FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9766, 933 aa 1>>>pF1KB9766 933 - 933 aa - 933 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.3546+/-0.0004; mu= -4.8507+/- 0.025 mean_var=394.3053+/-82.401, 0's: 0 Z-trim(123.2): 400 B-trim: 549 in 1/58 Lambda= 0.064589 statistics sampled from 42081 (42493) to 42081 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.498), width: 16 Scan time: 14.300 The best scores are: opt bits E(85289) NP_000917 (OMIM: 264080,607311) progesterone recep ( 933) 6327 604.3 8.8e-172 XP_006718921 (OMIM: 264080,607311) PREDICTED: prog ( 797) 5378 515.9 3.3e-145 NP_001189403 (OMIM: 264080,607311) progesterone re ( 769) 5189 498.2 6.4e-140 XP_011541171 (OMIM: 264080,607311) PREDICTED: prog ( 611) 4081 394.9 6.5e-109 NP_001258090 (OMIM: 264080,607311) progesterone re ( 667) 3253 317.8 1.2e-85 NP_001258091 (OMIM: 264080,607311) progesterone re ( 339) 2259 224.9 5.4e-58 NP_000035 (OMIM: 176807,300068,300633,312300,31320 ( 920) 1525 156.9 4.3e-37 NP_001011645 (OMIM: 176807,300068,300633,312300,31 ( 388) 1497 153.9 1.4e-36 XP_005268476 (OMIM: 138040,615962) PREDICTED: gluc ( 778) 1195 126.1 6.9e-28 XP_005268477 (OMIM: 138040,615962) PREDICTED: gluc ( 778) 1195 126.1 6.9e-28 XP_005268480 (OMIM: 138040,615962) PREDICTED: gluc ( 778) 1195 126.1 6.9e-28 NP_001019265 (OMIM: 138040,615962) glucocorticoid ( 778) 1195 126.1 6.9e-28 XP_005268479 (OMIM: 138040,615962) PREDICTED: gluc ( 778) 1195 126.1 6.9e-28 XP_011535939 (OMIM: 138040,615962) PREDICTED: gluc ( 380) 975 105.3 6.1e-22 NP_001191193 (OMIM: 138040,615962) glucocorticoid ( 442) 975 105.4 6.8e-22 NP_001191192 (OMIM: 138040,615962) glucocorticoid ( 447) 975 105.4 6.9e-22 NP_001191191 (OMIM: 138040,615962) glucocorticoid ( 462) 975 105.4 7e-22 NP_001191190 (OMIM: 138040,615962) glucocorticoid ( 680) 975 105.5 9.3e-22 NP_001191189 (OMIM: 138040,615962) glucocorticoid ( 688) 975 105.5 9.4e-22 NP_001191188 (OMIM: 138040,615962) glucocorticoid ( 692) 975 105.5 9.4e-22 NP_001191187 (OMIM: 138040,615962) glucocorticoid ( 751) 975 105.6 1e-21 NP_001018087 (OMIM: 138040,615962) glucocorticoid ( 777) 975 105.6 1e-21 XP_016864887 (OMIM: 138040,615962) PREDICTED: gluc ( 777) 975 105.6 1e-21 NP_001018085 (OMIM: 138040,615962) glucocorticoid ( 777) 975 105.6 1e-21 NP_001018086 (OMIM: 138040,615962) glucocorticoid ( 777) 975 105.6 1e-21 XP_016864886 (OMIM: 138040,615962) PREDICTED: gluc ( 777) 975 105.6 1e-21 NP_000167 (OMIM: 138040,615962) glucocorticoid rec ( 777) 975 105.6 1e-21 NP_001018084 (OMIM: 138040,615962) glucocorticoid ( 777) 975 105.6 1e-21 NP_000892 (OMIM: 177735,600983,605115) mineralocor ( 984) 967 104.9 2e-21 XP_016863706 (OMIM: 177735,600983,605115) PREDICTE ( 984) 967 104.9 2e-21 XP_011530279 (OMIM: 177735,600983,605115) PREDICTE ( 988) 967 104.9 2.1e-21 XP_011530278 (OMIM: 177735,600983,605115) PREDICTE ( 988) 967 104.9 2.1e-21 XP_011530277 (OMIM: 177735,600983,605115) PREDICTE ( 988) 967 104.9 2.1e-21 NP_001018661 (OMIM: 138040,615962) glucocorticoid ( 742) 807 89.9 5.1e-17 NP_001159576 (OMIM: 177735,600983,605115) mineralo ( 867) 766 86.1 8.1e-16 XP_016856122 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_016856125 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_011507579 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_016856121 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_016856120 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_016856123 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_011507576 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_011507578 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_016856126 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_011507577 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_011507582 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_011507580 