FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9644, 179 aa 1>>>pF1KB9644 179 - 179 aa - 179 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.8131+/-0.000324; mu= -4.8535+/- 0.020 mean_var=289.6260+/-58.146, 0's: 0 Z-trim(125.1): 196 B-trim: 33 in 1/60 Lambda= 0.075363 statistics sampled from 47847 (48043) to 47847 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.842), E-opt: 0.2 (0.563), width: 16 Scan time: 7.230 The best scores are: opt bits E(85289) NP_057642 (OMIM: 610416) SCAN domain-containing pr ( 179) 1174 139.3 3.3e-33 NP_361012 (OMIM: 610416) SCAN domain-containing pr ( 242) 1174 139.4 4.1e-33 XP_016881664 (OMIM: 605467) PREDICTED: neurotrophi ( 296) 289 43.2 0.00044 NP_001295052 (OMIM: 194534) zinc finger protein 24 ( 193) 284 42.5 0.00046 XP_011525566 (OMIM: 194550) PREDICTED: myeloid zin ( 764) 297 44.5 0.00048 XP_005259261 (OMIM: 194550) PREDICTED: myeloid zin ( 775) 297 44.5 0.00049 NP_001253962 (OMIM: 194550) myeloid zinc finger 1 ( 290) 285 42.8 0.00058 NP_057409 (OMIM: 605467) neurotrophin receptor-int ( 621) 290 43.6 0.0007 NP_001265663 (OMIM: 605467) neurotrophin receptor- ( 611) 289 43.5 0.00075 NP_008896 (OMIM: 194534) zinc finger protein 24 is ( 368) 284 42.8 0.00075 XP_005258398 (OMIM: 194534) PREDICTED: zinc finger ( 368) 284 42.8 0.00075 NP_598009 (OMIM: 605467) neurotrophin receptor-int ( 653) 289 43.5 0.00079 XP_006711901 (OMIM: 613911) PREDICTED: zinc finger ( 381) 282 42.6 0.00089 NP_001316662 (OMIM: 613911) zinc finger protein 49 ( 386) 282 42.6 0.0009 XP_016858082 (OMIM: 613911) PREDICTED: zinc finger ( 405) 282 42.6 0.00093 XP_011542618 (OMIM: 613911) PREDICTED: zinc finger ( 412) 282 42.6 0.00095 XP_011542616 (OMIM: 613911) PREDICTED: zinc finger ( 427) 282 42.6 0.00097 XP_011542617 (OMIM: 613911) PREDICTED: zinc finger ( 427) 282 42.6 0.00097 NP_001309220 (OMIM: 609600) zinc finger protein 39 ( 210) 275 41.6 0.00097 XP_016858081 (OMIM: 613911) PREDICTED: zinc finger ( 443) 282 42.6 0.001 NP_057408 (OMIM: 605467) neurotrophin receptor-int ( 548) 284 42.9 0.001 XP_016881663 (OMIM: 605467) PREDICTED: neurotrophi ( 548) 284 42.9 0.001 XP_011524629 (OMIM: 605467) PREDICTED: neurotrophi ( 548) 284 42.9 0.001 NP_006289 (OMIM: 602240) zinc finger protein with ( 578) 283 42.8 0.0011 XP_011513172 (OMIM: 602240) PREDICTED: zinc finger ( 578) 283 42.8 0.0011 NP_001265048 (OMIM: 602240) zinc finger protein wi ( 578) 283 42.8 0.0011 XP_016866755 (OMIM: 602240) PREDICTED: zinc finger ( 578) 283 42.8 0.0011 NP_001027463 (OMIM: 603900) zinc finger protein 17 ( 234) 274 41.5 0.0011 NP_003413 (OMIM: 194550) myeloid zinc finger 1 iso ( 734) 285 43.1 0.0012 NP_932172 (OMIM: 194550) myeloid zinc finger 1 iso ( 734) 285 43.1 0.0012 XP_016881178 (OMIM: 609600) PREDICTED: zinc finger ( 266) 275 41.7 0.0012 NP_116141 (OMIM: 613911) zinc finger protein 496 i ( 587) 282 42.7 0.0012 NP_001333508 (OMIM: 601260) zinc finger protein wi ( 321) 276 41.8 0.0012 XP_016868074 (OMIM: 601261) PREDICTED: zinc finger ( 450) 279 42.3 0.0013 XP_016858079 (OMIM: 613911) PREDICTED: zinc finger ( 618) 282 42.7 0.0013 XP_011542614 (OMIM: 613911) PREDICTED: zinc finger ( 618) 282 42.7 