FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9785, 189 aa 1>>>pF1KB9785 189 - 189 aa - 189 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0446+/-0.000364; mu= 14.2530+/- 0.023 mean_var=64.5102+/-12.234, 0's: 0 Z-trim(113.6): 20 B-trim: 0 in 0/51 Lambda= 0.159683 statistics sampled from 23024 (23041) to 23024 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.27), width: 16 Scan time: 5.590 The best scores are: opt bits E(85289) NP_076918 (OMIM: 147660) interferon alpha-1/13 pre ( 189) 1251 296.7 1.5e-80 NP_008831 (OMIM: 147578) interferon alpha-1/13 pre ( 190) 1246 295.5 3.4e-80 NP_002160 (OMIM: 147565) interferon alpha-5 precur ( 189) 1064 253.6 1.4e-67 NP_066282 (OMIM: 147566) interferon alpha-6 precur ( 189) 1037 247.4 1e-65 NP_002163 (OMIM: 147579) interferon alpha-14 precu ( 189) 1033 246.4 2e-65 NP_002166 (OMIM: 147584) interferon alpha-21 precu ( 189) 1001 239.1 3.3e-63 NP_066546 (OMIM: 147564) interferon alpha-4 precur ( 189) 995 237.7 8.5e-63 NP_000596 (OMIM: 147562) interferon alpha-2 precur ( 188) 994 237.5 1e-62 NP_067091 (OMIM: 147583) interferon alpha-17 precu ( 189) 985 235.4 4.2e-62 NP_002162 (OMIM: 147577) interferon alpha-10 precu ( 189) 985 235.4 4.2e-62 NP_066401 (OMIM: 147567) interferon alpha-7 precur ( 189) 958 229.2 3.1e-60 NP_002164 (OMIM: 147580) interferon alpha-16 precu ( 189) 939 224.8 6.5e-59 NP_002161 (OMIM: 147568) interferon alpha-8 precur ( 189) 917 219.7 2.2e-57 NP_002168 (OMIM: 147553) interferon omega-1 precur ( 195) 667 162.1 4.9e-40 NP_795372 (OMIM: 615223) interferon epsilon precur ( 208) 383 96.7 2.6e-20 NP_002167 (OMIM: 147640) interferon beta precursor ( 187) 310 79.9 2.7e-15 NP_064509 (OMIM: 615326) interferon kappa precurso ( 207) 162 45.8 5.4e-05 >>NP_076918 (OMIM: 147660) interferon alpha-1/13 precurs (189 aa) initn: 1251 init1: 1251 opt: 1251 Z-score: 1567.1 bits: 296.7 E(85289): 1.5e-80 Smith-Waterman score: 1251; 100.0% identity (100.0% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN 130 140 150 160 170 180 pF1KB9 LQERLRRKE ::::::::: NP_076 LQERLRRKE >>NP_008831 (OMIM: 147578) interferon alpha-1/13 precurs (190 aa) initn: 1246 init1: 1246 opt: 1246 Z-score: 1560.8 bits: 295.5 E(85289): 3.4e-80 Smith-Waterman score: 1246; 99.5% identity (100.0% similar) in 189 aa overlap (1-189:2-190) 10 20 30 40 50 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDF :::::::::.::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MMASPFALLMALVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 GFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 GFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 EACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 EACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLST 130 140 150 160 170 180 180 pF1KB9 NLQERLRRKE :::::::::: NP_008 NLQERLRRKE 190 >>NP_002160 (OMIM: 147565) interferon alpha-5 precursor (189 aa) initn: 1064 init1: 1064 opt: 1064 Z-score: 1334.3 bits: 253.6 E(85289): 1.4e-67 Smith-Waterman score: 1064; 84.1% identity (94.2% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :: ::.:::.::::.::: ::::::::.::::.::::::..:::.:::: ::: :::::: NP_002 MALPFVLLMALVVLNCKSICSLGCDLPQTHSLSNRRTLMIMAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE :::::::::::::: :::::::.::: ::::.::::::.::: ::::: ::::::::::: NP_002 FPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWDETLLDKFYTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN ::.::: : .:::::.::::.:.:::.::::::::::::::::::::::::::.:::.: NP_002 ACMMQEVGVEDTPLMNVDSILTVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSAN 130 140 150 160 170 180 pF1KB9 LQERLRRKE ::::::::: NP_002 LQERLRRKE >>NP_066282 (OMIM: 147566) interferon alpha-6 precursor (189 aa) initn: 1037 init1: 1037 opt: 1037 Z-score: 1300.7 bits: 247.4 E(85289): 1e-65 Smith-Waterman score: 1037; 84.7% identity (90.5% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :: ::::::.:::::::::::: ::::.:::: .:::.:::::: ::: ::: ::::: NP_066 MALPFALLMALVVLSCKSSCSLDCDLPQTHSLGHRRTMMLLAQMRRISLFSCLKDRHDFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE :::::::::::::: :::::::.::: ::::.:::::.:::: ::::. ::::::::::: NP_066 FPQEEFDGNQFQKAEAISVLHEVIQQTFNLFSTKDSSVAWDERLLDKLYTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN :::::: :: ::::: ::::::.:::.::::::::::::::::::::::::::.: : : NP_066 ACVMQEVWVGGTPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSSSRN 130 140 150 160 170 180 pF1KB9 LQERLRRKE ::::::::: NP_066 LQERLRRKE >>NP_002163 (OMIM: 147579) interferon alpha-14 precursor (189 aa) initn: 1092 init1: 1033 opt: 1033 Z-score: 1295.7 bits: 246.4 E(85289): 2e-65 Smith-Waterman score: 1033; 