FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9619, 347 aa 1>>>pF1KB9619 347 - 347 aa - 347 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5166+/-0.000346; mu= 5.1961+/- 0.022 mean_var=280.8366+/-56.243, 0's: 0 Z-trim(124.1): 24 B-trim: 0 in 0/57 Lambda= 0.076533 statistics sampled from 45112 (45140) to 45112 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.803), E-opt: 0.2 (0.529), width: 16 Scan time: 10.930 The best scores are: opt bits E(85289) NP_002220 (OMIM: 165161) transcription factor jun- ( 347) 2336 270.5 3.9e-72 NP_002219 (OMIM: 165160) transcription factor AP-1 ( 331) 711 91.0 3.9e-18 NP_001273897 (OMIM: 165162) transcription factor j ( 304) 660 85.4 1.8e-16 NP_005345 (OMIM: 165162) transcription factor jun- ( 347) 660 85.4 2e-16 >>NP_002220 (OMIM: 165161) transcription factor jun-B [H (347 aa) initn: 2336 init1: 2336 opt: 2336 Z-score: 1416.1 bits: 270.5 E(85289): 3.9e-72 Smith-Waterman score: 2336; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KB9 MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 EGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPPP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 VYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VYTNLSSYSPASASSGGAGAAVGTGSSYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 EEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLERIARLEDKV 250 260 270 280 290 300 310 320 330 340 pF1KB9 KTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF ::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF 310 320 330 340 >>NP_002219 (OMIM: 165160) transcription factor AP-1 [Ho (331 aa) initn: 876 init1: 454 opt: 711 Z-score: 446.6 bits: 91.0 E(85289): 3.9e-18 Smith-Waterman score: 859; 47.7% identity (67.9% similar) in 365 aa overlap (1-347:1-331) 10 20 30 40 50 60 pF1KB9 MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGP : .::: :: ::. .:. : . . :.:: :...::::: ::: : :. . NP_002 MTAKMETTFY-DDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLK-PHLRAKNS 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 EGGGGGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGG . ... :.: ::::: ::::::. .::: ::::::: :.. :.. NP_002 D------LLTSP--DVGL-LKLASPELERLIIQSSNGHITTTPTPT-QFLCPKN------ 60 70 80 90 100 130 140 150 160 pF1KB9 AGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSL------GATGGPPA------- ::.::::::.:::.:: .::..: : :.:. :: :: NP_002 -------VTDEQEGFAEGFVRALAELHSQN--TLPSVTSAAQPVNGAGMVAPAVASVAGG 110 120 130 140 150 170 180 190 200 210 220 pF1KB9 -GPGGVYAG-PEPPPVYTNLSSYSPASASSGGAGAAVGT-GSSYPTTTISYLPHAPPFAG : :: :. ::::.:::...:.. ::::.. . :. : ..:. . :: NP_002 SGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQ--PQQQQQPPH-- 160 170 180 190 200 230 240 250 260 270 280 pF1KB9 GH-PAQLGLGRGA-STFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAA : : :. . . ...::::::::: .. :::.:::.::.:::::.::::.:::.:: NP_002 -HLPQQMPVQHPRLQALKEEPQTVPEMPGE--TPPLSPIDMESQERIKAERKRMRNRIAA 210 220 230 240 250 260 290 300 310 320 330 340 pF1KB9 TKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGV .::::::::::::::.:::::::.:. :.:::..:::::::::::::.::..::::.: NP_002 SKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQ 270 280 290 300 310 320 pF1KB9 KGHAF . ..: NP_002 QLQTF 330 >>NP_001273897 (OMIM: 165162) transcription factor jun-D (304 aa) initn: 605 init1: 545 opt: 660 Z-score: 416.6 bits: 85.4 E(85289): 