Result of FASTA (omim) for
pF1KB9632
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9632, 214 aa
1>>>pF1KB9632 214 - 214 aa - 214 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3119+/-0.00026; mu= 11.8641+/- 0.017
mean_var=125.9793+/-25.211, 0's: 0 Z-trim(123.7): 68 B-trim: 0 in 0/54
Lambda= 0.114268
statistics sampled from 43914 (43982) to 43914 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.83), E-opt: 0.2 (0.516), width: 16
Scan time: 7.680
The best scores are: opt bits E(85289)
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 1442 247.5 1.3e-65
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 1442 247.5 1.3e-65
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 474 87.9 1.5e-17
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 414 78.1 1.6e-14
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 291 57.9 2.3e-08
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 285 56.9 5e-08
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 277 55.6 1.2e-07
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 260 52.5 5.3e-07
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 260 52.8 7.9e-07
NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 238 49.2 1e-05
NP_005161 (OMIM: 601886) achaete-scute homolog 2 [ ( 193) 227 47.1 2.3e-05
NP_786923 (OMIM: 609323) oligodendrocyte transcrip ( 272) 225 46.9 3.7e-05
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 219 45.8 5.9e-05
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 219 45.8 5.9e-05
NP_004600 (OMIM: 601010) transcription factor 15 [ ( 199) 213 44.8 0.00012
NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241) 206 43.7 0.0003
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 206 43.9 0.00037
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 196 41.9 0.00067
NP_003197 (OMIM: 603306) transcription factor 21 [ ( 179) 196 42.0 0.00076
NP_938206 (OMIM: 603306) transcription factor 21 [ ( 179) 196 42.0 0.00076
XP_011513798 (OMIM: 101400,123100,180750,601622) P ( 202) 193 41.5 0.0012
NP_000465 (OMIM: 101400,123100,180750,601622) twis ( 202) 193 41.5 0.0012
NP_005089 (OMIM: 603628) musculin [Homo sapiens] ( 206) 191 41.2 0.0015
XP_005259969 (OMIM: 151440) PREDICTED: protein lyl ( 206) 190 41.0 0.0017
NP_005574 (OMIM: 151440) protein lyl-1 [Homo sapie ( 280) 190 41.2 0.0021
XP_016882306 (OMIM: 151440) PREDICTED: protein lyl ( 302) 190 41.2 0.0022
NP_620450 (OMIM: 606385) oligodendrocyte transcrip ( 271) 189 41.0 0.0023
XP_016882305 (OMIM: 151440) PREDICTED: protein lyl ( 351) 190 41.3 0.0024
NP_001035047 (OMIM: 277300,605195,608681) mesoderm ( 397) 189 41.1 0.003
NP_689627 (OMIM: 613483) class E basic helix-loop- ( 381) 185 40.5 0.0046
NP_476527 (OMIM: 200110,209885,227260,607556) twis ( 160) 179 39.1 0.0049
NP_001258822 (OMIM: 200110,209885,227260,607556) t ( 160) 179 39.1 0.0049
NP_061140 (OMIM: 608689) mesoderm posterior protei ( 268) 181 39.7 0.0056
NP_001157877 (OMIM: 607539,609432,615416) class A ( 235) 179 39.3 0.0064
>>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap (214 aa)
initn: 1442 init1: 1442 opt: 1442 Z-score: 1299.2 bits: 247.5 E(85289): 1.3e-65
Smith-Waterman score: 1442; 99.5% identity (99.5% similar) in 214 aa overlap (1-214:1-214)
10 20 30 40 50 60
pF1KB9 MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 LRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 KIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 KIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAG
130 140 150 160 170 180
190 200 210
pF1KB9 SLSPAASLEERPGLLGATSSACLSPGSLAFSDFL
:::::::::::::::::: :::::::::::::::
NP_066 SLSPAASLEERPGLLGATFSACLSPGSLAFSDFL
190 200 210
>>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen (214 aa)
initn: 1442 init1: 1442 opt: 1442 Z-score: 1299.2 bits: 247.5 E(85289): 1.3e-65
Smith-Waterman score: 1442; 99.5% identity (99.5% similar) in 214 aa overlap (1-214:1-214)
10 20 30 40 50 60
pF1KB9 MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 LRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 KIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAG
130 140 150 160 170 180
190 200 210
pF1KB9 SLSPAASLEERPGLLGATSSACLSPGSLAFSDFL
:::::::::::::::::: :::::::::::::::
XP_016 SLSPAASLEERPGLLGATFSACLSPGSLAFSDFL
190 200 210
>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens] (237 aa)
initn: 442 init1: 412 opt: 474 Z-score: 436.2 bits: 87.9 E(85289): 1.5e-17
Smith-Waterman score: 489; 53.7% identity (70.9% similar) in 175 aa overlap (34-193:42-213)
10 20 30 40 50 60
pF1KB9 QPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRG--NCAEAEEGGCRGAPRKL
:.::.:.: :: : ..: : ..
