Result of FASTA (omim) for
pF1KB9805
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9805, 225 aa
1>>>pF1KB9805 225 - 225 aa - 225 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4156+/-0.000283; mu= 12.7119+/- 0.018
mean_var=148.8473+/-29.546, 0's: 0 Z-trim(123.4): 47 B-trim: 2228 in 1/58
Lambda= 0.105124
statistics sampled from 43193 (43264) to 43193 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.817), E-opt: 0.2 (0.507), width: 16
Scan time: 7.290
The best scores are: opt bits E(85289)
NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241) 1512 239.6 3.5e-63
NP_689627 (OMIM: 613483) class E basic helix-loop- ( 381) 487 84.3 3e-16
NP_005797 (OMIM: 606386) oligodendrocyte transcrip ( 323) 347 63.0 6.5e-10
XP_005260965 (OMIM: 606386) PREDICTED: oligodendro ( 323) 347 63.0 6.5e-10
NP_786923 (OMIM: 609323) oligodendrocyte transcrip ( 272) 335 61.1 2.1e-09
NP_620450 (OMIM: 606385) oligodendrocyte transcrip ( 271) 296 55.2 1.2e-07
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 266 50.5 2.3e-06
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 237 46.2 5.6e-05
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 240 46.9 5.6e-05
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 237 46.4 7.1e-05
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 232 45.6 0.00012
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 227 44.9 0.0002
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 204 41.2 0.0017
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 204 41.2 0.0017
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 203 41.2 0.0025
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 197 40.2 0.0041
>>NP_542173 (OMIM: 609331) class E basic helix-loop-heli (241 aa)
initn: 1512 init1: 1512 opt: 1512 Z-score: 1255.3 bits: 239.6 E(85289): 3.5e-63
Smith-Waterman score: 1512; 100.0% identity (100.0% similar) in 225 aa overlap (1-225:17-241)
10 20 30 40
pF1KB9 MAELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPG
::::::::::::::::::::::::::::::::::::::::::::
NP_542 MSIRPPGEPPSPGGAAMAELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB9 PGGDLPAAPAPRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 PGGDLPAAPAPRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB9 INARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 INARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB9 VAFLNQGQGLAAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHCHEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 VAFLNQGQGLAAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHCHEK
190 200 210 220 230 240
pF1KB9 P
:
NP_542 P
>>NP_689627 (OMIM: 613483) class E basic helix-loop-heli (381 aa)
initn: 618 init1: 466 opt: 487 Z-score: 412.8 bits: 84.3 E(85289): 3e-16
Smith-Waterman score: 599; 50.2% identity (68.5% similar) in 235 aa overlap (9-225:154-381)
10 20 30
pF1KB9 MAELKSLSGDAYLALSHGYAA--AAAGLAYGAAREPEA
: :.: : : :. : . :.:. :.
NP_689 ALCLKYGESASRGSVAESSGGEQSPDDDSDGRCELVLRAGVADPRASPGAGGGGAKAAEG
130 140 150 160 170 180
40 50 60 70 80 90
pF1KB9 ARGYGTPGPGGDLPAAPAPRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPR
. : :...: :. . . .. ::. .:: . . .:.... .. .
NP_689 CSNAHLHG-GASVP--PGGLGGGGGGGSSSGSSGGGGGS--GSGSGGSSSSSSSSSKKSK
190 200 210 220 230
100 110 120 130 140 150
pF1KB9 EQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQ
::..:::.::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_689 EQKALRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQ
240 250 260 270 280 290
160 170 180 190 200
pF1KB9 ALDEMRRLVAFLNQGQGL---------AAPVNAAPLTP----FGQATVCPFSAGAALGP-
::.:::::::.:::::.. :: . :: : : . ::. ::::: : :
NP_689 ALEEMRRLVAYLNQGQAISAASLPSSAAAAAAAAALHPALGAYEQAAGYPFSAG--LPPA
300 310 320 330 340 350
210 220
pF1KB9 --CPDKCAAFSGTPSALCKHCHEKP
::.::: :... :.:::.: :::
NP_689 ASCPEKCALFNSVSSSLCKQCTEKP
360 370 380
>>NP_005797 (OMIM: 606386) oligodendrocyte transcription (323 aa)
initn: 394 init1: 336 opt: 347 Z-score: 298.9 bits: 63.0 E(85289): 6.5e-10
Smith-Waterman score: 364; 41.5% identity (67.0% similar) in 188 aa overlap (37-199:24-211)
10 20 30 40 50 60
pF1KB9 LSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGP---GGDLPAA-PAPRAPAQAA
::. :. : :: . .. :. : .:
NP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSA
10 20 30 40 50
70 80 90 100