0.0013 XP_005273385 (OMIM: 613911) PREDICTED: zinc finger ( 623) 282 42.8 0.0013 NP_666019 (OMIM: 601261) zinc finger and SCAN doma ( 473) 279 42.3 0.0013 XP_006716176 (OMIM: 601261) PREDICTED: zinc finger ( 473) 279 42.3 0.0013 XP_005250625 (OMIM: 601261) PREDICTED: zinc finger ( 473) 279 42.3 0.0013 XP_016868073 (OMIM: 601261) PREDICTED: zinc finger ( 473) 279 42.3 0.0013 XP_016858078 (OMIM: 613911) PREDICTED: zinc finger ( 649) 282 42.8 0.0013 XP_016858077 (OMIM: 613911) PREDICTED: zinc finger ( 654) 282 42.8 0.0013 XP_011542612 (OMIM: 613911) PREDICTED: zinc finger ( 654) 282 42.8 0.0013 NP_665699 (OMIM: 609600) zinc finger protein 396 i ( 333) 275 41.8 0.0014 XP_016881176 (OMIM: 609600) PREDICTED: zinc finger ( 335) 275 41.8 0.0014 XP_006722495 (OMIM: 609600) PREDICTED: zinc finger ( 335) 275 41.8 0.0014 NP_001309219 (OMIM: 609600) zinc finger protein 39 ( 335) 275 41.8 0.0014 NP_001309215 (OMIM: 609600) zinc finger protein 39 ( 335) 275 41.8 0.0014 XP_016881177 (OMIM: 609600) PREDICTED: zinc finger ( 335) 275 41.8 0.0014 >>NP_057642 (OMIM: 610416) SCAN domain-containing protei (179 aa) initn: 1174 init1: 1174 opt: 1174 Z-score: 717.3 bits: 139.3 E(85289): 3.3e-33 Smith-Waterman score: 1174; 100.0% identity (100.0% similar) in 179 aa overlap (1-179:1-179) 10 20 30 40 50 60 pF1KB9 MAATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MAATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 IPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 IPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAA 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 GPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG 130 140 150 160 170 >>NP_361012 (OMIM: 610416) SCAN domain-containing protei (242 aa) initn: 1174 init1: 1174 opt: 1174 Z-score: 715.5 bits: 139.4 E(85289): 4.1e-33 Smith-Waterman score: 1174; 100.0% identity (100.0% similar) in 179 aa overlap (1-179:64-242) 10 20 30 pF1KB9 MAATEPILAATGSPAAVPPEKLEGAGSSSA :::::::::::::::::::::::::::::: NP_361 RFRLPQALRWCRRSAEHTATGQRVTPGAGVMAATEPILAATGSPAAVPPEKLEGAGSSSA 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB9 PERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_361 PERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAE 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB9 ARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_361 ARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEM 160 170 180 190 200 210 160 170 pF1KB9 LVQEQLLAILPEAARARRIRRRTDVRITG ::::::::::::::::::::::::::::: NP_361 LVQEQLLAILPEAARARRIRRRTDVRITG 220 230 240 >>XP_016881664 (OMIM: 605467) PREDICTED: neurotrophin re (296 aa) initn: 295 init1: 272 opt: 289 Z-score: 194.3 bits: 43.2 E(85289): 0.00044 Smith-Waterman score: 289; 42.5% identity (60.6% similar) in 127 aa overlap (40-165:99-218) 10 20 30 40 50 60 pF1KB9 ATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAAS :: :: .. . . :: : XP_016 AEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQI 70 80 90 100 110 120 70 80 90 100 110 120 pF1KB9 AALELPLGPAPVSVAPQAEAEARST-PGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQ :: : .. ::. ... .. :: ::. :::::::::.: .:::::. : XP_016 