FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9783, 251 aa 1>>>pF1KB9783 251 - 251 aa - 251 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0878+/-0.000274; mu= 8.1212+/- 0.017 mean_var=138.9454+/-27.423, 0's: 0 Z-trim(123.3): 31 B-trim: 335 in 1/54 Lambda= 0.108806 statistics sampled from 42772 (42806) to 42772 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.825), E-opt: 0.2 (0.502), width: 16 Scan time: 8.370 The best scores are: opt bits E(85289) NP_783640 (OMIM: 608457) chromobox protein homolog ( 251) 1719 280.2 2.4e-75 XP_016884168 (OMIM: 608457) PREDICTED: chromobox p ( 250) 1702 277.5 1.5e-74 XP_006724237 (OMIM: 608457) PREDICTED: chromobox p ( 259) 1693 276.1 4.2e-74 XP_006724238 (OMIM: 608457) PREDICTED: chromobox p ( 258) 1676 273.4 2.7e-73 XP_006724240 (OMIM: 608457) PREDICTED: chromobox p ( 192) 764 130.2 2.7e-30 XP_006724239 (OMIM: 608457) PREDICTED: chromobox p ( 200) 764 130.2 2.7e-30 XP_005261470 (OMIM: 608457) PREDICTED: chromobox p ( 158) 559 97.9 1.1e-20 XP_006724241 (OMIM: 608457) PREDICTED: chromobox p ( 166) 540 95.0 9.1e-20 XP_011528327 (OMIM: 608457) PREDICTED: chromobox p ( 165) 533 93.9 1.9e-19 NP_003646 (OMIM: 603079) E3 SUMO-protein ligase CB ( 560) 447 80.8 5.8e-15 NP_116036 (OMIM: 602770,613080) chromobox protein ( 211) 345 64.4 1.8e-10 NP_005180 (OMIM: 602770,613080) chromobox protein ( 532) 348 65.2 2.6e-10 XP_011523684 (OMIM: 602770,613080) PREDICTED: chro ( 586) 348 65.3 2.9e-10 NP_001120700 (OMIM: 604511) chromobox protein homo ( 185) 185 39.3 0.0059 NP_006798 (OMIM: 604511) chromobox protein homolog ( 185) 185 39.3 0.0059 XP_005249668 (OMIM: 604477) PREDICTED: chromobox p ( 183) 182 38.8 0.0081 NP_057671 (OMIM: 604477) chromobox protein homolog ( 183) 182 38.8 0.0081 NP_009207 (OMIM: 604477) chromobox protein homolog ( 183) 182 38.8 0.0081 NP_001120794 (OMIM: 604478) chromobox protein homo ( 191) 182 38.8 0.0084 NP_001120793 (OMIM: 604478) chromobox protein homo ( 191) 182 38.8 0.0084 NP_036249 (OMIM: 604478) chromobox protein homolog ( 191) 182 38.8 0.0084 >>NP_783640 (OMIM: 608457) chromobox protein homolog 7 [ (251 aa) initn: 1719 init1: 1719 opt: 1719 Z-score: 1473.6 bits: 280.2 E(85289): 2.4e-75 Smith-Waterman score: 1719; 100.0% identity (100.0% similar) in 251 aa overlap (1-251:1-251) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_783 DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA 190 200 210 220 230 240 250 pF1KB9 EGFFRDRSGKF ::::::::::: NP_783 EGFFRDRSGKF 250 >>XP_016884168 (OMIM: 608457) PREDICTED: chromobox prote (250 aa) initn: 1378 init1: 1378 opt: 1702 Z-score: 1459.2 bits: 277.5 E(85289): 1.5e-74 Smith-Waterman score: 1702; 99.6% identity (99.6% similar) in 251 aa overlap (1-251:1-250) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB9 DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: XP_016 DVLQAAGEWEPAAQPPEEE-DADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA 190 200 210 220 230 250 pF1KB9 EGFFRDRSGKF ::::::::::: XP_016 EGFFRDRSGKF 240 250 >>XP_006724237 (OMIM: 608457) PREDICTED: chromobox prote (259 aa) initn: 1705 init1: 1309 opt: 1693 Z-score: 1451.3 bits: 276.1 E(85289): 4.2e-74 Smith-Waterman score: 1693; 96.9% identity (96.9% similar) in 259 aa overlap (1-251:1-259) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 --------EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSG :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGVLGTAGEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 SPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRREL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 FLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITV 190 200 210 220 230 240 240 250 pF1KB9 TFREAQAAEGFFRDRSGKF ::::::::::::::::::: XP_006 TFREAQAAEGFFRDRSGKF 250 >>XP_006724238 (OMIM: 608457) PREDICTED: chromobox prote (258 aa) initn: 1364 init1: 968 opt: 1676 Z-score: 1436.9 bits: 273.4 E(85289): 2.7e-73 Smith-Waterman score: 1676; 96.5% identity (96.5% similar) in 259 aa overlap (1-251:1-258) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 --------EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSG :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGVLGTAGEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 SPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRREL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRREL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB9 FLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITV ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_006 FLQEPPAPDVLQAAGEWEPAAQPPEEE-DADLAEGPPPWTPALPSSEVTVTDITANSITV 190 200 210 220 230 240 250 pF1KB9 TFREAQAAEGFFRDRSGKF ::::::::::::::::::: XP_006 TFREAQAAEGFFRDRSGKF 240 250 >>XP_006724240 (OMIM: 608457) PREDICTED: chromobox prote (192 aa) initn: 762 init1: 762 opt: 764 Z-score: 665.0 bits: 130.2 E(85289): 2.7e-30 Smith-Waterman score: 1189; 76.5% identity (76.5% similar) in 251 aa overlap (1-251:1-192) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA :::::::::::::::::::::: XP_006 EERDRASGYRKRGPKPKRLLLQ-------------------------------------- 70 80 