FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9786, 191 aa 1>>>pF1KB9786 191 - 191 aa - 191 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6781+/-0.000359; mu= 18.0466+/- 0.023 mean_var=90.4650+/-17.805, 0's: 0 Z-trim(116.9): 376 B-trim: 777 in 1/54 Lambda= 0.134845 statistics sampled from 27975 (28412) to 27975 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.333), width: 16 Scan time: 5.890 The best scores are: opt bits E(85289) NP_001656 (OMIM: 179505) rho-related GTP-binding p ( 191) 1305 263.2 1.9e-70 XP_005252973 (OMIM: 179505) PREDICTED: rho-related ( 191) 1305 263.2 1.9e-70 XP_016873208 (OMIM: 179505) PREDICTED: rho-related ( 191) 1305 263.2 1.9e-70 NP_008839 (OMIM: 602048) ras-related C3 botulinum ( 192) 936 191.4 7.7e-49 NP_005043 (OMIM: 602050) ras-related C3 botulinum ( 192) 922 188.7 5.1e-48 NP_002863 (OMIM: 602049,608203) ras-related C3 bot ( 192) 913 186.9 1.7e-47 NP_001782 (OMIM: 116952,616737) cell division cont ( 191) 837 172.1 4.8e-43 NP_001034891 (OMIM: 116952,616737) cell division c ( 191) 837 172.1 4.8e-43 NP_426359 (OMIM: 116952,616737) cell division cont ( 191) 814 167.6 1.1e-41 NP_001303236 (OMIM: 602050) ras-related C3 botulin ( 170) 759 156.9 1.7e-38 XP_006724349 (OMIM: 602049,608203) PREDICTED: ras- ( 161) 758 156.7 1.8e-38 NP_001300870 (OMIM: 165390) transforming protein R ( 193) 724 150.1 2e-36 NP_001655 (OMIM: 165390) transforming protein RhoA ( 193) 724 150.1 2e-36 NP_036381 (OMIM: 605857) rho-related GTP-binding p ( 205) 724 150.2 2.1e-36 NP_001036143 (OMIM: 165380) rho-related GTP-bindin ( 193) 713 148.0 8.8e-36 NP_786886 (OMIM: 165380) rho-related GTP-binding p ( 193) 713 148.0 8.8e-36 NP_001036144 (OMIM: 165380) rho-related GTP-bindin ( 193) 713 148.0 8.8e-36 NP_004031 (OMIM: 165370) rho-related GTP-binding p ( 196) 674 140.4 1.7e-33 NP_065714 (OMIM: 607653) rho-related GTP-binding p ( 214) 669 139.5 3.6e-33 NP_067028 (OMIM: 606366) rho-related GTP-binding p ( 258) 635 133.0 3.9e-31 NP_055393 (OMIM: 605781) rho-related GTP-binding p ( 210) 614 128.8 5.9e-30 XP_011531028 (OMIM: 605857) PREDICTED: rho-related ( 192) 611 128.1 8.3e-30 XP_016859205 (OMIM: 605857) PREDICTED: rho-related ( 172) 609 127.7 1e-29 NP_001300872 (OMIM: 165390) transforming protein R ( 187) 569 120.0 2.3e-27 NP_001241667 (OMIM: 602924) rho-related GTP-bindin ( 244) 565 119.3 4.8e-27 NP_005159 (OMIM: 602924) rho-related GTP-binding p ( 244) 565 119.3 4.8e-27 XP_006720277 (OMIM: 607653) PREDICTED: rho-related ( 176) 561 118.4 6.6e-27 NP_005431 (OMIM: 601555) rho-related GTP-binding p ( 227) 532 112.9 3.9e-25 XP_011523618 (OMIM: 601555) PREDICTED: rho-related ( 234) 532 112.9 4e-25 NP_061485 (OMIM: 602048) ras-related C3 botulinum ( 211) 512 108.9 5.5e-24 NP_001265294 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265296 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 XP_016863678 (OMIM: 602037) PREDICTED: rho-related ( 191) 479 102.5 4.4e-22 NP_001265289 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265292 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265290 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265288 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265293 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265291 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265297 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265295 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 NP_001265298 (OMIM: 602037) rho-related GTP-bindin ( 191) 479 102.5 4.4e-22 XP_011511994 (OMIM: 602037) PREDICTED: rho-related ( 191) 479 102.5 4.4e-22 NP_004301 (OMIM: 602037) rho-related GTP-binding p ( 191) 479 102.5 4.4e-22 XP_016863677 (OMIM: 602037) PREDICTED: rho-related ( 191) 479 102.5 4.4e-22 XP_011531030 (OMIM: 605857) PREDICTED: rho-related ( 157) 471 100.8 1.2e-21 NP_001300873 (OMIM: 165390) transforming protein R ( 173) 469 100.5 1.6e-21 NP_055285 (OMIM: 609038) rho-related GTP-binding p ( 232) 467 100.2 2.5e-21 XP_011523619 (OMIM: 601555) PREDICTED: rho-related ( 206) 450 96.9 2.3e-20 NP_001300874 (OMIM: 165390) transforming protein R ( 112) 386 84.1 8.9e-17 >>NP_001656 (OMIM: 179505) rho-related GTP-binding prote (191 aa) initn: 1305 init1: 1305 opt: 1305 Z-score: 1385.8 bits: 263.2 E(85289): 1.9e-70 Smith-Waterman score: 1305; 100.0% identity (100.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB9 PIKRGRSCILL ::::::::::: NP_001 PIKRGRSCILL 190 >>XP_005252973 (OMIM: 179505) PREDICTED: rho-related GTP (191 aa) initn: 1305 init1: 1305 opt: 1305 Z-score: 1385.8 bits: 263.2 E(85289): 1.9e-70 Smith-Waterman score: 1305; 100.0% identity (100.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB9 PIKRGRSCILL ::::::::::: XP_005 PIKRGRSCILL 190 >>XP_016873208 (OMIM: 179505) PREDICTED: rho-related GTP (191 aa) initn: 1305 init1: 1305 opt: 1305 Z-score: 1385.8 bits: 263.2 E(85289): 1.9e-70 Smith-Waterman score: 1305; 100.0% identity (100.