QALYAEDGSLSAD-APSEQVQQQGKHPG------DPEAARQRFRQFRYKDMTGPREALDQ 130 140 150 160 170 180 130 140 150 160 170 pF1KB9 LRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG :::: .:::.: :.::::.:.:: ::.:. :: : XP_016 LRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTW 190 200 210 220 230 240 XP_016 MSEEEGASDLPGCGCGLQPGGVGAAGPDTEDRVPRCDAGDLWAPGLCGVGDYTGK 250 260 270 280 290 >>NP_001295052 (OMIM: 194534) zinc finger protein 24 iso (193 aa) initn: 340 init1: 284 opt: 284 Z-score: 193.9 bits: 42.5 E(85289): 0.00046 Smith-Waterman score: 284; 69.5% identity (84.7% similar) in 59 aa overlap (104-162:48-106) 80 90 100 110 120 130 pF1KB9 LPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELS :: :::::::: :::. ::::: ::::: NP_001 DEEEKILRVKLEEDPDGEEGSSIPWNHLPDPEIFRQRFRQFGYQDSPGPREAVSQLRELC 20 30 40 50 60 70 140 150 160 170 pF1KB9 RQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG : ::::. .:::::.:..: ::..::::. NP_001 RLWLRPETHTKEQILELVVLEQFVAILPKELQTWVRDHHPENGEEAVTVLEDLESELDDP 80 90 100 110 120 130 >>XP_011525566 (OMIM: 194550) PREDICTED: myeloid zinc fi (764 aa) initn: 318 init1: 283 opt: 297 Z-score: 193.6 bits: 44.5 E(85289): 0.00048 Smith-Waterman score: 297; 45.1% identity (68.1% similar) in 113 aa overlap (57-167:24-133) 30 40 50 60 70 80 pF1KB9 SSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAP- .:. .:. : :.: : : . .: XP_011 MPTHGFEAGSMGRSGQEGRHWPQIPDLVPSMRP---AVLGSPDRAPPEDEGPV 10 20 30 40 50 90 100 110 120 130 140 pF1KB9 QAEAEARSTPGPAGS-RLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTK ... : : :. :::. : ::: :::..:.::.::. ::::: ::::::..:.: XP_011 MVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSK 60 70 80 90 100 110 150 160 170 pF1KB9 EQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG ::..:.:: ::.:. :: .:: XP_011 EQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQ 120 130 140 150 160 170 >>XP_005259261 (OMIM: 194550) PREDICTED: myeloid zinc fi (775 aa) initn: 318 init1: 283 opt: 297 Z-score: 193.5 bits: 44.5 E(85289): 0.00049 Smith-Waterman score: 297; 45.1% identity (68.1% similar) in 113 aa overlap (57-167:35-144) 30 40 50 60 70 80 pF1KB9 SSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAP- .:. .:. : :.: : : . .: XP_005 CHPLHKRRFLPKAAAAEGTARGGRGRHWPQIPDLVPSMRP---AVLGSPDRAPPEDEGPV 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB9 QAEAEARSTPGPAGS-RLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTK ... : : :. :::. : ::: :::..:.::.::. ::::: ::::::..:.: XP_005 MVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSK 70 80 90 100 110 120 150 160 170 pF1KB9 EQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG ::..:.:: ::.:. :: .:: XP_005 EQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQ 130 140 150 160 170 180 >>NP_001253962 (OMIM: 194550) myeloid zinc finger 1 isof (290 aa) initn: 318 init1: 283 opt: 285 Z-score: 192.1 bits: 42.8 E(85289): 0.00058 Smith-Waterman score: 285; 49.5% identity (71.4% similar) in 91 aa overlap (77-167:18-103) 50 60 70 80 90 100 pF1KB9 APEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRLGPET ::. :.. . : . : :::. NP_001 MRPAVLGSPDRAPPEDEGPVMVKLEDSEEEGEAALWDP-----GPEA 10 20 30 40 110 120 130 140 150 160 pF1KB9 FRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARA : ::: :::..:.::.::. ::::: ::::::..:.:::..:.:: ::.:. :: .: NP_001 ARLRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQA 50 60 70 80 90 100 170 pF1KB9 RRIRRRTDVRITG : NP_001 RVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEPPT 110 120 130 140 150 160 >>NP_057409 (OMIM: 605467) neurotrophin receptor-interac (621 aa) initn: 295 init1: 272 opt: 290 Z-score: 190.6 bits: 43.6 E(85289): 0.0007 Smith-Waterman score: 290; 43.2% identity (59.6% similar) in 146 aa overlap (33-165:48-186) 10 20 30 40 50 pF1KB9 ATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEAS-PPA--PEPS-SP--NAA :: :. :: . : : :. :: : NP_057 DVTLGFTPEEWGLLDLKQKSLYREVMLENYRNLVSVEYPELQLDPKLDPLPAESPLMNIE 20 30 40 50 60 70 60 70 80 90 100 pF1KB9 VPEA------IPTPRAAASAALELPLGPAPVSVAPQAEAEARST-PGPAGSRLGPETFRQ : :. . :: : :: : .. ::. ... .. :: ::. :: NP_057 VVEVLTLNQEVAGPRNAQIQALYAEDGSLSAD-APSEQVQQQGKHPGD------PEAARQ 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB9 RFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRI :::::::.: .:::::. ::::: .:::.: :.::::.:.:: ::.:. :: : NP_057 RFRQFRYKDMTGPREALDQLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVE 140 150 160 170 180 190 170 pF1KB9 RRRTDVRITG NP_057 SQHPENCQEVVALVEGVTWMSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVL 200 210 220 230 240 250 >>NP_001265663 (OMIM: 605467) neurotrophin receptor-inte (611 aa) initn: 295 init1: 272 opt: 289 Z-score: 190.2 bits: 43.5 E(85289): 0.00075 Smith-Waterman score: 289; 42.5% identity (60.6% similar) in 127 aa overlap (40-165:57-176) 10 20 30 40 50 60 pF1KB9 ATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAAS :: :: .. . . :: : NP_001 AEDFWPVERGIPQDTIPEYPELQLDPKLDPLPAESPLMNIEVVEVLTLNQEVAGPRNAQI 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB9 AALELPLGPAPVSVAPQAEAEARST-PGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQ :: : .. ::. ... .. :: ::. :::::::::.: .:::::. : NP_001 QALYAEDGSLSAD-APSEQVQQQGKHPG------DPEAARQRFRQFRYKDMTGPREALDQ 90 100 110 120 130 130 140 150 160 170 pF1KB9 LRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG :::: .:::.: :.::::.:.:: ::.:. :: : NP_001 LRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTW 140 150 160 170 180 190 NP_001 MSEEEVLPAGQPAEGTTCCLEVTAQQEEKQEDAAICPVTVLPEEPVTFQDVAVDFSREEW 200 210 220 230 240 250 >>NP_008896 (OMIM: 194534) zinc finger protein 24 isofor (368 aa) initn: 340 init1: 284 opt: 284 Z-score: 190.1 bits: 42.8 E(85289): 0.00075 Smith-Waterman score: 284; 69.5% identity (84.7% similar) in 59 aa overlap (104-162:48-106) 80 90 100 110 120 130 pF1KB9 LPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELS :: :::::::: :::. ::::: ::::: NP_008 DEEEKILRVKLEEDPDGEEGSSIPWNHLPDPEIFRQRFRQFGYQDSPGPREAVSQLRELC 20 30 40 50 60 70 140 150 160 170 pF1KB9 RQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG : ::::. .:::::.:..: ::..::::. NP_008 RLWLRPETHTKEQILELVVLEQFVAILPKELQTWVRDHHPENGEEAVTVLEDLESELDDP 80 90 100 110 120 130 179 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:56:17 2016 done: Fri Nov 4 17:56:19 2016 Total Scan time: 7.230 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]