FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9716, 393 aa 1>>>pF1KB9716 393 - 393 aa - 393 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7942+/-0.000349; mu= 1.4393+/- 0.022 mean_var=182.5098+/-37.504, 0's: 0 Z-trim(120.2): 68 B-trim: 0 in 0/55 Lambda= 0.094936 statistics sampled from 35058 (35127) to 35058 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.753), E-opt: 0.2 (0.412), width: 16 Scan time: 8.420 The best scores are: opt bits E(85289) XP_016871777 (OMIM: 120330,167409,191830,616002) P ( 424) 2663 376.7 5.6e-104 NP_000269 (OMIM: 120330,167409,191830,616002) pair ( 394) 2641 373.7 4.3e-103 NP_001291498 (OMIM: 120330,167409,191830,616002) p ( 425) 2641 373.7 4.6e-103 NP_003980 (OMIM: 120330,167409,191830,616002) pair ( 409) 2488 352.7 9e-97 XP_016871775 (OMIM: 120330,167409,191830,616002) P ( 440) 2488 352.7 9.6e-97 NP_003979 (OMIM: 120330,167409,191830,616002) pair ( 396) 2278 324.0 4e-88 XP_016871776 (OMIM: 120330,167409,191830,616002) P ( 427) 2278 324.0 4.2e-88 XP_005251538 (OMIM: 167414,615545) PREDICTED: pair ( 390) 1934 276.8 6e-74 NP_057953 (OMIM: 167414,615545) paired box protein ( 391) 1848 265.1 2.1e-70 XP_011510096 (OMIM: 167415,218700) PREDICTED: pair ( 387) 1657 238.9 1.6e-62 XP_011510095 (OMIM: 167415,218700) PREDICTED: pair ( 444) 1646 237.4 5e-62 NP_001267477 (OMIM: 167414,615545) paired box prot ( 362) 1552 224.5 3.2e-58 NP_003978 (OMIM: 120330,167409,191830,616002) pair ( 417) 1399 203.6 7.3e-52 XP_016871774 (OMIM: 120330,167409,191830,616002) P ( 448) 1399 203.6 7.7e-52 NP_003981 (OMIM: 120330,167409,191830,616002) pair ( 432) 1394 202.9 1.2e-51 XP_016871773 (OMIM: 120330,167409,191830,616002) P ( 463) 1394 202.9 1.3e-51 NP_001267476 (OMIM: 167414,615545) paired box prot ( 357) 1352 197.1 5.5e-50 NP_001267481 (OMIM: 167414,615545) paired box prot ( 328) 1338 195.2 1.9e-49 XP_011516199 (OMIM: 167414,615545) PREDICTED: pair ( 409) 1332 194.4 4.1e-49 NP_039246 (OMIM: 167415,218700) paired box protein ( 398) 1287 188.2 2.9e-47 XP_016860368 (OMIM: 167415,218700) PREDICTED: pair ( 402) 1283 187.7 4.3e-47 XP_011510094 (OMIM: 167415,218700) PREDICTED: pair ( 455) 1276 186.8 9.2e-47 XP_016860367 (OMIM: 167415,218700) PREDICTED: pair ( 459) 1272 186.2 1.4e-46 NP_003457 (OMIM: 167415,218700) paired box protein ( 450) 1267 185.5 2.1e-46 XP_011510093 (OMIM: 167415,218700) PREDICTED: pair ( 500) 1256 184.0 6.6e-46 XP_011510092 (OMIM: 167415,218700) PREDICTED: pair ( 507) 1256 184.0 6.7e-46 XP_011516198 (OMIM: 167414,615545) PREDICTED: pair ( 410) 1246 182.6 1.5e-45 NP_001267478 (OMIM: 167414,615545) paired box prot ( 324) 1228 180.1 6.6e-45 NP_001267485 (OMIM: 167414,615545) paired box prot ( 283) 1225 179.7 7.8e-45 NP_001267479 (OMIM: 167414,615545) paired box prot ( 295) 1214 178.2 2.3e-44 NP_039247 (OMIM: 167415,218700) paired box protein ( 321) 1186 174.3 3.5e-43 NP_054698 (OMIM: 167415,218700) paired box protein ( 287) 1166 171.6 2.1e-42 XP_016871770 (OMIM: 120330,167409,191830,616002) P ( 496) 1115 164.7 4.3e-40 XP_016871778 (OMIM: 120330,167409,191830,616002) P ( 374) 923 138.4 2.8e-32 XP_016871771 (OMIM: 120330,167409,191830,616002) P ( 483) 905 136.0 1.9e-31 XP_016871772 (OMIM: 120330,167409,191830,616002) P ( 483) 905 136.0 1.9e-31 NP_001267482 (OMIM: 167414,615545) paired box prot ( 319) 875 131.8 2.3e-30 NP_001267483 (OMIM: 167414,615545) paired box prot ( 348) 875 131.8 2.5e-30 NP_001297088 (OMIM: 106210,120430,136520,148190,16 ( 401) 780 118.8 2.3e-26 NP_001245393 (OMIM: 106210,120430,136520,148190,16 ( 422) 780 118.8 2.4e-26 NP_000271 (OMIM: 106210,120430,136520,148190,16555 ( 422) 780 118.8 2.4e-26 NP_001245394 (OMIM: 106210,120430,136520,148190,16 ( 422) 780 118.8 2.4e-26 NP_001121084 (OMIM: 106210,120430,136520,148190,16 ( 422) 780 118.8 2.4e-26 NP_006183 (OMIM: 167411,615560) paired box protein ( 534) 723 111.1 6.6e-24 NP_001267480 (OMIM: 167414,615545) paired box prot ( 220) 715 109.7 6.8e-24 NP_001244025 (OMIM: 167411,615560) paired box prot ( 457) 700 107.9 5.2e-23 NP_006185 (OMIM: 167416,604625) paired box protein ( 341) 669 103.6 7.7e-22 NP_001120838 (OMIM: 122880,148820,193500,268220,60 ( 483) 654 101.6 4.3e-21 NP_039230 (OMIM: 122880,148820,193500,268220,60659 ( 206) 642 99.7 6.6e-21 NP_000429 (OMIM: 122880,148820,193500,268220,60659 ( 215) 642 