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB9 PIKRGRSCILL ::::::::::: XP_016 PIKRGRSCILL 190 >>NP_008839 (OMIM: 602048) ras-related C3 botulinum toxi (192 aa) initn: 918 init1: 918 opt: 936 Z-score: 997.8 bits: 191.4 E(85289): 7.7e-49 Smith-Waterman score: 936; 71.9% identity (86.5% similar) in 192 aa overlap (1-191:1-192) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. :::. :::.:::::: NP_008 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR ::.::::: ::::::.::.::::..:: :.:::: ::.::: ::::..::.::::: ::: NP_008 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT . ::...:::. .::: :: :.::.: ::.::::::: : :.: :: ::.:::: : NP_008 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB9 PIK-RGRSCILL :.: : :.:.:: NP_008 PVKKRKRKCLLL 190 >>NP_005043 (OMIM: 602050) ras-related C3 botulinum toxi (192 aa) initn: 947 init1: 909 opt: 922 Z-score: 983.1 bits: 188.7 E(85289): 5.1e-48 Smith-Waterman score: 922; 69.8% identity (85.9% similar) in 192 aa overlap (1-191:1-192) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. :::. :::.:::::: NP_005 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR ::.::::: ::::::.::.::::..:: :.:::: ::.::: :::: .:::::::: ::: NP_005 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT . ::..::... :::: :: :.:..: .:.::::::: : :.: :: ::.:::: : NP_005 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB9 PIKR-GRSCILL :.:. :..: .. NP_005 PVKKPGKKCTVF 190 >>NP_002863 (OMIM: 602049,608203) ras-related C3 botulin (192 aa) initn: 941 init1: 900 opt: 913 Z-score: 973.6 bits: 186.9 E(85289): 1.7e-47 Smith-Waterman score: 913; 71.4% identity (84.9% similar) in 192 aa overlap (1-191:1-192) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. ::.. :::.:::::: NP_002 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR ::.::::: ::::::.::.::::..:: :::::: :: ::: ::::..::.::::: ::: NP_002 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT . ::...:::. :::: :: ::::.: .:.::::::: : :.: :: ::.:::: : NP_002 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ 130 140 150 160 170 180 190 pF1KB9 PIKRG-RSCILL : .. :.: :: NP_002 PTRQQKRACSLL 190 >>NP_001782 (OMIM: 116952,616737) cell division control (191 aa) initn: 837 init1: 837 opt: 837 Z-score: 893.8 bits: 172.1 E(85289): 4.8e-43 Smith-Waterman score: 837; 60.7% identity (85.3% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG ::.:::::::::::::::::: :::: ::.::.:::::::.. . :. .:.:.:::: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR ::.::::: ::::::.::..:::..:: :.:::..:: ::. :::: .:.:::::. ::: NP_001 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT .:.:...: .. : ::::. .. ::....::.:.::::: : :.:.:: ::. :.:.: NP_001 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB9 PIKRGRSCILL :..: :.:: NP_001 EPKKSRRCVLL 190 >>NP_001034891 (OMIM: 116952,616737) cell division contr (191 aa) initn: 837 init1: 837 opt: 837 Z-score: 893.8 bits: 172.1 E(85289): 4.8e-43 Smith-Waterman score: 837; 60.7% identity (85.3% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG ::.:::::::::::::::::: :::: ::.::.:::::::.. . :. .:.:.:::: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR ::.::::: ::::::.::..:::..:: :.:::..:: ::. :::: .:.:::::. ::: NP_001 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT .:.:...: .. : ::::. .. ::....::.:.::::: : :.:.:: ::. :.:.: NP_001 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB9 PIKRGRSCILL :..: :.:: NP_001 EPKKSRRCVLL 190 >>NP_426359 (OMIM: 116952,616737) cell division control (191 aa) initn: 814 init1: 799 opt: 814 Z-score: 869.6 bits: 167.6 E(85289): 1.1e-41 Smith-Waterman score: 814; 59.2% identity (84.3% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG ::.:::::::::::::::::: :::: ::.::.:::::::.. . :. .:.:.:::: NP_426 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR ::.::::: ::::::.::..:::..:: :.:::..:: ::. :::: .:.:::::. ::: NP_426 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT .:.:...: .. : ::::. .. ::....::.:.::::: : :.:.:: ::. :.:.: NP_426 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB9 PIKRGRSCILL . :.: .. NP_426 ETQPKRKCCIF 190 >>NP_001303236 (OMIM: 602050) ras-related C3 botulinum t (170 aa) initn: 797 init1: 759 opt: 759 Z-score: 812.3 bits: 156.9 E(85289): 1.7e-38 Smith-Waterman score: 759; 73.8% identity (87.9% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KB9 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. :::. :::.:::::: NP_001 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR ::.::::: ::::::.::.::::..:: :.:::: ::.::: :::: .:::::::: ::: NP_001 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT . ::..::... :::: :: :.:..: NP_001 DDKDTIERLRDKKLAPITYPQGLAMAREIGGLCEIPGVLSPDPAGPEDSV 130 140 150 160 170 191 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:55:52 2016 done: Fri Nov 4 18:55:53 2016 Total Scan time: 5.890 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]