130 140 150 160 170 180 pF1KB9 GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP ::::::::::::::::::::::::::::::::::::::: XP_006 ---------------------PRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP 90 100 110 120 190 200 210 220 230 240 pF1KB9 DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA 130 140 150 160 170 180 250 pF1KB9 EGFFRDRSGKF ::::::::::: XP_006 EGFFRDRSGKF 190 >>XP_006724239 (OMIM: 608457) PREDICTED: chromobox prote (200 aa) initn: 1158 init1: 762 opt: 764 Z-score: 664.8 bits: 130.2 E(85289): 2.7e-30 Smith-Waterman score: 1163; 74.1% identity (74.1% similar) in 259 aa overlap (1-251:1-200) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 --------EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSG :::::::::::::::::::::: XP_006 YGVLGTAGEERDRASGYRKRGPKPKRLLLQ------------------------------ 70 80 90 120 130 140 150 160 170 pF1KB9 SPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRREL ::::::::::::::::::::::::::::::: XP_006 -----------------------------PRKAHKYLRLSRKKFPPRGPNLESHSHRREL 100 110 120 180 190 200 210 220 230 pF1KB9 FLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITV 130 140 150 160 170 180 240 250 pF1KB9 TFREAQAAEGFFRDRSGKF ::::::::::::::::::: XP_006 TFREAQAAEGFFRDRSGKF 190 200 >>XP_005261470 (OMIM: 608457) PREDICTED: chromobox prote (158 aa) initn: 559 init1: 559 opt: 559 Z-score: 492.3 bits: 97.9 E(85289): 1.1e-20 Smith-Waterman score: 882; 62.9% identity (62.9% similar) in 251 aa overlap (1-251:1-158) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA :::::::::::::::::::::: XP_005 EERDRASGYRKRGPKPKRLLLQ-------------------------------------- 70 80 130 140 150 160 170 180 pF1KB9 GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP ::::: XP_005 -------------------------------------------------------EPPAP 190 200 210 220 230 240 pF1KB9 DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA 90 100 110 120 130 140 250 pF1KB9 EGFFRDRSGKF ::::::::::: XP_005 EGFFRDRSGKF 150 >>XP_006724241 (OMIM: 608457) PREDICTED: chromobox prote (166 aa) initn: 936 init1: 540 opt: 540 Z-score: 475.9 bits: 95.0 E(85289): 9.1e-20 Smith-Waterman score: 856; 61.0% identity (61.0% similar) in 259 aa overlap (1-251:1-166) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 --------EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSG :::::::::::::::::::::: XP_006 YGVLGTAGEERDRASGYRKRGPKPKRLLLQ------------------------------ 70 80 90 120 130 140 150 160 170 pF1KB9 SPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRREL XP_006 ------------------------------------------------------------ 180 190 200 210 220 230 pF1KB9 FLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ---EPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITV 100 110 120 130 140 240 250 pF1KB9 TFREAQAAEGFFRDRSGKF ::::::::::::::::::: XP_006 TFREAQAAEGFFRDRSGKF 150 160 >>XP_011528327 (OMIM: 608457) PREDICTED: chromobox prote (165 aa) initn: 892 init1: 410 opt: 533 Z-score: 470.0 bits: 93.9 E(85289): 1.9e-19 Smith-Waterman score: 839; 60.6% identity (60.6% similar) in 259 aa overlap (1-251:1-165) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 --------EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSG :::::::::::::::::::::: XP_011 YGVLGTAGEERDRASGYRKRGPKPKRLLLQ------------------------------ 70 80 90 120 130 140 150 160 170 pF1KB9 SPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRREL XP_011 ------------------------------------------------------------ 180 190 200 210 220 230 pF1KB9 FLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITV :::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_011 ---EPPAPDVLQAAGEWEPAAQPPEEE-DADLAEGPPPWTPALPSSEVTVTDITANSITV 100 110 120 130 140 240 250 pF1KB9 TFREAQAAEGFFRDRSGKF ::::::::::::::::::: XP_011 TFREAQAAEGFFRDRSGKF 150 160 >>NP_003646 (OMIM: 603079) E3 SUMO-protein ligase CBX4 [ (560 aa) initn: 505 init1: 426 opt: 447 Z-score: 389.7 bits: 80.8 E(85289): 5.8e-15 Smith-Waterman score: 447; 39.0% identity (63.8% similar) in 213 aa overlap (1-207:1-206) 10 20 30 40 50 60 pF1KB9 MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK ::: :.::.:::::::.:::.:::.:::::::.:: :::.::::::.::::::..:.... NP_003 MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA :.... :::::::::: :..: : :. : . . : :. .: .. NP_003 ERQEQLMGYRKRGPKPKPLVVQ--VPTFARRSNVLTGLQDSSTDNRAKLDLGA-QGKGQG 70 80 90 100 110 130 140 150 160 170 pF1KB9 GAPELVDKG--PLVPTLPFPLRKP----RKAHKYLRLSRKKFPPRGPNLESHSHRRELFL :: .: : :: .... : .:. :: : :. . .. . . NP_003 HQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGH 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB9 QEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTF .: :.: . ... ..::.. :.. :.: NP_003 KEAPSPTCPDLGAK----SHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGM 180 190 200 210 220 230 240 250 pF1KB9 REAQAAEGFFRDRSGKF NP_003 MPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPS 240 250 260 270 280 290 251 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:05:39 2016 done: Fri Nov 4 20:05:40 2016 Total Scan time: 8.370 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]