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_016856124 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_011507581 (OMIM: 602969) PREDICTED: estrogen-re ( 442) 636 73.8 2.2e-12 XP_016856119 (OMIM: 602969) PREDICTED: estrogen-re ( 447) 636 73.8 2.2e-12 >>NP_000917 (OMIM: 264080,607311) progesterone receptor (933 aa) initn: 6327 init1: 6327 opt: 6327 Z-score: 3205.0 bits: 604.3 E(85289): 8.8e-172 Smith-Waterman score: 6327; 100.0% identity (100.0% similar) in 933 aa overlap (1-933:1-933) 10 20 30 40 50 60 pF1KB9 MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB9 LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB9 DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB9 FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA 850 860 870 880 890 900 910 920 930 pF1KB9 LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK ::::::::::::::::::::::::::::::::: NP_000 LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK 910 920 930 >>XP_006718921 (OMIM: 264080,607311) PREDICTED: progeste (797 aa) initn: 5546 init1: 5378 opt: 5378 Z-score: 2728.0 bits: 515.9 E(85289): 3.3e-145 Smith-Waterman score: 5378; 99.9% identity (100.0% similar) in 786 aa overlap (1-786:1-786) 10 20 30 40 50 60 pF1KB9 MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB9 GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB9 LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB9 DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ :::::. XP_006 DLILNDSFGRATKSNPV 790 >>NP_001189403 (OMIM: 264080,607311) progesterone recept (769 aa) initn: 5189 init1: 5189 opt: 5189 Z-score: 2633.0 bits: 498.2 E(85289): 6.4e-140 Smith-Waterman score: 5189; 100.0% identity (100.0% similar) in 769 aa overlap (165-933:1-769) 140 150 160 170 180 190 pF1KB9 EVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQ :::::::::::::::::::::::::::::: NP_001 MSRSGCKVGDSSGTAAAHKVLPRGLSPARQ 10 20 30 200 210 220 230 240 250 pF1KB9 LLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAA 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB9 AVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHA 100 110 120 130 140 150 320 330 340 350 360 370 pF1KB9 LLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAY 160 170 180 190 200 210 380 390 400 410 420 430 pF1KB9 PLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRP 220 230 240 250 260 270 440 450 460 470 480 490 pF1KB9 GEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDG 280 290 300 310 320 330 500 510 520 530 540 550 pF1KB9 LPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQS 340 350 360 370 380 390 560 570 580 590 600 610 pF1KB9 PQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKI 400 410 420 430 440 450 620 630 640 650 660 670 pF1KB9 RRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFT 460 470 480 490 500 510 680 690 700 710 720 730 pF1KB9 FSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSK 520 530 540 550 560 570 740 750 760 770 780 790 pF1KB9 SLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSF 580 590 600 610 620 630 800 810 820 830 840 850 pF1KB9 YSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIK 640 650 660 670 680 690 860 870 880 890 900 910 pF1KB9 AIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIA 700 710 720 730 740 750 920 930 pF1KB9 AQLPKILAGMVKPLLFHKK ::::::::::::::::::: NP_001 AQLPKILAGMVKPLLFHKK 760 >>XP_011541171 (OMIM: 264080,607311) PREDICTED: progeste (611 aa) initn: 4081 init1: 4081 opt: 4081 Z-score: 2076.4 bits: 394.9 E(85289): 6.5e-109 Smith-Waterman score: 4081; 100.0% identity (100.0% similar) in 596 aa overlap (1-596:1-596) 10 20 30 40 50 60 pF1KB9 MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB9 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB9 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB9 