FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9600, 373 aa 1>>>pF1KB9600 373 - 373 aa - 373 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.8316+/-0.000384; mu= -0.8575+/- 0.024 mean_var=404.0314+/-85.181, 0's: 0 Z-trim(124.0): 156 B-trim: 782 in 1/59 Lambda= 0.063807 statistics sampled from 44561 (44733) to 44561 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.798), E-opt: 0.2 (0.524), width: 16 Scan time: 10.460 The best scores are: opt bits E(85289) NP_004464 (OMIM: 241850,602617,616534) forkhead bo ( 373) 2582 251.3 2.8e-66 NP_036318 (OMIM: 107250,601094,610256) forkhead bo ( 319) 793 86.5 9.4e-17 NP_004463 (OMIM: 601091) forkhead box protein D1 [ ( 465) 739 81.7 3.7e-15 NP_004465 (OMIM: 602211) forkhead box protein D2 [ ( 495) 721 80.1 1.2e-14 NP_036315 (OMIM: 607836,611539) forkhead box prote ( 478) 707 78.8 2.9e-14 NP_075555 (OMIM: 110100,605597,608996) forkhead bo ( 376) 629 71.5 3.6e-12 NP_001444 (OMIM: 601090,601631,602482) forkhead bo ( 553) 629 71.7 4.6e-12 NP_954714 (OMIM: 611085) forkhead box protein D4-l ( 416) 617 70.4 8.3e-12 NP_954586 (OMIM: 611086) forkhead box protein D4-l ( 417) 608 69.6 1.5e-11 NP_036316 (OMIM: 611084) forkhead box protein D4-l ( 408) 607 69.5 1.6e-11 NP_997188 (OMIM: 601092) forkhead box protein D4 [ ( 439) 599 68.8 2.7e-11 NP_005241 (OMIM: 603252) forkhead box protein L1 [ ( 345) 593 68.1 3.4e-11 NP_005242 (OMIM: 153400,602402) forkhead box prote ( 501) 574 66.6 1.5e-10 NP_001443 (OMIM: 603250) forkhead box protein F2 [ ( 444) 567 65.9 2.1e-10 NP_004109 (OMIM: 602939) forkhead box protein S1 [ ( 330) 555 64.6 3.8e-10 NP_005240 (OMIM: 164874,613454) forkhead box prote ( 489) 546 64.0 8.6e-10 NP_004488 (OMIM: 602295) hepatocyte nuclear factor ( 350) 528 62.1 2.2e-09 NP_710141 (OMIM: 600288) hepatocyte nuclear factor ( 457) 527 62.2 2.8e-09 NP_068556 (OMIM: 600288) hepatocyte nuclear factor ( 463) 527 62.2 2.8e-09 NP_036320 (OMIM: 274600,600791,601093) forkhead bo ( 378) 523 61.7 3.2e-09 NP_001129121 (OMIM: 612351) forkhead box protein I ( 420) 511 60.7 7.3e-09 XP_016876735 (OMIM: 602294) PREDICTED: hepatocyte ( 439) 511 60.7 7.5e-09 NP_150285 (OMIM: 612788) forkhead box protein Q1 [ ( 403) 510 60.6 7.6e-09 NP_004487 (OMIM: 602294) hepatocyte nuclear factor ( 472) 511 60.7 7.8e-09 NP_001442 (OMIM: 265380,601089) forkhead box prote ( 379) 493 59.0 2.1e-08 NP_004505 (OMIM: 147685) forkhead box protein K2 [ ( 660) 445 54.8 6.5e-07 XP_011513493 (OMIM: 616302) PREDICTED: forkhead bo ( 570) 409 51.4 5.9e-06 NP_001032242 (OMIM: 616302) forkhead box protein K ( 733) 409 51.6 6.9e-06 XP_006710521 (OMIM: 616035) PREDICTED: forkhead bo ( 607) 379 48.7 4.2e-05 NP_001185780 (OMIM: 616035) forkhead box protein J ( 622) 379 48.7 4.2e-05 XP_011539328 (OMIM: 616035) PREDICTED: forkhead bo ( 622) 379 48.7 4.2e-05 NP_055762 (OMIM: 616035) forkhead box protein J3 i ( 622) 379 48.7 4.2e-05 NP_001185779 (OMIM: 616035) forkhead box protein J ( 622) 379 48.7 4.2e-05 XP_005270689 (OMIM: 616035) PREDICTED: forkhead bo ( 630) 379 48.7 4.3e-05 NP_001445 (OMIM: 602291) forkhead box protein J1 [ ( 421) 370 47.7 5.9e-05 XP_016856182 (OMIM: 616035) PREDICTED: forkhead bo ( 573) 372 48.0 6.3e-05 NP_001185781 (OMIM: 616035) forkhead box protein J ( 588) 372 48.1 6.4e-05 XP_006710522 (OMIM: 616035) PREDICTED: forkhead bo ( 596) 372 48.1 6.4e-05 NP_003914 (OMIM: 