FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9610, 523 aa 1>>>pF1KB9610 523 - 523 aa - 523 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6872+/-0.000401; mu= 3.1479+/- 0.025 mean_var=184.6968+/-36.797, 0's: 0 Z-trim(119.2): 71 B-trim: 1027 in 1/59 Lambda= 0.094372 statistics sampled from 32941 (33013) to 32941 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.73), E-opt: 0.2 (0.387), width: 16 Scan time: 8.130 The best scores are: opt bits E(85289) NP_060509 (OMIM: 609766) lysine-specific demethyla ( 523) 3644 508.6 1.9e-143 NP_001155102 (OMIM: 616581) lysine-specific demeth ( 506) 2197 311.5 3.7e-84 NP_055830 (OMIM: 609765) lysine-specific demethyla (1096) 1909 272.5 4.4e-72 XP_016881993 (OMIM: 609765) PREDICTED: lysine-spec ( 473) 1898 270.8 6.3e-72 XP_005259578 (OMIM: 609765) PREDICTED: lysine-spec (1130) 1898 271.0 1.3e-71 XP_016881992 (OMIM: 609765) PREDICTED: lysine-spec (1130) 1898 271.0 1.3e-71 XP_011526120 (OMIM: 609765) PREDICTED: lysine-spec ( 429) 1880 268.3 3.2e-71 XP_016869993 (OMIM: 605469) PREDICTED: lysine-spec ( 763) 1734 248.6 4.9e-65 XP_016869992 (OMIM: 605469) PREDICTED: lysine-spec ( 793) 1734 248.6 5.1e-65 XP_016869991 (OMIM: 605469) PREDICTED: lysine-spec ( 811) 1734 248.6 5.2e-65 NP_001140167 (OMIM: 605469) lysine-specific demeth ( 813) 1734 248.6 5.2e-65 NP_001140168 (OMIM: 605469) lysine-specific demeth ( 835) 1734 248.6 5.3e-65 XP_016869987 (OMIM: 605469) PREDICTED: lysine-spec ( 999) 1734 248.7 6.1e-65 NP_001291268 (OMIM: 605469) lysine-specific demeth (1023) 1734 248.7 6.3e-65 NP_055876 (OMIM: 605469) lysine-specific demethyla (1056) 1734 248.7 6.4e-65 XP_006716804 (OMIM: 605469) PREDICTED: lysine-spec (1089) 1734 248.7 6.6e-65 XP_005271412 (OMIM: 609764) PREDICTED: lysine-spec (1064) 1713 245.8 4.7e-64 NP_055478 (OMIM: 609764) lysine-specific demethyla (1064) 1713 245.8 4.7e-64 XP_005271411 (OMIM: 609764) PREDICTED: lysine-spec (1064) 1713 245.8 4.7e-64 XP_011526124 (OMIM: 609765) PREDICTED: lysine-spec ( 312) 1668 239.4 1.2e-62 XP_016881994 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 1668 239.4 1.3e-62 XP_011526123 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 1668 239.4 1.3e-62 XP_011526121 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 1668 239.4 1.3e-62 XP_011526122 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 1668 239.4 1.3e-62 XP_011526116 (OMIM: 609765) PREDICTED: lysine-spec (1038) 1461 211.5 9.8e-54 XP_016858401 (OMIM: 609764) PREDICTED: lysine-spec ( 973) 1333 194.1 1.6e-48 XP_005271413 (OMIM: 609764) PREDICTED: lysine-spec ( 973) 1333 194.1 1.6e-48 XP_016869988 (OMIM: 605469) PREDICTED: lysine-spec ( 949) 1103 162.8 4.3e-39 NP_001291269 (OMIM: 605469) lysine-specific demeth ( 801) 936 140.0 2.6e-32 XP_016869989 (OMIM: 605469) PREDICTED: lysine-spec ( 908) 936 140.0 2.9e-32 XP_011516113 (OMIM: 605469) PREDICTED: lysine-spec ( 908) 936 140.0 2.9e-32 XP_016869990 (OMIM: 605469) PREDICTED: lysine-spec ( 858) 726 111.4 1.1e-23 XP_011516114 (OMIM: 605469) PREDICTED: lysine-spec ( 886) 726 111.4 1.1e-23 NP_001291270 (OMIM: 605469) lysine-specific demeth ( 151) 632 98.2 1.9e-20 NP_001036068 (OMIM: 180202) lysine-specific demeth (1690) 494 80.0 6.3e-14 NP_001140177 (OMIM: 415000,426000) lysine-specific (1570) 489 79.3 9.4e-14 XP_011529133 (OMIM: 300534,314690) PREDICTED: lysi (1232) 466 76.1 6.8e-13 NP_001140174 (OMIM: 300534,314690) lysine-specific (1379) 466 76.1 7.4e-13 XP_011529131 (OMIM: 300534,314690) PREDICTED: lysi (1395) 466 76.1 7.5e-13 XP_011529132 (OMIM: 300534,314690) PREDICTED: lysi (1395) 466 76.1 7.5e-13 XP_016885378 (OMIM: 300534,314690) PREDICTED: lysi (1444) 466 76.1 7.7e-13 XP_011529130 (OMIM: 300534,314690) PREDICTED: lysi (1447) 466 76.1 7.7e-13 XP_016885377 (OMIM: 300534,314690) PREDICTED: lysi (1448) 466 76.1 7.7e-13 XP_016885376 (OMIM: 300534,314690) PREDICTED: lysi (1449) 466 76.1 7.8e-13 XP_016885375 (OMIM: 300534,314690) PREDICTED: lysi (1451) 466 76.1 7.8e-13 XP_011529129 (OMIM: 300534,314690) PREDICTED: lysi (1452) 466 76.1 7.8e-13 XP_011529128 (OMIM: 