FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9705, 335 aa 1>>>pF1KB9705 335 - 335 aa - 335 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7207+/-0.000897; mu= 4.0220+/- 0.055 mean_var=287.4366+/-60.265, 0's: 0 Z-trim(114.9): 79 B-trim: 0 in 0/56 Lambda= 0.075649 statistics sampled from 15345 (15422) to 15345 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.474), width: 16 Scan time: 2.470 The best scores are: opt bits E(32554) CCDS2264.2 HOXD13 gene_id:3239|Hs108|chr2 ( 343) 2236 256.8 1.9e-68 CCDS5412.1 HOXA13 gene_id:3209|Hs108|chr7 ( 388) 931 114.4 1.6e-25 CCDS8865.1 HOXC13 gene_id:3229|Hs108|chr12 ( 330) 814 101.5 9.7e-22 CCDS11536.1 HOXB13 gene_id:10481|Hs108|chr17 ( 284) 669 85.6 5.1e-17 >>CCDS2264.2 HOXD13 gene_id:3239|Hs108|chr2 (343 aa) initn: 2236 init1: 2236 opt: 2236 Z-score: 1342.3 bits: 256.8 E(32554): 1.9e-68 Smith-Waterman score: 2236; 100.0% identity (100.0% similar) in 335 aa overlap (1-335:9-343) 10 20 30 40 50 pF1KB9 MDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAA :::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 MSRAGSWDMDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 AAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 AAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 SAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 SAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 NEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 NEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 QVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 QVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKF 250 260 270 280 290 300 300 310 320 330 pF1KB9 INKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS ::::::::::::::::::::::::::::::::::::::::::: CCDS22 INKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS 310 320 330 340 >>CCDS5412.1 HOXA13 gene_id:3209|Hs108|chr7 (388 aa) initn: 1043 init1: 401 opt: 931 Z-score: 571.9 bits: 114.4 E(32554): 1.6e-25 Smith-Waterman score: 931; 50.1% identity (71.1% similar) in 353 aa overlap (6-333:53-387) 10 20 pF1KB9 MDGLRADGGG--------AGGAPASSSSSSVAAAA : ::: ::: . ......:::: CCDS54 GGGLVADELNKNMEGAAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAA 30 40 50 60 70 80 30 40 50 60 70 80 pF1KB9 ASGQCRGFLS--APVFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERTGSSSSSSSSA :..:::.... ::. :. :. ..: . : .:::::.. : ... ..:::.. . : CCDS54 AANQCRNLMAHPAPLAPGAASAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGGPGPA 90 100 110 120 130 140 90 100 110 120 130 140 pF1KB9 VVAARPEAPPAKECPAPTPAAAAAAPPSAPA-LGYGYHFGNGYYSC-RMSHGVGLQQNAL :. : ::.: .: .::: :.:: : ::: ::.::: : :: : . ::. CCDS54 GPAG---AEAAKQC---SPCSAAAQSSSGPAALPYGY-FGSGYYPCARM----GPHPNAI 150 160 170 180 190 150 160 170 180 190 pF1KB9 KSSPH----ASLGGFPVEKYMDVSGLASSSVPANEVPARAKEVSFY-QGYTS-PYQH--- :: . :. ..: ..::::..: : :.: .:::: .:: :::.. ::.: CCDS54 KSCAQPASAAAAAAF-ADKYMDTAGPA-----AEEFSSRAKEFAFYHQGYAAGPYHHHQP 200 210 220 230 240 200 210 220 230 240 250 pF1KB9 VPGYIDM--VSTFGS-GEPRHEAY-ISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSS .:::.:: : .:. :: ::: . ::.:: :.: ::::.:.:: :.: : :.:::. CCDS54 MPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQAQPPHLWKST 250 260 270 280 290 300 260 270 280 290 300 310 pF1KB9 FPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSER .: ::. . : :::::::::::::.:::::: ::: ::::.:::::::::.:::::: CCDS54 