FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9731, 474 aa 1>>>pF1KB9731 474 - 474 aa - 474 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7474+/-0.000863; mu= 13.1508+/- 0.053 mean_var=122.0177+/-23.824, 0's: 0 Z-trim(111.1): 126 B-trim: 0 in 0/51 Lambda= 0.116108 statistics sampled from 12017 (12143) to 12017 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.373), width: 16 Scan time: 3.410 The best scores are: opt bits E(32554) CCDS13330.1 HNF4A gene_id:3172|Hs108|chr20 ( 474) 3183 544.0 1.2e-154 CCDS74728.1 HNF4A gene_id:3172|Hs108|chr20 ( 449) 2945 504.2 1.2e-142 CCDS42876.1 HNF4A gene_id:3172|Hs108|chr20 ( 452) 2945 504.2 1.2e-142 CCDS46605.1 HNF4A gene_id:3172|Hs108|chr20 ( 464) 2812 481.9 6.2e-136 CCDS46604.1 HNF4A gene_id:3172|Hs108|chr20 ( 442) 2574 442.0 6e-124 CCDS13331.1 HNF4A gene_id:3172|Hs108|chr20 ( 417) 2497 429.1 4.3e-120 CCDS68131.1 HNF4A gene_id:3172|Hs108|chr20 ( 395) 2259 389.2 4.2e-108 CCDS6220.2 HNF4G gene_id:3174|Hs108|chr8 ( 445) 2080 359.3 4.9e-99 CCDS83303.1 HNF4G gene_id:3174|Hs108|chr8 ( 408) 1946 336.8 2.6e-92 CCDS35172.1 RXRA gene_id:6256|Hs108|chr9 ( 462) 907 162.8 7.1e-40 CCDS4768.1 RXRB gene_id:6257|Hs108|chr6 ( 533) 907 162.8 7.9e-40 CCDS1248.1 RXRG gene_id:6258|Hs108|chr1 ( 463) 903 162.1 1.1e-39 CCDS72970.1 RXRG gene_id:6258|Hs108|chr1 ( 340) 896 160.9 2e-39 CCDS10375.1 NR2F2 gene_id:7026|Hs108|chr15 ( 414) 787 142.7 7.3e-34 CCDS4068.1 NR2F1 gene_id:7025|Hs108|chr5 ( 423) 786 142.5 8.3e-34 CCDS59007.1 RXRB gene_id:6257|Hs108|chr6 ( 537) 602 111.7 1.9e-24 CCDS45359.1 NR2F2 gene_id:7026|Hs108|chr15 ( 261) 431 82.9 4.5e-16 CCDS45358.1 NR2F2 gene_id:7026|Hs108|chr15 ( 281) 431 82.9 4.8e-16 CCDS41821.1 NR2C1 gene_id:7181|Hs108|chr12 ( 467) 431 83.1 7.2e-16 CCDS44953.1 NR2C1 gene_id:7181|Hs108|chr12 ( 483) 431 83.1 7.3e-16 CCDS9051.1 NR2C1 gene_id:7181|Hs108|chr12 ( 603) 431 83.1 8.7e-16 CCDS74905.1 NR2C2 gene_id:7182|Hs108|chr3 ( 596) 414 80.3 6.2e-15 CCDS2621.1 NR2C2 gene_id:7182|Hs108|chr3 ( 615) 414 80.3 6.4e-15 CCDS12352.1 NR2F6 gene_id:2063|Hs108|chr19 ( 404) 402 78.2 1.9e-14 CCDS8850.1 RARG gene_id:5916|Hs108|chr12 ( 454) 393 76.7 5.8e-14 CCDS58236.1 RARG gene_id:5916|Hs108|chr12 ( 382) 389 76.0 8e-14 CCDS41790.1 RARG gene_id:5916|Hs108|chr12 ( 443) 389 76.0 9e-14 CCDS2642.1 RARB gene_id:5915|Hs108|chr3 ( 448) 387 75.7 1.1e-13 CCDS69165.1 NR2E1 gene_id:7101|Hs108|chr6 ( 422) 381 74.7 2.2e-13 CCDS5063.1 NR2E1 gene_id:7101|Hs108|chr6 ( 385) 376 73.8 3.7e-13 CCDS42317.1 RARA gene_id:5914|Hs108|chr17 ( 457) 377 74.0 3.7e-13 CCDS11366.1 RARA gene_id:5914|Hs108|chr17 ( 462) 377 74.0 3.8e-13 CCDS2201.1 NR4A2 gene_id:4929|Hs108|chr2 ( 598) 369 72.7 1.2e-12 CCDS73751.1 NR2E3 gene_id:10002|Hs108|chr15 ( 367) 363 71.6 1.6e-12 CCDS73750.1 NR2E3 gene_id:10002|Hs108|chr15 ( 410) 363 71.6 1.7e-12 CCDS6744.1 NR4A3 gene_id:8013|Hs108|chr9 ( 443) 358 70.8 3.3e-12 CCDS6743.1 NR4A3 gene_id:8013|Hs108|chr9 ( 626) 357 70.8 4.9e-12 CCDS6742.1 NR4A3 gene_id:8013|Hs108|chr9 ( 637) 357 70.8 4.9e-12 CCDS58060.1 ESRRG gene_id:2104|Hs108|chr1 ( 396) 352 69.8 6.1e-12 CCDS2641.1 THRB gene_id:7068|Hs108|chr3 ( 461) 353 70.0 6.1e-12 CCDS42316.1 THRA gene_id:7067|Hs108|chr17 ( 410) 346 68.8 1.2e-11 CCDS58546.1 THRA gene_id:7067|Hs108|chr17 ( 451) 346 68.8 1.3e-11 CCDS11360.1 THRA gene_id:7067|Hs108|chr17 ( 490) 346 68.8 1.4e-11 CCDS8818.1 NR4A1 gene_id:3164|Hs108|chr12 ( 598) 345 68.7 1.9e-11 CCDS55828.1 NR4A1 gene_id:3164|Hs108|chr12 ( 611) 345 68.7 1.9e-11 CCDS73471.1 NR4A1 gene_id:3164|Hs108|chr12 ( 652) 345 68.8 2e-11 CCDS30856.1 RORC gene_id:6097|Hs108|chr1 ( 497) 340 67.8 2.9e-11 CCDS1004.1 RORC gene_id:6097|Hs108|chr1 ( 518) 340 67.8 3e-11 CCDS8757.1 VDR gene_id:7421|Hs108|chr12 ( 427) 337 67.3 3.7e-11 CCDS6646.1 RORB gene_id:6096|Hs108|chr9 ( 459) 337 67.3 3.9e-11 >>CCDS13330.1 HNF4A gene_id:3172|Hs108|chr20 (474 aa) initn: 3183 init1: 3183 opt: 3183 Z-score: 2889.7 bits: 544.0 E(32554): 1.2e-154 Smith-Waterman score: 3183; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KB9 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW 370 380 390 400 410 420 430 440 450 460 470 pF1KB9 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 430 440 450 460 470 >>CCDS74728.1 HNF4A gene_id:3172|Hs108|chr20 (449 aa) initn: 2945 init1: 2945 opt: 2945 Z-score: 2674.6 bits: 504.2 E(32554): 