FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9788, 195 aa 1>>>pF1KB9788 195 - 195 aa - 195 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4763+/-0.000369; mu= 12.2264+/- 0.023 mean_var=67.6189+/-13.951, 0's: 0 Z-trim(114.4): 19 B-trim: 1788 in 2/49 Lambda= 0.155970 statistics sampled from 24160 (24179) to 24160 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.283), width: 16 Scan time: 5.880 The best scores are: opt bits E(85289) NP_002168 (OMIM: 147553) interferon omega-1 precur ( 195) 1286 298.0 6.4e-81 NP_002162 (OMIM: 147577) interferon alpha-10 precu ( 189) 725 171.7 6.3e-43 NP_002161 (OMIM: 147568) interferon alpha-8 precur ( 189) 717 169.9 2.2e-42 NP_000596 (OMIM: 147562) interferon alpha-2 precur ( 188) 715 169.5 3e-42 NP_002160 (OMIM: 147565) interferon alpha-5 precur ( 189) 715 169.5 3e-42 NP_066546 (OMIM: 147564) interferon alpha-4 precur ( 189) 709 168.1 7.6e-42 NP_067091 (OMIM: 147583) interferon alpha-17 precu ( 189) 708 167.9 8.9e-42 NP_002163 (OMIM: 147579) interferon alpha-14 precu ( 189) 699 165.9 3.6e-41 NP_002166 (OMIM: 147584) interferon alpha-21 precu ( 189) 692 164.3 1.1e-40 NP_066401 (OMIM: 147567) interferon alpha-7 precur ( 189) 685 162.7 3.2e-40 NP_066282 (OMIM: 147566) interferon alpha-6 precur ( 189) 683 162.3 4.4e-40 NP_002164 (OMIM: 147580) interferon alpha-16 precu ( 189) 681 161.8 6e-40 NP_008831 (OMIM: 147578) interferon alpha-1/13 pre ( 190) 672 159.8 2.4e-39 NP_076918 (OMIM: 147660) interferon alpha-1/13 pre ( 189) 667 158.7 5.3e-39 NP_795372 (OMIM: 615223) interferon epsilon precur ( 208) 368 91.4 1e-18 NP_002167 (OMIM: 147640) interferon beta precursor ( 187) 334 83.8 1.9e-16 NP_064509 (OMIM: 615326) interferon kappa precurso ( 207) 170 46.9 2.7e-05 >>NP_002168 (OMIM: 147553) interferon omega-1 precursor (195 aa) initn: 1286 init1: 1286 opt: 1286 Z-score: 1573.7 bits: 298.0 E(85289): 6.4e-81 Smith-Waterman score: 1286; 100.0% identity (100.0% similar) in 195 aa overlap (1-195:1-195) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS ::::::::::::::: NP_002 MQERLRSKDRDLGSS 190 >>NP_002162 (OMIM: 147577) interferon alpha-10 precursor (189 aa) initn: 725 init1: 725 opt: 725 Z-score: 891.7 bits: 171.7 E(85289): 6.3e-43 Smith-Waterman score: 725; 58.7% identity (80.4% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR ::: : :: :... ::. . ::::::::.:.: .: .:.:: :: ::::: :::::.::: NP_002 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLGQMGRISPFSCLKDRHDFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE .::: :.:.:::...::::::.:: :.:: :: :::::...::... : :.:::. :: NP_002 IPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: :. . :..:.::: : .:: :.::: ::::::: :::.:: .::: NP_002 ACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLIERKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS .:.::: :: NP_002 LQKRLRRKD >>NP_002161 (OMIM: 147568) interferon alpha-8 precursor (189 aa) initn: 733 init1: 717 opt: 717 Z-score: 882.0 bits: 169.9 E(85289): 2.2e-42 Smith-Waterman score: 717; 59.3% identity (79.9% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR ::: : ::.:::. ::. .::::::::.:.: .: .:.:: :::::::: :::::.::. NP_002 MALTFYLLVALVVLSYKSFSSLGCDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE :::: .:.:::...::::::.:: :.:: :. :::: . ::::... : :::. :: NP_002 FPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: :: . :..:.::: : .:: :::::.::::::: :::.:. :: : NP_002 SCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSIN 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS .:.::.::. NP_002 LQKRLKSKE >>NP_000596 (OMIM: 147562) interferon alpha-2 precursor (188 aa) initn: 699 init1: 453 opt: 715 Z-score: 879.6 bits: 169.5 E(85289): 3e-42 Smith-Waterman score: 715; 60.8% identity (79.9% similar) in 189 aa overlap (1-189:1-188) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR ::: : ::.::.. : . :.::::::.:.: :: ::.:: :::::: : :::::.:: NP_000 MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE :::: :.:.:::... :::::.::::.:: :. :::::. ::::...: :.:::. :: NP_000 FPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLE 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: :. . :..:.::: : .:::::::: ::::::: :::.:. :::: NP_000 ACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTN 120 130 140 150 160 170 190 pF1KB9 MQERLRSKDRDLGSS .:: ::::. NP_000 LQESLRSKE 180 >>NP_002160 (OMIM: 147565) interferon alpha-5 precursor (189 aa) initn: 715 init1: 715 opt: 715 Z-score: 879.6 bits: 169.5 E(85289): 3e-42 Smith-Waterman score: 715; 58.2% identity (79.4% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR ::: : :: :::. . . . ::::::::.:.: .: ::... :: ::::: :::::.:: NP_002 MALPFVLLMALVVLNCKSICSLGCDLPQTHSLSNRRTLMIMAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE :::: :.:.:::...::::::.:: :.:: :. :::.:. ::::...: :.:::. :: NP_002 FPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWDETLLDKFYTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: .. . ::.:.::: : .:: ::::: ::::::: :::.:. ::.: NP_002 ACMMQEVGVEDTPLMNVDSILTVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSAN 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS .::::: :. NP_002 LQERLRRKE >>NP_066546 (OMIM: 147564) interferon alpha-4 precursor (189 aa) initn: 709 init1: 709 opt: 709 Z-score: 872.3 bits: 168.1 E(85289): 7.6e-42 Smith-Waterman score: 709; 58.2% identity (78.8% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR ::: : :: :... ::. . ::::::::.:.: .: .:.:: :: ::: : :::::.:: NP_066 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE ::.: : :.:::...::::::.:: :.:: :: :::::...::... : :.:::. :: NP_066 FPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: :. . :..:.::: : .:: ::::: ::::::: :::.:: .::: NP_066 ACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS .:.::: :: NP_066 LQKRLRRKD >>NP_067091 (OMIM: 147583) interferon alpha-17 precursor (189 aa) initn: 708 init1: 708 opt: 708 Z-score: 871.0 bits: 167.9 E(85289): 8.9e-42 Smith-Waterman score: 708; 57.7% identity (79.9% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR ::: : :: :... ::. . ::::::::.:.: .: .:.:: :: ::::: :::::.:: NP_067 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE .::: :.:.::....::::::.:: :.:: :: :::::...::... : :.:::..:: NP_067 LPQEEFDGNQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNNLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: :. . :..:.::: : .:: ::::: ::::::: :::.:: .::: NP_067 ACVIQEVGMEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS .:. :: :: NP_067 LQKILRRKD >>NP_002163 (OMIM: 147579) interferon alpha-14 precursor (189 aa) initn: 699 init1: 699 opt: 699 Z-score: 860.1 bits: 165.9 E(85289): 3.6e-41 Smith-Waterman score: 699; 57.1% identity (78.3% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR ::: : :. :::. : . ::::.: :.:.: .: ::.:. :::::::: :::::.::. NP_002 MALPFALMMALVVLSCKSSCSLGCNLSQTHSLNNRRTLMLMAQMRRISPFSCLKDRHDFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE :::: :.:.:::...::::::.:: :.:: :. :::::. :::.... : ::.. :: NP_002 FPQEEFDGNQFQKAQAISVLHEMMQQTFNLFSTKNSSAAWDETLLEKFYIELFQQMNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: :. . :....::: : .:: ::::: ::::::: :::.:: .::: NP_002 ACVIQEVGVEETPLMNEDSILAVKKYFQRITLYLMEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS .:.::: :: NP_002 LQKRLRRKD >>NP_002166 (OMIM: 147584) interferon alpha-21 precursor (189 aa) initn: 706 init1: 692 opt: 692 Z-score: 851.6 bits: 164.3 E(85289): 1.1e-40 Smith-Waterman score: 692; 56.6% identity (78.8% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR ::: : :: :... ::. . ::::::::.:.: .: .:.:: :: ::::: :::::.:: NP_002 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE :::: :.:.:::...::::::.:: :.:: :. :::.:...::... : :.:::. :: NP_002 FPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWEQSLLEKFSTELNQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: :. . :....::: : .:: ::::: ::::::: :::.:. :: NP_002 ACVIQEVGVEETPLMNVDSILAVKKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSKI 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS .::::: :. NP_002 FQERLRRKE >>NP_066401 (OMIM: 147567) interferon alpha-7 precursor (189 aa) initn: 685 init1: 685 opt: 685 Z-score: 843.1 bits: 162.7 E(85289): 3.2e-40 Smith-Waterman score: 685; 55.6% identity (78.8% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB9 MALLFPLLAALVMTSYSPVGSLGCDLPQNHGLLSRNTLVLLHQMRRISPFLCLKDRRDFR :: : :: .... ::. . ::::::::.:.: .: .:.:: :: ::::: :::::..:: NP_066 MARSFSLLMVVLVLSYKSICSLGCDLPQTHSLRNRRALILLAQMGRISPFSCLKDRHEFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 FPQEMVKGSQLQKAHVMSVLHEMLQQIFSLFHTERSSAAWNMTLLDQLHTGLHQQLQHLE ::.: : :.::....::::::.:: :.:: :: :::::...::... : :.:::. :: NP_066 FPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 TCLLQVVGEGESAGAISSPALTLRRYFQGIRVYLKEKKYSDCAWEVVRMEIMKSLFLSTN .:..: :: :. . :..:.::: : .:: ::::: ::::::: :::.:. .::: NP_066 ACVIQEVGVEETPLMNEDFILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSFSFSTN 130 140 150 160 170 180 190 pF1KB9 MQERLRSKDRDLGSS ... :: :: NP_066 LKKGLRRKD 195 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:57:02 2016 done: Fri Nov 4 18:57:03 2016 Total Scan time: 5.880 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]