FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9652, 317 aa 1>>>pF1KB9652 317 - 317 aa - 317 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0046+/-0.00029; mu= 9.6138+/- 0.018 mean_var=144.8902+/-30.744, 0's: 0 Z-trim(121.4): 178 B-trim: 331 in 1/59 Lambda= 0.106550 statistics sampled from 37683 (37920) to 37683 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.772), E-opt: 0.2 (0.445), width: 16 Scan time: 8.670 The best scores are: opt bits E(85289) NP_003097 (OMIM: 184429,189960,206900) transcripti ( 317) 2167 344.1 2.3e-94 NP_005625 (OMIM: 300123,312000,313430) transcripti ( 446) 923 152.9 1.1e-36 NP_005977 (OMIM: 602148) transcription factor SOX- ( 391) 780 130.9 4.1e-30 NP_009015 (OMIM: 604974) transcription factor SOX- ( 276) 620 106.2 8e-23 NP_004180 (OMIM: 604747) transcription factor SOX- ( 240) 601 103.2 5.5e-22 NP_008873 (OMIM: 601297) protein SOX-15 [Homo sapi ( 233) 499 87.5 2.8e-17 NP_071899 (OMIM: 610928,613674) transcription fact ( 414) 466 82.7 1.5e-15 NP_055402 (OMIM: 605923) transcription factor SOX- ( 446) 433 77.6 5.2e-14 NP_003131 (OMIM: 400044,400045,480000) sex-determi ( 204) 424 76.0 7.5e-14 NP_060889 (OMIM: 137940,601618,607823) transcripti ( 384) 422 75.9 1.5e-13 NP_008874 (OMIM: 601947) transcription factor SOX- ( 315) 415 74.7 2.7e-13 NP_008872 (OMIM: 602229,609136,611584,613266) tran ( 466) 412 74.4 5e-13 NP_003099 (OMIM: 600898,615866) transcription fact ( 441) 410 74.1 5.9e-13 NP_000337 (OMIM: 114290,608160,616425) transcripti ( 509) 407 73.7 9.1e-13 NP_003098 (OMIM: 184430) transcription factor SOX- ( 474) 402 72.9 1.5e-12 NP_113627 (OMIM: 612202) transcription factor SOX- ( 388) 386 70.3 7e-12 NP_821078 (OMIM: 604975,616803) transcription fact ( 377) 338 63.0 1.1e-09 XP_011519144 (OMIM: 604975,616803) PREDICTED: tran ( 415) 338 63.0 1.2e-09 NP_001248343 (OMIM: 604975,616803) transcription f ( 642) 338 63.2 1.7e-09 XP_016875389 (OMIM: 604975,616803) PREDICTED: tran ( 715) 338 63.2 1.8e-09 XP_016875387 (OMIM: 604975,616803) PREDICTED: tran ( 715) 338 63.2 1.8e-09 XP_016875390 (OMIM: 604975,616803) PREDICTED: tran ( 715) 338 63.2 1.8e-09 XP_016875388 (OMIM: 604975,616803) PREDICTED: tran ( 715) 338 63.2 1.8e-09 XP_016875386 (OMIM: 604975,616803) PREDICTED: tran ( 716) 338 63.2 1.8e-09 NP_001317714 (OMIM: 604975,616803) transcription f ( 728) 338 63.2 1.9e-09 XP_011519140 (OMIM: 604975,616803) PREDICTED: tran ( 729) 338 63.2 1.9e-09 NP_694534 (OMIM: 604975,616803) transcription fact ( 750) 338 63.2 1.9e-09 XP_016875385 (OMIM: 604975,616803) PREDICTED: tran ( 750) 338 63.2 1.9e-09 XP_016875384 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 XP_016875382 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 XP_016875383 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 XP_016875380 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 XP_016875379 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 XP_011519139 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 XP_016875381 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 XP_011519136 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 XP_011519137 (OMIM: 604975,616803) PREDICTED: tran ( 751) 338 63.2 1.9e-09 NP_001248344 (OMIM: 604975,616803) transcription f ( 753) 338 63.2 1.9e-09 XP_011519135 (OMIM: 604975,616803) PREDICTED: tran ( 754) 338 63.2 1.9e-09 NP_008871 (OMIM: 604975,616803) transcription fact ( 763) 338 63.2 1.9e-09 XP_011519134 (OMIM: 604975,616803) PREDICTED: tran ( 764) 338 63.2 1.9e-09 XP_016875378 (OMIM: 604975,616803) PREDICTED: tran ( 792) 338 63.2 2e-09 