NP_006 LDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPAR-RGAPNISRASEVPGAQDDEQE
20 30 40 50 60 70
70 80 90 100 110 120
pF1KB9 RARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTK
: :: ::.: .:: : . ::::: ::::::::::::::.::::::.:::.::::.::::
NP_006 RRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLPSFPDDTKLTK
80 90 100 110 120 130
130 140 150 160 170
pF1KB9 IETLRFAHNYIWALTQTLRIADHSLYA------LEPP--APHCGELGSPGGSPGDWGS--
:::::::.::::::..:::.::..: . : :: .: ::... .:::
NP_006 IETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPASDAESWGSGA
140 150 160 170 180 190
180 190 200 210
pF1KB9 -LYSPVSQAGSLSPAAS--LEERPGLLGATSSACLSPGSLAFSDFL
::.:. .: :::: . :::
NP_006 AAASPLSDPSS--PAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH
200 210 220 230
>>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens] (272 aa)
initn: 419 init1: 372 opt: 414 Z-score: 381.9 bits: 78.1 E(85289): 1.6e-14
Smith-Waterman score: 428; 48.4% identity (64.6% similar) in 192 aa overlap (43-211:64-239)
20 30 40 50 60
pF1KB9 VTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRA------RRG
::. : . :: :: : .: . ::
NP_076 SSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEG-CR--PARLLGLVHDCKRRP
40 50 60 70 80 90
70 80 90 100 110 120
pF1KB9 GRSRP-----KSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTK
.:.: :. .... ...:: :::.::::::::::.:::::: ::::::.::::::
NP_076 SRARAVSRGAKTAETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTK
100 110 120 130 140 150
130 140 150 160 170
pF1KB9 IETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGS---LYSP---
:::::::::::::::.:::.::: :: :. :: :: : : ::
NP_076 IETLRFAHNYIWALTETLRLADH-----------CG--GGGGGLPGALFSEAVLLSPGGA
160 170 180 190
180 190 200 210
pF1KB9 ---VSQAG-SLSPAA--SLEERPGLLGATSSACLSPGSLAFSDFL
.:..: : :::. : . :. ...:: :: : ..:
NP_076 SAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPD
200 210 220 230 240 250
NP_076 KHRYAPHLPIARDCI
260 270
>>NP_073565 (OMIM: 611513) neurogenic differentiation fa (337 aa)
initn: 262 init1: 262 opt: 291 Z-score: 271.1 bits: 57.9 E(85289): 2.3e-08
Smith-Waterman score: 293; 39.5% identity (57.3% similar) in 157 aa overlap (1-141:1-152)
10 20 30 40
pF1KB9 MTPQPSGAPTVQVTRETERSFPRASEDE--VTCPTS--------------APPSPTRTRG
: : .:. . :.: : ::. . : : :: :. .
NP_073 MLTLPFDESVVMPESQMCRKFSRECEDQKQIKKPESFSKQIVLRGKSIKRAPGEETEKEE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB9 NCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALD
. . :: : :: ::: :.. ..: : .. . ::..:: :::::::.::.:::
NP_073 EEEDREEEDENGLPR----RRGLRKKKTTKLRL-ERVKFRRQEANARERNRMHGLNDALD
70 80 90 100 110
110 120 130 140 150 160
pF1KB9 ALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGG
:: :.: . ::.::::::.:.::::::.. :::
NP_073 NLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLTFVQNLCKGLSQPTTN
120 130 140 150 160 170
170 180 190 200 210
pF1KB9 SPGDWGSLYSPVSQAGSLSPAASLEERPGLLGATSSACLSPGSLAFSDFL
NP_073 LVAGCLQLNARSFLMGQGGEAAHHTRSPYSTFYPPYHSPELTTPPGHGTLDNSKSMKPYN
180 190 200 210 220 230
>>NP_006151 (OMIM: 601725) neurogenic differentiation fa (382 aa)
initn: 254 init1: 254 opt: 285 Z-score: 265.1 bits: 56.9 E(85289): 5e-08
Smith-Waterman score: 285; 40.7% identity (60.7% similar) in 140 aa overlap (3-140:40-178)
10 20 30
pF1KB9 MTPQPSGAPTVQVTRETERSFPRASEDEVTCP
: :. .: . .. . : .: : :
NP_006 GLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPARAAKPVPLRGE-EGTEA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 TSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRS--RRKKAND
: : . :. : :: .: . : :. : ... .. .:: ::.:::
NP_006 TLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKANA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 RERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYALE
:::::::.::.::: :: :.: . ::.::::::.:.::::::.. ::
NP_006 RERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVSY
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 PPAPHCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGATSSACLSPGSLAF
NP_006 VQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLAG
190 200 210 220 230 240
>>NP_002491 (OMIM: 125853,601724,606394) neurogenic diff (356 aa)
initn: 279 init1: 247 opt: 277 Z-score: 258.3 bits: 55.6 E(85289): 1.2e-07
