FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9801, 185 aa 1>>>pF1KB9801 185 - 185 aa - 185 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6408+/-0.000289; mu= 13.1375+/- 0.018 mean_var=97.3048+/-19.364, 0's: 0 Z-trim(119.7): 112 B-trim: 0 in 0/52 Lambda= 0.130019 statistics sampled from 33862 (33991) to 33862 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.768), E-opt: 0.2 (0.399), width: 16 Scan time: 5.750 The best scores are: opt bits E(85289) NP_631960 (OMIM: 400025) homeobox protein TGIF2LY ( 185) 1248 243.3 1.6e-64 NP_620410 (OMIM: 300411) homeobox protein TGIF2LX ( 241) 983 193.7 1.8e-49 NP_733796 (OMIM: 142946,602630) homeobox protein T ( 401) 383 81.4 2e-15 NP_775301 (OMIM: 142946,602630) homeobox protein T ( 252) 379 80.4 2.4e-15 NP_001265615 (OMIM: 142946,602630) homeobox protei ( 252) 379 80.4 2.4e-15 XP_011524037 (OMIM: 142946,602630) PREDICTED: home ( 252) 379 80.4 2.4e-15 NP_777480 (OMIM: 142946,602630) homeobox protein T ( 252) 379 80.4 2.4e-15 NP_775302 (OMIM: 142946,602630) homeobox protein T ( 252) 379 80.4 2.4e-15 NP_775303 (OMIM: 142946,602630) homeobox protein T ( 252) 379 80.4 2.4e-15 XP_016881448 (OMIM: 142946,602630) PREDICTED: home ( 252) 379 80.4 2.4e-15 XP_016881447 (OMIM: 142946,602630) PREDICTED: home ( 272) 379 80.5 2.6e-15 NP_775300 (OMIM: 142946,602630) homeobox protein T ( 272) 379 80.5 2.6e-15 NP_003235 (OMIM: 142946,602630) homeobox protein T ( 272) 379 80.5 2.6e-15 NP_001265613 (OMIM: 142946,602630) homeobox protei ( 272) 379 80.5 2.6e-15 NP_001265611 (OMIM: 142946,602630) homeobox protei ( 275) 379 80.5 2.6e-15 NP_775299 (OMIM: 142946,602630) homeobox protein T ( 286) 379 80.5 2.6e-15 NP_001186444 (OMIM: 607294) homeobox protein TGIF2 ( 237) 369 78.5 8.5e-15 NP_001186442 (OMIM: 607294) homeobox protein TGIF2 ( 237) 369 78.5 8.5e-15 NP_001186443 (OMIM: 607294) homeobox protein TGIF2 ( 237) 369 78.5 8.5e-15 NP_068581 (OMIM: 607294) homeobox protein TGIF2 [H ( 237) 369 78.5 8.5e-15 XP_006718957 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 270 60.1 4.3e-09 XP_011541249 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 270 60.1 4.3e-09 XP_016873600 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 270 60.1 4.3e-09 XP_005271700 (OMIM: 613066) PREDICTED: homeobox pr ( 443) 270 60.2 5.2e-09 XP_011541246 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 270 60.2 5.5e-09 XP_016873599 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 270 60.2 5.5e-09 XP_011541247 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 270 60.2 5.5e-09 XP_005271699 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 270 60.2 5.5e-09 NP_071345 (OMIM: 613066) homeobox protein PKNOX2 [ ( 472) 270 60.2 5.5e-09 XP_016859632 (OMIM: 601739) PREDICTED: homeobox pr ( 352) 259 58.1 1.8e-08 XP_006720592 (OMIM: 601740) PREDICTED: homeobox pr ( 255) 257 57.6 1.9e-08 XP_016859631 (OMIM: 601739) PREDICTED: homeobox pr ( 417) 259 58.1 2.1e-08 XP_016859630 (OMIM: 601739) PREDICTED: homeobox pr ( 433) 259 58.1 2.1e-08 XP_016877694 (OMIM: 601740) PREDICTED: homeobox pr ( 306) 257 57.6 2.2e-08 NP_758527 (OMIM: 601740) homeobox protein Meis2 is ( 306) 257 57.6 2.2e-08 XP_011519893 (OMIM: 601740) PREDICTED: homeobox pr ( 331) 257 57.7 2.3e-08 