FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9649, 441 aa 1>>>pF1KB9649 441 - 441 aa - 441 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2293+/-0.000332; mu= 2.0606+/- 0.021 mean_var=257.5928+/-52.886, 0's: 0 Z-trim(124.1): 117 B-trim: 2468 in 1/59 Lambda= 0.079911 statistics sampled from 44949 (45118) to 44949 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.809), E-opt: 0.2 (0.529), width: 16 Scan time: 9.420 The best scores are: opt bits E(85289) NP_003099 (OMIM: 600898,615866) transcription fact ( 441) 2950 352.7 1.1e-96 NP_003098 (OMIM: 184430) transcription factor SOX- ( 474) 718 95.4 3.4e-19 NP_008874 (OMIM: 601947) transcription factor SOX- ( 315) 586 80.0 9.6e-15 NP_005977 (OMIM: 602148) transcription factor SOX- ( 391) 433 62.5 2.3e-09 NP_009015 (OMIM: 604974) transcription factor SOX- ( 276) 415 60.3 7.5e-09 NP_008873 (OMIM: 601297) protein SOX-15 [Homo sapi ( 233) 412 59.9 8.4e-09 NP_003097 (OMIM: 184429,189960,206900) transcripti ( 317) 410 59.7 1.2e-08 NP_004180 (OMIM: 604747) transcription factor SOX- ( 240) 400 58.5 2.2e-08 NP_113627 (OMIM: 612202) transcription factor SOX- ( 388) 400 58.7 3.2e-08 NP_005625 (OMIM: 300123,312000,313430) transcripti ( 446) 400 58.7 3.5e-08 NP_055402 (OMIM: 605923) transcription factor SOX- ( 446) 400 58.7 3.5e-08 NP_008872 (OMIM: 602229,609136,611584,613266) tran ( 466) 381 56.5 1.7e-07 NP_000337 (OMIM: 114290,608160,616425) transcripti ( 509) 379 56.4 2.1e-07 NP_071899 (OMIM: 610928,613674) transcription fact ( 414) 377 56.0 2.1e-07 NP_060889 (OMIM: 137940,601618,607823) transcripti ( 384) 361 54.2 7.1e-07 NP_003131 (OMIM: 400044,400045,480000) sex-determi ( 204) 342 51.7 2e-06 XP_005245680 (OMIM: 604748) PREDICTED: transcripti ( 621) 349 53.0 2.6e-06 NP_005677 (OMIM: 604748) transcription factor SOX- ( 622) 349 53.0 2.7e-06 NP_821078 (OMIM: 604975,616803) transcription fact ( 377) 343 52.1 3e-06 XP_011519144 (OMIM: 604975,616803) PREDICTED: tran ( 415) 343 52.1 3.2e-06 NP_001248343 (OMIM: 604975,616803) transcription f ( 642) 343 52.3 4.4e-06 XP_016875389 (OMIM: 604975,616803) PREDICTED: tran ( 715) 343 52.3 4.7e-06 XP_016875390 (OMIM: 604975,616803) PREDICTED: tran ( 715) 343 52.3 4.7e-06 XP_016875387 (OMIM: 604975,616803) PREDICTED: tran ( 715) 343 52.3 4.7e-06 XP_016875388 (OMIM: 604975,616803) PREDICTED: tran ( 715) 343 52.3 4.7e-06 XP_016875386 (OMIM: 604975,616803) PREDICTED: tran ( 716) 343 52.3 4.8e-06 NP_001317714 (OMIM: 604975,616803) transcription f ( 728) 343 52.3 4.8e-06 XP_011519140 (OMIM: 604975,616803) PREDICTED: tran ( 729) 343 52.3 4.8e-06 NP_694534 (OMIM: 604975,616803) transcription fact ( 750) 343 52.3 4.9e-06 XP_016875385 (OMIM: 604975,616803) PREDICTED: tran ( 750) 343 52.3 4.9e-06 XP_011519139 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 XP_016875379 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 XP_016875380 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 XP_016875382 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 XP_016875384 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 XP_016875381 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 XP_011519137 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 XP_016875383 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 XP_011519136 (OMIM: 604975,616803) PREDICTED: tran ( 751) 343 52.3 4.9e-06 NP_001248344 (OMIM: 604975,616803) transcription f ( 753) 343 52.4 4.9e-06 XP_011519135 (OMIM: 604975,616803) PREDICTED: tran ( 754) 343 52.4 4.9e-06 NP_008871 (OMIM: 604975,616803) transcription fact ( 763) 343 52.4 5e-06 XP_011519134 (OMIM: 604975,616803) PREDICTED: tran ( 764) 343 52.4 5e-06 XP_016875378 (OMIM: 604975,616803) PREDICTED: tran ( 792) 343 52.4 5.1e-06 XP_016875377 (OMIM: 604975,616803) PREDICTED: tran ( 793) 343 52.4 5.1e-06 NP_201583 (OMIM: 607257) transcription factor SOX- ( 808) 337 51.7 8.4e-06 NP_001139283 (OMIM: 607257) transcription factor S ( 801) 335 51.5 9.8e-06 NP_059978 (OMIM: 607257) transcription factor SOX- ( 804) 335 51.5 9.8e-06 NP_001139291 (OMIM: 607257) transcription factor S ( 841) 335 51.5 1e-05 NP_008948 (OMIM: 606698) transcription factor SOX- ( 501) 275 44.4 0.00084 >>NP_003099 (OMIM: 600898,615866) transcription factor S (441 aa) initn: 2950 init1: 2950 opt: 2950 Z-score: 1856.7 bits: 352.7 E(85289): 1.1e-96 Smith-Waterman score: 2950; 100.0% identity (100.0% similar) in 441 aa overlap (1-441:1-441) 10 20 30 40 50 60 pF1KB9 MVQQAESLEAESNLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MVQQAESLEAESNLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 KIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 RKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 GAGKAAQSGDYGGAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GAGKAAQSGDYGGAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 QEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRAG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 ATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDADD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDADD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 LMFDLSLNFSQSAHSASEQQLGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LMFDLSLNFSQSAHSASEQQLGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPE 370 380 390 400 410 420 430 440 pF1KB9 LSEMIAGDWLEANFSDLVFTY ::::::::::::::::::::: NP_003 LSEMIAGDWLEANFSDLVFTY 430 440 >>NP_003098 (OMIM: 184430) transcription factor SOX-4 [H (474 aa) initn: 1098 init1: 628 opt: 718 Z-score: 465.6 bits: 95.4 E(85289): 3.4e-19 Smith-Waterman score: 1010; 43.8% identity (64.6% similar) in 491 aa overlap (1-441:1-474) 10 20 30 40 50 pF1KB9 MVQQAESLE-AESNLPREALDTEEG-EF-MACSPVALDES-------DPDWCKTASGHIK ::::... : .:. : :. :. : :. .: ::. . . ::.:::: ::::: NP_003 MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 RPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHM ::::::::::.:::::::::::::::::::::::::::.::::.:::::::::::::::: NP_003 RPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHM 70 80 90 100 110 120 120 130 140 150 160 pF1KB9 ADYPDYKYRPRKKPK---MDPSAKPSASQSP-EKS--AAGGGGGSAGGGAGGAKTSKGSS ::::::::::::: : . :.. .::..: ::. ..:.:::. :::.::.... :.. NP_003 ADYPDYKYRPRKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGG 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB9 KKCGKLKAPAAAGAKAGAGKAAQSGDYGGAGDDYVLGSLRVSGSGGGGAGKTVKCV---F : . ..:..: . :. : :::: .. .::::.::.. . : NP_003 ---GGGASGGGANSKPAQKKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASF 190 200 210 220 230 230 240 250 260 270 pF1KB9 LDEDDDD------DDDDDELQLQIKQEPDEE---DEEPPHQQLLQPPGQQ--PSQLLRRY :. :. .: . :. . . : ::.. ... : : NP_003 AAEQAGAAALLPLGAAADHHSLYKARTPSASASASSAASASAALAAPGKHLAEKKVKRVY 240 250 260 270 280 290 280 290 300 310 pF1KB9 NVAKV--PASPT--LSSSAESPEGASLYDEVRAG--------------ATSGAGGGSRL- . . .::. ....:. . .::.: :: :.: :.: : NP_003 LFGGLGTSSSPVGGVGAGADPSDPLGLYEEEGAGCSPDAPSLSGRSSAASSPAAGRSPAD 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB9 YYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDADDLMFDLSLNFSQ . .. .. : : . : : ::: . : ::::::..::.:. : ::: :.:: :. NP_003 HRGYASLRAASPAPSSAP--SHASSSASSHSSSSSSSGSSSSDDEFEDDL---LDLNPSS 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB9 SAHSASEQQLGGGAAAGNLSLSLVDKDLD-SFSEGSLGSHFEFPDYCTPELSEMIAGDWL . .: : ::. ... : .:.::: .: :: :::::::::::::.::::.:::: NP_003 NFESMS---LGSFSSS-----SALDRDLDFNFEPGS-GSHFEFPDYCTPEVSEMISGDWL 420 430 440 450 460 440 pF1KB9 EANFSDLVFTY :...:.::::: NP_003 ESSISNLVFTY 470 >>NP_008874 (OMIM: 601947) transcription factor SOX-12 [ (315 