FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9791, 210 aa 1>>>pF1KB9791 210 - 210 aa - 210 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7230+/-0.000256; mu= 8.5702+/- 0.016 mean_var=110.1372+/-22.068, 0's: 0 Z-trim(123.4): 30 B-trim: 0 in 0/54 Lambda= 0.122210 statistics sampled from 43080 (43110) to 43080 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.82), E-opt: 0.2 (0.505), width: 16 Scan time: 7.400 The best scores are: opt bits E(85289) XP_005259019 (OMIM: 162662,613100) PREDICTED: neur ( 210) 1451 265.2 5.4e-71 NP_006170 (OMIM: 162662,613100) neurotrophin-4 pre ( 210) 1451 265.2 5.4e-71 XP_011525312 (OMIM: 162662,613100) PREDICTED: neur ( 210) 1451 265.2 5.4e-71 XP_006723295 (OMIM: 162662,613100) PREDICTED: neur ( 210) 1451 265.2 5.4e-71 XP_011525311 (OMIM: 162662,613100) PREDICTED: neur ( 210) 1451 265.2 5.4e-71 XP_011525310 (OMIM: 162662,613100) PREDICTED: neur ( 220) 1451 265.2 5.6e-71 NP_002518 (OMIM: 162660) neurotrophin-3 isoform 2 ( 257) 502 98.0 1.5e-20 XP_011519265 (OMIM: 162660) PREDICTED: neurotrophi ( 257) 502 98.0 1.5e-20 NP_001096124 (OMIM: 162660) neurotrophin-3 isoform ( 270) 502 98.0 1.6e-20 NP_001137277 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_001137280 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_001137284 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_001137278 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_733929 (OMIM: 113505,164230,209880,607499,61026 ( 247) 475 93.2 3.9e-19 NP_733931 (OMIM: 113505,164230,209880,607499,61026 ( 247) 475 93.2 3.9e-19 NP_001137288 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_733928 (OMIM: 113505,164230,209880,607499,61026 ( 247) 475 93.2 3.9e-19 NP_001137285 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_001137286 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_001137279 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_001700 (OMIM: 113505,164230,209880,607499,61026 ( 247) 475 93.2 3.9e-19 NP_001137283 (OMIM: 113505,164230,209880,607499,61 ( 247) 475 93.2 3.9e-19 NP_733927 (OMIM: 113505,164230,209880,607499,61026 ( 255) 475 93.2 4e-19 NP_733930 (OMIM: 113505,164230,209880,607499,61026 ( 262) 475 93.2 4.1e-19 NP_001137281 (OMIM: 113505,164230,209880,607499,61 ( 276) 475 93.2 4.3e-19 NP_001137282 (OMIM: 113505,164230,209880,607499,61 ( 329) 475 93.3 5e-19 XP_011518582 (OMIM: 113505,164230,209880,607499,61 ( 329) 475 93.3 5e-19 XP_006710726 (OMIM: 162030,608654) PREDICTED: beta ( 241) 371 74.8 1.3e-13 NP_002497 (OMIM: 162030,608654) beta-nerve growth ( 241) 371 74.8 1.3e-13 XP_011539820 (OMIM: 162030,608654) PREDICTED: beta ( 296) 371 74.9 1.5e-13 >>XP_005259019 (OMIM: 162662,613100) PREDICTED: neurotro (210 aa) initn: 1451 init1: 1451 opt: 1451 Z-score: 1395.5 bits: 265.2 E(85289): 5.4e-71 Smith-Waterman score: 1451; 100.0% identity (100.0% similar) in 210 aa overlap (1-210:1-210) 10 20 30 40 50 60 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL 130 140 150 160 170 180 190 200 210 pF1KB9 TADAQGRVGWRWIRIDTACVCTLLSRTGRA :::::::::::::::::::::::::::::: XP_005 TADAQGRVGWRWIRIDTACVCTLLSRTGRA 190 200 210 >>NP_006170 (OMIM: 162662,613100) neurotrophin-4 preprop (210 aa) initn: 1451 init1: 1451 opt: 1451 Z-score: 1395.5 bits: 265.2 E(85289): 5.4e-71 Smith-Waterman score: 1451; 100.0% identity (100.0% similar) in 210 aa overlap (1-210:1-210) 10 20 30 40 50 60 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL 130 140 150 160 170 180 190 200 210 pF1KB9 