XP_006720590 (OMIM: 601740) PREDICTED: homeobox pr ( 331) 257 57.7 2.3e-08 NP_002390 (OMIM: 601740) homeobox protein Meis2 is ( 381) 257 57.7 2.5e-08 NP_758526 (OMIM: 601740) homeobox protein Meis2 is ( 388) 257 57.7 2.6e-08 XP_006720589 (OMIM: 601740) PREDICTED: homeobox pr ( 389) 257 57.7 2.6e-08 XP_006720588 (OMIM: 601740) PREDICTED: homeobox pr ( 393) 257 57.7 2.6e-08 NP_733774 (OMIM: 601740) homeobox protein Meis2 is ( 394) 257 57.7 2.6e-08 XP_006720587 (OMIM: 601740) PREDICTED: homeobox pr ( 400) 257 57.7 2.6e-08 NP_733777 (OMIM: 601740) homeobox protein Meis2 is ( 401) 257 57.7 2.6e-08 NP_001273187 (OMIM: 602100) homeobox protein PKNOX ( 319) 255 57.3 2.9e-08 NP_001207411 (OMIM: 601740) homeobox protein Meis2 ( 470) 257 57.8 3e-08 NP_733776 (OMIM: 601740) homeobox protein Meis2 is ( 470) 257 57.8 3e-08 XP_006720586 (OMIM: 601740) PREDICTED: homeobox pr ( 476) 257 57.8 3e-08 NP_733775 (OMIM: 601740) homeobox protein Meis2 is ( 477) 257 57.8 3e-08 XP_016859635 (OMIM: 601739) PREDICTED: homeobox pr ( 246) 252 56.6 3.5e-08 >>NP_631960 (OMIM: 400025) homeobox protein TGIF2LY [Hom (185 aa) initn: 1248 init1: 1248 opt: 1248 Z-score: 1279.2 bits: 243.3 E(85289): 1.6e-64 Smith-Waterman score: 1248; 100.0% identity (100.0% similar) in 185 aa overlap (1-185:1-185) 10 20 30 40 50 60 pF1KB9 MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 SVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 SVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 IIGHKTGKDAHATHLQSTEASVPAKSGPVVQTMYKACPCGPCQRARCQERSNQIRSRPLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 IIGHKTGKDAHATHLQSTEASVPAKSGPVVQTMYKACPCGPCQRARCQERSNQIRSRPLA 130 140 150 160 170 180 pF1KB9 RSSPE ::::: NP_631 RSSPE >>NP_620410 (OMIM: 300411) homeobox protein TGIF2LX [Hom (241 aa) initn: 972 init1: 972 opt: 983 Z-score: 1009.0 bits: 193.7 E(85289): 1.8e-49 Smith-Waterman score: 983; 84.9% identity (91.1% similar) in 179 aa overlap (1-178:1-179) 10 20 30 40 50 60 pF1KB9 MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 SVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDP :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: NP_620 SVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLQISNWFINARRRILPDMLQQRRNDP 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 IIGHKTGKDAHATHLQSTEASVPAKSGPVVQTMYKACPCGPCQRAR-CQERSNQIRSRPL :::::::::::::::::::::::::::: .. : : ... .:.. . .: : NP_620 IIGHKTGKDAHATHLQSTEASVPAKSGPSGPDNVQSLPLWPLPKGQMSREKQPDPESAPS 130 140 150 160 170 180 180 pF1KB9 ARSSPE NP_620 QKLTGIAQPKKKVKVSVTSPSSPELVSPEEHADFSSFLLLVDAAVQRAAELELEKKQEPN 190 200 210 220 230 240 >>NP_733796 (OMIM: 142946,602630) homeobox protein TGIF1 (401 aa) initn: 369 init1: 351 opt: 383 Z-score: 397.8 bits: 81.4 E(85289): 2e-15 Smith-Waterman score: 383; 40.4% identity (68.1% similar) in 166 aa overlap (5-161:120-277) 10 20 30 pF1KB9 MEAAADGPAETQSPVE--KDSPAKTQSPAQDTSI :.::: . .: : : . : ..: . NP_733 QPRALSPELGTKAGPRRPHRWELPRSPSQGAQGPAPRRRLLETMKGIVAASGSETEDEDS 90 100 110 120 130 140 40 50 60 70 80 pF1KB9 MS-----RNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLS :. ..: .: :..:.:::: :::.:::::.:.::..:::::.:: .:: NP_733 MDIPLDLSSSAGSG--------KRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLS 150 160 170 180 190 200 90 