aa) initn: 820 init1: 562 opt: 586 Z-score: 385.7 bits: 80.0 E(85289): 9.6e-15 Smith-Waterman score: 720; 39.6% identity (55.1% similar) in 412 aa overlap (31-441:22-315) 10 20 30 40 50 60 pF1KB9 MVQQAESLEAESNLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWS :. .: :::: ::::::::::::::: NP_008 MVQQRGARAKRDGGPPPPGPGPAEEGAREPGWCKTPSGHIKRPMNAFMVWS 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 KIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRP . ::::::.: :::::::::::::.::..:.:::::::.::::::::::::::::::::: NP_008 QHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRP 60 70 80 90 100 110 130 140 150 160 170 pF1KB9 RKKPKMDPS-AKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAK ::: : :. :.: . : ::..::.. . : . :. .: . NP_008 RKKSKGAPAKARP---RPP------------GGSGGGSRLKPGP-------QLPGRGGRR 120 130 140 180 190 200 210 220 230 pF1KB9 AGAGKAAQSGDYGGAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQI : :: : ::::. .:::.:::.:: :.. NP_008 A-AG-----------------------GPLGGGAAAP--------EDDDEDDDEEL-LEV 150 160 170 240 250 260 270 280 290 pF1KB9 KQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRA . :.. ::.. : :. :::. . ..:: :: NP_008 R--------------LVETPGRE----LWRM----VPAGRAARGQAE-----------RA 180 190 200 300 310 320 330 340 350 pF1KB9 GATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDAD . :: :.. : : ::. :.. .... ::. NP_008 QGPSGEGAA------------------AAAAASPTPSED-EEPEEEEEEAAAAEEGEEET 210 220 230 240 360 370 380 390 400 410 pF1KB9 DLMFDLSLNFSQSAHSASEQQLGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTP . ::.: . .: : :. :. : .:.: : .. : ::::::::::: NP_008 VASGEESLGFLS--------RLPPGPAG--LDCSALDRDPD-LQPPSGTSHFEFPDYCTP 250 260 270 280 290 420 430 440 pF1KB9 ELSEMIAGDWLEANFSDLVFTY :..::::::: ....:::::: NP_008 EVTEMIAGDWRPSSIADLVFTY 300 310 >>NP_005977 (OMIM: 602148) transcription factor SOX-1 [H (391 aa) initn: 393 init1: 393 opt: 433 Z-score: 289.1 bits: 62.5 E(85289): 2.3e-09 Smith-Waterman score: 466; 33.1% identity (58.8% similar) in 323 aa overlap (43-353:45-325) 20 30 40 50 60 70 pF1KB9 NLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSP :. . ..:::::::::::. .:::. ...: NP_005 GAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMNAFMVWSRGQRRKMAQENP 20 30 40 50 60 70 80 90 100 110 120 130 pF1KB9 DMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPK-MDPSAK :::.::::::: .::.....:: ::: ::.::: :: ..::::::::.: : . . : NP_005 KMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDK 80 90 100 110 120 130 140 150 160 170 180 190 pF1KB9 PSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKAGAGKAAQSGDY : . . ..:::::.... :.: .. :.. .:..: :. ::.: : .: NP_005 YSLAGGLLAAGAGGGGAAVAMGVG---VGVGAAAVGQRLESP---GGAAGGGYAHVNGWA 140 150 160 170 180 200 210 220 230 240 250 pF1KB9 GGAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQIKQEPDEEDEEP- .:: ::. .....:. .. : :: :.: .: NP_005 NGAYP----GSV----AAAAAAAAMMQ---------------EAQLAYGQHPGAGGAHPH 190 200 210 220 260 270 280 290 300 pF1KB9 -------PHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSS---AESPEGASLYDEVRAG ::. .: . :: ..::... . :: .:. . :: : . :. NP_005 AHPAHPHPHHPHAHPHNPQP---MHRYDMGALQYSPISNSQGYMSASPSGYGGLPYGAAA 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB9 ATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDADD :...:.::.. :. : : . ::: .... .: .. ::: NP_005 AAAAAAGGAH----------QNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHS 290 300 310 320 330 370 380 390 400 410 420 pF1KB9 LMFDLSLNFSQSAHSASEQQLGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPE NP_005 RAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI 340 350 360 370 380 390 >>NP_009015 (OMIM: 604974) transcription factor SOX-21 [ (276 aa) initn: 457 init1: 401 opt: 415 Z-score: 279.9 bits: 60.3 E(85289): 7.5e-09 