pF1KB9 E------SSGEQSGDE--DDAFEQRRRRRGPGS---AADGRRRPREQ------RSLRLSI
: :.: . ::. ..:.. . .. ::.. .. ..: ..:::.:
NP_005 ELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB9 NARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLV
:.:::.:::::: :.:::: :.::::.:::::::::::::::.::::: ...:.::.:::
NP_005 NSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB9 AFLNQGQ--GL--AAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHC
. . :. :. .: . : .:. ::. : .:. :
NP_005 SEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAA
180 190 200 210 220 230
pF1KB9 HEKP
NP_005 AAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPC
240 250 260 270 280 290
>>XP_005260965 (OMIM: 606386) PREDICTED: oligodendrocyte (323 aa)
initn: 394 init1: 336 opt: 347 Z-score: 298.9 bits: 63.0 E(85289): 6.5e-10
Smith-Waterman score: 364; 41.5% identity (67.0% similar) in 188 aa overlap (37-199:24-211)
10 20 30 40 50 60
pF1KB9 LSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGP---GGDLPAA-PAPRAPAQAA
::. :. : :: . .. :. : .:
XP_005 MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSA
10 20 30 40 50
70 80 90 100
pF1KB9 E------SSGEQSGDE--DDAFEQRRRRRGPGS---AADGRRRPREQ------RSLRLSI
: :.: . ::. ..:.. . .. ::.. .. ..: ..:::.:
XP_005 ELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKI
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB9 NARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLV
:.:::.:::::: :.:::: :.::::.:::::::::::::::.::::: ...:.::.:::
XP_005 NSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB9 AFLNQGQ--GL--AAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHC
. . :. :. .: . : .:. ::. : .:. :
XP_005 SEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAA
180 190 200 210 220 230
pF1KB9 HEKP
XP_005 AAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPC
240 250 260 270 280 290
>>NP_786923 (OMIM: 609323) oligodendrocyte transcription (272 aa)
initn: 346 init1: 327 opt: 335 Z-score: 290.0 bits: 61.1 E(85289): 2.1e-09
Smith-Waterman score: 335; 60.4% identity (83.5% similar) in 91 aa overlap (84-172:65-155)
60 70 80 90 100 110
pF1KB9 APRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQ--RSLRLSINARERR
: .: ... :: ..:::.::.:::.
NP_786 SRLNSVSSTQGDMMQKMPGESLSRAGAKAAGESSKYKIKKQLSEQDLQQLRLKINGRERK
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB9 RMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQG
:::::: :.:::: :.::::.:::::::::::::::.::::: ...:.::.:::. . :
NP_786 RMHDLNLAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTSSLEEMKRLVGEIYGG
100 110 120 130 140 150
180 190 200 210 220
pF1KB9 QGLAAPVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHCHEKP
.
NP_786 HHSAFHCGTVGHSAGHPAHAANSVHPVHPILGGALSSGNASSPLSAASLPAIGTIRPPHS
160 170 180 190 200 210
>>NP_620450 (OMIM: 606385) oligodendrocyte transcription (271 aa)
initn: 328 init1: 141 opt: 296 Z-score: 258.0 bits: 55.2 E(85289): 1.2e-07
Smith-Waterman score: 296; 48.5% identity (70.6% similar) in 136 aa overlap (84-205:83-212)
60 70 80 90 100
pF1KB9 APRAPAQAAESSGEQSGDEDDAFEQRRRRRGPGSAAD--GRRRP----REQRSLRLSINA
::::.: : :: ..:..:: .::.
NP_620 SSTSSSSTTAPLLPKAAREKPEAPAEPPGPGPGSGAHPGGSARPDAKEEQQQQLRRKINS
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB9 RERRRMHDLNDALDGLRAVI-PY--AHSPSV--RKLSKIATLLLAKNYILMQAQALDEMR
:::.::.::: :.:.:: :: :: :: .. ::::::::::::.::::. ...:.:.:
NP_620 RERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELR
120 130 140 150 160 170
170 180 190 200 210
pF1KB9 RLVAFLNQGQGLAAP---VNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCK
: :..: : ::: . . :: . ..: . : .:.:: ::
NP_620 RA---LGEGAGPAAPRLLLAGLPLLAAAPGSV--LLAPGAVGP-PDALRPAKYLSLALDE
180 190 200 210 220
220
pF1KB9 HCHEKP
NP_620 PPCGQFALPGGGAGGPGLCTCAVCKFPHLVPASLGLAAVQAQFSK
230 240 250 260 270
>>NP_803238 (OMIM: 608606) class A basic helix-loop-heli (189 aa)
initn: 170 init1: 112 opt: 266 Z-score: 235.3 bits: 50.5 E(85289): 2.3e-06
Smith-Waterman score: 266; 48.3% identity (66.7% similar) in 120 aa overlap (32-151:15-124)
10 20 30 40 50 60
pF1KB9 AELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQA
.. ::. : ::: :.:: :.:. ::..
NP_803 MKTKNRPPRRRAPVQDTEATPGEGTPD--GSLPN-PGPE-PAKG
10 20 30 40
70 80 90 100 110 120
pF1KB9 AESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALD
.: ... . . : :::: :: :. ::: :: :: : :::.::: ::.:..