1.8e-16 Smith-Waterman score: 791; 49.1% identity (69.5% similar) in 318 aa overlap (35-339:19-296) 10 20 30 40 50 60 pF1KB9 MEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKPSLAVNLADPYRSLKAPGARGPGPEGGG :::. : : :.: :: . .: : NP_001 MMKKDALTLSLSEQVAAALKPAA----APPPTPLRADGAPSAAPPDGL 10 20 30 40 70 80 90 100 110 120 pF1KB9 GGSYFSGQGSDTGASLKLASSELERLIVPNSNGVITTTPTPPGQYFYPRGGGSGGGAGGA .: : : ::::: ::::::. .:::..::::: .:..::. ..: NP_001 LAS------PDLGL-LKLASPELERLII-QSNGLVTTTPTS-SQFLYPKVAAS------- 50 60 70 80 130 140 150 160 170 pF1KB9 GGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGATGGPPAGPGGVYAGPEPP----- :::: ::.::::::.::::.:.. ... .:... .::.:. .: :: NP_001 -----EEQE-FAEGFVKALEDLHKQNQLGA-GAAAAAAAAAAGGPSGTATGSAPPGELAP 90 100 110 120 130 140 180 190 200 210 220 230 pF1KB9 -------PVYTNLSSYSPASASSGGAGAAVGTGS-SYPTTTISYLPHAPPFAGGHPAQLG :::.:::::. ::::.: :... .. . . . : :: : : : NP_001 AAAAPEAPVYANLSSYA------GGAGGAGGAATVAFAAEPVPFPPPPPPGALGPP---- 150 160 170 180 190 240 250 260 270 280 290 pF1KB9 LGRGASTFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNRLAATKCRKRKLE : :. .:.::::::.. : .::.:::.:. :::::.::::::::.::.:::::::: NP_001 --RLAA-LKDEPQTVPDVPSFGESPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLE 200 210 220 230 240 300 310 320 330 340 pF1KB9 RIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQKVMTHVSNGCQLLLGVKGHAF ::.:::.::::::..:. :.:::.:::::::::::::..::..::::: NP_001 RISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY 250 260 270 280 290 300 >>NP_005345 (OMIM: 165162) transcription factor jun-D is (347 aa) initn: 605 init1: 545 opt: 660 Z-score: 416.0 bits: 85.4 E(85289): 2e-16 Smith-Waterman score: 804; 45.0% identity (66.7% similar) in 369 aa overlap (5-339:1-339) 10 20 30 40 pF1KB9 MCTKMEQPFYHDDSYTATGYGRAPGGLSLHDYKLLKP---------------SLAVNLAD :: ::: :.. .. : : . .: :. . : : .:...:.. NP_005 METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSE 10 20 30 40 50 50 60 70 80 90 pF1KB9 PYRS-LKAPGARGPGP-EGGGGGSYFSGQG----SDTGASLKLASSELERLIVPNSNGVI . :: .: : : .. :. : .: : : ::::: ::::::. .:::.. NP_005 QVAAALKPAAAPPPTPLRADGAPSAAPPDGLLASPDLGL-LKLASPELERLII-QSNGLV 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB9 TTTPTPPGQYFYPRGGGSGGGAGGAGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSL ::::: .:..::. ..: :::: ::.::::::.::::.:.. ... NP_005 TTTPTS-SQFLYPKVAAS------------EEQE-FAEGFVKALEDLHKQNQLGA-GAAA 120 130 140 150 160 170 180 190 200 pF1KB9 GATGGPPAGPGGVYAGPEPP------------PVYTNLSSYSPASASSGGAGAAVGTGS- .:... .::.:. .: :: :::.:::::. ::::.: :... NP_005 AAAAAAAGGPSGTATGSAPPGELAPAAAAPEAPVYANLSSYA------GGAGGAGGAATV 160 170 180 190 200 210 210 220 230 240 250 260 pF1KB9 SYPTTTISYLPHAPPFAGGHPAQLGLGRGASTFKEEPQTVPEARSRDATPPVSPINMEDQ .. . . . : :: : : : : :. .:.::::::.. : .::.:::.:. : NP_005 AFAAEPVPFPPPPPPGALGPP------RLAA-LKDEPQTVPDVPSFGESPPLSPIDMDTQ 220 230 240 250 260 270 280 290 300 310 320 pF1KB9 ERIKVERKRLRNRLAATKCRKRKLERIARLEDKVKTLKAENAGLSSTAGLLREQVAQLKQ ::::.::::::::.::.::::::::::.:::.::::::..:. :.:::.::::::::::: NP_005 ERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQ 270 280 290 300 310 320 330 340 pF1KB9 KVMTHVSNGCQLLLGVKGHAF ::..::..::::: NP_005 KVLSHVNSGCQLLPQHQVPAY 330 340 347 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:45:03 2016 done: Fri Nov 4 17:45:05 2016 Total Scan time: 10.930 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]