Smith-Waterman score: 277; 38.5% identity (60.1% similar) in 148 aa overlap (3-140:14-158)
10 20 30 40
pF1KB9 MTPQPSGAPTVQ---VTRETERSFPRASEDEVTCPTSAPPSPTRTRG--
:::.: :. .. . :. .::.. .: . :. :
NP_002 MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDDLEA-MNAEEDSLRNGGEE
10 20 30 40 50
50 60 70 80 90
pF1KB9 -----NCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNL
. : :: . .: . ::: ... .. : . . :: ::: :::::::.:
NP_002 EDEDEDLEEEEEEEEEDDDQKPK-RRGPKKKKMTKARLER-FKLRRMKANARERNRMHGL
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB9 NSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGEL
:.::: :: :.: . ::.::::::.:.::::::.. ::
NP_002 NAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLS
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB9 GSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGATSSACLSPGSLAFSDFL
NP_002 QPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSS
180 190 200 210 220 230
>>NP_803238 (OMIM: 608606) class A basic helix-loop-heli (189 aa)
initn: 247 init1: 194 opt: 260 Z-score: 246.8 bits: 52.5 E(85289): 5.3e-07
Smith-Waterman score: 260; 42.9% identity (65.4% similar) in 133 aa overlap (24-154:19-147)
10 20 30 40 50
pF1KB9 MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAP-PSPTRTRGNCAEAEEGGCRGAPR
:. : : : : :.: ..: .. ... : ::
NP_803 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAAR-APG
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 KLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKL
. : :: : : : .. : ::: ..:.:::.:::.::.:..::: :.: : ::
NP_803 EGRRRRPGPSGPGGRRDSSIQRRL---ESNERERQRMHKLNNAFQALREVIPHVRADKKL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 TKIETLRFAHNYIWALTQT-LRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQ
.::::: .:.::: .:: : : ... : .:: :.:
NP_803 SKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQP
120 130 140 150 160 170
180 190 200 210
pF1KB9 AGSLSPAASLEERPGLLGATSSACLSPGSLAFSDFL
NP_803 QGHLQRYSTQIHSFREGT
180
>>NP_067014 (OMIM: 611635) neurogenic differentiation fa (331 aa)
initn: 233 init1: 233 opt: 260 Z-score: 243.6 bits: 52.8 E(85289): 7.9e-07
Smith-Waterman score: 260; 50.0% identity (72.8% similar) in 92 aa overlap (48-139:59-143)
20 30 40 50 60 70
pF1KB9 ERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELAL
: :: : . :. ::: ... .. :
NP_067 NEVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEK--PK----RRGPKKKKMTKARL
30 40 50 60 70 80
80 90 100 110 120 130
pF1KB9 SKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQ
.. :.:: ::: :::.:::.::.::: :: :.: . ::.::::::.:.::::::..
NP_067 -ERFRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSE
90 100 110 120 130 140
140 150 160 170 180 190
pF1KB9 TLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGA
.:
NP_067 VLETGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHN
150 160 170 180 190 200
>>NP_005163 (OMIM: 601461) protein atonal homolog 1 [Hom (354 aa)
initn: 280 init1: 214 opt: 238 Z-score: 223.6 bits: 49.2 E(85289): 1e-05
Smith-Waterman score: 247; 28.7% identity (54.0% similar) in 237 aa overlap (3-213:61-297)
10 20 30
pF1KB9 MTPQPSGAPTVQ-VTRETERSFPRASEDEVTC
:. :::.: . .. : . .
NP_005 PPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGAS
40 50 60 70 80 90
40 50 60 70
pF1KB9 PTSAPPSPTRTRGNCAEAEEGGCRGA----PRKLRAR----RGG---------RSRPKSE
..:: . . ::. .. :: .. : :.: . .:: :.: :
NP_005 EAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSS
100 110 120 130 140 150
80 90 100 110 120 130
pF1KB9 LALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWA
.. ...:: :: ::: :::.:: :.: ::.:.:.: .: ::.: :::..:. :: :
NP_005 KQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINA
160 170 180 190 200 210
140 150 160 170 180
pF1KB9 LTQTLRIADHSLYALEPPAP------HCGELGSPGGSPGDWGSLYSPVSQAGSL--SPAA
:.. :. . . ::: : .: :. :. . . ...:: .: .
NP_005 LSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPG
220 230 240 250 260 270
190 200 210
pF1KB9 SLEERPGLLGATSSACLSPGSLAFSDFL
: . : . ..... .. .: :: :
NP_005 SCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKT
280 290 300 310 320 330
214 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:51:36 2016 done: Fri Nov 4 17:51:37 2016
Total Scan time: 7.680 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]