FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9728, 444 aa 1>>>pF1KB9728 444 - 444 aa - 444 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.1809+/-0.000331; mu= -2.1436+/- 0.021 mean_var=310.3040+/-62.977, 0's: 0 Z-trim(125.2): 133 B-trim: 110 in 1/56 Lambda= 0.072808 statistics sampled from 48440 (48577) to 48440 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.827), E-opt: 0.2 (0.57), width: 16 Scan time: 9.600 The best scores are: opt bits E(85289) NP_001443 (OMIM: 603250) forkhead box protein F2 [ ( 444) 3121 340.8 4.4e-93 NP_001442 (OMIM: 265380,601089) forkhead box prote ( 379) 972 115.0 3.5e-25 NP_004465 (OMIM: 602211) forkhead box protein D2 [ ( 495) 663 82.6 2.5e-15 NP_004463 (OMIM: 601091) forkhead box protein D1 [ ( 465) 620 78.1 5.5e-14 NP_036315 (OMIM: 607836,611539) forkhead box prote ( 478) 575 73.4 1.5e-12 NP_004464 (OMIM: 241850,602617,616534) forkhead bo ( 373) 567 72.4 2.2e-12 NP_150285 (OMIM: 612788) forkhead box protein Q1 [ ( 403) 556 71.3 5.2e-12 NP_075555 (OMIM: 110100,605597,608996) forkhead bo ( 376) 519 67.4 7.3e-11 NP_001444 (OMIM: 601090,601631,602482) forkhead bo ( 553) 521 67.7 8.5e-11 NP_004109 (OMIM: 602939) forkhead box protein S1 [ ( 330) 507 66.1 1.6e-10 NP_001129121 (OMIM: 612351) forkhead box protein I ( 420) 505 66.0 2.2e-10 NP_004488 (OMIM: 602295) hepatocyte nuclear factor ( 350) 500 65.4 2.8e-10 NP_036316 (OMIM: 611084) forkhead box protein D4-l ( 408) 500 65.4 3.1e-10 NP_005240 (OMIM: 164874,613454) forkhead box prote ( 489) 490 64.4 7.4e-10 NP_036318 (OMIM: 107250,601094,610256) forkhead bo ( 319) 480 63.2 1.1e-09 NP_954714 (OMIM: 611085) forkhead box protein D4-l ( 416) 480 63.3 1.4e-09 NP_954586 (OMIM: 611086) forkhead box protein D4-l ( 417) 480 63.3 1.4e-09 XP_016876735 (OMIM: 602294) PREDICTED: hepatocyte ( 439) 480 63.4 1.4e-09 NP_005241 (OMIM: 603252) forkhead box protein L1 [ ( 345) 477 62.9 1.5e-09 NP_004487 (OMIM: 602294) hepatocyte nuclear factor ( 472) 480 63.4 1.5e-09 NP_005242 (OMIM: 153400,602402) forkhead box prote ( 501) 480 63.4 1.6e-09 NP_710141 (OMIM: 600288) hepatocyte nuclear factor ( 457) 475 62.8 2.1e-09 NP_068556 (OMIM: 600288) hepatocyte nuclear factor ( 463) 475 62.8 2.1e-09 NP_997188 (OMIM: 601092) forkhead box protein D4 [ ( 439) 472 62.5 2.5e-09 NP_036320 (OMIM: 274600,600791,601093) forkhead bo ( 378) 425 57.5 6.9e-08 XP_011513493 (OMIM: 616302) PREDICTED: forkhead bo ( 570) 421 57.3 1.3e-07 NP_001032242 (OMIM: 616302) forkhead box protein K ( 733) 421 57.3 1.5e-07 NP_003914 (OMIM: 603621) forkhead box protein H1 [ ( 365) 412 56.1 1.7e-07 NP_004505 (OMIM: 147685) forkhead box protein K2 [ ( 660) 404 55.5 4.8e-07 XP_016856182 (OMIM: 616035) PREDICTED: forkhead bo ( 573) 369 51.8 5.6e-06 NP_001185781 (OMIM: 616035) forkhead box protein J ( 588) 369 51.8 5.7e-06 XP_006710522 (OMIM: 616035) PREDICTED: forkhead bo ( 596) 369 51.8 5.7e-06 XP_006710521 (OMIM: 616035) PREDICTED: forkhead bo ( 607) 369 51.8 5.8e-06 NP_001185780 (OMIM: 616035) forkhead box protein J ( 622) 369 51.8 5.9e-06 NP_001185779 (OMIM: 616035) forkhead box protein J ( 622) 369 51.8 5.9e-06 NP_055762 (OMIM: 616035) forkhead