603621) forkhead box protein H1 [ ( 365) 357 46.4 0.00012 NP_001078940 (OMIM: 602628) forkhead box protein N ( 490) 324 43.5 0.0012 NP_658982 (OMIM: 274600,600791,601093) forkhead bo ( 283) 315 42.4 0.0015 NP_005188 (OMIM: 602628) forkhead box protein N3 i ( 468) 318 43.0 0.0017 XP_011523670 (OMIM: 600838,601705) PREDICTED: fork ( 436) 314 42.6 0.0021 XP_011523671 (OMIM: 600838,601705) PREDICTED: fork ( 436) 314 42.6 0.0021 XP_011523672 (OMIM: 600838,601705) PREDICTED: fork ( 436) 314 42.6 0.0021 XP_011523669 (OMIM: 600838,601705) PREDICTED: fork ( 462) 314 42.6 0.0022 XP_005258103 (OMIM: 600838,601705) PREDICTED: fork ( 648) 314 42.8 0.0027 XP_016880717 (OMIM: 600838,601705) PREDICTED: fork ( 648) 314 42.8 0.0027 NP_003584 (OMIM: 600838,601705) forkhead box prote ( 648) 314 42.8 0.0027 XP_011523664 (OMIM: 600838,601705) PREDICTED: fork ( 648) 314 42.8 0.0027 >>NP_004464 (OMIM: 241850,602617,616534) forkhead box pr (373 aa) initn: 2582 init1: 2582 opt: 2582 Z-score: 1311.0 bits: 251.3 E(85289): 2.8e-66 Smith-Waterman score: 2582; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KB9 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 FPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 SGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAA 310 320 330 340 350 360 370 pF1KB9 AYPGGIDRFVSAM ::::::::::::: NP_004 AYPGGIDRFVSAM 370 >>NP_036318 (OMIM: 107250,601094,610256) forkhead box pr (319 aa) initn: 766 init1: 697 opt: 793 Z-score: 421.8 bits: 86.5 E(85289): 9.4e-17 Smith-Waterman score: 857; 51.7% identity (63.5% similar) in 323 aa overlap (3-309:23-301) 10 20 30 pF1KB9 MTAESGPPPPQPEVLATVKEERGETAAGAG--VPGEATGR : ::::: .: . : .: :.::: : .: : : NP_036 MAGRSDMDPPAAFSGFPALPAVAPSGPPP-SPLAGAEPGREPEEAAAGRGEAAPTPAPG- 10 20 30 40 50 40 50 60 70 80 90 pF1KB9 GAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQ ::::.:::::::::::::::::::.:::: :::::..::.:::::: ::::.:.::: NP_036 --PGRRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQ 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB9 NSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYP :::::::::::::.:.::: : :::::::.::: : :::..::::::::::::..: : NP_036 NSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRKRFKRAEL---P 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB9 AYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAP---PSLAAPPPVYYPA : : ::: :: :: : :: ::: :.: .::: :. NP_036 A--HAAAA---------------PG------PPLPFP-YAPYAPAPGPALLVPPPSAGPG 180 190 200 220 230 240 250 260 270 pF1KB9 ASPGPCRVFGLVPERPLSPELGP--APSGPGGSCAFASAGAPATTTGYQPAGCTGARPAN :: : :.:.. :.:::. :: : :: .:.: : . : :..: :. NP_036 PSP-PARLFSVDSLVNLQPELAGLGAPEPP--CCAAPDAAAAA----FPP--CAAA--AS 210 220 230 240 250 280 290 300 310 320 pF1KB9 PSAYA---------AAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDF : :. :. :: : : :. . :. : :: :: NP_036 PPLYSQVPDRLVLPATRPGP-GPLPAEPLLALAGPAAAL-GPLSPGEAYLRQPGFASGLE 260 270 280 290 300 310 330 340 350 360 370 pF1KB9 YGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM NP_036 RYL >>NP_004463 (OMIM: 601091) forkhead box protein D1 [Homo (465 aa) initn: 553 init1: 553 opt: 739 Z-score: 393.1 bits: 81.7 E(85289): 3.7e-15 Smith-Waterman score: 751; 41.6% identity (60.8% similar) in 365 aa overlap (3-353:83-414) 10 20 30 pF1KB9 MTAESGPPPPQPEVLATVKEERGETAAGAGVP : ..: :: : : : :.:.: NP_004 