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB9 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB9 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB9 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEDTCI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB9 YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV XP_011 DPTFKSCLCWD 610 >>NP_001258090 (OMIM: 264080,607311) progesterone recept (667 aa) initn: 3250 init1: 3250 opt: 3253 Z-score: 1658.9 bits: 317.8 E(85289): 1.2e-85 Smith-Waterman score: 4314; 86.7% identity (86.7% similar) in 769 aa overlap (165-933:1-667) 140 150 160 170 180 190 pF1KB9 EVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQ :::::::::::::::::::::::::::::: NP_001 MSRSGCKVGDSSGTAAAHKVLPRGLSPARQ 10 20 30 200 210 220 230 240 250 pF1KB9 LLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAA 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB9 AVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHA 100 110 120 130 140 150 320 330 340 350 360 370 pF1KB9 LLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAY 160 170 180 190 200 210 380 390 400 410 420 430 pF1KB9 PLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRP 220 230 240 250 260 270 440 450 460 470 480 490 pF1KB9 GEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDG 280 290 300 310 320 330 500 510 520 530 540 550 pF1KB9 LPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQS 340 350 360 370 380 390 560 570 580 590 600 610 pF1KB9 PQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKI 400 410 420 430 440 450 620 630 640 650 660 670 pF1KB9 RRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFT :::::::::::::::::::::: NP_001 RRKNCPACRLRKCCQAGMVLGG-------------------------------------- 460 470 680 690 700 710 720 730 pF1KB9 FSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSK NP_001 ------------------------------------------------------------ 740 750 760 770 780 790 pF1KB9 SLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ----FRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSF 480 490 500 510 520 800 810 820 830 840 850 pF1KB9 YSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIK 530 540 550 560 570 580 860 870 880 890 900 910 pF1KB9 AIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIA 590 600 610 620 630 640 920 930 pF1KB9 AQLPKILAGMVKPLLFHKK ::::::::::::::::::: NP_001 AQLPKILAGMVKPLLFHKK 650 660 >>NP_001258091 (OMIM: 264080,607311) progesterone recept (339 aa) initn: 2259 init1: 2259 opt: 2259 Z-score: 1162.2 bits: 224.9 E(85289): 5.4e-58 Smith-Waterman score: 2259; 100.0% identity (100.0% similar) in 339 aa overlap (595-933:1-339) 570 580 590 600 610 620 pF1KB9 KICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRL :::::::::::::::::::::::::::::: NP_001 MEGQHNYLCAGRNDCIVDKIRRKNCPACRL 10 20 30 630 640 650 660 670 680 pF1KB9 RKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLI 40 50 60 70 80 90 690 700 710 720 730 740 pF1KB9 PPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHI 100 110 120 130 140 150 750 760 770 780 790 800 pF1KB9 DDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQI 160 170 180 190 200 210 810 820 830 840 850 860 pF1KB9 PQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVV 220 230 240 250 260 270 870 880 890 900 910 920 pF1KB9 SSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGM 280 290 300 310 320 330 930 pF1KB9 VKPLLFHKK ::::::::: NP_001 VKPLLFHKK >>NP_000035 (OMIM: 176807,300068,300633,312300,313200,31 (920 aa) initn: 1551 init1: 980 opt: 1525 Z-score: 786.8 bits: 156.9 E(85289): 4.3e-37 Smith-Waterman score: 1614; 35.8% identity (60.4% similar) in 950 aa overlap (46-933:42-920) 20 30 40 50 60 70 pF1KB9 GGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEV-SAIPISLDGLLFPRPCQGQDPSDEKT ::. :: : . . ::. . : :. .... NP_000 PRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQ 20 30 40 50 60 70 80 90 100 110 120 130 pF1KB9 QDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQS---QPS- :.::. .. : . . . .: :: .. . .: : ::: :: : .. .: NP_000 QQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYL--VLDEEQQPSQPQSALECHPER 80 90 100 110 120 140 150 160 170 180 pF1KB9 ---P-PACEVTSSWCLFGPELP----EDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAH : :. :..: : .:: :: :::.: .:.: . : :: .: . NP_000 GCVPEPGAAVAASKGL-PQQLPAPPDEDDSAAPSTLSLLGPTFP------GLSSCSADLK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 KVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPR .: . . . ::: . : :: .: : :..: ..: NP_000 DILSE--ASTMQLL---------------QQQQQEAVSEGSSSGRAREASGAPT-SSKDN 190 200 210 220 250 260 270 280 290 300 pF1KB9 ALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVAL-VEQDAPMAPGRSPLATTVM :::... . : :: . . ..: :: ..::.. . NP_000 YLGGTSTISDNA---------------KELCKAVSVSMGLGVEALEHLSPGEQLRG---- 230 240 250 260 310 320 330 340 350 pF1KB9 DFIHVPILPLNHALLAARTRQLLEDES--YDGGAGAASAFAPPRSSPCASSTPVAVGDFP : ...:.: . :. . : : .. : .:: .. . : .. : :. NP_000 DCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESL 270 280 290 300 310 320 360 370 380 390 400 410 pF1KB9 DCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPL :. : .. . : : .:.. . ::.: . :.: : :. : NP_000 GCS-GSAAAGSSGTLEL-----PSTLSLYKSGALDEAAAYQSRDYY---NFPLALAGPPP 330 340 350 360 370 420 430 440 450 pF1KB9 GPPPPLP--------P---------RATPSRPGEAAV-----TAAPASASVSSASSSGST :::: : : :. : :. : .:.:.:.: :.:.::. NP_000 PPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWH 380 390 400 410 420 430 460 470 480 490 500 510 pF1KB9 LECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGA-APALY--PA :. :: .: . : : . :..: : . ..... ::: :: : : NP_000 T---LFTAE-----EGQLYGP-CGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPP 440 450 460 470 480 520 530 540 550 pF1KB9 LGLNGL------PQLGYQAAVLKEGLPQVYP--------PYLNY-------LRPDSEASQ :: : :.. : ...... .: : :... .: .. .. NP_000 QGLAGQESDFTAPDVWYPGGMVSR-VPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDH 490 500 510 520 530 540 560 570 580 590 600 610 pF1KB9 SPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDK .. ::: ::::::::::::::.::::::::::::: ::...::::.:::: .:: NP_000 VLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDK 550 560 570 580 590 600 620 630 640 650 660 670 pF1KB9 IRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRF .::::::.:::::: .:::.::.::.::...... . .: . .: .. .:.. NP_000 FRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSP------TEETTQKL 610 620 630 640 650 660 680 690 700 710 720 730 pF1KB9 TFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWS : : . . : ..:.: .::: :. :::::..::. ..::.:::.::::::. ::::. NP_000 TVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA 670 680 690 700 710 720 740 750 760 770 780 790 pF1KB9 KSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESS :.::::::::.:::...::::::.::::..::::. .:...::::::::..:: ::..: NP_000 KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSR 730 740 750 760 770 780 800 810 820 830 840 850 pF1KB9 FYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELI .:: :. : .. ::: ::.. .::::::.:::.. ::..::..: :.:.: .::.:: NP_000 MYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELD 790 800 810 820 830 840 860 870 880 890 900 910 pF1KB9 KAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVI . :. ..:. .: :.::::::::::... ....:: . .. .:.:. .::.:::::.:.: NP_000 RIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEII 850 860 870 880 890 900 920 930 pF1KB9 AAQLPKILAGMVKPLLFHKK ..:.::::.: :::. :: . NP_000 SVQVPKILSGKVKPIYFHTQ 910 920 >>NP_001011645 (OMIM: 176807,300068,300633,312300,313200 (388 aa) initn: 1462 init1: 980 opt: 1497 Z-score: 777.7 bits: 153.9 E(85289): 1.4e-36 