TADAQGRVGWRWIRIDTACVCTLLSRTGRA :::::::::::::::::::::::::::::: NP_006 TADAQGRVGWRWIRIDTACVCTLLSRTGRA 190 200 210 >>XP_011525312 (OMIM: 162662,613100) PREDICTED: neurotro (210 aa) initn: 1451 init1: 1451 opt: 1451 Z-score: 1395.5 bits: 265.2 E(85289): 5.4e-71 Smith-Waterman score: 1451; 100.0% identity (100.0% similar) in 210 aa overlap (1-210:1-210) 10 20 30 40 50 60 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL 130 140 150 160 170 180 190 200 210 pF1KB9 TADAQGRVGWRWIRIDTACVCTLLSRTGRA :::::::::::::::::::::::::::::: XP_011 TADAQGRVGWRWIRIDTACVCTLLSRTGRA 190 200 210 >>XP_006723295 (OMIM: 162662,613100) PREDICTED: neurotro (210 aa) initn: 1451 init1: 1451 opt: 1451 Z-score: 1395.5 bits: 265.2 E(85289): 5.4e-71 Smith-Waterman score: 1451; 100.0% identity (100.0% similar) in 210 aa overlap (1-210:1-210) 10 20 30 40 50 60 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL 130 140 150 160 170 180 190 200 210 pF1KB9 TADAQGRVGWRWIRIDTACVCTLLSRTGRA :::::::::::::::::::::::::::::: XP_006 TADAQGRVGWRWIRIDTACVCTLLSRTGRA 190 200 210 >>XP_011525311 (OMIM: 162662,613100) PREDICTED: neurotro (210 aa) initn: 1451 init1: 1451 opt: 1451 Z-score: 1395.5 bits: 265.2 E(85289): 5.4e-71 Smith-Waterman score: 1451; 100.0% identity (100.0% similar) in 210 aa overlap (1-210:1-210) 10 20 30 40 50 60 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL 130 140 150 160 170 180 190 200 210 pF1KB9 TADAQGRVGWRWIRIDTACVCTLLSRTGRA :::::::::::::::::::::::::::::: XP_011 TADAQGRVGWRWIRIDTACVCTLLSRTGRA 190 200 210 >>XP_011525310 (OMIM: 162662,613100) PREDICTED: neurotro (220 aa) initn: 1451 init1: 1451 opt: 1451 Z-score: 1395.2 bits: 265.2 E(85289): 5.6e-71 Smith-Waterman score: 1451; 100.0% identity (100.0% similar) in 210 aa overlap (1-210:11-220) 10 20 30 40 50 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSR :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRHHTRVLREMLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 GAPAGPPLLFLLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAPAGPPLLFLLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB9 VDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSEC 130 140 150 160 170 180 180 190 200 210 pF1KB9 KAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA :::::::::::::::::::::::::::::::::::::::: XP_011 KAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA 190 200 210 220 >>NP_002518 (OMIM: 162660) neurotrophin-3 isoform 2 prep (257 aa) initn: 602 init1: 268 opt: 502 Z-score: 489.9 bits: 98.0 E(85289): 1.5e-20 Smith-Waterman score: 578; 46.3% identity (69.2% similar) in 201 aa overlap (18-209:69-256) 10 20 30 40 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLL----- : : .. : :.. : .: . .:: NP_002 IQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRR 40 50 60 70 80 90 50 60 70 80 90 pF1KB9 --SPRVVLSRGAPAGPPLLFLLEAGAFRESAGAP--ANRSRRGVSETAPASRRGELAVCD ::::.:: ..: :: :.:.: . .:.: :::. : . :.::: .::: NP_002 YNSPRVLLSDSTPLEPPPLYLME-----DYVGSPVVANRTSRRKRYAEHKSHRGEYSVCD 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB9 AVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGC . : ::::. .:.:.::..: ::::. . :.::..:::.::::: :. : .: : NP_002 SESLWVTDKSSAIDIRGHQVTVLGEIKT-GNSPVKQYFYETRCK-----EARPVKNG--C 160 170 180 190 200 160 170 180 190 200 210 pF1KB9 RGVDRRHWVSECKAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA ::.: .:: :.::..:.::::::.. . ::::::::::.:::.: . :: NP_002 RGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT 210 220 230 240 