RRRRRSYAGEDELEDLEEEEDDDDILLAPPAGGSPAPPGPAPAA------GAGAGGGGGG 60 70 80 90 100 40 50 60 70 80 90 pF1KB9 GEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRD : : : :..: : :: ::::::::::.::: ..:..::::. : .::. :::.::. NP_004 GGAGGGGSAGSGAKNPLV--KPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYRE 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB9 NPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRS . :::::::::.:::::.::::: : :::::::.:::.. :::..::::::::::::. NP_004 KFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQ 170 180 190 200 210 220 160 170 180 190 200 pF1KB9 DL-----STYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAP----- : .. . . .:.::..:. :::::.:: :: :: : .: ::.: NP_004 PLLPPNAAAAESLLLRGAGAAGGAGDPAAAAALFP---PA--PPPPPHAY-GYGPYGCGY 230 240 250 260 270 210 220 230 240 250 pF1KB9 ----PSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATT : : : .. ::. . .: .: :: : : : : :.: :. NP_004 GLQLPPYAPPSALFAAAAAAAAAAAF-----HPHSP---PPPPPPHG----AAAELARTA 280 290 300 310 320 260 270 280 290 300 310 pF1KB9 TGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGV ::.: .: :. : :: .:: .. . .: . : :::. :....... NP_004 FGYRPHPLGAALPGPLPASAAKAGGPGASALARSPFSIESIIGGSLGPAAAAAAAAQAAA 330 340 350 360 370 380 320 330 340 350 360 370 pF1KB9 ETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM . .. ::. .: : ::.. :: .: : NP_004 AAQAS----PSPSPVAAPPA---PGSSGGGCAAQAAVGPAAALTRSLVAAAAAAASSVSS 390 400 410 420 430 NP_004 SAALGTLHQGTALSSVENFTARISNC 440 450 460 >>NP_004465 (OMIM: 602211) forkhead box protein D2 [Homo (495 aa) initn: 536 init1: 536 opt: 721 Z-score: 383.8 bits: 80.1 E(85289): 1.2e-14 Smith-Waterman score: 763; 42.0% identity (59.8% similar) in 388 aa overlap (4-365:73-423) 10 20 30 pF1KB9 MTAESGP-PPPQPEVLATVKEERGETAA-GAGV ::: .:..::. :: .:: :. NP_004 SGPRAPRDVLPHGHEPPAEEAEADLAEDEEESGGCSDGEPRALAS----RGAAAAAGSPG 50 60 70 80 90 40 50 60 70 80 pF1KB9 PGEATGRGA---------GGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKF :: :..::: :: . :: ::::::::::.::: ..:..::::. : .: NP_004 PGAAAARGAAGPGPGPPSGGAATRSPLV--KPPYSYIALITMAILQSPKKRLTLSEICEF 100 110 120 130 140 150 90 100 110 120 130 140 pF1KB9 ITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSF :. :::.::.. :::::::::.:::::.::::: : :::::::.:::.. :::..::: NP_004 ISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSF 160 170 180 190 200 210 150 160 170 180 190 pF1KB9 LRRRKRFKRSDLST-YP-AYMHDAAAAAAAAAAAAAAAAIFPG--AVPAARPPYPGAVYA :::::::::. : .: . : ..::::. .:..:: : : : :. : NP_004 LRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPA 220 230 240 250 260 270 200 210 220 230 240 250 pF1KB9 GYAPPSLAAPPPVYYP-------AASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFAS ::: :: : .: ::. .::.. .. : : .: : :: . .::. NP_004 YGAPPPGPAPHPHPHPHAFAFAAAAAAAPCQL-SVPPGRAAAP-----PPGPPTASVFAG 280 290 300 310 320 330 260 270 280 290 300 310 pF1KB9 AG-APATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPP :: ::: :: .:. :. : :: : : :. . : . :. ::: NP_004 AGSAPA------PAPASGSGPG-P--------GPAG-LPAFLGAELGCAKAFYAASLSPP 340 350 360 370 320 330 340 350 360 pF1KB9 AGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAG---AYHARHAAAYPGGID :.:...:. :.. : . . :: :: :::.:: .. : .. :: NP_004 AAGTAAGLPTALLRQGLKTDAGGGA-------GG--GGAGAGQRPSFSIDHIMGHGGGGA 380 390 400 410 420 370 pF1KB9 RFVSAM NP_004 APPGAGEGSPGPPFAAAAGPGGQAQVLAMLTAPALAPVAGHIRLSHPGDALLSSGSRFAS 430 440 450 