FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9720, 404 aa 1>>>pF1KB9720 404 - 404 aa - 404 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1042+/-0.000301; mu= 15.4306+/- 0.019 mean_var=109.3161+/-21.957, 0's: 0 Z-trim(120.5): 410 B-trim: 0 in 0/52 Lambda= 0.122668 statistics sampled from 35354 (35770) to 35354 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.419), width: 16 Scan time: 10.140 The best scores are: opt bits E(85289) NP_005225 (OMIM: 132880) nuclear receptor subfamil ( 404) 2748 496.5 4.8e-140 NP_005645 (OMIM: 132890,615722) COUP transcription ( 423) 1243 230.2 7.4e-60 NP_066285 (OMIM: 107773,615779) COUP transcription ( 414) 1200 222.6 1.4e-57 XP_016865286 (OMIM: 132890,615722) PREDICTED: COUP ( 273) 1164 216.0 8.7e-56 NP_001138629 (OMIM: 107773,615779) COUP transcript ( 261) 1162 215.7 1.1e-55 NP_001138628 (OMIM: 107773,615779) COUP transcript ( 261) 1162 215.7 1.1e-55 NP_001138627 (OMIM: 107773,615779) COUP transcript ( 281) 1162 215.7 1.1e-55 XP_016876575 (OMIM: 602167,608565) PREDICTED: ster ( 508) 667 128.3 4.1e-29 NP_004443 (OMIM: 602167,608565) steroid hormone re ( 508) 667 128.3 4.1e-29 XP_011534856 (OMIM: 602167,608565) PREDICTED: ster ( 529) 667 128.3 4.3e-29 XP_011534855 (OMIM: 602167,608565) PREDICTED: ster ( 531) 667 128.3 4.3e-29 XP_011534852 (OMIM: 602167,608565) PREDICTED: ster ( 552) 667 128.3 4.4e-29 XP_016876574 (OMIM: 602167,608565) PREDICTED: ster ( 552) 667 128.3 4.4e-29 XP_011534849 (OMIM: 602167,608565) PREDICTED: ster ( 573) 667 128.4 4.5e-29 NP_001269379 (OMIM: 601998) steroid hormone recept ( 423) 653 125.8 2e-28 NP_004442 (OMIM: 601998) steroid hormone receptor ( 423) 653 125.8 2e-28 XP_016872802 (OMIM: 601998) PREDICTED: steroid hor ( 433) 653 125.8 2e-28 NP_001269380 (OMIM: 601998) steroid hormone recept ( 422) 648 124.9 3.7e-28 NP_055064 (OMIM: 268100,604485,611131) photorecept ( 410) 633 122.2 2.3e-27 XP_016856123 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_016856126 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_011507578 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_016856122 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_011507582 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_011507581 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_011507577 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_016856124 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_011507579 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_016856120 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_016856121 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_016856125 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_011507576 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_011507580 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 627 121.2 5e-27 XP_011507573 (OMIM: 602969) PREDICTED: estrogen-re ( 447) 627 121.2 5.1e-27 XP_016856119 (OMIM: 602969) PREDICTED: estrogen-re ( 447) 627 121.2 5.1e-27 XP_016856118 (OMIM: 602969) PREDICTED: estrogen-re ( 447) 627 121.2 5.1e-27 XP_016856117 (OMIM: 602969) PREDICTED: estrogen-re ( 461) 627 121.2 5.2e-27 XP_011507572 (OMIM: 602969) PREDICTED: estrogen-re ( 465) 627 121.2 5.2e-27 XP_011507570 (OMIM: 602969) PREDICTED: estrogen-re ( 470) 627 121.2 5.3e-27 XP_011507569 (OMIM: 602969) PREDICTED: estrogen-re ( 470) 627 121.2 5.3e-27 NP_001230447 (OMIM: 602969) estrogen-related recep ( 470) 627 121.2 5.3e-27 XP_011507571 (OMIM: 602969) PREDICTED: estrogen-re ( 470) 627 121.2 5.3e-27 XP_016856110 (OMIM: 602969) PREDICTED: estrogen-re ( 477) 627 121.2 5.3e-27 XP_016856112 (OMIM: 602969) PREDICTED: estrogen-re ( 477) 627 121.2 5.3e-27 XP_016856113 (OMIM: 602969) PREDICTED: estrogen-re ( 477) 627 121.2 5.3e-27 XP_011507567 (OMIM: 602969) PREDICTED: estrogen-re ( 477) 627 121.2 5.3e-27 XP_016856114 (OMIM: 602969) PREDICTED: estrogen-re ( 477) 627 121.2 5.3e-27 XP_016856111 (OMIM: 602969) PREDICTED: estrogen-re ( 477) 627 121.2 5.3e-27 XP_016856136 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 624 120.6 7.2e-27 