box protein J3 i ( 622) 369 51.8 5.9e-06 XP_011539328 (OMIM: 616035) PREDICTED: forkhead bo ( 622) 369 51.8 5.9e-06 XP_005270689 (OMIM: 616035) PREDICTED: forkhead bo ( 630) 369 51.8 6e-06 NP_001445 (OMIM: 602291) forkhead box protein J1 [ ( 421) 356 50.3 1.1e-05 NP_001230018 (OMIM: 602341) forkhead box protein M ( 747) 334 48.2 8.6e-05 NP_973732 (OMIM: 602341) forkhead box protein M1 i ( 748) 334 48.2 8.7e-05 NP_001230017 (OMIM: 602341) forkhead box protein M ( 748) 334 48.2 8.7e-05 XP_011519233 (OMIM: 602341) PREDICTED: forkhead bo ( 749) 334 48.2 8.7e-05 XP_011523671 (OMIM: 600838,601705) PREDICTED: fork ( 436) 319 46.4 0.00017 XP_011523670 (OMIM: 600838,601705) PREDICTED: fork ( 436) 319 46.4 0.00017 XP_011523672 (OMIM: 600838,601705) PREDICTED: fork ( 436) 319 46.4 0.00017 XP_011523669 (OMIM: 600838,601705) PREDICTED: fork ( 462) 319 46.5 0.00018 XP_005258103 (OMIM: 600838,601705) PREDICTED: fork ( 648) 319 46.6 0.00023 NP_003584 (OMIM: 600838,601705) forkhead box prote ( 648) 319 46.6 0.00023 XP_016880717 (OMIM: 600838,601705) PREDICTED: fork ( 648) 319 46.6 0.00023 >>NP_001443 (OMIM: 603250) forkhead box protein F2 [Homo (444 aa) initn: 3121 init1: 3121 opt: 3121 Z-score: 1792.1 bits: 340.8 E(85289): 4.4e-93 Smith-Waterman score: 3121; 100.0% identity (100.0% similar) in 444 aa overlap (1-444:1-444) 10 20 30 40 50 60 pF1KB9 MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPETTSSSSSSSSASCASSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPETTSSSSSSSSASCASSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 SSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPAS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 EFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 GGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 PAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFH 370 380 390 400 410 420 430 440 pF1KB9 PSASGSYYHHHHQSVCQDIKPCVM :::::::::::::::::::::::: NP_001 PSASGSYYHHHHQSVCQDIKPCVM 430 440 >>NP_001442 (OMIM: 265380,601089) forkhead box protein F (379 aa) initn: 1115 init1: 819 opt: 972 Z-score: 573.1 bits: 115.0 E(85289): 3.5e-25 Smith-Waterman score: 1300; 55.0% identity (72.4% similar) in 413 aa overlap (66-444:2-379) 40 50 60 70 80 pF1KB9 AAAAAAPETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGA------- .::: ::::.:.:.::: NP_001 MSSAPEKQQPPHGGGGGGGGGGGAAMDPASS 10 20 30 90 100 110 120 130 140 pF1KB9 -----KKASSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQG ::...:.::::::::::::::::::::::.:::::::::::::.:::::::.::: NP_001 GPSKAKKTNAGIRRPEKPPYSYIALIVMAIQSSPTKRLTLSEIYQFLQSRFPFFRGSYQG 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB9 WKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQAL 100 110 120 130 140 150 210 220 230 240 250 pF1KB9 KPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGC--HSQGGYGGLDMM----PAGYDAGA :::: ...::::. ::. . ::. .. :.: .: . ::: :: :.. : : NP_001 KPMYS-MMNGLGFNH--LPDTYGFQGSAGG-LSCPPNSLALEGGLGMMNGHLPGNVD-GM 160 170 180 190 200 260 270 280 290 300 310 pF1KB9 GAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPV . :::. :::. : : .::..: ::...:.: : .:: : NP_001 ALPSHS---------VPHLPSNGGHSYMGGC------------GGAAAGEY-PHHDSS-V 