99.7 6.8e-21 >>XP_016871777 (OMIM: 120330,167409,191830,616002) PREDI (424 aa) initn: 2663 init1: 2663 opt: 2663 Z-score: 1987.7 bits: 376.7 E(85289): 5.6e-104 Smith-Waterman score: 2663; 100.0% identity (100.0% similar) in 393 aa overlap (1-393:32-424) 10 20 30 pF1KB9 MDMHCKADPFSAMHRHGGVNQLGGVFVNGR :::::::::::::::::::::::::::::: XP_016 EERAGPAVLKLSLRGDTAAAAALLPLLCLPMDMHCKADPFSAMHRHGGVNQLGGVFVNGR 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 PLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 TPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTP 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB9 DGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEGS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB9 VPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLP 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB9 ALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYP 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB9 TSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAY 370 380 390 400 410 420 pF1KB9 DRH ::: XP_016 DRH >>NP_000269 (OMIM: 120330,167409,191830,616002) paired b (394 aa) initn: 2642 init1: 2547 opt: 2641 Z-score: 1971.9 bits: 373.7 E(85289): 4.3e-103 Smith-Waterman score: 2641; 99.5% identity (99.5% similar) in 394 aa overlap (1-393:1-394) 10 20 30 40 50 pF1KB9 MDMHCKADPFSAMHR-HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV :::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_000 MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 EGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASND 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 PVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 LDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 TYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEA 310 320 330 340 350 360 360 370 380 390 pF1KB9 WRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH :::::::::::::::::::::::::::::::::: NP_000 WRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH 370 380 390 >>NP_001291498 (OMIM: 120330,167409,191830,616002) paire (425 aa) initn: 2642 init1: 2547 opt: 2641 Z-score: 1971.4 bits: 373.7 E(85289): 4.6e-103 Smith-Waterman score: 2641; 99.5% identity (99.5% similar) in 394 aa overlap (1-393:32-425) 10 20 pF1KB9 MDMHCKADPFSAMHR-HGGVNQLGGVFVNG :::::::::::::: :::::::::::::: NP_001 EERAGPAVLKLSLRGDTAAAAALLPLLCLPMDMHCKADPFSAMHPGHGGVNQLGGVFVNG 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB9 RPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 ATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPT 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 PDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 SVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSL 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 PALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSY 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 PTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAA 370 380 390 400 410 420 390 pF1KB9 YDRH :::: NP_001 YDRH >>NP_003980 (OMIM: 120330,167409,191830,616002) paired b (409 aa) initn: 2482 init1: 2387 opt: 2488 Z-score: 1858.4 bits: 352.7 E(85289): 9e-97 Smith-Waterman score: 2488; 94.4% identity (95.2% similar) in 394 aa overlap (1-393:1-394) 10 20 30 40 50 pF1KB9 MDMHCKADPFSAMHR-HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV :::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_003 MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 EGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASND 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 PVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 LDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 TYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEA 310 320 330 340 350 360 360 370 380 390 pF1KB9 WRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH ::::::::: : : : .:.. : NP_003 WRFSNPALLMPPPGAPPLPLLPLPMTATSYRGDHIKLQADSFGLHIVPV 370 380 390 400 >>XP_016871775 (OMIM: 120330,167409,191830,616002) PREDI (440 aa) initn: 2482 init1: 2387 opt: 2488 Z-score: 1857.9 bits: 352.7 E(85289): 9.6e-97 Smith-Waterman score: 2488; 94.4% identity (95.2% similar) in 394 aa overlap (1-393:32-425) 10 20 pF1KB9 MDMHCKADPFSAMHR-HGGVNQLGGVFVNG :::::::::::::: :::::::::::::: XP_016 