LP-DVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLSER 310 320 330 340 350 360 320 330 pF1KB9 QVTIWFQNRRVKDKKIVSKLKDTVS ::::::::::::.::...::: : CCDS54 QVTIWFQNRRVKEKKVINKLKTTS 370 380 >>CCDS8865.1 HOXC13 gene_id:3229|Hs108|chr12 (330 aa) initn: 888 init1: 392 opt: 814 Z-score: 503.7 bits: 101.5 E(32554): 9.7e-22 Smith-Waterman score: 898; 48.3% identity (70.8% similar) in 329 aa overlap (8-331:29-323) 10 20 30 pF1KB9 MDGLRADGGGAGGAPASSSSSSVAAAAASGQCRGFLSAP :::.::. ..... :.: : : ..: CCDS88 MTTSLLLHPRWPESLMYVYEDSAAESGIGGGGGGGGGGTGG-------AGGGCSG--ASP 10 20 30 40 50 40 50 60 70 80 90 pF1KB9 VFAGTHSGRAAAAAAAAAAAAAAASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKEC : . .: ... :. .. : . :. ... . . : ::: :..: CCDS88 GKAPSMDGLGSSCPASHCRDLLPHPVLGRPPAP--LGAPQGAVYTDIPA--PEA--ARQC 60 70 80 90 100 100 110 120 130 140 150 pF1KB9 PAPTPAAAAAAPP--SAPALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVE :: :: :: :. .::::: ::..::.::.::.:.:::. : : : . CCDS88 -APPPA-----PPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQK-----PCAY---HPGD 110 120 130 140 150 160 170 180 190 200 210 pF1KB9 KYMDVSGLASSSVPANEVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFG-SG--EPRHEA :: . :: ..:.... .:::: .:: ...: :: .:::.:. . : :: ::::.: CCDS88 KYPEPSG----ALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDA 160 170 180 190 200 220 230 240 250 260 270 pF1KB9 YISMEGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVP : .:::: :.:.:::.:::::.:.: :..:.::: :: ::. ::.. :::::::::: CCDS88 LIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFP-DVVPLQPEVSSYRRGRKKRVP 210 220 230 240 250 260 280 290 300 310 320 330 pF1KB9 YTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTV :::.::::::.::: .:::.:.:::::::.::::::::::::::::::.::.::: : CCDS88 YTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPH 270 280 290 300 310 320 pF1KB9 S CCDS88 LHST 330 >>CCDS11536.1 HOXB13 gene_id:10481|Hs108|chr17 (284 aa) initn: 726 init1: 568 opt: 669 Z-score: 419.0 bits: 85.6 E(32554): 5.1e-17 Smith-Waterman score: 749; 47.8% identity (74.1% similar) in 247 aa overlap (93-335:57-283) 70 80 90 100 110 120 pF1KB9 ASGFAYPGTSERTGSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPPSAPALGYGYH : : :.: : :.. .. : :: . ::: CCDS11 LVAHSPLTSHPAAPTLMPAVNYAPLDLPGSAEPPKQCH-PCPGVPQGTSP-AP-VPYGY- 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB9 FGNGYYSCRMSHGVGLQQNALKSSPHA-SLGGFPVEKYMDVSGLASSSVPANEVPARAKE ::.::::::.: ...:: .: .:...:.: . . ..: :.: : CCDS11 FGGGYYSCRVS------RSSLKPCAQAATLAAYPAE----------TPTAGEEYPSRPTE 90 100 110 120 190 200 210 220 230 pF1KB9 VSFYQGYTSPYQHVPGYIDM--VSTFGS-GEPRHEAYISMEGYQSWTLANGWNSQVYCTK .:: :: . :: . .:.:. :.:.:. :::::.. . ...::::.::.:::::. : CCDS11 FAFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNSQMCCQG 130 140 150 160 170 180 240 250 260 270 280 290 pF1KB9 DQPQGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKR .: . :::..: . . . :: :..:::::::.::.: ::.::: ::: ::::.:::: CCDS11 EQNPPGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKR 190 200 210 220 230 240 300 310 320 330 pF1KB9 RRISAATNLSERQVTIWFQNRRVKDKKIVSKLKDTVS :.:::::.:::::.::::::::::.::...:.:.... CCDS11 RKISAATSLSERQITIWFQNRRVKEKKVLAKVKNSATP 250 260 270 280 335 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:26:34 2016 done: Fri Nov 4 18:26:34 2016 Total Scan time: 2.470 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]