210 220 230 240 320 330 340 350 360 pF1KB9 PSSPAMASA----IECHSPYTSPAAHWSSPGASP-------YLKQPPALTPSSNPAASAG :.:: . .. .: :. :.. :: : :.:: :.:: : :.: ::::. NP_001 PASPLLPTGAGGVMEPHAVYSGSAAAWP-PSASAALNSGASYIKQQP-LSPC-NPAANP- 250 260 270 280 290 370 380 390 400 410 420 pF1KB9 LHSSMSSYSLEQSYLHQNARE---DLSVGLPRYQHHSTPVCDRKDFVLNFNGI--SSFHP : .:.:..:::: :::::... .:. :.:::. .: .::::.::..::.. ::.: NP_001 LSGSLSTHSLEQPYLHQNSHNAPAELQ-GIPRYHSQSPSMCDRKEFVFSFNAMASSSMHS 300 310 320 330 340 350 430 440 pF1KB9 SASGSYYHHHHQSVCQDIKPCVM ...:::::. : . :::::::: NP_001 AGGGSYYHQ--QVTYQDIKPCVM 360 370 >>NP_004465 (OMIM: 602211) forkhead box protein D2 [Homo (495 aa) initn: 616 init1: 521 opt: 663 Z-score: 396.1 bits: 82.6 E(85289): 2.5e-15 Smith-Waterman score: 663; 37.7% identity (57.7% similar) in 366 aa overlap (5-355:36-386) 10 20 30 pF1KB9 MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAA :: :: :. .: . :: NP_004 CCCEIMSSESSPAALSEADADIDVVGGGSGGGELPA---RSGPRAPRDVLPHGHEPPAEE 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 AAAAAAAPETTSSSSSSSSASCASSSSSSNSASAP---SAACKSAGGGGAGAGSGGAKKA : : : : :.. :.. .: ... .:..: .:: ..:.: : : :::: NP_004 AEADLAEDEEESGGCSDGEPRALASRGAAAAAGSPGPGAAAARGAAGPGPGPPSGGA--- 70 80 90 100 110 100 110 120 130 140 150 pF1KB9 SSGLRRPE-KPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRH . : : ::::::::::.::: .::.:::::::: .:...:::..: . .:.::.:: NP_004 --ATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRH 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB9 NLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRV :::::.::.:.:. : ::::.:::.:: : ::..::: :: . :.: : : : . . NP_004 NLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKR--QPLPPPHPH- 180 190 200 210 220 230 220 230 240 250 260 pF1KB9 VSGLGFGASLLPQGFDFQAPPSAPL-GCHSQGGYG-GLDMMPAGYDAGAGAPS-HAHPHH :: : . :.: : : . :.:: : . .: : .:. : ::: NP_004 --PHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYGAPPPGPAPHPHPHP 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB9 HHHHHVPHMSPNPGSTYM----ASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSS--- : . . : . . :. : :. : . ::.:.. .: :.:.: :. NP_004 HAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSAPAPAPASGSGPGPGPAGL 300 310 320 330 340 350 330 340 350 360 370 pF1KB9 PAMASA-IECHSPYTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQS ::. .: . : . . :: : :.:. : :: NP_004 PAFLGAELGCAKAFY--AASLSPPAAGTAAGLPTALLRQGLKTDAGGGAGGGGAGAGQRP 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB9 YLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDI NP_004 SFSIDHIMGHGGGGAAPPGAGEGSPGPPFAAAAGPGGQAQVLAMLTAPALAPVAGHIRLS 420 430 440 450 460 470 >>NP_004463 (OMIM: 601091) forkhead box protein D1 [Homo (465 aa) initn: 528 init1: 528 opt: 620 Z-score: 372.1 bits: 78.1 E(85289): 5.5e-14 Smith-Waterman score: 681; 40.4% identity (59.1% similar) in 369 aa overlap (58-383:83-448) 30 40 50 60 70 80 pF1KB9 MSPPPAAAAAAAAAPETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGG ...: . . :: :: .:::::.:.:.:: NP_004 RRRRRSYAGEDELEDLEEEEDDDDILLAPPAGGSPAPPGPAP-AAGAGAGGGGGGGGAGG 60 70 80 90 100 110 90 100 110 120 130 140 pF1KB9 