NP_803 LRSRPARAAARAPG-EGRRRRPGP-SGPGGRRDSSIQR--RLESNERERQRMHKLNNAFQ
50 60 70 80 90
130 140 150 160 170 180
pF1KB9 GLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQGQGLAAPVNAA
.:: ::: : . .::::: :: ::::::
NP_803 ALREVIP--HVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQ
100 110 120 130 140 150
>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens] (237 aa)
initn: 200 init1: 160 opt: 237 Z-score: 210.4 bits: 46.2 E(85289): 5.6e-05
Smith-Waterman score: 237; 37.2% identity (54.4% similar) in 180 aa overlap (33-205:29-198)
10 20 30 40 50 60
pF1KB9 ELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQAA
: . :: . . .: : ::: :. . .
NP_006 MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASG--PPAPARRGAPNIS
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 ESSGEQSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLSINARERRRMHDLNDALDG
..: : : .:: ..:::::: . . .:: :.. : ::: :::.:: :::.
NP_006 RAS-EVPGAQDDE-QERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDA
60 70 80 90 100 110
130 140 150 160 170
pF1KB9 LRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQGQG----LAAP-
::.:.: :. ::.:: :: .: ::: :: : ::. : : : :
NP_006 LRSVLP--SFPDDTKLTKIETLRFAYNYI----WALAETLRLADQGLPGGGARERLLPPQ
120 130 140 150 160
180 190 200 210 220
pF1KB9 -VNAAPLTPFGQATVCPFSAGAALG-PCPDKCAAFSGTPSALCKHCHEKP
: : : . . ...::: . : :
NP_006 CVPCLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLH
170 180 190 200 210 220
>>NP_006151 (OMIM: 601725) neurogenic differentiation fa (382 aa)
initn: 287 init1: 152 opt: 240 Z-score: 210.3 bits: 46.9 E(85289): 5.6e-05
Smith-Waterman score: 267; 34.5% identity (54.5% similar) in 220 aa overlap (34-219:40-252)
10 20 30 40 50 60
pF1KB9 LKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQAAE
: : : :.:::. : :.: ...:
NP_006 GLLSDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPAR--AAKPVPLRGEEGTE
10 20 30 40 50 60
70 80 90 100
pF1KB9 SS-------GEQSGDE----------DDAFEQRRRRRGPGSAADGRRRPREQRSLRLSIN
.. :: .:.: :.: .: ..::: . . : .... : . :
NP_006 ATLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKAN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB9 ARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRR--L
:::: :::::: :::.:: :.: .: . .::::: :: :::::: .. : .: :
NP_006 ARERNRMHDLNAALDNLRKVVP-CYSKT-QKLSKIETLRLAKNYIWALSEILRSGKRPDL
130 140 150 160 170 180
170 180 190 200
pF1KB9 VAFLNQ-GQGLAAP----------VNAAP-LTPFGQATVCPF--SAGA-ALGPCPDKCAA
:.... .::. : .:. :: : . : :.: :. : : :.
NP_006 VSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSR
190 200 210 220 230 240
210 220
pF1KB9 FSGTPSALCKHCHEKP
..: : :.
NP_006 LAG---AQCQAAGGLGGGAAHALRTHGYCAAYETLYAAAGGGGASPDYNSSEYEGPLSPP
250 260 270 280 290 300
>>NP_073565 (OMIM: 611513) neurogenic differentiation fa (337 aa)
initn: 239 init1: 165 opt: 237 Z-score: 208.5 bits: 46.4 E(85289): 7.1e-05
Smith-Waterman score: 237; 41.6% identity (62.4% similar) in 125 aa overlap (56-177:50-172)
30 40 50 60 70 80
pF1KB9 LAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQAAESSGEQSGDEDDAFEQRRRRRGP
:::.. .:. :. :.. . ::::
NP_073 KFSRECEDQKQIKKPESFSKQIVLRGKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGL
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB9 GSAADGRRRPREQRSLRLSINARERRRMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLL
. . : .. . : ::::: ::: ::::::.:: :.: .: . .::::: ::
NP_073 RKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVP-CYSKT-QKLSKIETLR
80 90 100 110 120 130
150 160 170 180 190 200
pF1KB9 LAKNYILMQAQALDEMRR--LVAFL-NQGQGLAAPVNAAPLTPFGQATVCPFSAGAALGP
:::::: .. : .: :..:. : .::. :
NP_073 LAKNYIWALSEILRIGKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAA
140 150 160 170 180 190
210 220
pF1KB9 CPDKCAAFSGTPSALCKHCHEKP
NP_073 HHTRSPYSTFYPPYHSPELTTPPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFE
200 210 220 230 240 250
225 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 19:07:04 2016 done: Fri Nov 4 19:07:05 2016
Total Scan time: 7.290 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]