Smith-Waterman score: 444; 43.2% identity (67.0% similar) in 185 aa overlap (48-211:7-188) 20 30 40 50 60 70 pF1KB9 ALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNA :.:::::::::::. .:::. ...: :::. NP_009 MSKPVDHVKRPMNAFMVWSRAQRRKMAQENPKMHNS 10 20 30 80 90 100 110 120 130 pF1KB9 EISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKM----DPSAKP- ::::::: .::.: .::: ::: ::.::: :: ..::::::::.::: : : : NP_009 EISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFPV 40 50 60 70 80 90 140 150 160 170 pF1KB9 -------SASQSPEKSAAGGGGGSAGGG-------AGGAKTSKGSSKKCGKLKAPAAAGA . .. : .:..: ..:::: :. :.. ... ... : .:.: NP_009 PYGLGGVADAEHPALKAGAGLHAGAGGGLVPESLLANPEKAAAAAAAAAARVFFPQSAAA 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB9 KAGAGKAAQSGDYGGAGDDYVLGS--LRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQ :.:. :: .:. . : ::: ..:.:..: NP_009 AAAAAAAAAAGSPYSLLD---LGSKMAEISSSSSGLPYASSLGYPTAGAGAFHGAAAAAA 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB9 LQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDE NP_009 AAAAAAGGHTHSHPSPGNPGYMIPCNCSAWPSPGLQPPLAYILLPGMGKPQLDPYPAAYA 220 230 240 250 260 270 >>NP_008873 (OMIM: 601297) protein SOX-15 [Homo sapiens] (233 aa) initn: 400 init1: 400 opt: 412 Z-score: 279.0 bits: 59.9 E(85289): 8.4e-09 Smith-Waterman score: 412; 52.1% identity (74.8% similar) in 119 aa overlap (49-162:49-160) 20 30 40 50 60 70 pF1KB9 LDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAE .:::::::::::. .::.. .:.: :::.: NP_008 ATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSE 20 30 40 50 60 70 80 90 100 110 120 130 pF1KB9 ISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKMDPSAKPSASQSP :::::: .::.: ..:: ::..::.::: .:. ::::::::::.: : :.. .: NP_008 ISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAK-------SSGAGP 80 90 100 110 120 130 140 150 160 170 180 190 pF1KB9 EKSAAGGGGGSAGG---GAGGAKT--SKGSSKKCGKLKAPAAAGAKAGAGKAAQSGDYGG . . : :. ..:: : : : : :.: NP_008 SRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGSYGSSHCKLEAPSPCS 140 150 160 170 180 190 >>NP_003097 (OMIM: 184429,189960,206900) transcription f (317 aa) initn: 448 init1: 370 opt: 410 Z-score: 276.0 bits: 59.7 E(85289): 1.2e-08 Smith-Waterman score: 410; 53.4% identity (76.3% similar) in 118 aa overlap (43-155:35-152) 20 30 40 50 60 70 pF1KB9 NLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSP :.. ..:::::::::::. .:::. ...: NP_003 METELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENP 10 20 30 40 50 60 80 90 100 110 120 pF1KB9 DMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKM----DP :::.::::::: .::.:...:: ::: ::.::: :: ..::::::::.: : : NP_003 KMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 SAKPSASQSPE-KSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKAGAGKAAQ . :.. .: .: :.: : .:: ::: NP_003 YTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHP 130 140 150 160 170 180 >>NP_004180 (OMIM: 604747) transcription factor SOX-14 [ (240 aa) initn: 429 init1: 400 opt: 400 Z-score: 271.4 bits: 58.5 E(85289): 2.2e-08 Smith-Waterman score: 400; 66.2% identity (88.8% similar) in 80 aa overlap (46-125:5-84) 20 30 40 50 60 70 pF1KB9 REALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMH : :::::::::::::. .:::. ...: :: NP_004 MSKPSDHIKRPMNAFMVWSRGQRRKMAQENPKMH 10 20 30 80 90 100 110 120 130 pF1KB9 NAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKMDPSAKPSAS :.::::::: .::.:...:: :.: ::.::: .:: ..::::::::.::: NP_004 NSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVF 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB9 QSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKAGAGKAAQSGDYGGAG NP_004 PLPYLGDTDPLKAAGLPVGASDGLLSAPEKARAFLPPASAPYSLLDPAQFSSSAIQKMGE 100 110 120 130 140 150 >>NP_113627 (OMIM: 612202) transcription factor SOX-7 [H (388 aa) initn: 483 init1: 377 opt: 400 Z-score: 268.6 bits: 58.7 E(85289): 3.2e-08 Smith-Waterman score: 417; 30.4% identity (51.4% similar) in 385 aa overlap (18-395:18-360) 10 20 30 40 50 60 pF1KB9 MVQQAESLEAESNLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWS :::.: .. . :: :. . : : . ..:.:::::::::. NP_113 MASLLGAYPWPEGLECPALDAELSD--GQSPPAVPRPPGD--KGSESRIRRPMNAFMVWA 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 KIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRP : ::... :.::.::::.:: ::: :: : :.: :.. :::::::.:: :::.::::: NP_113 KDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 RKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKA :.: . .. : . : :. . .: : : :... NP_113 RRKKQ---------AKRLCKRVDPGFLLSSLSRDQNALPEKRS-------------GSRG 120 130 140 150 190 200 210 220 230 pF1KB9 GAGKAAQSGDYG-GAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQI . :. . :.:. :.. . : . . .::::.: . .: :.. NP_113 ALGEKEDRGEYSPGTALPSLRGCYHEGPAGGGGGGTPSS---VDTYPYGLPTPPEMSPLD 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB9 KQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPA----SPTLSSSA--ESPEGASL ::.. : :. : . : . :. .:. : :.: : .:: :.:. NP_113 VLEPEQTFFSSPCQEEHGHPRRIPHLPGHPYSPEYAPSPLHCSHPLGSLALGQSP-GVSM 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB9 YDEVRAGATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGS .. : . : : . :. ... . : :. : :. . . :. : NP_113 MSPVPGCPPSPAYYSPATYHPLHSNLQAHLGQLSPPPEHPGFDALDQLSQVELLG----- 280 290 300 310 320 360 370 380 390 400 410 pF1KB9 SGEDADDLMFDLSLNFSQSAHSASEQQLGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEF : : :: :: ::. :. : .:.. .: : NP_113 ---DMDRNEFDQYLNTPGHPDSAT----GAMALSGHVPVSQVTPTGPTETSLISVLADAT 330 340 350 360 370 420 430 440 pF1KB9 PDYCTPELSEMIAGDWLEANFSDLVFTY NP_113 ATYYNSYSVS 380 >>NP_005625 (OMIM: 300123,312000,313430) transcription f (446 aa) initn: 373 init1: 373 opt: 400 Z-score: 267.8 bits: 58.7 E(85289): 3.5e-08 Smith-Waterman score: 405; 33.5% identity (53.9% similar) in 310 aa overlap (44-349:134-372) 20 30 40 50 60 70 pF1KB9 LPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPD : . ..:::::::::::. .:::. ..: NP_005 GGAGKSSANAAGGANSGGGSSGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALENPK 110 120 130 140 150 160 80 90 100 110 120 pF1KB9 MHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKM----DPS :::.::::::: ::.: :.:: ::: ::.::: :: .:::::::::.: : : NP_005 MHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKY 170 180 190 200 210 220 130 140 150 160 170 180 pF1KB9 AKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKAGAGKAAQSG . ::. : :..:...:..: : :::.. .:.:. NP_005 SLPSGLLPP--------GAAAAAAAAAA--------------AAAAASSPVGVGQRL--- 230 240 250 190 200 210 220 230 240 pF1KB9 DYGGAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQIKQEPDEEDEE : :. .:.: ..:: . :. :: : :. . NP_005 ------DTYT----HVNG-WANGAYSLVQ----------------EQLGYAQPPSMSSP- 260 270 280 290 250 260 270 280 290 300 pF1KB9 PPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRAGATSGAGGGS :: ::. : ..::..: . :: . : ::. : .: :.:....: :. NP_005 PP------PPALPP---MHRYDMAGLQYSPMM------PPGAQSYMNVAAAAAAASGYGG 300 310 320 330 310 320 330 340 350 360 pF1KB9 RLYYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDADDLMFDLSLNF . . . ::: . :.. .... : . :: NP_005 MAPSATAAAAAAYGQ---QPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIASHSQRA 340 350 360 370 380 390 370 380 390 400 410 420 pF1KB9 SQSAHSASEQQLGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPELSEMIAGDW NP_005 CLGDLRDMISMYLPPGGDAADAASPLPGGRLHGVHQHYQGAGTAVNGTVPLTHI 400 410 420 430 440 441 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:57:27 2016 done: Fri Nov 4 17:57:28 2016 Total Scan time: 9.420 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]