XP_016875377 (OMIM: 604975,616803) PREDICTED: tran ( 793) 338 63.2 2e-09 NP_001139283 (OMIM: 607257) transcription factor S ( 801) 329 61.9 5.2e-09 NP_059978 (OMIM: 607257) transcription factor SOX- ( 804) 329 61.9 5.2e-09 NP_201583 (OMIM: 607257) transcription factor SOX- ( 808) 329 61.9 5.2e-09 NP_001139291 (OMIM: 607257) transcription factor S ( 841) 329 61.9 5.4e-09 XP_005245680 (OMIM: 604748) PREDICTED: transcripti ( 621) 316 59.8 1.7e-08 NP_005677 (OMIM: 604748) transcription factor SOX- ( 622) 316 59.8 1.7e-08 XP_005258732 (OMIM: 612082) PREDICTED: protein cap (1605) 311 59.3 5.9e-08 >>NP_003097 (OMIM: 184429,189960,206900) transcription f (317 aa) initn: 2167 init1: 2167 opt: 2167 Z-score: 1815.1 bits: 344.1 E(85289): 2.3e-94 Smith-Waterman score: 2167; 100.0% identity (100.0% similar) in 317 aa overlap (1-317:1-317) 10 20 30 40 50 60 pF1KB9 MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 KKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 PQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 GSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQS 250 260 270 280 290 300 310 pF1KB9 GPVPGTAINGTLPLSHM ::::::::::::::::: NP_003 GPVPGTAINGTLPLSHM 310 >>NP_005625 (OMIM: 300123,312000,313430) transcription f (446 aa) initn: 1183 init1: 656 opt: 923 Z-score: 779.6 bits: 152.9 E(85289): 1.1e-36 Smith-Waterman score: 1153; 52.8% identity (74.0% similar) in 377 aa overlap (1-317:76-446) 10 20 pF1KB9 MYNMMETELKPP-G-PQQTSG-------GG ::...::::: : : : :..: :: NP_005 ESQGLFTVAAPAPGAPSPPATLAHLLPAPAMYSLLETELKNPVGTPTQAAGTGGPAAPGG 50 60 70 80 90 100 30 40 50 60 pF1KB9 GGNSTAAAAGGNQKNS--------------PDRVKRPMNAFMVWSRGQRRKMAQENPKMH .:.:.: :::: .... :::::::::::::::::::::: :::::: NP_005 AGKSSANAAGGANSGGGSSGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALENPKMH 110 120 130 140 150 160 70 80 90 100 110 120 pF1KB9 NSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTL ::::::::::.::::...::::::::::::::.::::.::::::::::::::.:::::.: NP_005 NSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSL 170 180 190 200 210 220 130 140 150 160 170 180 pF1KB9 PGGLLAPGGNSMASGVGVGAGLGA---GVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHP :.::: ::. . :......:. .. ::.::.:.:.:.:::.::.::..:.:::: : : NP_005 PSGLLPPGAAAAAAAAAAAAAAASSPVGVGQRLDTYTHVNGWANGAYSLVQEQLGYAQPP 230 240 250 260 270 280 190 200 210 220 pF1KB9 GLNAHGAAQ-MQPMHRYDVSALQYNSMT--SSQTYMN---------G----SPTYSMS-- .... . ::::::...:::. : ..:.::: : .:. . . NP_005 SMSSPPPPPALPPMHRYDMAGLQYSPMMPPGAQSYMNVAAAAAAASGYGGMAPSATAAAA 290 300 310 320 330 340 230 240 250 260 270 pF1KB9 --YSQQ---------GTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMIS :.:: .. .:.:: :::::::: :: ::.. .:::. : :::::::: NP_005 AAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAI--ASHSQRACL-GDLRDMIS 350 360 370 380 390 400 280 290 300 310 pF1KB9 MYLP-GAEVPEPAAP---SRLH-MSQHYQSGPVPGTAINGTLPLSHM :::: :... . :.: .::: . ::::.. :::.:::.::.:. NP_005 MYLPPGGDAADAASPLPGGRLHGVHQHYQGA---GTAVNGTVPLTHI 410 420 430 440 >>NP_005977 (OMIM: 602148) transcription factor SOX-1 [H (391 aa) initn: 1037 init1: 728 opt: 780 Z-score: 661.6 bits: 130.9 E(85289): 4.1e-30 Smith-Waterman score: 1095; 54.0% identity (69.7% similar) in 363 aa overlap (1-288:1-358) 10 20 30 40 50 pF1KB9 MYNMM-ETELKPPGPQQT---------SGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMV ::.:: ::.:. :: :. .:::::.. ....::. : . :::::::::::: NP_005 MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMNAFMV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 WSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKY ::::::::::::::::::::::::::::::..::.::::::::::::::::::::::::: NP_005 WSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKY 70 80 90 100 110 120 120 130 140 150 pF1KB9 RPRRKTKTLMKKDKYTLPGGLLAPG----GNSMASGVGVGAGLGAGVNQRMDS------- :::::::::.:::::.: ::::: : : ..: :::::.: .:.:.::..: NP_005 RPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVGVG-AAAVGQRLESPGGAAGG 130 140 150 160 170 160 170 180 190 pF1KB9 -YAHMNGWSNGSY-----------SMMQD-QLGYPQHPGL-----NAHGAAQM------- :::.:::.::.: .:::. ::.: :::: .:: : NP_005 GYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPGAGGAHPHAHPAHPHPHHPHAH 180 190 200 210 220 230 200 210 220 230 pF1KB9 ----QPMHRYDVSALQYNSMTSSQTYMNGSPT------YSMSYSQQGTPGMA-------- :::::::..::::. ...:: ::..::. :. . . .. : : NP_005 PHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGLPYGAAAAAAAAAGGAHQNSAVAA 240 250 260 270 280 290 240 250 260 270 280 pF1KB9 -----------LGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPE ::..::.:::: :.::: . .:::::: ::::.:::::::..: . NP_005 AAAAAAASSGALGALGSLVKSEPSGSPP---APAHSRAPCP-GDLREMISMYLPAGEGGD 300 310 320 330 340 350 290 300 310 pF1KB9 PAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM ::: NP_005 PAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI 360 370 380 390 >>NP_009015 (OMIM: 604974) transcription factor SOX-21 [ (276 aa) initn: 624 init1: 569 opt: 620 Z-score: 530.7 bits: 106.2 E(85289): 8e-23 Smith-Waterman score: 620; 43.0% identity (62.9% similar) in 272 aa overlap (39-304:6-269) 10 20 30 40 50 60 pF1KB9 LKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHN :.:::::::::::::.:::::::::::::: NP_009 MSKPVDHVKRPMNAFMVWSRAQRRKMAQENPKMHN 10 20 30 70 80 90 100 110 120 pF1KB9 SEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLP ::::::::::::::.:.::::::::::::::.::::::::::::::: :::.::::...: NP_009 SEISKRLGAEWKLLTESEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLLKKDKFAFP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB9 -----GGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQH ::. .. .:.:. :: :.:. .: . .. . .. .:: NP_009 VPYGLGGVADAEHPALKAGAGLHAGAGGGLVP--ESLLANPEKAAAAAAAAAARVFFPQS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB9 PGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSM-GS . : .:: :.. : ..:. .. .: : :. :. : : . :.. :. NP_009 AAAAAAAAAAAAAGSPYSLLDLG-SKMAEISSSSSGLP-YA---SSLGYPTAGAGAFHGA 160 170 180 190 200 250 260 270 280 290 300 pF1KB9 VVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGP .. . :... . :: .: . : . :. . : : : . : : NP_009 AAAAAAAAAAAGGHTHSHP-SPGNPGYMIPCNCSAWPSPGLQPPLAYILLPGMGKPQLDP 210 220 230 240 250 260 310 pF1KB9 VPGTAINGTLPLSHM : NP_009 YPAAYAAAL 270 >>NP_004180 (OMIM: 604747) transcription factor SOX-14 [ (240 aa) initn: 626 init1: 574 opt: 601 Z-score: 515.7 bits: 103.2 E(85289): 5.5e-22 Smith-Waterman score: 601; 48.6% identity (69.5% similar) in 220 aa overlap (39-254:6-216) 10 20 30 40 50 60 pF1KB9 LKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHN :..::::::::::::::::::::::::::: NP_004 MSKPSDHIKRPMNAFMVWSRGQRRKMAQENPKMHN 10 20 30 70 80 90 100 110 120 pF1KB9 SEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLP ::::::::::::::::.::::.::::::::: ::::::::::::::: :.:.:::.:..: NP_004 SEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB9 GGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNA :. :.:. :::. : .. . : . ... ::... : . . .: NP_004 LPYLGDTDPLKAAGLPVGASDGL-LSAPEKARAFLPP-ASAPYSLLD-----PAQFSSSA 100 110 120 130 140 190 200 210 220 230 240 pF1KB9 HGAAQMQPMHRYDVSALQYNSMTSSQTYMNGS---PT-YSMSYSQQGTPGMALGSMGSVV : : ..:: : : . :. :: :. .. .. . .::... . .. NP_004 