82.0% identity (91.5% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :: ::::.:.::::::::::::::.: .::::.:::::::.::: :::: ::: ::::: NP_002 MALPFALMMALVVLSCKSSCSLGCNLSQTHSLNNRRTLMLMAQMRRISPFSCLKDRHDFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE :::::::::::::: :::::::..:: ::::.::.::::::: ::.:: ::.::.:::: NP_002 FPQEEFDGNQFQKAQAISVLHEMMQQTFNLFSTKNSSAAWDETLLEKFYIELFQQMNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN :::.:: : :::::: ::::::::::.:::::: :::::::::::::::::::::.::: NP_002 ACVIQEVGVEETPLMNEDSILAVKKYFQRITLYLMEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 pF1KB9 LQERLRRKE ::.:::::. NP_002 LQKRLRRKD >>NP_002166 (OMIM: 147584) interferon alpha-21 precursor (189 aa) initn: 1001 init1: 1001 opt: 1001 Z-score: 1255.8 bits: 239.1 E(85289): 3.3e-63 Smith-Waterman score: 1001; 81.0% identity (91.5% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :: :.:::...::: :: ::::::::.:::: :::.:.:::::.:::: ::: :::::: NP_002 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE :::::::::::::: :::::::.::: ::::.::::::.:...::.:: ::: ::::::: NP_002 FPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWEQSLLEKFSTELNQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN :::.:: : ::::::.::::::::::.::::::::::::::::::::::::::.::: NP_002 ACVIQEVGVEETPLMNVDSILAVKKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSKI 130 140 150 160 170 180 pF1KB9 LQERLRRKE .:::::::: NP_002 FQERLRRKE >>NP_066546 (OMIM: 147564) interferon alpha-4 precursor (189 aa) initn: 1010 init1: 995 opt: 995 Z-score: 1248.4 bits: 237.7 E(85289): 8.5e-63 Smith-Waterman score: 995; 79.9% identity (92.1% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :: :.:::...::: :: ::::::::.:::: :::.:.:::::.::: ::: :::::: NP_066 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE ::.:::::.::::: :::::::.::: ::::.:.::::::...::.:: ::::::::::: NP_066 FPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN :::.:: : :::::: ::::::.:::.::::::::::::::::::::::::::::.::: NP_066 ACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 pF1KB9 LQERLRRKE ::.:::::. NP_066 LQKRLRRKD >>NP_000596 (OMIM: 147562) interferon alpha-2 precursor (188 aa) initn: 992 init1: 650 opt: 994 Z-score: 1247.1 bits: 237.5 E(85289): 1e-62 Smith-Waterman score: 994; 82.0% identity (89.4% similar) in 189 aa overlap (1-189:1-188) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :: ::::..:.:::::::::.:::::.:::: .:::::::::: ::: ::: :::::: NP_000 MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE :::::: ::::::: .: ::::.::::::::.:::::::::: ::::: ::::::::::: NP_000 FPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLE 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN :::.: : :::::. ::::::.:::.:::::: :::::::::::::::::::.::::: NP_000 ACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTN 120 130 140 150 160 170 pF1KB9 LQERLRRKE ::: :: :: NP_000 LQESLRSKE 180 >>NP_067091 (OMIM: 147583) interferon alpha-17 precursor (189 aa) initn: 1005 init1: 985 opt: 985 Z-score: 1235.9 bits: 235.4 E(85289): 4.2e-62 Smith-Waterman score: 985; 78.8% identity (92.1% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :: :.:::...::: :: ::::::::.:::: :::.:.:::::.:::: ::: :::::: NP_067 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE .::::::::::::. :::::::.::: ::::.:.::::::...::.:: ::::::::.:: NP_067 LPQEEFDGNQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNNLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN :::.:: . :::::: ::::::.:::.::::::::::::::::::::::::::::.::: NP_067 ACVIQEVGMEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 pF1KB9 LQERLRRKE ::. ::::. NP_067 LQKILRRKD >>NP_002162 (OMIM: 147577) interferon alpha-10 precursor (189 aa) initn: 1000 init1: 985 opt: 985 Z-score: 1235.9 bits: 235.4 E(85289): 4.2e-62 Smith-Waterman score: 985; 78.8% identity (91.5% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFG :: :.:::...::: :: ::::::::.:::: :::.:.::.::.:::: ::: ::::: NP_002 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLGQMGRISPFSCLKDRHDFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLE .::::::::::::: :::::::.::: ::::.:.::::::...::.:: ::::::::::: NP_002 IPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 ACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTN :::.:: : :::::: ::::::.:::.:::::: :.:::::::::::::::::::.::: NP_002 ACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLIERKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 pF1KB9 LQERLRRKE ::.:::::. NP_002 LQKRLRRKD 189 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:54:54 2016 done: Fri Nov 4 18:54:55 2016 Total Scan time: 5.590 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]