460 470 480 >>NP_036315 (OMIM: 607836,611539) forkhead box protein D (478 aa) initn: 687 init1: 574 opt: 707 Z-score: 377.0 bits: 78.8 E(85289): 2.9e-14 Smith-Waterman score: 712; 44.1% identity (63.2% similar) in 345 aa overlap (24-342:112-434) 10 20 30 40 50 pF1KB9 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRG- : .:..: :: ..: .::: ..: . NP_036 PKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGPGAGSG-SAGGLAPSKPKNSLV 90 100 110 120 130 140 60 70 80 90 100 110 pF1KB9 KPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFL ::::::::::.::: ..:...:::.:: .::..:::.::.. :::::::::.:::::. NP_036 KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFV 150 160 170 180 190 200 120 130 140 150 160 pF1KB9 KIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSD---LSTYPAYMHDAAAAAA ::::: : :::::::.:::..::::..:::::::::::: . : : : .. .: . NP_036 KIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYS 210 220 230 240 250 260 170 180 190 200 210 220 pF1KB9 AAAAAAAAAAIFPGAVPAARPP--YPGAVYAGYAPPSLAAPPP----VYYPAASPGPCRV ::::.::. : .:: .:.:. ..:. :. :: . :: : : : NP_036 LAAAAGAAG-------PYGRPYGLHPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPV 270 280 290 300 310 230 240 250 260 270 pF1KB9 FGLVPERPLSP--ELGPAPS------GPGGSCAFASAGAPATTTGYQPAGCTGA-----R : : :: : ::: . ::: . . : :: :...: :. : : . NP_036 --LPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSE 320 330 340 350 360 370 280 290 300 310 320 pF1KB9 P-ANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTS : : :: : : : .:::. .:: .: .:::.:: .:.. . : NP_036 PSARPSFSIENIIGGGPAAP--GGSAV--GAGVAGG-----TGGSGGG--STAQSFLRP- 380 390 400 410 330 340 350 360 370 pF1KB9 PG--QFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM :: : .:: : ..: NP_036 PGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ 420 430 440 450 460 470 >>NP_075555 (OMIM: 110100,605597,608996) forkhead box pr (376 aa) initn: 678 init1: 496 opt: 629 Z-score: 339.4 bits: 71.5 E(85289): 3.6e-12 Smith-Waterman score: 629; 36.9% identity (60.3% similar) in 320 aa overlap (12-330:18-324) 10 20 30 40 50 pF1KB9 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKP ::. :::: .: . ::.. : :.:: ..: :: NP_075 MMASYPEPEDAAGALLAPETGRTVKEPEGPPPS----PGKGGG-GGGGTAPEKPDPAQKP 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 PYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKI ::::.::::::: .. :.::::.:::..: .::::. : : :::::::::.::.::.:. NP_075 PYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 PREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAA :::.: :::::.::: :::::.:.. :::.:.:: . ::... . . .:..:: NP_075 PREGGGERKGNYWTLDPACEDMFEKGNY-RRRRRMKRP-FRPPPAHFQPGKGLFGAGGAA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 AAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAP-PPVYYPAASPGPCRVFGLVPERPLS .. .. :: . : . .:. : : :: .: :: :.. . . . NP_075 GGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYAS---CQM-AAAAAAAAA 180 190 200 210 220 240 250 260 270 280 290 pF1KB9 PELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAG . .:..::.. . . ..::.. : . : : . . .:: .: : NP_075 AAAAAGPGSPGAAAVVKGLAGPAASYGPYTRVQSMALPPGVVNSYNGLGGPPAAPPPPPH 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB9 SAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGA : .: . :.:: . :. . :. :: NP_075 PHPHPHAHHLHAAAAPPPAPPHHGAAAPPP--GQLSPASPATAAPPAPAPTSAPGLQFAC 290 300 310 320 