IQKMGEVP-HTLATGALPYASTLGYQNGAFGSLSCPSQHTHTHPSPTNPGYVV-PCNCTA 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB9 KSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVP : .. .::: NP_004 WSASTLQPPVAYILFPGMTKTGIDPYSSAHATAM 210 220 230 240 >>NP_008873 (OMIM: 601297) protein SOX-15 [Homo sapiens] (233 aa) initn: 477 init1: 458 opt: 499 Z-score: 431.2 bits: 87.5 E(85289): 2.8e-17 Smith-Waterman score: 499; 43.9% identity (64.5% similar) in 214 aa overlap (13-221:28-227) 10 20 30 40 pF1KB9 MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSP-DRVKRP :::. :.: . :: : . : ..:::: NP_008 MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAG----SPAAPG----TLPLEKVKRP 10 20 30 40 50 50 60 70 80 90 100 pF1KB9 MNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKE :::::::: .:::.:::.:::::::::::::::.::::.: :::::..::::::: :... NP_008 MNAFMVWSSAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRD 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB9 HPDYKYRPRRKTKTLMKKDKYTLPG-GLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHM .::::::::::.:. . : : :: :: . : .. . : . : ::. NP_008 YPDYKYRPRRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQP-SRGFGYRPPSYS-- 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 NGWSNGSYSMMQDQLGYPQH---PGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGS ... :::. . .: :. : . . ... : . . : .: : . . :. NP_008 TAYLPGSYGSSHCKLEAPSPCSLPQSDPRLQGELLPTYTH---YLPPGSPTPYNPPLAGA 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB9 PTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPG : NP_008 PMPLTHL 230 >>NP_071899 (OMIM: 610928,613674) transcription factor S (414 aa) initn: 467 init1: 398 opt: 466 Z-score: 400.4 bits: 82.7 E(85289): 1.5e-15 Smith-Waterman score: 468; 31.7% identity (56.7% similar) in 312 aa overlap (9-305:36-331) 10 20 30 pF1KB9 MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSP :.: : ....: . .:: : :..... .. NP_071 AGYASDDQSQTQSALPAVMAGLGPCPWAESLSPIGDMKVKGEAPANSGAPAGAAGRAKGE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLR .:..:::::::::.. .:...::.:: .::.:.:: :: :: :. .:::::..::.::: NP_071 SRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 ALHMKEHPDYKYRPRRKTKTLMKKDKYTLPG---GLLAPGGNSMASGVGVGAGLGAGVNQ . ::..::.:::::::. . .:. : . : :: : . ... : : : :.. NP_071 VQHMQDHPNYKYRPRRRKQ--VKRLKRVEGGFLHGLAEPQAAALGPEGGRVAMDGLGLQF 130 140 150 160 170 180 160 170 180 190 200 pF1KB9 RMDSYA--------HMNGWSNGSYSMMQDQL-GYPQHPGLNAHGAAQMQPMHRYDVSALQ ... ::.: :. : ::: : . . .:. : . NP_071 PEQGFPAGPPLLPPHMGGHYRDCQSLGAPPLDGYPL-P------TPDTSPLDGVDPDPAF 190 200 210 220 230 210 220 230 240 250 260 pF1KB9 YNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSE-ASSSPPVVTSSSHSRAPC . . .. :. .:.. . : : : : . : :. : : . :: NP_071 FAAPMPGDCPAAGTYSYAQVSDYAGPPEPPAGPMHPRLGPEPAGPSIPGLL------APP 240 250 260 270 280 290 270 280 290 300 310 pF1KB9 QAGDLRDMISMYLPGAEVPE--PAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM .: . . .: ::: . :.. :. :: . : :: NP_071 SALHVY-YGAMGSPGAGGGRGFQMQPQHQHQHQHQHHPPGPGQPSPPPEALPCRDGTDPS 300 310 320 330 340 NP_071 QPAELLGEVDRTEFEQYLHFVCKPEMGLPYQGHDSGVNLPDSHGAISSVVSDASSAVYYC 350 360 370 380 390 400 >>NP_055402 (OMIM: 605923) transcription factor SOX-8 [H (446 aa) initn: 387 init1: 387 opt: 433 Z-score: 372.6 bits: 77.6 E(85289): 5.2e-14 Smith-Waterman score: 441; 31.5% identity (56.0% similar) in 327 aa overlap (14-313:85-396) 10 20 30 40 pF1KB9 MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKR :. . :::: : : .: .::: NP_055 DPAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGG---------GALKAKP-HVKR 60 