250 >>XP_011519265 (OMIM: 162660) PREDICTED: neurotrophin-3 (257 aa) initn: 602 init1: 268 opt: 502 Z-score: 489.9 bits: 98.0 E(85289): 1.5e-20 Smith-Waterman score: 578; 46.3% identity (69.2% similar) in 201 aa overlap (18-209:69-256) 10 20 30 40 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLL----- : : .. : :.. : .: . .:: XP_011 IQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRR 40 50 60 70 80 90 50 60 70 80 90 pF1KB9 --SPRVVLSRGAPAGPPLLFLLEAGAFRESAGAP--ANRSRRGVSETAPASRRGELAVCD ::::.:: ..: :: :.:.: . .:.: :::. : . :.::: .::: XP_011 YNSPRVLLSDSTPLEPPPLYLME-----DYVGSPVVANRTSRRKRYAEHKSHRGEYSVCD 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB9 AVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGC . : ::::. .:.:.::..: ::::. . :.::..:::.::::: :. : .: : XP_011 SESLWVTDKSSAIDIRGHQVTVLGEIKT-GNSPVKQYFYETRCK-----EARPVKNG--C 160 170 180 190 200 160 170 180 190 200 210 pF1KB9 RGVDRRHWVSECKAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA ::.: .:: :.::..:.::::::.. . ::::::::::.:::.: . :: XP_011 RGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT 210 220 230 240 250 >>NP_001096124 (OMIM: 162660) neurotrophin-3 isoform 1 p (270 aa) initn: 586 init1: 268 opt: 502 Z-score: 489.6 bits: 98.0 E(85289): 1.6e-20 Smith-Waterman score: 578; 46.3% identity (69.2% similar) in 201 aa overlap (18-209:82-269) 10 20 30 40 pF1KB9 MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLL----- : : .. : :.. : .: . .:: NP_001 IQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRR 60 70 80 90 100 110 50 60 70 80 90 pF1KB9 --SPRVVLSRGAPAGPPLLFLLEAGAFRESAGAP--ANRSRRGVSETAPASRRGELAVCD ::::.:: ..: :: :.:.: . .:.: :::. : . :.::: .::: NP_001 YNSPRVLLSDSTPLEPPPLYLME-----DYVGSPVVANRTSRRKRYAEHKSHRGEYSVCD 120 130 140 150 160 100 110 120 130 140 150 pF1KB9 AVSGWVTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGC . : ::::. .:.:.::..: ::::. . :.::..:::.::::: :. : .: : NP_001 SESLWVTDKSSAIDIRGHQVTVLGEIKT-GNSPVKQYFYETRCK-----EARPVKNG--C 170 180 190 200 210 160 170 180 190 200 210 pF1KB9 RGVDRRHWVSECKAKQSYVRALTADAQGRVGWRWIRIDTACVCTLLSRTGRA ::.: .:: :.::..:.::::::.. . ::::::::::.:::.: . :: NP_001 RGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT 220 230 240 250 260 270 >>NP_001137277 (OMIM: 113505,164230,209880,607499,610269 (247 aa) initn: 480 init1: 284 opt: 475 Z-score: 464.5 bits: 93.2 E(85289): 3.9e-19 Smith-Waterman score: 547; 51.7% identity (70.9% similar) in 172 aa overlap (40-209:88-247) 10 20 30 40 50 60 pF1KB9 PILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLFLLEAGAFRE :: . ::.:: .: :::::::: ... NP_001 SLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLE--EYKN 60 70 80 90 100 110 70 80 90 100 110 120 pF1KB9 SAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVT--DRRTAVDLRGREVEVLGEVPAA : :: : : .. :: :::::.:::..: ::: :..::::. : : :: .::.. NP_001 YLDA-ANMSMRVRRHSDPA-RRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVS 120 130 140 150 160 170 130 140 150 160 170 180 pF1KB9 GGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRALTADAQGR :. :.:::.::.:. : ::::.:.::: :.:.. :::::::: :.. : NP_001 KGQ-LKQYFYETKCNP-------MGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKR 180 190 200 210 220 190 200 210 pF1KB9 VGWRWIRIDTACVCTLLSRTGRA .:::.:::::.::::: . :: NP_001 IGWRFIRIDTSCVCTLTIKRGR 230 240 210 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 18:58:06 2016 done: Fri Nov 4 18:58:07 2016 Total Scan time: 7.400 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]