Smith-Waterman score: 1497; 55.3% identity (84.4% similar) in 371 aa overlap (563-933:24-388) 540 550 560 570 580 590 pF1KB9 GLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFK ::: ::::::::::::::.::::::::::: NP_001 MILWLHSLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFK 10 20 30 40 50 600 610 620 630 640 650 pF1KB9 RAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALD :: ::...::::.:::: .::.::::::.:::::: .:::.::.::.::...... . . NP_001 RAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGE 60 70 80 90 100 110 660 670 680 690 700 710 pF1KB9 AVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSS : . .: .. .:..: : . . : ..:.: .::: :. :::::..::. . NP_001 ASSTTSP------TEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFA 120 130 140 150 160 720 730 740 750 760 770 pF1KB9 SLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVS .::.:::.::::::. ::::.:.::::::::.:::...::::::.::::..::::. .:. NP_001 ALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVN 170 180 190 200 210 220 780 790 800 810 820 830 pF1KB9 GQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPL ..::::::::..:: ::..: .:: :. : .. ::: ::.. .::::::.:::.. ::. NP_001 SRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPV 230 240 250 260 270 280 840 850 860 870 880 890 pF1KB9 EGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCL .::..: :.:.: .::.:: . :. ..:. .: :.::::::::::... ....:: . . NP_001 DGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTF 290 300 310 320 330 340 900 910 920 930 pF1KB9 NTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK . .:.:. .::.:::::.:.:..:.::::.: :::. :: . NP_001 DLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ 350 360 370 380 >>XP_005268476 (OMIM: 138040,615962) PREDICTED: glucocor (778 aa) initn: 1243 init1: 840 opt: 1195 Z-score: 621.6 bits: 126.1 E(85289): 6.9e-28 Smith-Waterman score: 1459; 41.5% identity (66.5% similar) in 632 aa overlap (320-933:190-778) 290 300 310 320 330 340 pF1KB9 APGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGA-GAASAFAPPRSS--- : ..:.: ...:. : . .: ::. XP_005 HSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLI 160 170 180 190 200 210 350 360 370 380 390 pF1KB9 --PCASSTPVAVGDFPDCAYPPDAEPKDDAYPLY-SDFQPPALKIKEEEEGAEAS----- : : :.: :. : .. ... ..: :: : .: :::.. . . .: XP_005 DENCLLS-PLA-GE--DDSFLLEGNSNEDCKPLILPDTKP---KIKDNGDLVLSSPSNVT 220 230 240 250 260 270 400 410 420 430 440 450 pF1KB9 ---ARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSS ... . .. .:... . :: : :: . .. :: ..:.: XP_005 LPQVKTEKEDFIELCTPGVIKQEKLGTV-----YCQASFPGANIIGNKMSAISVHGVSTS 280 290 300 310 320 460 470 480 490 500 510 pF1KB9 GSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSAS-AAAAGAAPALYP :. . ... . :: . : . ..: .: : . :.. XP_005 GGQMYHYDMNTASLSQQQD-------QKPIFN--VIP--PIPVGSENWNRCQGSGDDNLT 330 340 350 360 370 520 530 540 550 560 570 pF1KB9 ALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPD-SEASQSPQYSFESLPQKICLICGD .:: ..: : .:...: . : .::: : .: . . . : :.::.:.: XP_005 SLGTLNFP--GR--TVFSNGYSS--PS----MRPDVSSPPSSSSTATTGPPPKLCLVCSD 380 390 400 410 420 580 590 600 610 620 630 pF1KB9 EASGCHYGVLTCGSCKVFFKRAMEG-QHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAG ::::::::::::::::::::::.:: :::::::::::::.:::::::::::: ::: ::: XP_005 EASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAG 430 440 450 460 470 480 640 650 660 670 680 690 pF1KB9 MVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLL : : .:: :: :.. .. .:: .:.. :. :. :: : :..:: XP_005 MNLEARKTKK--KIKGIQQ-------ATTGVSQETSENPGNKTIVPATLPQLTPTLVSLL 490 500 510 520 530 700 710 720 730 740 750 pF1KB9 MSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLI :::.:.:::.:.. ::.. ..:.::.:: ::....:::.:..:::::::.:::.::. XP_005 EVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLL 540 550 560 570 580 590 