EERAGPAVLKLSLRGDTAAAAALLPLLCLPMDMHCKADPFSAMHPGHGGVNQLGGVFVNG 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB9 RPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 ATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPT 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 PDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 SVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSL 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 PALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSY 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 PTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAA ::::::::::::::::::::::::::::::::::::::: : : : .:.. XP_016 PTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLMPPPGAPPLPLLPLPMTATSY 370 380 390 400 410 420 390 pF1KB9 YDRH : XP_016 RGDHIKLQADSFGLHIVPV 430 440 >>NP_003979 (OMIM: 120330,167409,191830,616002) paired b (396 aa) initn: 2267 init1: 2172 opt: 2278 Z-score: 1703.1 bits: 324.0 E(85289): 4e-88 Smith-Waterman score: 2278; 91.3% identity (94.0% similar) in 381 aa overlap (1-378:1-380) 10 20 30 40 50 pF1KB9 MDMHCKADPFSAMHR-HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV :::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_003 MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 EGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASND 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 PVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB9 LDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQ 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB9 TYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEF--SGNPYSHPQYTAYN :::::::::::::::::::::::::::::::::::::::: . :.. .:.: NP_003 TYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPEAAVGPSSSLMSKPGRK-LA 310 320 330 340 350 360 370 380 390 pF1KB9 EAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH :. .:. ::: .:.: NP_003 EVPPCVQPTGASSPATRTATPSTRPTTRLGDSATPPY 360 370 380 390 >>XP_016871776 (OMIM: 120330,167409,191830,616002) PREDI (427 aa) initn: 2267 init1: 2172 opt: 2278 Z-score: 1702.6 bits: 324.0 E(85289): 4.2e-88 Smith-Waterman score: 2278; 91.3% identity (94.0% similar) in 381 aa overlap (1-378:32-411) 10 20 pF1KB9 MDMHCKADPFSAMHR-HGGVNQLGGVFVNG :::::::::::::: :::::::::::::: XP_016 EERAGPAVLKLSLRGDTAAAAALLPLLCLPMDMHCKADPFSAMHPGHGGVNQLGGVFVNG 10 20 30 40 50 60 30 40 50 60 70 80 pF1KB9 RPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 ATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPT 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 PDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 SVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSL 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 PALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSY 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 PTSTLAGMVPGSEF--SGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAA :::::::::: . :.. .:.: :. .:. ::: .:.: XP_016 PTSTLAGMVPEAAVGPSSSLMSKPGRK-LAEVPPCVQPTGASSPATRTATPSTRPTTRLG 370 380 390 400 410 420 390 pF1KB9 AAYDRH XP_016 DSATPPY >>XP_005251538 (OMIM: 167414,615545) PREDICTED: paired b (390 aa) initn: 1642 init1: 962 opt: 1934 Z-score: 1448.6 bits: 276.8 E(85289): 6e-74 Smith-Waterman score: 1934; 72.6% identity (86.9% similar) in 398 aa overlap (1-393:1-390) 10 20 30 40 50 60 pF1KB9 MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVS :..::: :::..:::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEIHCKHDPFASMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 HGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAE :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: XP_005 HGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAE 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 GICDNDTVPSVSSINRIIRTKVQQPFH-PTPDGAGTGVTAPGHTIVPSTASPPVSSASND .::::::::::::::::::::::: . :.: : .:.:: . . :::.:.: XP_005 RVCDNDTVPSVSSINRIIRTKVQQPPNQPVP--------ASSHSIVSTGSVTQVSSVSTD 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 PVGS-YSINGILGI--PRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQ .:: :::.::::: : .. .:::::: ..:. :::: : : : :::..:.: ::::: XP_005 SAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 LEALDRVFERPSYPDVFQASEHIKSEQGNEYS-LPALTPGLDEVKSSLSASTNPELGSNV ::.::::::: : :.: ..: :: :: .::: . .:. :::..:..:.. : ..::.: XP_005 LEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGSSV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 SGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTA : :.::.:::::.::::::::::::::.::::: . ::.::::::::::.:::::::.. XP_005 PGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQYSS 300 310 320 330 340 350 360 370 380 390 pF1KB9 YNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH ::..::: ::.::.:::::::: ::.:: :::.::::: XP_005 YNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH 360 370 380 390 >>NP_057953 (OMIM: 167414,615545) paired box protein Pax (391 aa) initn: 1552 init1: 872 opt: 1848 Z-score: 1384.9 bits: 265.1 E(85289): 2.1e-70 Smith-Waterman score: 1848; 71.0% identity (84.8% similar) in 400 aa overlap (1-393:1-391) 10 20 30 40 50 pF1KB9 MDMHCKADPFSAMHR--HGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLR ::.. : : : ::::::::::::::::::::::::::::::::::::::::::: NP_057 MDLE-KNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLR 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 VSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLL :::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::: NP_057 VSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 AEGICDNDTVPSVSSINRIIRTKVQQPFH-PTPDGAGTGVTAPGHTIVPSTASPPVSSAS :: .::::::::::::::::::::::: . :.: : .:.:: . . :::.: NP_057 AERVCDNDTVPSVSSINRIIRTKVQQPPNQPVP--------ASSHSIVSTGSVTQVSSVS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 NDPVGS-YSINGILGI--PRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQ .: .:: :::.::::: : .. .:::::: ..:. :::: : : : :::..:.: ::: NP_057 TDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 QQLEALDRVFERPSYPDVFQASEHIKSEQGNEYS-LPALTPGLDEVKSSLSASTNPELGS ::::.::::::: : :.: ..: :: :: .::: . .:. :::..:..:.. : ..:: NP_057 QQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDDMKANLASPTPADIGS 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 NVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQY .: : :.::.:::::.::::::::::::::.::::: . ::.::::::::::.::::::: NP_057 SVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPYSHPQY 300 310 320 330 340 350 360 370 380 390 pF1KB9 TAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH ..::..::: ::.::.:::::::: ::.:: :::.::::: NP_057 SSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH 360 370 380 390 >>XP_011510096 (OMIM: 167415,218700) PREDICTED: paired b (387 aa) initn: 1466 init1: 1191 opt: 1657 Z-score: 1243.6 bits: 238.9 E(85289): 1.6e-62 Smith-Waterman score: 1657; 65.3% identity (84.9% similar) in 378 aa overlap (16-391:10-385) 10 20 30 40 50 60 pF1KB9 MDMHCKADPFSAMHRHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVS :::.:::::.::::::::.:::::::.:::::::::::::::::: XP_011 MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVS 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 HGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAE :::::::::::::::::.:::::::::::::::::.::..:::::::::::::::::::: XP_011 HGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAE 60 70 80 90 100 110 130 140 150 160 170 pF1KB9 GICDNDTVPSVSSINRIIRTKVQQPFH-PTPDGAGTGVTAPGHTIVPSTASPPVSSASND :.::::::::::::::::::::::::. : . ..: .::::..::.: : : ..: XP_011 GVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSD 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 PVGS-YSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLE .:: :::::.::: . ...::: :.. ... . ::::. .. :::::.:.:.:..:: XP_011 SLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 ALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGT :. ::: ::... . : :.::: : :: :. ::. :..:. :..: :: :.: XP_011 PLECPFERQHYPEAYASPSHTKGEQG-LYPLPLLNSTLDDGKATLTPSNTP-LGRNLSTH 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 QTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNE ::::::.::.:.. ::::::::.: .::::: .:..:::: :::.::: :.: :..:.: XP_011 QTYPVVAGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSE 300 310 320 330 340 350 360 370 380 390 pF1KB9 AWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH :::: : .:::::::::.. : ::: ..:.:.: XP_011 AWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL 360 370 380 393 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:29:38 2016 done: Fri Nov 4 18:29:40 2016 Total Scan time: 8.420 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]