330 340 360 370 pF1KB9 YHARHAAAYPGGIDRFVSAM NP_075 ARQPELAMMHCSYWDHDSKTGALHSRLDL 350 360 370 >>NP_001444 (OMIM: 601090,601631,602482) forkhead box pr (553 aa) initn: 684 init1: 540 opt: 629 Z-score: 337.5 bits: 71.7 E(85289): 4.6e-12 Smith-Waterman score: 641; 37.3% identity (56.9% similar) in 362 aa overlap (32-369:57-393) 10 20 30 40 50 60 pF1KB9 TAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRR-RKRPLQRGKPPYSYIA :: . .:. : . .: . :::::::: NP_001 RAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPG-GMARAYGPYTPQPQPKDMVKPPYSYIA 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB9 LIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGR ::.::: .::....::.:::.:: .:::::::: . :::::::::.::.::.:.::. . NP_001 LITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKK 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB9 PGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAI ::::.::.:::.. .:::.:::::::.:::..: .. .: NP_001 PGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKD-AVKDKEEKDRLHLKEPPP-------- 150 160 170 180 190 190 200 210 220 230 pF1KB9 FPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASP--GPCRVFGLVPERPLSPE--L :: : :: : : :: :::: . : : : .:::: : NP_001 -PGRQP---PPAPPEQADGNAPG--PQPPPVRIQDIKTENGTCP----SPPQPLSPAAAL 200 210 220 230 240 240 250 260 270 280 pF1KB9 G-------PAPSGPGGSCAFASAGA--PATTTGYQPAGCTGAR----PANPSAYAAAYA- : : .: .: . :.:. :.. . .: . :: : ::: .. NP_001 GSGSAAAVPKIESPDSSSSSLSSGSSPPGSLPSARPLSLDGADSAPPPPAPSAPPPHHSQ 250 260 270 280 290 300 290 300 310 320 330 pF1KB9 --GPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGA-C . :. . . :: ::: .: . :..: .:. . . : :::: . .. : NP_001 GFSVDNIMTSLRGSPQSAAAELSSGLLASAAASSRAGIAPPLAL-GAYSPGQSSLYSSPC 310 320 330 340 350 360 340 350 360 370 pF1KB9 Y--NPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM . .:. ::...:: ::. :: . NP_001 SQTSSAGSSGGGGGGA----GAAGGAGGAGTYHCNLQAMSLYAAGERGGHLQGAPGGAGG 370 380 390 400 410 420 NP_001 SAVDDPLPDYSLPPVTSSSSSSLSHGGGGGGGGGGQEAGHHPAAHQGRLTSWYLNQAGGD 430 440 450 460 470 480 >>NP_954714 (OMIM: 611085) forkhead box protein D4-like (416 aa) initn: 566 init1: 544 opt: 617 Z-score: 332.9 bits: 70.4 E(85289): 8.3e-12 Smith-Waterman score: 617; 49.3% identity (67.0% similar) in 215 aa overlap (30-240:87-295) 10 20 30 40 50 pF1KB9 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYI :. .: :.:.. . : : .::::::: NP_954 PGLQVARWGGVALPREHIEGGGGPSDPSEFGTKFRAPPRSAAASEDAR--QPAKPPYSYI 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB9 ALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAG :::.::: . :..::::.:: ::. :::.:: . :::::::::.:::::.::::: : NP_954 ALITMAILQNPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPG 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB9 RPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAA .:::::::.::: ..:::..:::::::::::: .:. : :: :: . NP_954 HPGKGNYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHLPHPFPLPAAHAALHNPHPG 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB9 IFPGAVPAARPPYPGA---VYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPEL . :: :: : ::: . : : .: : :. : : ::.. .:.. . .: NP_954 PLLGA-PAPPQPVPGAYPNTAPGRRPYALLHPHPLRYLLLSA---RVYAGAPKKAEGADL 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB9 G-PAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSA . ::: NP_954 ATPAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVLCKGSGERVQGLRRVCPRPRG 