FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9747, 545 aa 1>>>pF1KB9747 545 - 545 aa - 545 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2680+/-0.000832; mu= 11.3607+/- 0.050 mean_var=138.1616+/-27.182, 0's: 0 Z-trim(112.7): 35 B-trim: 5 in 1/49 Lambda= 0.109114 statistics sampled from 13415 (13446) to 13415 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.744), E-opt: 0.2 (0.413), width: 16 Scan time: 3.840 The best scores are: opt bits E(32554) CCDS11629.1 TBX4 gene_id:9496|Hs108|chr17 ( 545) 3739 599.9 2.5e-171 CCDS82180.1 TBX4 gene_id:9496|Hs108|chr17 ( 546) 3727 598.0 9.4e-171 CCDS9173.1 TBX5 gene_id:6910|Hs108|chr12 ( 518) 1710 280.5 3.4e-75 CCDS9174.1 TBX5 gene_id:6910|Hs108|chr12 ( 468) 1677 275.2 1.2e-73 CCDS13767.1 TBX1 gene_id:6899|Hs108|chr22 ( 495) 897 152.5 1.1e-36 CCDS11627.2 TBX2 gene_id:6909|Hs108|chr17 ( 712) 899 152.9 1.2e-36 CCDS13766.1 TBX1 gene_id:6899|Hs108|chr22 ( 398) 874 148.8 1.2e-35 CCDS13765.1 TBX1 gene_id:6899|Hs108|chr22 ( 372) 866 147.5 2.6e-35 CCDS9175.1 TBX3 gene_id:6926|Hs108|chr12 ( 723) 843 144.1 5.4e-34 CCDS31621.1 TBX10 gene_id:347853|Hs108|chr11 ( 385) 824 140.9 2.6e-33 CCDS10670.1 TBX6 gene_id:6911|Hs108|chr16 ( 436) 819 140.2 5e-33 CCDS43568.1 TBX20 gene_id:57057|Hs108|chr7 ( 447) 804 137.8 2.6e-32 CCDS34495.1 TBX18 gene_id:9096|Hs108|chr6 ( 607) 786 135.1 2.4e-31 CCDS81360.1 TBX15 gene_id:6913|Hs108|chr1 ( 602) 775 133.3 7.9e-31 CCDS30816.1 TBX15 gene_id:6913|Hs108|chr1 ( 496) 767 132.0 1.6e-30 CCDS14445.1 TBX22 gene_id:50945|Hs108|chrX ( 520) 724 125.2 1.8e-28 CCDS11514.1 TBX21 gene_id:30009|Hs108|chr17 ( 535) 713 123.5 6.2e-28 CCDS5290.1 T gene_id:6862|Hs108|chr6 ( 435) 689 119.7 7.2e-27 CCDS59045.1 T gene_id:6862|Hs108|chr6 ( 377) 674 117.3 3.3e-26 CCDS55960.1 MGA gene_id:23269|Hs108|chr15 (2856) 682 119.1 6.9e-26 CCDS55959.1 MGA gene_id:23269|Hs108|chr15 (3065) 682 119.2 7.3e-26 CCDS1272.1 TBX19 gene_id:9095|Hs108|chr1 ( 448) 653 114.0 3.8e-25 CCDS63585.1 EOMES gene_id:8320|Hs108|chr3 ( 705) 654 114.3 4.8e-25 CCDS33310.1 TBR1 gene_id:10716|Hs108|chr2 ( 682) 648 113.4 9e-25 CCDS2646.1 EOMES gene_id:8320|Hs108|chr3 ( 686) 642 112.4 1.7e-24 CCDS9176.1 TBX3 gene_id:6926|Hs108|chr12 ( 743) 551 98.1 3.8e-20 CCDS63584.1 EOMES gene_id:8320|Hs108|chr3 ( 410) 544 96.8 5.1e-20 >>CCDS11629.1 TBX4 gene_id:9496|Hs108|chr17 (545 aa) initn: 3739 init1: 3739 opt: 3739 Z-score: 3189.3 bits: 599.9 E(32554): 2.5e-171 Smith-Waterman score: 3739; 100.0% identity (100.0% similar) in 545 aa overlap (1-545:1-545) 10 20 30 40 50 60 pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 PADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 FGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 FGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 ENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 ENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 QHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 QHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 VGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNMW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 VGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNMW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 TSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 TSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 QVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRESSLQYHSGMGTVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 QVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRESSLQYHSGMGTVE 490 500 510 520 530 540 pF1KB9 NWTDG ::::: CCDS11 NWTDG >>CCDS82180.1 TBX4 gene_id:9496|Hs108|chr17 (546 aa) initn: 2294 init1: 2294 opt: 3727 Z-score: 3179.0 bits: 598.0 E(32554): 9.4e-171 Smith-Waterman score: 3727; 99.8% identity (99.8% similar) in 546 aa overlap (1-545:1-546) 10 20 30 40 50 60 pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 FGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 FGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 ENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 ENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL 250 260 270 280 290 300 310 320 330 340 350 pF1KB9 QHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRR-DGTRHLDLPCKRSYLEAPS :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: CCDS82 QHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRRADGTRHLDLPCKRSYLEAPS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB9 SVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNM 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB9 WTSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 WTSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB9 SQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRESSLQYHSGMGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRESSLQYHSGMGTV 490 500 510 520 530 540 540 pF1KB9 ENWTDG :::::: CCDS82 ENWTDG >>CCDS9173.1 TBX5 gene_id:6910|Hs108|chr12 (518 aa) initn: 1586 init1: 1297 opt: 1710 Z-score: 1463.4 bits: 280.5 E(32554): 3.4e-75 Smith-Waterman score: 1761; 54.0% identity (71.5% similar) in 554 aa overlap (7-544:1-516) 10 20 30 40 50 pF1KB9 MLQDKGLSESEEAF---RAP-GPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVA .....:.: ..: : . . :: ::.::. :: .: CCDS91 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPS------KSPSSP-----Q 10 20 30 40 60 70 80 90 100 110 pF1KB9 AAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILL :: ..: .:.::: :::.::: ::::.:::::::::::::::::::::::.::::::::: CCDS91 AAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 IDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN .:::::::::::: :::: :.::::::::::::::::::::::::::::::::::::::: CCDS91 MDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB9 HLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKIT :::::::::::::::::::::::::::::.::::::::::::::::.::.:::::::::: CCDS91 HLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKIT 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB9 QLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLG :::::::::::::::::: .: :..:.:::::::. .: .::.. : . . . : CCDS91 QLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALST 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB9 THQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRDGT-RHLDLPCKR . . ..:: :::. . ::: : . .: .. : .::: ::.. : : :. CCDS91 SSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKK 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB9 SYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLP :.: .:: :: ..:: : .:: :. :: .: . :.::::..:.: : ...:. CCDS91 PYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDI- 350 360 370 380 390 420 430 440 450 460 pF1KB9 PPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGN ::: : :. :.: .:: :. .::: : .:::. ..::: .. ..: :. CCDS91 ----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGE 400 410 420 430 440 450 470 480 490 500 510 520 pF1KB9 AHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRE . :. .... : ::. :: . :: . .:: :::::. .. : CCDS91 GMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQPP--------EFLYSH--GVPRT 460 470 480 490 530 540 pF1KB9 -SSLQYHS--GMGTVENWTDG : :::: :.: : .:.: CCDS91 LSPHQYHSVHGVGMVPEWSDNS 500 510 >>CCDS9174.1 TBX5 gene_id:6910|Hs108|chr12 (468 aa) initn: 1564 init1: 1275 opt: 1677 Z-score: 1435.9 bits: 275.2 E(32554): 1.2e-73 Smith-Waterman score: 1726; 57.3% identity (73.8% similar) in 492 aa overlap (64-544:1-466) 40 50 60 70 80 90 pF1KB9 LAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAG .:.::: :::.::: ::::.:::::::::: CCDS91 MEGIKVFLHERELWLKFHEVGTEMIITKAG 10 20 30 100 110 120 130 140 150 pF1KB9 RRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPD :::::::::::::.:::::::::.:::::::::::: :::: :.:::::::::::::::: CCDS91 RRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPD 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB9 SPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTA ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: CCDS91 SPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB9 FCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISK :::::::::.::.:::::::::::::::::::::::::::: .: :..:.:::::::. . CCDS91 FCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB9 SIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDS : .::.. : . . . : . . ..:: :::. . ::: : . .: .. CCDS91 STVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSG---PSQDLLPPPNPYPLPQEH 220 230 240 250 260 340 350 360 370 380 pF1KB9 SLFYHCLKRRDGT-RHLDLPCKRSYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTP : .::: ::.. : : :. :.: .:: :: ..:: : .:: :. :: .: . CCDS91 SQIYHCTKRKEEECSTTDHPYKKPYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQ 270 280 290 300 310 320 390 400 410 420 430 440 pF1KB9 REACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTH :.::::..:.: : ...:. ::: : :. :.: .:: :. .::: : .: CCDS91 RQACMYASSAPPSEPVPSLEDI-----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAH 330 340 350 360 370 450 460 470 480 490 500 pF1KB9 FTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERK ::. ..::: .. ..: :.. :. .... : ::. :: . :: . . CCDS91 FTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQ 380 390 400 410 420 430 510 520 530 540 pF1KB9 PPSPHLNAANEFLYSQTFSLSRESSLQYHS--GMGTVENWTDG :: :::::. . : :::: :.: : .:.: CCDS91 PP--------EFLYSHGVPRTL-SPHQYHSVHGVGMVPEWSDNS 440 450 460 >>CCDS13767.1 TBX1 gene_id:6899|Hs108|chr22 (495 aa) initn: 924 init1: 392 opt: 897 Z-score: 772.0 bits: 152.5 E(32554): 1.1e-36 Smith-Waterman score: 897; 47.6% identity (69.8% similar) in 315 aa overlap (16-320:60-362) 10 20 30 40 pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALG :::: . :: : : . .: . CCDS13 AASPGADPYGPREPPPPPPRYDPCAAAAPGAPGPPPPPHAYPFAP-----AAGAATSAAA 30 40 50 60 70 80 50 60 70 80 90 100 pF1KB9 SPPGPGADVVAAAAA----EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYK : ::::. .::: : . . ...: :. : :: .:.. :::::.:::::::::... CCDS13 EPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQ 90 100 110 120 130 140 110 120 130 140 150 pF1KB9 VKVTGMNPKTKYILLIDIVPADDHRYK--FCDNKWMVAGKAEPAMPGRLYVHPDSPATGA ::. ::.: . :.::.:.::.::.::. : ...:.:::::.:: :::.. :::::: :: CCDS13 VKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGA 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB9 HWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKAD---ENNAFGSKNTAFCT .::.:.:::.::::::: :: :::::::::.::::.:.: .: ... .. .: : : CCDS13 QWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEEN--FKT 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB9 HVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIM :: :: : .::.::::.:::::: .:::::::: : : : : :..: .. CCDS13 FVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHR--PGALPLMS-AFA 270 280 290 300 310 280 290 300 310 320 330 pF1KB9 RQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYH :.: .: : : : . .: ...:.. :. . :..: : CCDS13 RSR--NPVASPTQPSGTEKDAAEARREFQRDAGGPAVLGDPAHPPQLLARVLSPSLPGAG 320 330 340 350 360 370 340 350 360 370 380 390 pF1KB9 CLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYS CCDS13 GAGGLVPLPGAPGGRPSPPNPELRLEAPGASEPLHHHPYKYPAAAYDHYLGAKSRPAPYP 380 390 400 410 420 430 >>CCDS11627.2 TBX2 gene_id:6909|Hs108|chr17 (712 aa) initn: 887 init1: 671 opt: 899 Z-score: 771.4 bits: 152.9 E(32554): 1.2e-36 Smith-Waterman score: 899; 57.9% identity (76.7% similar) in 240 aa overlap (17-254:53-290) 10 20 30 40 pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGS : :.:. :.:: : : : :: .::: CCDS11 DFPMSAFLAAAQPSFFPALALPPGALAKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGP 30 40 50 60 70 80 50 60 70 80 90 100 pF1KB9 -PPGPGADVVAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKV ::. . . :. .:. :: :. :::: .::. ::::.:::.:::::: .::.: CCDS11 HPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRV 90 100 110 120 130 140 110 120 130 140 150 160 pF1KB9 TGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQ .:.. :.:::::.::: ::: :::: ...:::::::.: :: :.:.:::::::: .:: . CCDS11 SGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAK 150 160 170 180 190 200 170 180 190 200 210 220 pF1KB9 LVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSF :.:.::::::: : : :::::::::::.:::.: :. . ..: :.:::::.: CCDS11 PVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRA--NDILKLPYSTFRTYVFPETDF 210 220 230 240 250 260 230 240 250 260 270 280 pF1KB9 ISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQL :.::.::: :::::::.::::::::: . . CCDS11 IAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAES 270 280 290 300 310 320 >>CCDS13766.1 TBX1 gene_id:6899|Hs108|chr22 (398 aa) initn: 898 init1: 392 opt: 874 Z-score: 753.8 bits: 148.8 E(32554): 1.2e-35 Smith-Waterman score: 874; 50.0% identity (70.2% similar) in 292 aa overlap (16-297:60-339) 10 20 30 40 pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALG :::: . :: : : . .: . CCDS13 AASPGADPYGPREPPPPPPRYDPCAAAAPGAPGPPPPPHAYPFAP-----AAGAATSAAA 30 40 50 60 70 80 50 60 70 80 90 100 pF1KB9 SPPGPGADVVAAAAA----EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYK : ::::. .::: : . . ...: :. : :: .:.. :::::.:::::::::... CCDS13 EPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQ 90 100 110 120 130 140 110 120 130 140 150 pF1KB9 VKVTGMNPKTKYILLIDIVPADDHRYK--FCDNKWMVAGKAEPAMPGRLYVHPDSPATGA ::. ::.: . :.::.:.::.::.::. : ...:.:::::.:: :::.. :::::: :: CCDS13 VKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGA 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB9 HWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKAD---ENNAFGSKNTAFCT .::.:.:::.::::::: :: :::::::::.::::.:.: .: ... .. .: : : CCDS13 QWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEEN--FKT 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB9 HVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIM :: :: : .::.::::.:::::: .:::::::: : : : : :..: .. CCDS13 FVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHR--PGALPLMS-AFA 270 280 290 300 310 280 290 300 310 320 330 pF1KB9 RQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYH :.: .: : : : : : CCDS13 RSR--NPVASPTQPSGTEKGGHVLKDKEVKAETSRNTPEREVELLRDAGGCVNLGLPCPA 320 330 340 350 360 370 >>CCDS13765.1 TBX1 gene_id:6899|Hs108|chr22 (372 aa) initn: 644 init1: 394 opt: 866 Z-score: 747.4 bits: 147.5 E(32554): 2.6e-35 Smith-Waterman score: 866; 50.0% identity (70.3% similar) in 290 aa overlap (16-295:60-337) 10 20 30 40 pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALG :::: . :: : : . .: . CCDS13 AASPGADPYGPREPPPPPPRYDPCAAAAPGAPGPPPPPHAYPFAP-----AAGAATSAAA 30 40 50 60 70 80 50 60 70 80 90 100 pF1KB9 SPPGPGADVVAAAAA----EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYK : ::::. .::: : . . ...: :. : :: .:.. :::::.:::::::::... CCDS13 EPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQ 90 100 110 120 130 140 110 120 130 140 150 pF1KB9 VKVTGMNPKTKYILLIDIVPADDHRYK--FCDNKWMVAGKAEPAMPGRLYVHPDSPATGA ::. ::.: . :.::.:.::.::.::. : ...:.:::::.:: :::.. :::::: :: CCDS13 VKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGA 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB9 HWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKAD---ENNAFGSKNTAFCT .::.:.:::.::::::: :: :::::::::.::::.:.: .: ... .. .: : : CCDS13 QWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEEN--FKT 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB9 HVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIM :: :: : .::.::::.:::::: .:::::::: : : : : :..: .. CCDS13 FVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHR--PGALPLMS-AFA 270 280 290 300 310 280 290 300 310 320 330 pF1KB9 RQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYH :.: .: : : : : CCDS13 RSR--NPVASPTQPSGTEKGLVTEGSGLQPGLLDVLLKPPSKKSESLRPPHCKDT 320 330 340 350 360 370 >>CCDS9175.1 TBX3 gene_id:6926|Hs108|chr12 (723 aa) initn: 860 init1: 646 opt: 843 Z-score: 723.7 bits: 144.1 E(32554): 5.4e-34 Smith-Waterman score: 857; 52.4% identity (71.8% similar) in 273 aa overlap (17-278:42-308) 10 20 30 40 pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA :. .: .:: : ::: : : :: CCDS91 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA 20 30 40 50 60 70 50 60 70 80 90 pF1KB9 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR : . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.::: CCDS91 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB9 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP ::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.::::: CCDS91 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB9 ATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFC ::: .:: ..:.:.::::::: : : :::::::::::.:::.: :. . ..: CCDS91 ATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRA--NDILKLPYSTFR 200 210 220 230 240 220 230 240 250 260 270 pF1KB9 THVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIM :..:::: ::.::.::: :::::::.::::::::: : .. : : . :. . : .. CCDS91 TYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTGNGR--REKRKQLTLQSMRVF 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB9 RQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYH .: CCDS91 DERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEH 310 320 330 340 350 360 >>CCDS31621.1 TBX10 gene_id:347853|Hs108|chr11 (385 aa) initn: 621 init1: 395 opt: 824 Z-score: 711.4 bits: 140.9 E(32554): 2.6e-33 Smith-Waterman score: 824; 39.9% identity (63.2% similar) in 378 aa overlap (16-381:13-374) 10 20 30 40 50 60 pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA ::. . ..... :: :..: :: .: ::..:: .. CCDS31 MAAFLSAGLGILAPSETYPLPTTSSGWEPRLGSPFPSGPCTSST---GAQAVAEPTG 10 20 30 40 50 70 80 90 100 110 pF1KB9 E----QTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILL . . . : :. : ::..:.. :::::.::::::::: ..::. ::. . : :: CCDS31 QGPKNPRVSRVTVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPPFQVKILGMDSLADYALL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 IDIVPADDHRYK--FCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLT .:..: ::.::. : .. :.:::::.:: :::.. :::::: ::.::::.:::.::::: CCDS31 MDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQWMRQIVSFDKLKLT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 NNHLDPFGHIILNSMHKYQPRLHIVKAD---ENNAFGSKNTAFCTHVFPETSFISVTSYQ :: :: :::::::::.::::.:.: .: ... ....: : . .: ::.: .::.:: CCDS31 NNLLDDNGHIILNSMHRYQPRFHVVFVDPRKDSERYAQEN--FKSFIFTETQFTAVTAYQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB9 NHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVG ::.:::::: .:::::::: :: .. :: :. :.: . ... . : . CCDS31 NHRITQLKIASNPFAKGFRESDLDSWPVAPRPLLSVPARSHSSLSPCVLKGATDREKDPN 240 250 260 270 280 290 300 310 320 330 340 pF1KB9 PLLGTHQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRDGTRHLDLP .. . . : :. : :. : : . :. .: .: . :: .: CCDS31 KASASTSKTPAWLH----HQLLPPPEVLLAPATYRPVTYQS--LYS-----GAPSHLGIP 300 310 320 330 340 350 360 370 380 390 400 pF1KB9 CKR-SYLEAPSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVD : . :. .. : : .:::. CCDS31 RTRPAPYPLPNIRADRDQGGLPLPAGLGLLSPTVVCLGPGQDSQ 350 360 370 380 410 420 430 440 450 460 pF1KB9 DLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGN 545 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:40:22 2016 done: Fri Nov 4 18:40:23 2016 Total Scan time: 3.840 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]