760 770 780 790 800 810 pF1KB9 QYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKL ::::: ::.:.::::::.. :...: ::::::.::::: .:. : : . .:. .: XP_005 QYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRL 600 610 620 630 640 650 820 830 840 850 860 870 pF1KB9 QVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFY ::: ::.::::.::::...: .::.:: :.:.: .::.:: ::: :. . .. :::: XP_005 QVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFY 660 670 680 690 700 710 880 890 900 910 920 930 pF1KB9 QLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFH :::::::..:..:..: ::..::.. ...:.:::::..:.:. :.:: : .: :::: XP_005 QLTKLLDSMHEVVENLLNYCFQTFLD-KTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFH 720 730 740 750 760 770 pF1KB9 KK .: XP_005 QK >>XP_005268477 (OMIM: 138040,615962) PREDICTED: glucocor (778 aa) initn: 1243 init1: 840 opt: 1195 Z-score: 621.6 bits: 126.1 E(85289): 6.9e-28 Smith-Waterman score: 1459; 41.5% identity (66.5% similar) in 632 aa overlap (320-933:190-778) 290 300 310 320 330 340 pF1KB9 APGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGA-GAASAFAPPRSS--- : ..:.: ...:. : . .: ::. XP_005 HSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLI 160 170 180 190 200 210 350 360 370 380 390 pF1KB9 --PCASSTPVAVGDFPDCAYPPDAEPKDDAYPLY-SDFQPPALKIKEEEEGAEAS----- : : :.: :. : .. ... ..: :: : .: :::.. . . .: XP_005 DENCLLS-PLA-GE--DDSFLLEGNSNEDCKPLILPDTKP---KIKDNGDLVLSSPSNVT 220 230 240 250 260 270 400 410 420 430 440 450 pF1KB9 ---ARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSS ... . .. .:... . :: : :: . .. :: ..:.: XP_005 LPQVKTEKEDFIELCTPGVIKQEKLGTV-----YCQASFPGANIIGNKMSAISVHGVSTS 280 290 300 310 320 460 470 480 490 500 510 pF1KB9 GSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSAS-AAAAGAAPALYP :. . ... . :: . : . ..: .: : . :.. XP_005 GGQMYHYDMNTASLSQQQD-------QKPIFN--VIP--PIPVGSENWNRCQGSGDDNLT 330 340 350 360 370 520 530 540 550 560 570 pF1KB9 ALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPD-SEASQSPQYSFESLPQKICLICGD .:: ..: : .:...: . : .::: : .: . . . : :.::.:.: XP_005 SLGTLNFP--GR--TVFSNGYSS--PS----MRPDVSSPPSSSSTATTGPPPKLCLVCSD 380 390 400 410 420 580 590 600 610 620 630 pF1KB9 EASGCHYGVLTCGSCKVFFKRAMEG-QHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAG ::::::::::::::::::::::.:: :::::::::::::.:::::::::::: ::: ::: XP_005 EASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAG 430 440 450 460 470 480 640 650 660 670 680 690 pF1KB9 MVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLL : : .:: :: :.. .. .:: .:.. :. :. :: : :..:: XP_005 MNLEARKTKK--KIKGIQQ-------ATTGVSQETSENPGNKTIVPATLPQLTPTLVSLL 490 500 510 520 530 700 710 720 730 740 750 pF1KB9 MSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLI :::.:.:::.:.. ::.. ..:.::.:: ::....:::.:..:::::::.:::.::. XP_005 EVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLL 540 550 560 570 580 590 760 770 780 790 800 810 pF1KB9 QYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKL ::::: ::.:.::::::.. :...: ::::::.::::: .:. : : . .:. .: XP_005 QYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRL 600 610 620 630 640 650 820 830 840 850 860 870 pF1KB9 QVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFY ::: ::.::::.::::...: .::.:: :.:.: .::.:: ::: :. . .. :::: XP_005 QVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFY 660 670 680 690 700 710 880 890 900 910 920 930 pF1KB9 QLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFH :::::::..:..:..: ::..::.. ...:.:::::..:.:. :.:: : .: :::: XP_005 QLTKLLDSMHEVVENLLNYCFQTFLD-KTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFH 720 730 740 750 760 770 pF1KB9 KK .: XP_005 QK 933 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:02:04 2016 done: Sun Nov 6 15:02:06 2016 Total Scan time: 14.300 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]