 GNPGKGNYWTLDPAAADMFDNGSFLRRRKRFKRAELPAHAAAAPGPPLPFPYAPYAPAPG 140 150 160 170 180 190 270 280 290 300 pF1KB9 --------AAGPYGRP----------YGLHPAAAA-GAYSHPAAAAAAAAAAALQYPYAL .::: : .:.: :. :: : :: ::::: .: NP_036 PALLVPPPSAGPGPSPPARLFSVDSLVNLQPELAGLGAPEPPCCAAPDAAAAA--FP--- 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB9 PPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASL : .: . :: .:. .: :. : :: : .:.. ::: : NP_036 PCAAAASPPLYSQVPD-RLVLPATRPGP--GPLPAEPLLALAGPAAALGPLSPGEAYLRQ 260 270 280 290 300 370 380 390 400 410 420 pF1KB9 IKSEPSARPSFSIENIIGGGPAAPGGSAVGAGVAGGTGGSGGGSTAQSFLRPPGTVQSAA NP_036 PGFASGLERYL 310 478 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:34:55 2016 done: Fri Nov 4 17:34:57 2016 Total Scan time: 11.290 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]