FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9682, 149 aa 1>>>pF1KB9682 149 - 149 aa - 149 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1713+/-0.000279; mu= 13.1846+/- 0.018 mean_var=68.5090+/-13.902, 0's: 0 Z-trim(118.4): 43 B-trim: 16 in 1/54 Lambda= 0.154953 statistics sampled from 31300 (31343) to 31300 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.744), E-opt: 0.2 (0.367), width: 16 Scan time: 5.390 The best scores are: opt bits E(85289) NP_851998 (OMIM: 600349) DNA-binding protein inhib ( 149) 950 220.4 8.8e-58 NP_002156 (OMIM: 600349) DNA-binding protein inhib ( 155) 903 209.9 1.3e-54 NP_002157 (OMIM: 600386) DNA-binding protein inhib ( 134) 286 71.9 3.9e-13 NP_002158 (OMIM: 600277) DNA-binding protein inhib ( 119) 275 69.4 1.9e-12 NP_001537 (OMIM: 600581) DNA-binding protein inhib ( 161) 257 65.5 4e-11 NP_005161 (OMIM: 601886) achaete-scute homolog 2 [ ( 193) 135 38.2 0.0076 >>NP_851998 (OMIM: 600349) DNA-binding protein inhibitor (149 aa) initn: 950 init1: 950 opt: 950 Z-score: 1158.4 bits: 220.4 E(85289): 8.8e-58 Smith-Waterman score: 950; 100.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KB9 MKVASGSTATAAAGPSCALKAGKTASGAGEVVRCLSEQSVAISRCAGGAGARLPALLDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 MKVASGSTATAAAGPSCALKAGKTASGAGEVVRCLSEQSVAISRCAGGAGARLPALLDEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGTPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_851 QVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGTPGG 70 80 90 100 110 120 130 140 pF1KB9 RGLPVRAPLSTLNGEISALTAEVRSRSDH ::::::::::::::::::::::::::::: NP_851 RGLPVRAPLSTLNGEISALTAEVRSRSDH 130 140 >>NP_002156 (OMIM: 600349) DNA-binding protein inhibitor (155 aa) initn: 903 init1: 903 opt: 903 Z-score: 1101.3 bits: 209.9 E(85289): 1.3e-54 Smith-Waterman score: 903; 100.0% identity (100.0% similar) in 142 aa overlap (1-142:1-142) 10 20 30 40 50 60 pF1KB9 MKVASGSTATAAAGPSCALKAGKTASGAGEVVRCLSEQSVAISRCAGGAGARLPALLDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MKVASGSTATAAAGPSCALKAGKTASGAGEVVRCLSEQSVAISRCAGGAGARLPALLDEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGTPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGTPGG 70 80 90 100 110 120 130 140 pF1KB9 RGLPVRAPLSTLNGEISALTAEVRSRSDH :::::::::::::::::::::: NP_002 RGLPVRAPLSTLNGEISALTAEAACVPADDRILCR 130 140 150 >>NP_002157 (OMIM: 600386) DNA-binding protein inhibitor (134 aa) initn: 307 init1: 249 opt: 286 Z-score: 356.8 bits: 71.9 E(85289): 3.9e-13 Smith-Waterman score: 293; 49.5% identity (73.0% similar) in 111 aa overlap (35-140:15-114) 10 20 30 40 50 60 pF1KB9 SGSTATAAAGPSCALKAGKTASGAGEVVRCLSEQSVAISRCAGGAGARLPALLDEQQVNV ::..:..::: .. : .:. . NP_002 MKAFSPVRSVRKNSLSDHSLGISR------SKTP--VDDPM--S 10 20 30 70 80 90 100 110 pF1KB9 LLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGT-----PG :::.:: :::.::::::..:::.::::.:::::::::: :::. :.:. . . :: NP_002 LLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPG 40 50 60 70 80 90 120 130 140 pF1KB9 GRGLPVRAPLSTLNGEISALTAEVRSRSDH .. :.::.::: .:: :. NP_002 -QNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG 100 110 120 130 >>NP_002158 (OMIM: 600277) DNA-binding protein inhibitor (119 aa) initn: 248 init1: 192 opt: 275 Z-score: 344.3 bits: 69.4 E(85289): 1.9e-12 Smith-Waterman score: 276; 49.1% identity (69.1% similar) in 110 aa overlap (19-126:1-100) 10 20 30 40 50 pF1KB9 MKVASGSTATAAAGPSCALKAGKTASGAGEVVRCLSEQSVAISRCAG-GAGARLP-ALLD .:: . . : :.: ::::.:.::.: : : .:. : .::: NP_002 MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLD 10 20 30 40 60 70 80 90 100 110 pF1KB9 EQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGTP ::: :::::.:::: .:.. ..:.:::::.::::: :::. : .: : : NP_002 ---------DMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL-AEPAPGPP 50 60 70 80 90 120 130 140 pF1KB9 GGRGLPVRAPLSTLNGEISALTAEVRSRSDH : ::.. NP_002 DGPHLPIQTAELTPELVISNDKRSFCH 100 110 >>NP_001537 (OMIM: 600581) DNA-binding protein inhibitor (161 aa) initn: 300 init1: 227 opt: 257 Z-score: 320.6 bits: 65.5 E(85289): 4e-11 Smith-Waterman score: 266; 42.5% identity (64.9% similar) in 134 aa overlap (20-133:12-144) 10 20 30 40 50 pF1KB9 MKVASGSTATAAAGPSCALKAGKTASGAGEV-VRCLSEQSVAI----SRCAGGAGARLPA . . .. :.::. .:::.:.. .. . :..:.:: : NP_001 MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARCKA 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 L---LDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSE :: . : ::: :::::..::::.: :.::::::::::::::: :::: :... NP_001 AEAAADEPAL-CLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETH 60 70 80 90 100 110 120 130 140 pF1KB9 SEV----------GTPGGR--GLPVRAPLSTLNGEISALTAEVRSRSDH . :.: . : :.::..:: NP_001 PALLRQPPPPAPPHHPAGTCPAAPPRTPLTALNTDPAGAVNKQGDSILCR 120 130 140 150 160 >>NP_005161 (OMIM: 601886) achaete-scute homolog 2 [Homo (193 aa) initn: 128 init1: 91 opt: 135 Z-score: 172.1 bits: 38.2 E(85289): 0.0076 Smith-Waterman score: 135; 31.8% identity (59.1% similar) in 132 aa overlap (6-128:3-130) 10 20 30 40 50 pF1KB9 MKVASGSTATAAAGPSCALKAGKTAS---GAGEVVRCLSEQSVAISRCAGGAGARLPALL :.: .: :. . .: .: .. :..:: .. : .. .:::.: : NP_005 MDGGTLPRSAPPAPPVPVGCAARRRPASPELLRCSRRRRPATAETGGGAAAV--ARR 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 DEQQVN-VLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEV- .:.. : : : ... .. :.. :: ..:.:::: :. ...::: :: : .. : NP_005 NERERNRVKLVNLG--FQALRQHVPHGGASKKLSKVETLRSAVEYIRALQRLLAEHDAVR 60 70 80 90 100 110 120 130 140 pF1KB9 -GTPGG-RGLPVR--APLSTLNGEISALTAEVRSRSDH . :: : :: :: NP_005 NALAGGLRPQAVRPSAPRGPPGTTPVAASPSRASSSPGRGGSSEPGSPRSAYSSDDSGCE 120 130 140 150 160 170 149 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:17:44 2016 done: Fri Nov 4 18:17:45 2016 Total Scan time: 5.390 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]