70 80 90 100 50 60 70 80 90 100 pF1KB9 PMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMK ::::::::... :::.:.. :..::.:.:: :: :.::::.:::::..::.:::. : : NP_055 PMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKK 110 120 130 140 150 160 110 120 130 140 150 160 pF1KB9 EHPDYKYRPRRKTKTLMKKDKYTLPGGLLAP--GGNSMASGVGVGAGLGAGVNQRMDSYA .::::::.:::. :. . . :. :.: ::... . . :::: : ... : . NP_055 DHPDYKYQPRRR-KSAKAGHSDSDSGAELGPHPGGGAVYK---AEAGLGDG-HHHGDHTG 170 180 190 200 210 170 180 190 200 210 pF1KB9 HMNGWSNGSYSMMQDQLGYPQHPGLNAHG------AAQMQPMHRYDVSALQYNSMTSSQT . .: . . . .: :. .: . : . :.: :. . : . .. NP_055 QTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDA 220 230 240 250 260 270 220 230 240 250 pF1KB9 --------YMN-GSPT-------YSMSYSQQG-TPGMALGSMGSVVKSEASSSPPVVTSS :. :.:. :. .: . : .: : : :. : . ..:: . NP_055 FDVHEFDQYLPLGGPAPPEPGQAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIK 280 290 300 310 320 330 260 270 280 290 300 310 pF1KB9 SHSRAPCQAGDLRDMISMY--LPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSH ... .: . :: : : ::::. ... . : . ... :. : NP_055 TEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYA 340 350 360 370 380 390 pF1KB9 M NP_055 PGLYQYPCFHSPRRPYASPLLNGLALPPAHSPTSHWDQPVYTTLTRP 400 410 420 430 440 >>NP_003131 (OMIM: 400044,400045,480000) sex-determining (204 aa) initn: 434 init1: 416 opt: 424 Z-score: 369.6 bits: 76.0 E(85289): 7.5e-14 Smith-Waterman score: 439; 45.6% identity (69.6% similar) in 171 aa overlap (31-200:49-198) 10 20 30 40 50 pF1KB9 MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQK-NSPDRVKRPMNAFMVWSRGQRRKM : :.: : ::::::::::.:::: ::::: NP_003 PAVQENIPALRRSSSFLCTESCNSKYQCETGENSKGNVQDRVKRPMNAFIVWSRDQRRKM 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB9 AQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTL : :::.:.::::::.:: .::.:.:.:: ::..::..:.:.: ...:.::::::::.: . NP_003 ALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAK-M 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB9 MKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLG . :. :: : .. . : : ..:. . . .....: :. ::: NP_003 LPKNCSLLP----ADPASVLCSEV------------QLDNRLYRDDCTKATHSRMEHQLG 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 YPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGS . : .:: :.. : :: NP_003 H--LPPINA--ASSPQQRDRYSHWTKL 190 200 >>NP_060889 (OMIM: 137940,601618,607823) transcription f (384 aa) initn: 439 init1: 383 opt: 422 Z-score: 364.3 bits: 75.9 E(85289): 1.5e-13 Smith-Waterman score: 422; 46.5% identity (74.4% similar) in 129 aa overlap (11-135:51-176) 10 20 30 pF1KB9 MYNMMETELKPPGPQQTSGGGG--GNSTAAAAGGNQKNSP ::.::.. . : . :: ..... NP_060 AWAPGHGAAADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGERQAA 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB9 D--RVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKR : :..:::::::::.. .:...::.:: .::. .:: :: :: :. .:::::..::.: NP_060 DESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAER 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB9 LRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQR ::. :...::.:::::::: .. .: . :: :: :: NP_060 LRVQHLRDHPNYKYRPRRKKQA--RKARRLEPG-LLLPGLAPPQPPPEPFPAASGSARAF 150 160 170 180 190 160 170 180 190 200 210 pF1KB9 MDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTY NP_060 RELPPLGAEFDGLGLPTPERSPLDGLEPGEAAFFPPPAAPEDCALRPFRAPYAPTELSRD 200 210 220 230 240 250 317 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:58:41 2016 done: Fri Nov 4 17:58:42 2016 Total Scan time: 8.670 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]