300 310 320 330 340 350 >>NP_954586 (OMIM: 611086) forkhead box protein D4-like (417 aa) initn: 544 init1: 544 opt: 608 Z-score: 328.4 bits: 69.6 E(85289): 1.5e-11 Smith-Waterman score: 608; 49.3% identity (67.0% similar) in 215 aa overlap (30-240:87-295) 10 20 30 40 50 pF1KB9 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYI :. .: :.:.. . : : .::::::: NP_954 PGLQVARWGGVALPREHIEGGGGPSDPSEFGTKFRAPPRSAAASEDAR--QPAKPPYSYI 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB9 ALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAG :::.::: . :..::::.:: ::. :::.:: . :::::::::.:::::.::::: : NP_954 ALITMAILQNPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPG 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB9 RPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAA .:::::::.::: ..:::..:::::::::::: .:. : :: :: . NP_954 HPGKGNYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHLPHPFPLPAAHAALHNPRPG 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB9 IFPGAVPAARPPYPGA---VYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPEL . :: :: : ::: . : : .: : :. : : .: :.. .:.. . : NP_954 PLLGA-PAPPQPVPGAYPNTAPGRRPYALLHPHPLRYLLLS-AP--VYAGAPKKAEGAAL 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB9 G-PAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSA . ::: NP_954 ATPAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVLCKGSGERVQGLRRICPRPRG 300 310 320 330 340 350 >>NP_036316 (OMIM: 611084) forkhead box protein D4-like (408 aa) initn: 574 init1: 538 opt: 607 Z-score: 328.0 bits: 69.5 E(85289): 1.6e-11 Smith-Waterman score: 667; 40.6% identity (58.5% similar) in 342 aa overlap (30-350:86-400) 10 20 30 40 50 pF1KB9 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYI :. .: :.:.. . : : .::::::: NP_036 QPGLQVARWGGVALPREHIEGGGPSDPSEFGTEFRAPPRSAAASEDAR--QPAKPPYSYI 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB9 ALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAG :::.::: ..:..::::.:: ::. :::.:: . :::::::::.:::::.::::: : NP_036 ALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLSLNDCFVKIPREPG 120 130 140 150 160 170 120 130 140 150 160 170 pF1KB9 RPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAA .::::.::.::: ..:::..:::::::::::: .:. : :: :: . NP_036 HPGKGTYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHLPHPFPLPAAHAALHNPRPG 180 190 200 210 220 230 180 190 200 210 220 230 pF1KB9 IFPGAVPAARPPYPGA---VYAGYAPPSLAAP-PPVYY----PAASPGPCRVFGLVPERP . :: :: : ::: . : : .: : :: : :: . .: .. : : NP_036 PLLGA-PALPQPVPGAYPNTAPGRRPYALLHPHPPRYLLLSAPAYAGAPKKAEGADLATP 240 250 260 270 280 290 240 250 260 270 pF1KB9 -----LSPELGPAP--------SGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYA :.: ::: : : :::.: : . . : . :: .:. .:.:.. NP_036 GTLPVLQPSLGPQPWEEGKGLASPPGGGC--ISFSIESIMQGVRGAGTGAAQSLSPTAWS 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB9 AAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGA : :.. : :::. :..:.::.. . :. :. :: NP_036 YC---PLLQRPSSL-SDNFAAT----------AAASGGGLRQRL----RSHQGR----GA 360 370 380 340 350 360 370 pF1KB9 CYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM : :..:.:. NP_036 GRAPVGRVGAAAVSGGGRGL 390 400 373 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:36:49 2016 done: Fri Nov 4 17:36:51 2016 Total Scan time: 10.460 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]