FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9688, 222 aa 1>>>pF1KB9688 222 - 222 aa - 222 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8984+/-0.00079; mu= 5.1450+/- 0.048 mean_var=197.8776+/-40.190, 0's: 0 Z-trim(116.0): 146 B-trim: 0 in 0/53 Lambda= 0.091175 statistics sampled from 16441 (16601) to 16441 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.817), E-opt: 0.2 (0.51), width: 16 Scan time: 2.510 The best scores are: opt bits E(32554) CCDS8872.1 HOXC5 gene_id:3222|Hs108|chr12 ( 222) 1530 212.4 1.9e-55 CCDS11530.1 HOXB5 gene_id:3215|Hs108|chr17 ( 269) 525 80.2 1.4e-15 CCDS5406.1 HOXA5 gene_id:3202|Hs108|chr7 ( 270) 524 80.1 1.5e-15 CCDS2269.1 HOXD4 gene_id:3233|Hs108|chr2 ( 255) 502 77.2 1.1e-14 CCDS8873.1 HOXC4 gene_id:3221|Hs108|chr12 ( 264) 458 71.4 6e-13 CCDS11529.1 HOXB4 gene_id:3214|Hs108|chr17 ( 251) 456 71.1 7e-13 CCDS5405.1 HOXA4 gene_id:3201|Hs108|chr7 ( 320) 457 71.4 7.6e-13 CCDS11531.1 HOXB6 gene_id:3216|Hs108|chr17 ( 224) 422 66.6 1.4e-11 CCDS41792.1 HOXC6 gene_id:3223|Hs108|chr12 ( 153) 413 65.3 2.5e-11 CCDS5407.1 HOXA6 gene_id:3203|Hs108|chr7 ( 233) 413 65.4 3.3e-11 CCDS8871.1 HOXC6 gene_id:3223|Hs108|chr12 ( 235) 413 65.5 3.4e-11 >>CCDS8872.1 HOXC5 gene_id:3222|Hs108|chr12 (222 aa) initn: 1530 init1: 1530 opt: 1530 Z-score: 1108.9 bits: 212.4 E(32554): 1.9e-55 Smith-Waterman score: 1530; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222) 10 20 30 40 50 60 pF1KB9 MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSLHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSLHG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 VDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 VDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 EQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS88 EQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYL 130 140 150 160 170 180 190 200 210 220 pF1KB9 TRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL :::::::::::::::::::::::::::::::::::::::::: CCDS88 TRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL 190 200 210 220 >>CCDS11530.1 HOXB5 gene_id:3215|Hs108|chr17 (269 aa) initn: 521 init1: 404 opt: 525 Z-score: 393.4 bits: 80.2 E(32554): 1.4e-15 Smith-Waterman score: 553; 41.0% identity (60.5% similar) in 256 aa overlap (8-218:8-257) 10 20 30 40 pF1KB9 MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASR------------YCYGGLDLSIT :: . :: : :.. ::::.: ...: : :.:.:::.. CCDS11 MSSYFVNSFSGRYPNGPDYQLL---NYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVN 10 20 30 40 50 50 60 70 80 90 pF1KB9 ------------------FPPPAPSNSLHGVDMAANPRAHPDRPACSAAAAPGHAPGRDE :: :: .. . .. . :. :. . . : : . CCDS11 RSSASSSHFGAVGESSRAFPAPAQEPRFRQA-ASSCSLSSPESLPCTNGDSHGAKP--SA 60 70 80 90 100 110 100 110 120 130 pF1KB9 AAPLNPGMYSQKAARPALEERAKSSGEIKEEQAQTGQPAGLSQPPAP------------P ..: . . ....: . ..:..:.: .: .: ..:. : : : CCDS11 SSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTP 120 130 140 150 160 170 140 150 160 170 180 190 pF1KB9 QIYPWMTKLHMSHET---DGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLN ::.::: :::.::. ::::.::.::::::::::::::::::::::::::::. :::. CCDS11 QIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLS 180 190 200 210 220 230 200 210 220 pF1KB9 ERQIKIWFQNRRMKWKKDSKMKSKEAL ::::::::::::::::::.:.:: CCDS11 ERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP 240 250 260 >>CCDS5406.1 HOXA5 gene_id:3202|Hs108|chr7 (270 aa) initn: 523 init1: 410 opt: 524 Z-score: 392.7 bits: 80.1 E(32554): 1.5e-15 Smith-Waterman score: 589; 45.0% identity (65.7% similar) in 251 aa overlap (9-218:9-258) 10 20 30 40 50 pF1KB9 MSSYVANSFYKQSPNIPAYNMQTCGNYGSASE-------VQASRYCYG--GLDLSITFPP : . :: : :.... :...:.:: ....:: :: :.:::. CCDS54 MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSG 10 20 30 40 50 60 60 70 80 90 100 pF1KB9 PAPSNS-LHGVDMAANPRAHPDRPACSAAAAPGHAPGRDE-----AAPLNPGMYSQKAAR . .: .. ..::. : : .: : :. :.: : .:: .:: :..... CCDS54 SGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAP-SPGSDSHHGGK 70 80 90 100 110 110 120 130 140 pF1KB9 PAL------------------EERAKSSGEIKEEQAQTGQPAGLSQP-PAPP---QIYPW .: : . .:: .. :.. : .. :.: :::: ::::: CCDS54 NSLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPW 120 130 140 150 160 170 150 160 170 180 190 pF1KB9 MTKLHMSHET----DGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQI : :::.::.. .:::.::.::::::::::::::::::::::::::::. :::.:::: CCDS54 MRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQI 180 190 200 210 220 230 200 210 220 pF1KB9 KIWFQNRRMKWKKDSKMKSKEAL ::::::::::::::.:.:: CCDS54 KIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP 240 250 260 270 >>CCDS2269.1 HOXD4 gene_id:3233|Hs108|chr2 (255 aa) initn: 513 init1: 366 opt: 502 Z-score: 377.3 bits: 77.2 E(32554): 1.1e-14 Smith-Waterman score: 502; 44.9% identity (64.4% similar) in 225 aa overlap (1-216:3-215) 10 20 30 40 50 pF1KB9 MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPA--PSN ::::..:: : . :..: . :.: . :.. : ::: . : ::. : CCDS22 MVMSSYMVNSKYVD-PKFPPCEEYLQGGYLGE---QGADY-YGGGAQGADFQPPGLYPRP 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 SLHGVDMAAN-PRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSS .. .... : :: . . :: .:: ::: .: . : :: :.. CCDS22 DFGEQPFGGSGPGPGSALPARGHGQEPG-GPGGHYAAPGEP-CPAPPAPPPAPLPGARAY 60 70 80 90 100 110 120 130 140 150 160 pF1KB9 GEIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLHMS----HETDG--KRSRTSYTRYQTLE .. .: .: ..:.:: . .:::: :.:.. . : : :::::.::: :.:: CCDS22 SQSDPKQPPSG--TALKQPAV---VYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLE 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 LEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL ::::::::::::::::::::..:::.:::::::::::::::::: :. CCDS22 LEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSS 170 180 190 200 210 220 CCDS22 SSCSSSVAPSQHLQPMAKDHHTDLTTL 230 240 250 >>CCDS8873.1 HOXC4 gene_id:3221|Hs108|chr12 (264 aa) initn: 494 init1: 360 opt: 458 Z-score: 345.9 bits: 71.4 E(32554): 6e-13 Smith-Waterman score: 468; 40.7% identity (57.7% similar) in 241 aa overlap (1-216:3-217) 10 20 30 40 50 pF1KB9 MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITF--------P ::::. .: : . :..: : .:.. : . : : : : CCDS88 MIMSSYLMDSNYID-PKFPP-----CEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYP 10 20 30 40 50 60 70 80 90 100 pF1KB9 