AKKASSGLRRPE-KPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKN . .:.:: . : ::::::::::.::: .::.:::::::: .:...:::..: . .:.: NP_004 GGSAGSGAKNPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQN 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB9 SVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPM :.:::::::.::.:.:. : ::::.:::.:: : ::..::: :: . :.:. : : NP_004 SIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQ-PLLPPN 180 190 200 210 220 230 210 220 230 240 250 pF1KB9 YHRVVSGLGFGASLLPQGFDFQA-----PPSAPLGCHSQG-G-YG---GLDMMP-----A . : : ::. . : : ::. : :. : : :: ::.. : : NP_004 AAAAESLLLRGAGAAGGAGDPAAAAALFPPAPPPPPHAYGYGPYGCGYGLQLPPYAPPSA 240 250 260 270 280 290 260 270 280 290 300 pF1KB9 GYDAGAGAPSHA--HPHHHHHHHVPHMSPNP-GSTYMASCPVPAG---PGGVGA----AG . :.:.: . : ::: :: . . : .. : : : :: . : :: NP_004 LFAAAAAAAAAAAFHPHSPPPPPPPHGAAAELARTAFGYRPHPLGAALPGPLPASAAKAG 300 310 320 330 340 350 310 320 330 340 pF1KB9 GGG---------------GGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPG-- : : ::. :: .... . .. : :.: :: ..: : :: : NP_004 GPGASALARSPFSIESIIGGSLGPAAAAAAAAQAAAAAQASPSPSPVAAPPAPGSSGGGC 360 370 380 390 400 410 350 360 370 380 390 400 pF1KB9 ASPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVC :. : : : ::.:. ::.:: : . ::: NP_004 AAQAAVGPAAALTRSLVAAAAAAASSVSS-SAALGTLHQGTALSSVENFTARISNC 420 430 440 450 460 410 420 430 440 pF1KB9 DRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM >>NP_036315 (OMIM: 607836,611539) forkhead box protein D (478 aa) initn: 558 init1: 504 opt: 575 Z-score: 346.4 bits: 73.4 E(85289): 1.5e-12 Smith-Waterman score: 603; 33.4% identity (58.7% similar) in 395 aa overlap (3-381:46-417) 10 20 30 pF1KB9 MTTEGGPPPAPLRRACSPVPGALQAALMSPP- . .::: : .: :.: . . .:: NP_036 TVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGPPELRLDEADEVPPAAPHHGQPQPPH 20 30 40 50 60 70 40 50 60 70 80 pF1KB9 ------PAAAAAAAAAPETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGS : ::.:.:.: .. .. . .: .. .. .... :.:: :::.:: NP_036 QQPLTLPKEAAGAGAGP--GGDVGAPEADGCKGGVGGEEGGA-------SGGGPGAGSGS 80 90 100 110 120 90 100 110 120 130 140 pF1KB9 GGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWK .:. :. ::::::::::.::: .::.:.:::: : .:.. :::..: . .:. NP_036 AGGLAPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQ 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB9 NSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQA-LK ::.:::::::.::.:.:. : ::::.:::.:: :: ::..::: :: . :.:. : :. NP_036 NSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLR 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB9 PMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAH . ... .::: : . .: . : : : .. :. . ::. :.:.: . . NP_036 EQTALMMQ--SFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAYSH-PAAAAAAAAAAALQY 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB9 PHHHHHHHVPHMSPNPGSTYMASCPVPAGPGG-VGAAGGGGGGDYGPDSSSSPVPSSPAM :. .: ..: . :: :.: .: ... :.. :: . . . : NP_036 PYA-----LPPVAP------VLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAA 310 320 330 340 350 330 340 350 360 370 pF1KB9 ASAIECHSPYTSPAAHWSSPGASPYLK-------QPPALTPSSNPAASAGLHSSMSSYSL :.: . :. . : :.: : .. : : :. :. :: .. .. : NP_036 AAAGTAGAAGTTASLIKSEPSARPSFSIENIIGGGPAAPGGSAVGAGVAGGTGGSGGGST 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB9 EQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVC ::.: NP_036 AQSFLRPPGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQ 420 430 440 450 460 470 >>NP_004464 (OMIM: 241850,602617,616534) forkhead box pr (373 aa) initn: 579 init1: 473 opt: 567 Z-score: 343.3 bits: 72.4 E(85289): 2.2e-12 Smith-Waterman score: 570; 35.2% identity (61.0% similar) in 318 aa overlap (70-374:25-325) 40 50 60 70 80 90 pF1KB9 AAPETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPE .:: .. : ..: :.:: .. . :.: NP_004 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGG-RRRKRPLQRG- 10 20 30 40 50 100 110 120 130 140 150 pF1KB9 KPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFI ::::::::::.::: .: .::::. ::.:. ::::.: . :.::.::::.::.::. NP_004 KPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFL 60 70 80 90 100 110 160 170 180 190 200 210 pF1KB9 KLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMY-HRVVSGLGFGA :.:. ::::::.::..:: .: ::: ::: :: . :.:. . : : : .... . .: NP_004 KIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAA 120 130 140 150 160 170 220 230 240 250 260 270 pF1KB9 SLLPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSP . . : : ..: .. : :.. :: . :: : : .. : :: NP_004 AAAAAAAIF--PGAVPA---ARPPY------PGAVYAGYAPPSLAAPPPVYY---PAASP 180 190 200 210 280 290 300 310 320 330 pF1KB9 NPGSTYMASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSS---PAMASAIECHSPYTS .: .. : .: .: : .: ::. . :...:. .. :: .. . .: . NP_004 GPCRVFGLVPERPLSPE-LGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAY 220 230 240 250 260 270 340 350 360 370 380 pF1KB9 PAAHWSSPGASPYLKQPPALT-------PSSNPA--ASAGLHSSMSSYSLEQSYLHQNAR ::. . :: : .. :.: :: .:.:...... : NP_004 AAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALG 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB9 EDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM NP_004 ACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM 340 350 360 370 >>NP_150285 (OMIM: 612788) forkhead box protein Q1 [Homo (403 aa) initn: 497 init1: 379 opt: 556 Z-score: 336.6 bits: 71.3 E(85289): 5.2e-12 Smith-Waterman score: 565; 33.8% identity (56.5% similar) in 379 aa overlap (5-364:25-386) 10 20 30 40 pF1KB9 MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAA :. :.:: : . :. . : :...: . NP_150 MKLEVFVPRAAHGDKQGSDLEGAGGSDAPSPLSAAGDDSLGSDGDCAANSPAAGGGARDT 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB9 APETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEK . .:.... .: : .... .. : .: .:: :..::::: . ... ::: : NP_150 QGDGEQSAGGGPGAEEAIPAAAAAAVVAEGAEAGAAGPGAGGAGSGEGARSKPYTRRP-K 70 80 90 100 110 110 120 130 140 150 160 pF1KB9 PPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIK :::::::::.:::..: . ::::.:: ..:...::::::.: ::.::::::::::.::.: NP_150 PPYSYIALIAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVK 120 130 140 150 160 170 170 180 190 200 210 pF1KB9 LPKGLGRP-GKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRV-VSGLGFGA . . .:: :: .:: ..: ::. : .: :::: :.. . ::. : . :. NP_150 VLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRR----RKR------LSHRAPVPAPGLRP 180 190 200 210 220 220 230 240 250 260 270 pF1KB9 SLLPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPH--HHHHHHVPHM : :. ::: :: . : . . . :: . : : .. . NP_150 EEAP-GLP-AAPPPAPAAPASPRMRSPARQEERASPAGKFSSSFAIDSILRKPFRSRRLR 230 240 250 260 270 280 280 290 300 310 320 pF1KB9 SPNPGSTYM---ASCP-VPAGPGGVGAA-----------GGGGGGDYGPDSSSSPVPSSP . ::.: . : :: .:: :. . :: :.: . : . : :..: NP_150 DTAPGTTLQWGAAPCPPLPAFPALLPAAPCRALLPLCAYGAGEPARLGAREAEVP-PTAP 290 300 310 320 330 340 330 340 350 360 370 380 pF1KB9 AMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQSYL . : : ..:: .:.:. : :.. ::: NP_150 PLLLA---PLPAAAPAKPLRGPAAGGAHLYCPLRLPAALQAASVRRPGPHLPYPVETLLA 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB9 HQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKP >>NP_075555 (OMIM: 110100,605597,608996) forkhead box pr (376 aa) initn: 474 init1: 449 opt: 519 Z-score: 316.0 bits: 67.4 E(85289): 7.3e-11 Smith-Waterman score: 571; 34.3% identity (53.4% similar) in 399 aa overlap (30-389:6-376) 10 20 30 40 50 60 pF1KB9 MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPETTSSSSSSSSASCASSS : : ::.: :::: NP_075 MMASYPEPEDAAGALLAPET---------------- 10 20 70 80 90 100 110 120 pF1KB9 SSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKR . ... : . : : ::.:.:. . .: . . .::::::.:::.:::. : :: NP_075 --GRTVKEPEGPPPSPGKGGGGGGGTAPEKPDPA----QKPPYSYVALIAMAIRESAEKR 30 40 50 60 70 130 140 150 160 170 180 pF1KB9 LTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPAS :::: :::.. :.:::.. .::.::.::::::::::::.:. : ::.:::.::: NP_075 LTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPAC 80 90 100 110 120 130 190 200 210 220 230 pF1KB9 EFMFEEGSFRRR---PRGFRRKCQALKP---MYHRVVSGLGFG-ASLLPQGFDFQAPP-- : :::.:..::: : :: ..: .. .. : : :. .:. . ::: NP_075 EDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAGGAAGGCGVAGAGADGYGYLAPPKY 140 150 160 170 180 190 240 250 260 270 280 pF1KB9 --------SAPLGCH-SQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGS : :: : :.. .: :. :.:.: . : : : . .:.. NP_075 LQSGFLNNSWPLPQPPSPMPYASCQMAAAAA-AAAAAAAAAGPGSPGAAAVVKGLAGPAA 200 210 220 230 240 250 290 300 310 320 330 pF1KB9 TY-----MASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPA .: . : .: :: :.. .: :: .: : : : .: .: NP_075 SYGPYTRVQSMALP--PGVVNSYNGLGGPPAAPPPPPHPHPH-PHAHHLHAAAAPPPAPP 260 270 280 290 300 310 340 350 360 370 380 pF1KB9 AHWSS---PG----ASPYLKQPPALTPSSNPAAS---------AGLHSSMSSYSLEQSYL : .. :: ::: ::: .:.: :. . : .: :. ... . . : NP_075 HHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGAL 320 330 340 350 360 370 390 400 410 420 430 440 pF1KB9 HQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKP : .: :: NP_075 H--SRLDL >>NP_001444 (OMIM: 601090,601631,602482) forkhead box pr (553 aa) initn: 621 init1: 481 opt: 521 Z-score: 314.9 bits: 67.7 E(85289): 8.5e-11 Smith-Waterman score: 557; 37.4% identity (56.5% similar) in 329 aa overlap (67-393:48-332) 40 50 60 70 80 90 pF1KB9 AAAAAPETTSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLR : :. : . :: . . : . . . NP_001 YLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGGMARAYGPYTPQPQPKDMV 20 30 40 50 60 70 100 110 120 130 140 150 pF1KB9 RPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNE ::::::::::.::::..:.:..::. ::::.. ::::.: :::.::.:::::::: NP_001 ---KPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNE 80 90 100 110 120 130 160 170 180 190 200 210 pF1KB9 CFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGF ::.:.:. .:::: :::.:: : :::.::: :: : :..: .:.: .. : NP_001 CFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKK-DAVKDKEEKDRLHLKE 140 150 160 170 180 190 220 230 240 250 260 270 pF1KB9 GASLLPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHM : : . :: :: : :..: .: .: : . NP_001 PP---PPG---RQPPPAP---------------PEQADGNAPGP---QP--------PPV 200 210 220 280 290 300 310 320 330 pF1KB9 SPNPGSTYMASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSP . .: ..:: : : . .:: :.:.. : . :: :: ...:. : . : NP_001 RIQDIKTENGTCPSPPQPLSPAAALGSGSAAAVP-KIESPDSSSSSLSSG--SSPPGSLP 230 240 250 260 270 340 350 360 370 380 390 pF1KB9 AAH-WSSPGASPYLKQPPALTPSSNPAA-SAGLHSSMSSYSLEQSYLHQNAREDLSVGLP .:. : ::. . :: .::. : : :. . ::. : :.: .:: :: NP_001 SARPLSLDGAD---SAPPPPAPSAPPPHHSQGFSVDNIMTSLRGS--PQSAAAELSSGLL 280 290 300 310 320 330 400 410 420 430 440 pF1KB9 RYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM NP_001 ASAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQTSSAGSSGGGGGGAGAAGGAGGAGTY 340 350 360 370 380 390 >>NP_004109 (OMIM: 602939) forkhead box protein S1 [Homo (330 aa) initn: 488 init1: 463 opt: 507 Z-score: 309.9 bits: 66.1 E(85289): 1.6e-10 Smith-Waterman score: 507; 37.8% identity (59.1% similar) in 286 aa overlap (98-366:16-283) 70 80 90 100 110 120 pF1KB9 APSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIY : ::::::::::.:::::::..: ::: :: NP_004 MQQQPLPGPGAPTTEPTKPPYSYIALIAMAIQSSPGQRATLSGIY 10 20 30 40 130 140 150 160 170 180 pF1KB9 QFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEG .....:: :.: ::.::.::::::::::.:.:. .:::: :::.:: . :::.: NP_004 RYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFEHG 50 60 70 80 90 100 190 200 210 220 230 240 pF1KB9 SFRRRPRGFRRKCQALK---PMYHRV----VSGLGFGASLLPQGFDFQAPPSAPLGCHSQ :: :: : : :. : : : ... :. : . . :: : . NP_004 SFLRRRRRFTRQTGAEGTRGPAKARRGPLRATSQDPGVPNATTGRQCSFPPELP---DPK 110 120 130 140 150 160 250 260 270 280 290 pF1KB9 G-GYGGL-DMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCP----VPAGP : ..::: :::.. : . ..:. : : :. :: .:: : .. NP_004 GLSFGGLVGAMPASM---CPATTDGRPR-------PPMEPKEISTPKPACPGELPVATSS 170 180 190 200 210 300 310 320 330 340 350 pF1KB9 GGVGAAGGGGGGDYGPDSSSSPVPS-SP--AMASAIECHSPYTSPAAHWSSPGASPYLKQ .. : : .: . . . ...:.: :: ...:. .:. : .. ::.: :.. NP_004 SSCPAFGFPAGFSEAESFNKAPTPVLSPESGIGSSYQCRLQ----ALNFCM-GADPGLEH 220 230 240 250 260 360 370 380 390 400 410 pF1KB9 PPA-LTPSSNPAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFV : .:: : . : NP_004 LLASAAPSPAPPTPPGSLRAPLPLPTDHKEPWVAGGFPVQGGSGYPLGLTPCLYRTPGMF 270 280 290 300 310 320 444 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 01:09:42 2016 done: Sat Nov 5 01:09:43 2016 Total Scan time: 9.600 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]