300534,314690) PREDICTED: lysi (1516) 466 76.2 8e-13 XP_011529127 (OMIM: 300534,314690) PREDICTED: lysi (1519) 466 76.2 8.1e-13 XP_011529126 (OMIM: 300534,314690) PREDICTED: lysi (1534) 466 76.2 8.1e-13 XP_005262092 (OMIM: 300534,314690) PREDICTED: lysi (1557) 466 76.2 8.2e-13 >>NP_060509 (OMIM: 609766) lysine-specific demethylase 4 (523 aa) initn: 3644 init1: 3644 opt: 3644 Z-score: 2696.4 bits: 508.6 E(85289): 1.9e-143 Smith-Waterman score: 3644; 100.0% identity (100.0% similar) in 523 aa overlap (1-523:1-523) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 AAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 AAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTT 430 440 450 460 470 480 490 500 510 520 pF1KB9 CTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP ::::::::::::::::::::::::::::::::::::::::::: NP_060 CTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP 490 500 510 520 >>NP_001155102 (OMIM: 616581) lysine-specific demethylas (506 aa) initn: 2261 init1: 2123 opt: 2197 Z-score: 1631.9 bits: 311.5 E(85289): 3.7e-84 Smith-Waterman score: 2219; 67.6% identity (80.3% similar) in 513 aa overlap (4-494:1-499) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR ::: . :: . .:: :.:: ::: ::. :.:::::::::.:::::.::::::::: NP_001 MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKAR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED . ::.: .::::::::::.::..::::::::::::: ::.::.::::::::::::::: : NP_001 QMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFAD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL ::..:::.. : ::::::::::::.:.:::::::::::: ::::.:::::::::::::: NP_001 LEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.:::::::::::::::.:::::::::: :::: : NP_001 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::::::::::::::::::: .:::::::::::::::::::::::::::::::::::: NP_001 FLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST ::::::::::::::. :::::: ::::.::: :.:::. :: :.:.: :::: :::::. NP_001 IDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSN 300 310 320 330 340 350 370 380 390 400 410 pF1KB9 QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLV-CSSLPRRSAVSGTATQPR .. . :::::::: ::. :. :.. :: .:.. :.. .:: :.: : NP_001 WRDDIVLRRAALGLRLLPNLTAQCPTQPVS--SG-HCYNPKGCGT----DAVPGSAFQ-- 360 370 380 390 400 420 430 440 450 pF1KB9 AAAVHSSKKPSSTPSSTPGPSAQIIHPSNGR----RGRGRPP----------------QK ..: :.. : : : : ::... ::.: ::::: .. NP_001 SSAYHTQ-----TQSLTLGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRE 410 420 430 440 450 460 460 470 480 490 500 510 pF1KB9 LRAQELTLQTPAKRPLLAGTTCTASGPEPE-PLPEDGALMDKPVPLSPGLQHPVKASGCS : ..: :.: .:: :: :: :.: .:. :: .: NP_001 LGTEEPTVQPASKRRLLMGTRSRAQGHRPQLPLANDLMTNLSL 470 480 490 500 520 pF1KB9 WAPVP >>NP_055830 (OMIM: 609765) lysine-specific demethylase 4 (1096 aa) initn: 1962 init1: 1882 opt: 1909 Z-score: 1415.0 bits: 272.5 E(85289): 4.4e-72 Smith-Waterman score: 1929; 54.8% identity (74.9% similar) in 546 aa overlap (4-515:1-539) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR : :. . ::::.:.:: :.:: :::.::.::.::.:::::::::::::::::::: : NP_055 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED .:::.:....: .:.:::..:..:.::::. .::::::::::.::::.:: :: ::.:.: NP_055 QTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::: . ::::::::::::.:... :::.: : :: :..:.:::..::::::::: NP_055 LERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.::::.::..:::::.:::::: .:::::.:: : NP_055 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::..:::: .::. ::::.::::::::::.::::::::::::::::::. :::: :: NP_055 FLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::.:.::.: . : .:::.::::::::::.:::.:.: .:.:: .: . .: :::. NP_055 IDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSS 300 310 320 330 340 350 370 380 390 400 410 pF1KB9 QKEVQLPRRAALGLRQLPSHWARHSPW------PMAARSGTRCHTLVCSSLPRRSAVSGT . . .: : ::. :: : .: : :: .:. . . .: NP_055 WSASRASLKAKL-LRR--SHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGP 360 370 380 390 400 410 420 430 440 450 pF1KB9 ATQPRAAAVHSSKKPSSTPSSTPGPSAQ-----IIHPSNGRRGRGR------------PP ..:. . ..:. : . . .:. ..:.... : . :: NP_055 EVDPE----EEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPP 420 430 440 450 460 470 460 470 480 490 500 pF1KB9 QKLRAQE-LTLQTPAKRPLLA-GTTCTASGPEPEPL----PE--DGALMDKPVPLSPGLQ .. ..: : : .: . :.:. : . .: : :: :: . : :: :. : : NP_055 AHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLY 480 490 500 510 520 530 510 520 pF1KB9 ---HPVKASGCSWAPVP .: ::. NP_055 VVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKAR 540 550 560 570 580 590 >>XP_016881993 (OMIM: 609765) PREDICTED: lysine-specific (473 aa) initn: 1926 init1: 1897 opt: 1898 Z-score: 1412.3 bits: 270.8 E(85289): 6.3e-72 Smith-Waterman score: 1898; 68.5% identity (87.5% similar) in 384 aa overlap (4-387:1-382) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR : :. . ::::.:.:: :.:: :::.::.::.::.:::::::::::::::::::: : XP_016 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED .:::.:....: .:.:::..:..:.::::. .::::::::::.::::.:: :: ::.:.: XP_016 QTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::: . ::::::::::::.:... :::.: : :: :..:.:::..::::::::: XP_016 LERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.::::.::..:::::.:::::: .:::::.:: : XP_016 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::..:::: .::. ::::.::::::::::.::::::::::::::::::. :::: :: XP_016 FLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::.:.::.: . : .:::.::::::::::.:::.:.: .:.:: .: . .: :::. XP_016 IDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB9 QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA . . .: : ::. . :: : XP_016 WSASRASLKAKLLRRQISLKENRH--WRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPK 360 370 380 390 400 410 >>XP_005259578 (OMIM: 609765) PREDICTED: lysine-specific (1130 aa) initn: 1977 init1: 1897 opt: 1898 Z-score: 1406.7 bits: 271.0 E(85289): 1.3e-71 Smith-Waterman score: 1921; 54.6% identity (73.3% similar) in 540 aa overlap (4-523:1-537) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR : :. . ::::.:.:: :.:: :::.::.::.::.:::::::::::::::::::: : XP_005 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED .:::.:....: .:.:::..:..:.::::. .::::::::::.::::.:: :: ::.:.: XP_005 QTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::: . ::::::::::::.:... :::.: : :: :..:.:::..::::::::: XP_005 LERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.::::.::..:::::.:::::: .:::::.:: : XP_005 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::..:::: .::. ::::.::::::::::.::::::::::::::::::. :::: :: XP_005 FLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::.:.::.: . : .:::.::::::::::.:::.:.: .:.:: .: . .: :::. XP_005 IDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSS 300 310 320 330 340 350 370 380 390 400 410 pF1KB9 QKEVQLPRRAALGLRQLP----SHWARHSPW--PMAARSGTRCHTLVCSSLPRRSAVS-- . . .: : ::. :: . : :. . . :: .:: . XP_005 WSASRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKP 360 370 380 390 400 410 420 430 440 450 460 pF1KB9 ----------GTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHP-SNGRRGRGRPPQKLR ::: . .: : . : : . .: .::...: . : XP_005 KPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEG-AEEDGR 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB9 AQELTLQTPAKRPLLA-GTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWA .. .. ..: . : : : .: . :: : :: : . : :. . XP_005 GKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW-LPSPLEPPVLGPGPAA-MEES 480 490 500 510 520 530 pF1KB9 PVP :.: XP_005 PLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPT 540 550 560 570 580 590 >>XP_016881992 (OMIM: 609765) PREDICTED: lysine-specific (1130 aa) initn: 1977 init1: 1897 opt: 1898 Z-score: 1406.7 bits: 271.0 E(85289): 1.3e-71 Smith-Waterman score: 1921; 54.6% identity (73.3% similar) in 540 aa overlap (4-523:1-537) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR : :. . ::::.:.:: :.:: :::.::.::.::.:::::::::::::::::::: : XP_016 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED .:::.:....: .:.:::..:..:.::::. .::::::::::.::::.:: :: ::.:.: XP_016 QTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::: . ::::::::::::.:... :::.: : :: :..:.:::..::::::::: XP_016 LERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.::::.::..:::::.:::::: .:::::.:: : XP_016 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::..:::: .::. ::::.::::::::::.::::::::::::::::::. :::: :: XP_016 FLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::.:.::.: . : .:::.::::::::::.:::.:.: .:.:: .: . .: :::. XP_016 IDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSS 300 310 320 330 340 350 370 380 390 400 410 pF1KB9 QKEVQLPRRAALGLRQLP----SHWARHSPW--PMAARSGTRCHTLVCSSLPRRSAVS-- . . .: : ::. :: . : :. . . :: .:: . XP_016 WSASRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKP 360 370 380 390 400 410 420 430 440 450 460 pF1KB9 ----------GTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHP-SNGRRGRGRPPQKLR ::: . .: : . : : . .: .::...: . : XP_016 KPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEG-AEEDGR 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB9 AQELTLQTPAKRPLLA-GTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWA .. .. ..: . : : : .: . :: : :: : . : :. . XP_016 GKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW-LPSPLEPPVLGPGPAA-MEES 480 490 500 510 520 530 pF1KB9 PVP :.: XP_016 PLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPT 540 550 560 570 580 590 >>XP_011526120 (OMIM: 609765) PREDICTED: lysine-specific (429 aa) initn: 1869 init1: 1869 opt: 1880 Z-score: 1399.7 bits: 268.3 E(85289): 3.2e-71 Smith-Waterman score: 1880; 69.7% identity (89.0% similar) in 373 aa overlap (4-376:1-372) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR : :. . ::::.:.:: :.:: :::.::.::.::.:::::::::::::::::::: : XP_011 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED .:::.:....: .:.:::..:..:.::::. .::::::::::.::::.:: :: ::.:.: XP_011 QTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::: . ::::::::::::.:... :::.: : :: :..:.:::..::::::::: XP_011 LERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.::::.::..:::::.:::::: .:::::.:: : XP_011 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::..:::: .::. ::::.::::::::::.::::::::::::::::::. :::: :: XP_011 FLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::.:.::.: . : .:::.::::::::::.:::.:.: .:.:: .: . .: :::. XP_011 IDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB9 QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA . . .: : ::. XP_011 WSASRASLKAKL-LRRPGLLCLDVSTPHGNSRPLQMIDSEEMRVAVSVKLCLQTLKSRSH 360 370 380 390 400 410 >>XP_016869993 (OMIM: 605469) PREDICTED: lysine-specific (763 aa) initn: 1728 init1: 1728 opt: 1734 Z-score: 1288.6 bits: 248.6 E(85289): 4.9e-65 Smith-Waterman score: 1741; 51.2% identity (74.4% similar) in 516 aa overlap (13-523:11-511) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR ::.:.:: :.:. ::: .:.::.:::::.:::::::::.::::::: : XP_016 MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED . ::.:...:: .:.::...:..:.::::. .:::::: :.:.:::: :: :: . ..:: XP_016 QCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYED 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::: . .:::::::.::..::.. .::...:.:. :..:.:::. ::::::::: XP_016 LERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.::::.::..:::::.::::::. .::.::.:: : XP_016 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::..::::.:::. ::::..:::::::::.::::::::::::::::::. :::: :: XP_016 FLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::.:. :.: . : .::: ::: .::.::.:::.:.: ..:: .: .::: . XP_016 IDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKP-TPAS---TP 300 310 320 330 340 350 370 380 390 400 410 pF1KB9 QKEVQLPRRAALGLRQLPSHWARH-SPWPMAARSGTRCHTLVCSSLPRRSAVSGT--ATQ . .. : :: . . . :: : : : . . . .: ..:. ... XP_016 EVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 PRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLA :::. . .:. . . :. . . . :: .. :.: . . . XP_016 KSEAAVKLRNTEASSEEESSASRMQVEQNLSDH-------IKLSGNS-CLSTSVTEDI-- 420 430 440 450 460 480 490 500 510 520 pF1KB9 GTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKA--SGCSWAPVP : .. . .: .. : .::: : ..: :. : :: : XP_016 -KTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGV 470 480 490 500 510 520 XP_016 LTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSP 530 540 550 560 570 580 >>XP_016869992 (OMIM: 605469) PREDICTED: lysine-specific (793 aa) initn: 1728 init1: 1728 opt: 1734 Z-score: 1288.3 bits: 248.6 E(85289): 5.1e-65 Smith-Waterman score: 1741; 51.2% identity (74.4% similar) in 516 aa overlap (13-523:11-511) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR ::.:.:: :.:. ::: .:.::.:::::.:::::::::.::::::: : XP_016 MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED . ::.:...:: .:.::...:..:.::::. .:::::: :.:.:::: :: :: . ..:: XP_016 QCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYED 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::: . .:::::::.::..::.. .::...:.:. :..:.:::. ::::::::: XP_016 LERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.::::.::..:::::.::::::. .::.::.:: : XP_016 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::..::::.:::. ::::..:::::::::.::::::::::::::::::. :::: :: XP_016 FLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::.:. :.: . : .::: ::: .::.::.:::.:.: ..:: .: .::: . XP_016 IDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKP-TPAS---TP 300 310 320 330 340 350 370 380 390 400 410 pF1KB9 QKEVQLPRRAALGLRQLPSHWARH-SPWPMAARSGTRCHTLVCSSLPRRSAVSGT--ATQ . .. : :: . . . :: : : : . . . .: ..:. ... XP_016 EVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 PRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLA :::. . .:. . . :. . . . :: .. :.: . . . XP_016 KSEAAVKLRNTEASSEEESSASRMQVEQNLSDH-------IKLSGNS-CLSTSVTEDI-- 420 430 440 450 460 480 490 500 510 520 pF1KB9 GTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKA--SGCSWAPVP : .. . .: .. : .::: : ..: :. : :: : XP_016 -KTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGV 470 480 490 500 510 520 XP_016 LTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSP 530 540 550 560 570 580 >>XP_016869991 (OMIM: 605469) PREDICTED: lysine-specific (811 aa) initn: 1728 init1: 1728 opt: 1734 Z-score: 1288.2 bits: 248.6 E(85289): 5.2e-65 Smith-Waterman score: 1741; 51.2% identity (74.4% similar) in 516 aa overlap (13-523:11-511) 10 20 30 40 50 60 pF1KB9 METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR ::.:.:: :.:. ::: .:.::.:::::.:::::::::.::::::: : XP_016 MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPR 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED . ::.:...:: .:.::...:..:.::::. .:::::: :.:.:::: :: :: . ..:: XP_016 QCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYED 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL :::::::: . .:::::::.::..::.. .::...:.:. :..:.:::. ::::::::: XP_016 LERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA :::::::::::::::::::::::::.::::.::..:::::.::::::. .::.::.:: : XP_016 YFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW :::::..::::.:::. ::::..:::::::::.::::::::::::::::::. :::: :: XP_016 FLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRW 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST :::::.:. :.: . : .::: ::: .::.::.:::.:.: ..:: .: .::: . XP_016 IDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKP-TPAS---TP 300 310 320 330 340 350 370 380 390 400 410 pF1KB9 QKEVQLPRRAALGLRQLPSHWARH-SPWPMAARSGTRCHTLVCSSLPRRSAVSGT--ATQ . .. : :: . . . :: : : : . . . .: ..:. ... XP_016 EVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 PRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLA :::. . .:. . . :. . . . :: .. :.: . . . XP_016 KSEAAVKLRNTEASSEEESSASRMQVEQNLSDH-------IKLSGNS-CLSTSVTEDI-- 420 430 440 450 460 480 490 500 510 520 pF1KB9 GTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKA--SGCSWAPVP : .. . .: .. : .::: : ..: :. : :: : XP_016 -KTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGV 470 480 490 500 510 520 XP_016 LTEGEESDVESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSP 530 540 550 560 570 580 523 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 20:05:36 2016 done: Sat Nov 5 20:05:37 2016 Total Scan time: 8.130 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]