1.2e-142 Smith-Waterman score: 2945; 100.0% identity (100.0% similar) in 436 aa overlap (39-474:14-449) 10 20 30 40 50 60 pF1KB9 DMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRAT :::::::::::::::::::::::::::::: CCDS74 MSDWGQGFPQDPPDTSPSEGTNLNAPNSLGVSALCAICGDRAT 10 20 30 40 70 80 90 100 110 120 pF1KB9 GKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 GKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB9 AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB9 ESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 ESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGND 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB9 YIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 YIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKI 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB9 KRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 KRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDN 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB9 LLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 LLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAA 350 360 370 380 390 400 430 440 450 460 470 pF1KB9 TPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI :::::::::::::::::::::::::::::::::::::::::::::: CCDS74 TPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 410 420 430 440 >>CCDS42876.1 HNF4A gene_id:3172|Hs108|chr20 (452 aa) initn: 2945 init1: 2945 opt: 2945 Z-score: 2674.5 bits: 504.2 E(32554): 1.2e-142 Smith-Waterman score: 2945; 100.0% identity (100.0% similar) in 436 aa overlap (39-474:17-452) 10 20 30 40 50 60 pF1KB9 DMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRAT :::::::::::::::::::::::::::::: CCDS42 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRAT 10 20 30 40 70 80 90 100 110 120 pF1KB9 GKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB9 AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB9 ESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGND 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB9 YIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 YIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKI 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB9 KRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDN 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB9 LLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAA 350 360 370 380 390 400 430 440 450 460 470 pF1KB9 TPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI :::::::::::::::::::::::::::::::::::::::::::::: CCDS42 TPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 410 420 430 440 450 >>CCDS46605.1 HNF4A gene_id:3172|Hs108|chr20 (464 aa) initn: 2783 init1: 2783 opt: 2812 Z-score: 2554.0 bits: 481.9 E(32554): 6.2e-136 Smith-Waterman score: 3061; 97.7% identity (97.9% similar) in 474 aa overlap (1-474:1-464) 10 20 30 40 50 60 pF1KB9 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQM--- 370 380 390 400 410 430 440 450 460 470 pF1KB9 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI .:::::::::::::::::::::::::::::::::::::::::::::: CCDS46 -------STPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 420 430 440 450 460 >>CCDS46604.1 HNF4A gene_id:3172|Hs108|chr20 (442 aa) initn: 2545 init1: 2545 opt: 2574 Z-score: 2338.8 bits: 442.0 E(32554): 6e-124 Smith-Waterman score: 2823; 97.5% identity (97.7% similar) in 436 aa overlap (39-474:17-442) 10 20 30 40 50 60 pF1KB9 DMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRAT :::::::::::::::::::::::::::::: CCDS46 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRAT 10 20 30 40 70 80 90 100 110 120 pF1KB9 GKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 GKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB9 AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB9 ESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 ESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGND 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB9 YIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 YIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKI 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB9 KRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS46 KRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDN 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB9 LLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAA ::::::::::::::::::::::::::::::::::::::::::::::::: . CCDS46 LLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQM----------S 350 360 370 380 390 430 440 450 460 470 pF1KB9 TPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI :::::::::::::::::::::::::::::::::::::::::::::: CCDS46 TPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI 400 410 420 430 440 >>CCDS13331.1 HNF4A gene_id:3172|Hs108|chr20 (417 aa) initn: 2495 init1: 2495 opt: 2497 Z-score: 2269.4 bits: 429.1 E(32554): 4.3e-120 Smith-Waterman score: 2501; 95.3% identity (95.8% similar) in 403 aa overlap (1-389:1-403) 10 20 30 40 50 60 pF1KB9 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL 310 320 330 340 350 360 370 380 390 400 pF1KB9 FGMAKIDNLLQEMLLGG-------------SPSDAPHA-HHPLHPHLMQEHMGTNVIVAN ::::::::::::::::: ::.: ::. :: CCDS13 FGMAKIDNLLQEMLLGGPCQAQEGRGWSGDSPGDRPHTVSSPLSSLASPLCRFGQVA 370 380 390 400 410 410 420 430 440 450 460 pF1KB9 TMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQP >>CCDS68131.1 HNF4A gene_id:3172|Hs108|chr20 (395 aa) initn: 2257 init1: 2257 opt: 2259 Z-score: 2054.3 bits: 389.2 E(32554): 4.2e-108 Smith-Waterman score: 2263; 94.8% identity (95.3% similar) in 365 aa overlap (39-389:17-381) 10 20 30 40 50 60 pF1KB9 DMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRAT :::::::::::::::::::::::::::::: CCDS68 MVSVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRAT 10 20 30 40 70 80 90 100 110 120 pF1KB9 GKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 GKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB9 AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 AVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB9 ESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 ESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGND 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB9 YIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 YIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKI 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB9 KRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS68 KRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDN 290 300 310 320 330 340 370 380 390 400 410 pF1KB9 LLQEMLLGG-------------SPSDAPHA-HHPLHPHLMQEHMGTNVIVANTMPTHLSN ::::::::: ::.: ::. :: CCDS68 LLQEMLLGGPCQAQEGRGWSGDSPGDRPHTVSSPLSSLASPLCRFGQVA 350 360 370 380 390 420 430 440 450 460 470 pF1KB9 GQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI >>CCDS6220.2 HNF4G gene_id:3174|Hs108|chr8 (445 aa) initn: 2028 init1: 1163 opt: 2080 Z-score: 1891.5 bits: 359.3 E(32554): 4.9e-99 Smith-Waterman score: 2153; 71.8% identity (86.8% similar) in 447 aa overlap (10-456:1-434) 10 20 30 40 50 60 pF1KB9 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC ::::.:: .:::.:::::::..:.: ..:.: : :..:. .. ::. :: CCDS62 MDMANYSEVLDPTYTTLEFETMQILYNSSDSSAPE-TSMNTTDN-GVNCLC 10 20 30 40 70 80 90 100 110 120 pF1KB9 AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC :::::::::::::::::::::::::::.::.:.::::::::::::::::::::::::.:: CCDS62 AICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKC 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB9 FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK ::::::::::::::::::::::... :..::::.: :::: ::::. : . :: .:: CCDS62 FRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVSSPGSSTDINVKK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB9 IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK ::::.:::::::.::::::::::::::::::::::::::::::::::::::::::::..: CCDS62 IASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYK 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB9 DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK :.:::::.:.. :. :. :.:::. :.::::: ::::.:::::::: ::::.::::::: CCDS62 DILLLGNNYVIHRNSCEV-EISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAK 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB9 GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL ::::: ::: .: :::..:::::::::::::::::::::::::::::::::::::::.:: CCDS62 GLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKL 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB9 FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW :::.:::::::::::::. .:. : :::.:::: :. . ..:. . : : . :. CCDS62 FGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMSTLVHADQI--- 350 360 370 380 390 400 430 440 450 460 470 pF1KB9 PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI .::::: :::: :::.: ::. . ...: CCDS62 -------STPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL 410 420 430 440 >>CCDS83303.1 HNF4G gene_id:3174|Hs108|chr8 (408 aa) initn: 2028 init1: 1163 opt: 1946 Z-score: 1770.8 bits: 336.8 E(32554): 2.6e-92 Smith-Waterman score: 2019; 74.1% identity (87.3% similar) in 402 aa overlap (55-456:7-397) 30 40 50 60 70 80 pF1KB9 TLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFF ::. :::::::::::::::::::::::::: CCDS83 MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFF 10 20 30 90 100 110 120 130 140 pF1KB9 RRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSY :::.::.:.::::::::::::::::::::::::.::::::::::::::::::::::::.. CCDS83 RRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTF 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB9 EDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKY . :..::::.: :::: ::::. : . :: .::::::.:::::::.::::::::::: CCDS83 DGSNIPSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKY 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB9 IPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRV :::::::::::::::::::::::::::::::::..::.:::::.:.. :. :. :.::: CCDS83 IPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEV-EISRV 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB9 SIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYIN . :.::::: ::::.:::::::: ::::.:::::::::::: ::: .: :::..:::::: CCDS83 ANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYIN 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB9 DRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH :::::::::::::::::::::::::::::::::.:::::.:::::::::::::. .:. : CCDS83 DRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSH 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB9 AHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSE :::.:::: :. . ..:. . : : . :. .::::: :::: :::.: CCDS83 LHHPMHPHLSQDPLTGQTILLGPMSTLVHADQI----------STPETPLPSPPQGSGQE 340 350 360 370 380 450 460 470 pF1KB9 PYKLLPGAVATIVKPLSAIPQPTITKQEVI ::. . ...: CCDS83 QYKIAANQASVISHQHLSKQKQL 390 400 >>CCDS35172.1 RXRA gene_id:6256|Hs108|chr9 (462 aa) initn: 910 init1: 515 opt: 907 Z-score: 829.4 bits: 162.8 E(32554): 7.1e-40 Smith-Waterman score: 909; 41.0% identity (70.5% similar) in 366 aa overlap (34-384:101-459) 10 20 30 40 50 pF1KB9 SKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTN--LNAP-NSLGVSA-- .. ..: .: : : :..: . : : CCDS35 PMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASF 80 90 100 110 120 130 60 70 80 90 100 110 pF1KB9 ---LCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYC .:::::::..:::::. ::.::::::.:.:::. :.:: ...:..:: .::.:.:: CCDS35 TKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYC 140 150 160 170 180 190 120 130 140 150 160 pF1KB9 RLKKCFRAGMKKEAVQNERDRISTRR------SSYEDSSLPSINALLQAEVLSRQITSPV : .::. :::.::::.::.: . : .: . ..: .. .:.::. . : CCDS35 RYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMP-VERILEAELAVEPKTETY 200 210 220 230 240 170 180 190 200 210 220 pF1KB9 SGINGDIRAKKIAS-IADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL : . .. . ....:.. .::..:::::: :: : :::::::: :::: .: : CCDS35 VEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELL 250 260 270 280 290 300 230 240 250 260 270 280 pF1KB9 LLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAY . . ..::.. :: .::.. : :. . : .. . :.: ::: ....:.: .: . CCDS35 IASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGC 310 320 330 340 350 360 290 300 310 320 330 340 pF1KB9 LKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSIT :.::..:.::.::::.:.... :: .: .::: : . . .. :::..::: ::.:.:: CCDS35 LRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIG 370 380 390 400 410 420 350 360 370 380 390 400 pF1KB9 WQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTM . .:.. :.::.: . ::..:.::: .::: CCDS35 LKCLEHLFFFKLIGDTPIDTFLMEML------EAPHQMT 430 440 450 460 410 420 430 440 450 460 pF1KB9 PTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTI 474 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:34:31 2016 done: Fri Nov 4 18:34:32 2016 Total Scan time: 3.410 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]