PPAPSNSLHGVDMAANPRAHPDRP-ACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALE :: : : .:.: .:.. .::.. :. .: . : . . .. .: CCDS88 PPPPRPS------------YPERQYSCTSLQGPGNSRGH---GPAQAGHHHPEKSQ-SLC 60 70 80 90 110 120 130 140 150 pF1KB9 ERAKSSGEIKEEQAQTGQPAGLSQPPAP----------PQIYPWMTKLHMSH---ETDG- : : :: . . : . ::: :: : .:::: :.:.: . .: CCDS88 EPAPLSGA---SASPSPAPPACSQP-APDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGG 100 110 120 130 140 150 160 170 180 190 200 210 pF1KB9 --KRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKD :::::.::: :.::::::::.:::::::::::::..:::.:::::::::::::::::: CCDS88 EPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKD 160 170 180 190 200 210 220 pF1KB9 SKMKSKEAL .. CCDS88 HRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL 220 230 240 250 260 >>CCDS11529.1 HOXB4 gene_id:3214|Hs108|chr17 (251 aa) initn: 469 init1: 360 opt: 456 Z-score: 344.7 bits: 71.1 E(32554): 7e-13 Smith-Waterman score: 456; 40.1% identity (56.5% similar) in 232 aa overlap (1-216:3-223) 10 20 30 40 50 pF1KB9 MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSL :::.. :: : . :..: . . ..: .. .. : :: .: : : CCDS11 MAMSSFLINSNYVD-PKFPPCEEYSQSDYLPSD--HSPGYYAGGQRRESSFQPEAG---- 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 HGVDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSSGEI : : . . . :: . : : : ::. . : : :. CCDS11 FGRRAACTVQRYA---ACRDPGPPPPPPPPPPPPP-PPGLSPRAPAPPPAGALLPEPGQR 60 70 80 90 100 120 130 140 150 160 pF1KB9 KEEQAQTGQPAGLSQ-P--PAP-------PQIYPWMTKLHMS----HETDG--KRSRTSY : ... : .: : :.: : .:::: :.:.: . . : :::::.: CCDS11 CEAVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAY 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 TRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL :: :.::::::::.:::::::::.:::. :::.:::::::::::::::::: :. CCDS11 TRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIR 170 180 190 200 210 220 CCDS11 SGGAAGSAGGPPGRPNGGPRAL 230 240 250 >>CCDS5405.1 HOXA4 gene_id:3201|Hs108|chr7 (320 aa) initn: 431 init1: 365 opt: 457 Z-score: 344.1 bits: 71.4 E(32554): 7.6e-13 Smith-Waterman score: 467; 42.3% identity (58.1% similar) in 227 aa overlap (2-216:71-276) 10 20 30 pF1KB9 MSSYVANSFYKQSPNIPAYNMQTCGNYGSAS .:: : .. : :: . .:.:. CCDS54 GYQQPPAPPTQHLPLQQPQLPHAGGGREPTASYYAPRTARE-PAYPAAALYP--AHGAAD 50 60 70 80 90 40 50 60 70 80 pF1KB9 EVQASRYCYGGLDLSITFP--PPA----PSNSLHGVDMAANPRAHPDRPACSAAAAPGHA . : :. : ::: :...::. . : .: :.: : CCDS54 TAYPYGYRGGASPGRPPQPEQPPAQAKGPAHGLHASHVLQPQLPPPLQPR----AVPPAA 100 110 120 130 140 150 90 100 110 120 130 140 pF1KB9 PGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKEEQAQTGQPAGLSQPPAPPQIYPWMT : : :::: .::. . .: :: ... : ::. : .:::: CCDS54 PRRCEAAPATPGVPAGGSA-PACPLLLADKS-----------PLGLKGKE--PVVYPWMK 160 170 180 190 150 160 170 180 190 pF1KB9 KLHMS------HETDGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQI :.:.: . . :::::.::: :.::::::::::::::::::::::..:::.:::. CCDS54 KIHVSAVNPSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQV 200 210 220 230 240 250 200 210 220 pF1KB9 KIWFQNRRMKWKKDSKMKSKEAL :::::::::::::: :. CCDS54 KIWFQNRRMKWKKDHKLPNTKMRSSNSASASAGPPGKAQTQSPHLHPHPHPSTSTPVPSS 260 270 280 290 300 310 >>CCDS11531.1 HOXB6 gene_id:3216|Hs108|chr17 (224 aa) initn: 430 init1: 347 opt: 422 Z-score: 321.2 bits: 66.6 E(32554): 1.4e-11 Smith-Waterman score: 429; 45.9% identity (64.7% similar) in 170 aa overlap (67-222:45-213) 40 50 60 70 80 90 pF1KB9 RYCYGGLDLSITFPPPAPSNSLHGVDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLN- : :. ... : . : .::: . CCDS11 ASGQESFLGQLPLYSSGYADPLRHYPAPYGPGPGQDKGFATSSYYPPAGGGYGRAAPCDY 20 30 40 50 60 70 100 110 120 130 140 pF1KB9 ---PGMYSQKAARPAL---EERAKSSGEI-KEEQAQTGQPAGLS--QPPAPPQIYPWMTK :..: .: . :: .:. : : . :: . : . : . : .:::: . CCDS11 GPAPAFYREKESACALSGADEQPPFHPEPRKSDCAQDKSVFGETEEQKCSTP-VYPWMQR 80 90 100 110 120 130 150 160 170 180 190 200 pF1KB9 LHMSHETD----GKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIW .. . .. :.:.: .::::::::::::::.:::::::::::::. :::.::::::: CCDS11 MNSCNSSSFGPSGRRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIW 140 150 160 170 180 190 210 220 pF1KB9 FQNRRMKWKKDSKMKSKEAL ::::::::::.::. : : CCDS11 FQNRRMKWKKESKLLSASQLSAEEEEEKQAE 200 210 220 >>CCDS41792.1 HOXC6 gene_id:3223|Hs108|chr12 (153 aa) initn: 382 init1: 338 opt: 413 Z-score: 316.9 bits: 65.3 E(32554): 2.5e-11 Smith-Waterman score: 413; 61.9% identity (79.0% similar) in 105 aa overlap (119-218:20-122) 90 100 110 120 130 140 pF1KB9 DEAAPLNPGMYSQKAARPALEERAKSSGEIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLH .. ... :. : .: : :::::: ... CCDS41 MLSNCRQNTLGHNTQTSIAQDFSSEQGRTAPQDQK-ASIQIYPWMQRMN 10 20 30 40 150 160 170 180 190 200 pF1KB9 MSHE-----TDGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWF :: .: .:.: :.::::::::::::::::::::::::::: :::.:::::::: CCDS41 -SHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWF 50 60 70 80 90 100 210 220 pF1KB9 QNRRMKWKKDSKMKSKEAL :::::::::.:.. : CCDS41 QNRRMKWKKESNLTSTLSGGGGGATADSLGGKEEKREETEEEKQKE 110 120 130 140 150 >>CCDS5407.1 HOXA6 gene_id:3203|Hs108|chr7 (233 aa) initn: 425 init1: 349 opt: 413 Z-score: 314.6 bits: 65.4 E(32554): 3.3e-11 Smith-Waterman score: 414; 38.8% identity (59.9% similar) in 232 aa overlap (1-216:1-216) 10 20 30 40 50 pF1KB9 MSSYVANSFYKQS-PN--------IPAYNMQTCGNYGSASEVQASRYCYGGLDL-SITFP :::: .: . : :. .: :. ..: . :: ::. .: . :. CCDS54 MSSYFVNPTFPGSLPSGQDSFLGQLPLYQ----AGYDALRPFPAS---YGASSLPDKTYT 10 20 30 40 50 60 70 80 90 100 pF1KB9 PPAPSNSLHGVDMAANPRAHPDRPAC--SAAAAPGHAPGRDEAAPLNPGMYSQKAARPAL : .. ..: .: : .. .: : : .:. . .:: : . . : CCDS54 SPCFYQQSNSV-LACNRASYEYGASCFYSDKDLSGASPS-GSGKQRGPGDYLHFS--PEQ 60 70 80 90 100 110 120 130 140 150 160 pF1KB9 EERAKSSGEIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLHMS----HETDGKRSRTSYTR . . ::. :... . : .. . : .:::: ... . . :.:.: .::: CCDS54 QYKPDSSSG----QGKALHDEGADRKYTSP-VYPWMQRMNSCAGAVYGSHGRRGRQTYTR 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 YQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL :::::::::::::::::::::::::: :::.:::::::::::::::::..:. CCDS54 YQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSG 170 180 190 200 210 220 CCDS54 EDSEAKAGE 230 222 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:20:04 2016 done: Fri Nov 4 18:20:05 2016 Total Scan time: 2.510 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]