XP_016856132 (OMIM: 602969) PREDICTED: estrogen-re ( 435) 624 120.6 7.2e-27 >>NP_005225 (OMIM: 132880) nuclear receptor subfamily 2 (404 aa) initn: 2748 init1: 2748 opt: 2748 Z-score: 2635.3 bits: 496.5 E(85289): 4.8e-140 Smith-Waterman score: 2748; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KB9 MAMVTGGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAMVTGGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 DKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 MRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 AAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 ELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 EYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPAL 310 320 330 340 350 360 370 380 390 400 pF1KB9 RAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ :::::::::::::::::::::::::::::::::::::::::::: NP_005 RAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ 370 380 390 400 >>NP_005645 (OMIM: 132890,615722) COUP transcription fac (423 aa) initn: 1660 init1: 1089 opt: 1243 Z-score: 1195.6 bits: 230.2 E(85289): 7.4e-60 Smith-Waterman score: 1713; 64.3% identity (82.0% similar) in 406 aa overlap (9-404:32-421) 10 20 30 pF1KB9 MAMVTGGWGGPGGDTNGVDKAG-GYPRAAEDDSASPPG :: :: . ..:: : :.. . . . :: NP_005 AMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQ--TPGQPG 10 20 30 40 50 40 50 60 70 80 pF1KB9 A-ASDAEPGDEER--PG-----LQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLS : :. . ::. . :: ...:::::::::::::: :::::::::::::.::::. NP_005 APATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLT 60 70 80 90 100 110 90 100 110 120 130 140 pF1KB9 YTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGS ::::.::.: :::::::::::::::::..::::.:::::::.: . : .: NP_005 YTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQP--------NPGQY 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB9 ALAAVASGGDLFPGQ-PVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAAR :: ..:: . :. .: :. ::::::::.. :.:. . ..::.:.:::::: NP_005 AL----TNGDPLNGHCYLSGYISLLLRAEPYPTS--RYGSQCMQPNNIMGIENICELAAR 180 190 200 210 220 210 220 230 240 250 260 pF1KB9 LLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAA ::::.:::::. ::::.: ..:::.::::.::::::::::: ..:::.:::::::::::. NP_005 LLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHAS 230 240 250 260 270 280 270 280 290 300 310 320 pF1KB9 PMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQ ::.:.:.:::::..: :::::.:: :.::::::.:::::.::: ::::::: ::.:::: NP_005 PMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQ 290 300 310 320 330 340 330 340 350 360 370 380 pF1KB9 EKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRD ::.: :: ::::.:::.::.:::.::::::.::.: .:.: ::::.:::::::::::::: NP_005 EKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRD 350 360 370 380 390 400 390 400 pF1KB9 MLLSGSTFNWPYGSGQ ::::::.::::: : : NP_005 MLLSGSSFNWPYMSIQCS 410 420 >>NP_066285 (OMIM: 107773,615779) COUP transcription fac (414 aa) initn: 1725 init1: 1111 opt: 1200 Z-score: 1154.6 bits: 222.6 E(85289): 1.4e-57 Smith-Waterman score: 1701; 64.2% identity (81.5% similar) in 400 aa overlap (9-404:31-414) 10 20 30 pF1KB9 MAMVTGGWGGPGGDTNGVDKAG-GYPRAAEDDSASPPG : : : . . : : : .. ..:. : NP_066 MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAG-G 10 20 30 40 50 40 50 60 70 80 90 pF1KB9 AASDAEPG-DEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNR .. . :: :... ...:::::::::::::: :::::::::::::.:::::::::.:: NP_066 QGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANR 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB9 DCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLP--GAVAASSGSPPGSALAAV .: :::::::::::::::::..::::.:::::::.: . : : : ..:.: NP_066 NCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDP-------- 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB9 ASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTV : . .: :. ::::::::.. :::. . ..::.:.::::::.:::.: NP_066 -----LNCHSYLSGYISLLLRAEPYPTS--RFGSQCMQPNNIMGIENICELAARMLFSAV 180 190 200 210 220 220 230 240 250 260 270 pF1KB9 EWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAER ::::. ::::.: ..::::::::.::::::::::: ..:::.:::::::::::.::.:.: NP_066 EWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADR 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB9 AVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVA .:::::..: :::::.:: :.::::::.:::::.::: ::::::: :::::::::.: : NP_066 VVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCA 290 300 310 320 330 340 340 350 360 370 380 390 pF1KB9 LTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGS : ::::.:::.:: :::.::::::.::.: .:.: ::::.:::::::::::::::::::: NP_066 LEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGS 350 360 370 380 390 400 400 pF1KB9 TFNWPYGSGQ .::::: . : NP_066 SFNWPYMAIQ 410 >>XP_016865286 (OMIM: 132890,615722) PREDICTED: COUP tra (273 aa) initn: 1195 init1: 1089 opt: 1164 Z-score: 1122.6 bits: 216.0 E(85289): 8.7e-56 Smith-Waterman score: 1187; 65.5% identity (83.6% similar) in 281 aa overlap (125-404:5-271) 100 110 120 130 140 150 pF1KB9 NRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAV .:::::.: . : .: :: XP_016 MFGYSVQRGRMPPTQP--------NPGQYAL--- 10 20 160 170 180 190 200 210 pF1KB9 ASGGDLFPGQ-PVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFST ..:: . :. .: :. ::::::::.. :.:. . ..::.:.::::::::::. XP_016 -TNGDPLNGHCYLSGYISLLLRAEPYPTS--RYGSQCMQPNNIMGIENICELAARLLFSA 30 40 50 60 70 80 220 230 240 250 260 270 pF1KB9 VEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAE :::::. ::::.: ..:::.::::.::::::::::: ..:::.:::::::::::.::.:. XP_016 VEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSAD 90 100 110 120 130 140 280 290 300 310 320 330 pF1KB9 RAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQV :.:::::..: :::::.:: :.::::::.:::::.::: ::::::: ::.::::::.: XP_016 RVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQC 150 160 170 180 190 200 340 350 360 370 380 390 pF1KB9 ALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSG :: ::::.:::.::.:::.::::::.::.: .:.: ::::.::::::::::::::::::: XP_016 ALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSG 210 220 230 240 250 260 400 pF1KB9 STFNWPYGSGQ :.::::: : : XP_016 SSFNWPYMSIQCS 270 >>NP_001138629 (OMIM: 107773,615779) COUP transcription (261 aa) initn: 1111 init1: 1111 opt: 1162 Z-score: 1120.9 bits: 215.7 E(85289): 1.1e-55 Smith-Waterman score: 1162; 67.7% identity (85.8% similar) in 260 aa overlap (145-404:4-261) 120 130 140 150 160 170 pF1KB9 KCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLL . : . :...: : . .: :. :: NP_001 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLL 10 20 30 180 190 200 210 220 230 pF1KB9 RAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVAL ::::::.. :::. . ..::.:.::::::.:::.:::::. ::::.: ..::::: NP_001 RAEPYPTS--RFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVAL 40 50 60 70 80 90 240 250 260 270 280 290 pF1KB9 LRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGR :::.::::::::::: ..:::.:::::::::::.::.:.:.:::::..: :::::.:: NP_001 LRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 100 110 120 130 140 150 300 310 320 330 340 350 pF1KB9 LQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLL :.::::::.:::::.::: ::::::: :::::::::.: :: ::::.:::.:: :::.:: NP_001 LHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLL 160 170 180 190 200 210 360 370 380 390 400 pF1KB9 LRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ ::::.::.: .:.: ::::.::::::::::::::::::::.::::: . : NP_001 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 220 230 240 250 260 >>NP_001138628 (OMIM: 107773,615779) COUP transcription (261 aa) initn: 1111 init1: 1111 opt: 1162 Z-score: 1120.9 bits: 215.7 E(85289): 1.1e-55 Smith-Waterman score: 1162; 67.7% identity (85.8% similar) in 260 aa overlap (145-404:4-261) 120 130 140 150 160 170 pF1KB9 KCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLL . : . :...: : . .: :. :: NP_001 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLL 10 20 30 180 190 200 210 220 230 pF1KB9 RAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVAL ::::::.. :::. . ..::.:.::::::.:::.:::::. ::::.: ..::::: NP_001 RAEPYPTS--RFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVAL 40 50 60 70 80 90 240 250 260 270 280 290 pF1KB9 LRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGR :::.::::::::::: ..:::.:::::::::::.::.:.:.:::::..: :::::.:: NP_001 LRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 100 110 120 130 140 150 300 310 320 330 340 350 pF1KB9 LQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLL :.::::::.:::::.::: ::::::: :::::::::.: :: ::::.:::.:: :::.:: NP_001 LHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLL 160 170 180 190 200 210 360 370 380 390 400 pF1KB9 LRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ ::::.::.: .:.: ::::.::::::::::::::::::::.::::: . : NP_001 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 220 230 240 250 260 >>NP_001138627 (OMIM: 107773,615779) COUP transcription (281 aa) initn: 1156 init1: 1111 opt: 1162 Z-score: 1120.5 bits: 215.7 E(85289): 1.1e-55 Smith-Waterman score: 1185; 65.6% identity (82.3% similar) in 282 aa overlap (125-404:15-281) 100 110 120 130 140 150 pF1KB9 NRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLP--GAVAASSGSPPGSALA ::::::.: . : : : ..:.: NP_001 MQAVWDLEQGKYGFAVQRGRMPPTQPTHGQFALTNGDP------ 10 20 30 160 170 180 190 200 210 pF1KB9 AVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFS : . .: :. ::::::::.. :::. . ..::.:.::::::.::: NP_001 -------LNCHSYLSGYISLLLRAEPYPTS--RFGSQCMQPNNIMGIENICELAARMLFS 40 50 60 70 80 220 230 240 250 260 270 pF1KB9 TVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAA .:::::. ::::.: ..::::::::.::::::::::: ..:::.:::::::::::.::.: NP_001 AVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSA 90 100 110 120 130 140 280 290 300 310 320 330 pF1KB9 ERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQ .:.:::::..: :::::.:: :.::::::.:::::.::: ::::::: :::::::::.: NP_001 DRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQ 150 160 170 180 190 200 340 350 360 370 380 390 pF1KB9 VALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLS :: ::::.:::.:: :::.::::::.::.: .:.: ::::.:::::::::::::::::: NP_001 CALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLS 210 220 230 240 250 260 400 pF1KB9 GSTFNWPYGSGQ ::.::::: . : NP_001 GSSFNWPYMAIQ 270 280 >>XP_016876575 (OMIM: 602167,608565) PREDICTED: steroid (508 aa) initn: 708 init1: 320 opt: 667 Z-score: 643.6 bits: 128.3 E(85289): 4.1e-29 Smith-Waterman score: 680; 32.6% identity (59.6% similar) in 399 aa overlap (5-390:42-429) 10 20 pF1KB9 MAMVTGGWG-GPGGDTNGVDKA--------GGYP .::.: . : .::.:. :: : XP_016 CGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTP 20 30 40 50 60 70 30 40 50 60 70 80 pF1KB9 -RAAEDDSASPPGAASDAEPGDEERPGL--QVDCVVCGDKSSGKHYGVFTCEGCKSFFKR : . .: :: : :. : . . :.:::: .:: :::: .::.::.:::: XP_016 CRKSYEDCAS--GIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKR 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 SIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPG-AVAA .:. :. :.: .. .:.: ...:..:: ::. ::..::: ::.:. :. . XP_016 TIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRL 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 SSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDN .: : : .: . .:...... :: ::: : . : : . .. . XP_016 DSESSPYLSLQISPPAK-----KPLTKIVSYLLVAEPDKLYA--MPPPGMPEGDIKALTT 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 VCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLA .:.:: : : . ::.: : : : ..::..::. .: :...:. . .:: :. XP_016 LCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDK--LV 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 AAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDP : . : ..... ::. . : . .:.:.. :. :::.:: . :. . : XP_016 YAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDL 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTP :..::. . :: .: .: .: : :.::: :: :: . :. ..... ..: ::.: XP_016 EAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP 370 380 390 400 410 420 390 400 pF1KB9 IETLIRDMLLSGSTFNWPYGSGQ .. :. .:: XP_016 MHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSP 430 440 450 460 470 480 >>NP_004443 (OMIM: 602167,608565) steroid hormone recept (508 aa) initn: 708 init1: 320 opt: 667 Z-score: 643.6 bits: 128.3 E(85289): 4.1e-29 Smith-Waterman score: 680; 32.6% identity (59.6% similar) in 399 aa overlap (5-390:42-429) 10 20 pF1KB9 MAMVTGGWG-GPGGDTNGVDKA--------GGYP .::.: . : .::.:. :: : NP_004 CGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTP 20 30 40 50 60 70 30 40 50 60 70 80 pF1KB9 -RAAEDDSASPPGAASDAEPGDEERPGL--QVDCVVCGDKSSGKHYGVFTCEGCKSFFKR : . .: :: : :. : . . :.:::: .:: :::: .::.::.:::: NP_004 CRKSYEDCAS--GIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKR 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 SIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPG-AVAA .:. :. :.: .. .:.: ...:..:: ::. ::..::: ::.:. :. . NP_004 TIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRL 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 SSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDN .: : : .: . .:...... :: ::: : . : : . .. . NP_004 DSESSPYLSLQISPPAK-----KPLTKIVSYLLVAEPDKLYA--MPPPGMPEGDIKALTT 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 VCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLA .:.:: : : . ::.: : : : ..::..::. .: :...:. . .:: :. NP_004 LCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDK--LV 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 AAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDP : . : ..... ::. . : . .:.:.. :. :::.:: . :. . : NP_004 YAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDL 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB9 AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTP :..::. . :: .: .: .: : :.::: :: :: . :. ..... ..: ::.: NP_004 EAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP 370 380 390 400 410 420 390 400 pF1KB9 IETLIRDMLLSGSTFNWPYGSGQ .. :. .:: NP_004 MHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSP 430 440 450 460 470 480 >>XP_011534856 (OMIM: 602167,608565) PREDICTED: steroid (529 aa) initn: 708 init1: 320 opt: 667 Z-score: 643.4 bits: 128.3 E(85289): 4.3e-29 Smith-Waterman score: 680; 32.6% identity (59.6% similar) in 399 aa overlap (5-390:63-450) 10 20 pF1KB9 MAMVTGGWG-GPGGDTNGVDKA--------GGYP .::.: . : .::.:. :: : XP_011 CGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTP 40 50 60 70 80 90 30 40 50 60 70 80 pF1KB9 -RAAEDDSASPPGAASDAEPGDEERPGL--QVDCVVCGDKSSGKHYGVFTCEGCKSFFKR : . .: :: : :. : . . :.:::: .:: :::: .::.::.:::: XP_011 CRKSYEDCAS--GIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKR 100 110 120 130 140 150 90 100 110 120 130 140 pF1KB9 SIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPG-AVAA .:. :. :.: .. .:.: ...:..:: ::. ::..::: ::.:. :. . XP_011 TIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRL 160 170 180 190 200 210 150 160 170 180 190 200 pF1KB9 SSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDN .: : : .: . .:...... :: ::: : . : : . .. . XP_011 DSESSPYLSLQISPPAK-----KPLTKIVSYLLVAEPDKLYA--MPPPGMPEGDIKALTT 220 230 240 250 260 210 220 230 240 250 260 pF1KB9 VCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLA .:.:: : : . ::.: : : : ..::..::. .: :...:. . .:: :. XP_011 LCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDK--LV 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB9 AAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDP : . : ..... ::. . : . .:.:.. :. :::.:: . :. . : XP_011 YAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDL 330 340 350 360 370 380 330 340 350 360 370 380 pF1KB9 AHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTP :..::. . :: .: .: .: : :.::: :: :: . :. ..... ..: ::.: XP_011 EAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVP 390 400 410 420 430 440 390 400 pF1KB9 IETLIRDMLLSGSTFNWPYGSGQ .. :. .:: XP_011 MHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSP 450 460 470 480 490 500 404 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:31:32 2016 done: Fri Nov 4 18:31:34 2016 Total Scan time: 10.140 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]