100 110 120 130 140 pF1KB9 EKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTEASVPAKS- ..:.:: :.. :::::::::.:::::.. .:: . . :. .. .:.:. . :. NP_733 QQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVESVMGIKNF 210 220 230 240 250 260 150 160 170 180 pF1KB9 GPVVQ-TMYKACPCGPCQRARCQERSNQIRSRPLARSSPE :... : ...: :: NP_733 MPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDVPFSLCQSV 270 280 290 300 310 320 >>NP_775301 (OMIM: 142946,602630) homeobox protein TGIF1 (252 aa) initn: 369 init1: 351 opt: 379 Z-score: 396.4 bits: 80.4 E(85289): 2.4e-15 Smith-Waterman score: 379; 48.2% identity (78.9% similar) in 114 aa overlap (50-161:15-128) 20 30 40 50 60 70 pF1KB9 PAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPS :..:.:::: :::.:::::.:.::..:::: NP_775 MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS 10 20 30 40 80 90 100 110 120 130 pF1KB9 EEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTE :.:: .::..:.:: :.. :::::::::.:::::.. .:: . . :. .. .:.: NP_775 EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVE 50 60 70 80 90 100 140 150 160 170 180 pF1KB9 ASVPAKS-GPVVQ-TMYKACPCGPCQRARCQERSNQIRSRPLARSSPE . . :. :... : ...: :: NP_775 SVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDV 110 120 130 140 150 160 >>NP_001265615 (OMIM: 142946,602630) homeobox protein TG (252 aa) initn: 369 init1: 351 opt: 379 Z-score: 396.4 bits: 80.4 E(85289): 2.4e-15 Smith-Waterman score: 379; 48.2% identity (78.9% similar) in 114 aa overlap (50-161:15-128) 20 30 40 50 60 70 pF1KB9 PAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPS :..:.:::: :::.:::::.:.::..:::: NP_001 MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS 10 20 30 40 80 90 100 110 120 130 pF1KB9 EEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTE :.:: .::..:.:: :.. :::::::::.:::::.. .:: . . :. .. .:.: NP_001 EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVE 50 60 70 80 90 100 140 150 160 170 180 pF1KB9 ASVPAKS-GPVVQ-TMYKACPCGPCQRARCQERSNQIRSRPLARSSPE . . :. :... : ...: :: NP_001 SVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDV 110 120 130 140 150 160 >>XP_011524037 (OMIM: 142946,602630) PREDICTED: homeobox (252 aa) initn: 369 init1: 351 opt: 379 Z-score: 396.4 bits: 80.4 E(85289): 2.4e-15 Smith-Waterman score: 379; 48.2% identity (78.9% similar) in 114 aa overlap (50-161:15-128) 20 30 40 50 60 70 pF1KB9 PAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPS :..:.:::: :::.:::::.:.::..:::: XP_011 MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS 10 20 30 40 80 90 100 110 120 130 pF1KB9 EEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTE :.:: .::..:.:: :.. :::::::::.:::::.. .:: . . :. .. .:.: XP_011 EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVE 50 60 70 80 90 100 140 150 160 170 180 pF1KB9 ASVPAKS-GPVVQ-TMYKACPCGPCQRARCQERSNQIRSRPLARSSPE . . :. :... : ...: :: XP_011 SVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDV 110 120 130 140 150 160 >>NP_777480 (OMIM: 142946,602630) homeobox protein TGIF1 (252 aa) initn: 369 init1: 351 opt: 379 Z-score: 396.4 bits: 80.4 E(85289): 2.4e-15 Smith-Waterman score: 379; 48.2% identity (78.9% similar) in 114 aa overlap (50-161:15-128) 20 30 40 50 60 70 pF1KB9 PAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPS :..:.:::: :::.:::::.:.::..:::: NP_777 MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS 10 20 30 40 80 90 100 110 120 130 pF1KB9 EEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTE :.:: .::..:.:: :.. :::::::::.:::::.. .:: . . :. .. .:.: NP_777 EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVE 50 60 70 80 90 100 140 150 160 170 180 pF1KB9 ASVPAKS-GPVVQ-TMYKACPCGPCQRARCQERSNQIRSRPLARSSPE . . :. :... : ...: :: NP_777 SVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDV 110 120 130 140 150 160 >>NP_775302 (OMIM: 142946,602630) homeobox protein TGIF1 (252 aa) initn: 369 init1: 351 opt: 379 Z-score: 396.4 bits: 80.4 E(85289): 2.4e-15 Smith-Waterman score: 379; 48.2% identity (78.9% similar) in 114 aa overlap (50-161:15-128) 20 30 40 50 60 70 pF1KB9 PAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPS :..:.:::: :::.:::::.:.::..:::: NP_775 MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS 10 20 30 40 80 90 100 110 120 130 pF1KB9 EEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTE :.:: .::..:.:: :.. :::::::::.:::::.. .:: . . :. .. .:.: NP_775 EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVE 50 60 70 80 90 100 140 150 160 170 180 pF1KB9 ASVPAKS-GPVVQ-TMYKACPCGPCQRARCQERSNQIRSRPLARSSPE . . :. :... : ...: :: NP_775 SVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDV 110 120 130 140 150 160 >>NP_775303 (OMIM: 142946,602630) homeobox protein TGIF1 (252 aa) initn: 369 init1: 351 opt: 379 Z-score: 396.4 bits: 80.4 E(85289): 2.4e-15 Smith-Waterman score: 379; 48.2% identity (78.9% similar) in 114 aa overlap (50-161:15-128) 20 30 40 50 60 70 pF1KB9 PAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPS :..:.:::: :::.:::::.:.::..:::: NP_775 MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS 10 20 30 40 80 90 100 110 120 130 pF1KB9 EEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTE :.:: .::..:.:: :.. :::::::::.:::::.. .:: . . :. .. .:.: NP_775 EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVE 50 60 70 80 90 100 140 150 160 170 180 pF1KB9 ASVPAKS-GPVVQ-TMYKACPCGPCQRARCQERSNQIRSRPLARSSPE . . :. :... : ...: :: NP_775 SVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDV 110 120 130 140 150 160 >>XP_016881448 (OMIM: 142946,602630) PREDICTED: homeobox (252 aa) initn: 369 init1: 351 opt: 379 Z-score: 396.4 bits: 80.4 E(85289): 2.4e-15 Smith-Waterman score: 379; 48.2% identity (78.9% similar) in 114 aa overlap (50-161:15-128) 20 30 40 50 60 70 pF1KB9 PAKTQSPAQDTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPS :..:.:::: :::.:::::.:.::..:::: XP_016 MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS 10 20 30 40 80 90 100 110 120 130 pF1KB9 EEEKQMLSEKTNLSLLRISNWFINARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTE :.:: .::..:.:: :.. :::::::::.:::::.. .:: . . :. .. .:.: XP_016 EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVE 50 60 70 80 90 100 140 150 160 170 180 pF1KB9 ASVPAKS-GPVVQ-TMYKACPCGPCQRARCQERSNQIRSRPLARSSPE . . :. :... : ...: :: XP_016 SVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDV 110 120 130 140 150 160 185 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:04:09 2016 done: Fri Nov 4 19:04:10 2016 Total Scan time: 5.750 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]