FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9806, 226 aa 1>>>pF1KB9806 226 - 226 aa - 226 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2723+/-0.000438; mu= -3.0504+/- 0.028 mean_var=243.1331+/-47.583, 0's: 0 Z-trim(118.6): 47 B-trim: 0 in 0/56 Lambda= 0.082253 statistics sampled from 31732 (31779) to 31732 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.373), width: 16 Scan time: 7.060 The best scores are: opt bits E(85289) NP_005313 (OMIM: 142711) histone H1.5 [Homo sapien ( 226) 1372 175.1 8.5e-44 NP_005312 (OMIM: 142220) histone H1.4 [Homo sapien ( 219) 1098 142.6 5.1e-34 NP_005311 (OMIM: 142210) histone H1.3 [Homo sapien ( 221) 1020 133.3 3.1e-31 NP_005310 (OMIM: 142710) histone H1.2 [Homo sapien ( 213) 978 128.3 9.6e-30 NP_005316 (OMIM: 142709) histone H1.1 [Homo sapien ( 215) 823 109.9 3.3e-24 NP_005314 (OMIM: 142712) histone H1t [Homo sapiens ( 207) 528 74.9 1.1e-13 NP_005309 (OMIM: 142708) histone H1.0 [Homo sapien ( 194) 363 55.3 8.3e-08 NP_006017 (OMIM: 602785) histone H1x [Homo sapiens ( 213) 319 50.1 3.3e-06 NP_066554 (OMIM: 105400,162230,616924) neurofilame (1020) 252 42.7 0.0027 >>NP_005313 (OMIM: 142711) histone H1.5 [Homo sapiens] (226 aa) initn: 1372 init1: 1372 opt: 1372 Z-score: 907.3 bits: 175.1 E(85289): 8.5e-44 Smith-Waterman score: 1372; 100.0% identity (100.0% similar) in 226 aa overlap (1-226:1-226) 10 20 30 40 50 60 pF1KB9 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAKAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAKAA 130 140 150 160 170 180 190 200 210 220 pF1KB9 AKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK :::::::::::::::::::::::::::::::::::::::::::::: NP_005 AKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK 190 200 210 220 >>NP_005312 (OMIM: 142220) histone H1.4 [Homo sapiens] (219 aa) initn: 972 init1: 652 opt: 1098 Z-score: 731.8 bits: 142.6 E(85289): 5.1e-34 Smith-Waterman score: 1098; 84.7% identity (91.0% similar) in 222 aa overlap (1-220:1-218) 10 20 30 40 50 60 pF1KB9 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL ::::::: :.:::.::.:.:::: :. ::::::::.::::::::::::::::::.:. NP_005 MSETAPAAPAAPAPAEKTPVKKKARKS---AGAAKRKASGPPVSELITKAVAASKERSGV 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK 60 70 80 90 100 110 130 140 150 160 170 pF1KB9 PKAKKAGAAKAKKPAGAT--PKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAK :::::::::::::::::. :::: :: ::..:::::::::::::. : :::::::: NP_005 PKAKKAGAAKAKKPAGAAKKPKKATGAATPKKSAKKTPKKAKKPAAAAGAKKAKSPKKAK 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 AAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK :: ::::: ::::: :::::::::::.::::::::: : ::: NP_005 AA-KPKKAPKSPAKAKAVKPKAAKPKTAKPKAAKPKKAAAKKK 180 190 200 210 >>NP_005311 (OMIM: 142210) histone H1.3 [Homo sapiens] (221 aa) initn: 682 init1: 682 opt: 1020 Z-score: 681.7 bits: 133.3 E(85289): 3.1e-31 Smith-Waterman score: 1020; 78.3% identity (89.1% similar) in 230 aa overlap (1-226:1-221) 10 20 30 40 50 60 pF1KB9 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL :::::: . :::.::.:.:::: : ::: :.::::.::::::::::::::::::.:. NP_005 MSETAPLAPTIPAPAEKTPVKKKAKK--AGATAGKRKASGPPVSELITKAVAASKERSGV 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK :::::::::::.::::::::::::::::::::::::::::::::::::::::::::::.: NP_005 SLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGK 60 70 80 90 100 110 130 140 150 160 170 pF1KB9 PKAKKAGAAKAKKPAGATPKKAKKAAGA---KKAVKKTPKKAKKPA-AAGVKKVAKSPKK :::::::::: .:::::. :: ::.::: ::..::::::.:::: :::.:::::: :: NP_005 PKAKKAGAAKPRKPAGAA-KKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKK 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 AKAAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK .:. .::::.::::: :: :: :::::::..:::..:::::: ::: NP_005 VKTP-QPKKAAKSPAKAKA--PK---PKAAKPKSGKPKVTKAKKAAPKKK 180 190 200 210 220 >>NP_005310 (OMIM: 142710) histone H1.2 [Homo sapiens] (213 aa) initn: 737 init1: 737 opt: 978 Z-score: 655.0 bits: 128.3 E(85289): 9.6e-30 Smith-Waterman score: 978; 79.4% identity (89.9% similar) in 218 aa overlap (1-214:1-211) 10 20 30 40 50 60 pF1KB9 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL ::::::: :. :.::.:.::::.::: :.. :::.::::::::::::::::::.:. NP_005 MSETAPAAPAAAPPAEKAPVKKKAAKKA---GGTPRKASGPPVSELITKAVAASKERSGV 10 20 30 40 50 70 80 90 100 110 120 pF1KB9 SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK 60 70 80 90 100 110 130 140 150 160 170 pF1KB9 PKAKKAGAAKAKKPAGATPKKAKKAAGA---KKAVKKTPKKAKKPAAAGV-KKVAKSPKK ::.::::..: :::.::. :: :::::. ::..::::::::::::: : ::::::::: NP_005 PKVKKAGGTKPKKPVGAA-KKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKK 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 AKAAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK ::.: :::::.:: : :::::::::::..::: : :: NP_005 AKVA-KPKKAAKSAA--KAVKPKAAKPKVVKPKKAAPKKK 180 190 200 210 >>NP_005316 (OMIM: 142709) histone H1.1 [Homo sapiens] (215 aa) initn: 675 init1: 554 opt: 823 Z-score: 555.5 bits: 109.9 E(85289): 3.3e-24 Smith-Waterman score: 823; 66.8% identity (83.2% similar) in 220 aa overlap (1-220:1-214) 10 20 30 40 50 60 pF1KB9 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL ::::.: :. : :: : ::: : : .:.:.:.: .:: :::::..:...::::.:. NP_005 MSETVPPAPAASAAPEKPLAGKKAKKPAKAAAASKKKPAGPSVSELIVQAASSSKERGGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK :::::::::::.::::::::::::::.:::::::::::::::::::::::::::.: :.: NP_005 SLAALKKALAAAGYDVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVETK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 PKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAKAA : :.:. : : .::. :: :::.::.: :::::::::::. .: .:.::: :.. NP_005 PGASKV--ATKTKATGAS-KKLKKATGASKKSVKTPKKAKKPAAT--RKSSKNPKKPKTV 130 140 150 160 170 190 200 210 220 pF1KB9 AKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK ::::..::::: ::::::::: ...:::.:::: : :: NP_005 -KPKKVAKSPAKAKAVKPKAAKARVTKPKTAKPKKAAPKKK 180 190 200 210 >>NP_005314 (OMIM: 142712) histone H1t [Homo sapiens] (207 aa) initn: 494 init1: 462 opt: 528 Z-score: 366.6 bits: 74.9 E(85289): 1.1e-13 Smith-Waterman score: 567; 51.4% identity (75.9% similar) in 216 aa overlap (1-214:1-206) 10 20 30 40 50 pF1KB9 MSETAPAETATP--APVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERN ::::.:: .:. : .:: :.::.. .: :: .:.::. . ::.:::.:...:.:: NP_005 MSETVPAASASAGVAAMEKLPTKKRG-RKPAGLISASRKVPNLSVSKLITEALSVSQERV 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 GLSLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGE :.::.::::::::.:::::::::::::.:::::.:: ::::.::::::::::.::. NP_005 GMSLVALKKALAAAGYDVEKNNSRIKLSLKSLVNKGILVQTRGTGASGSFKLSKKVIPKS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB9 AKPKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAK .. ::::. .::.:: . . .:. :.: :: :.:::: :. . :...: .::: NP_005 TRSKAKKSVSAKTKKLVLSRDSKSPKTA-------KTNKRAKKPRAT-TPKTVRSGRKAK 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 AAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK .: : :. :::.: .: : : .. . .. . : : NP_005 GA-KGKQQQKSPVKARASKSKLTQHHEVNVRKATSKK 180 190 200 >>NP_005309 (OMIM: 142708) histone H1.0 [Homo sapiens] (194 aa) initn: 259 init1: 145 opt: 363 Z-score: 261.1 bits: 55.3 E(85289): 8.3e-08 Smith-Waterman score: 402; 45.0% identity (64.4% similar) in 222 aa overlap (8-226:3-194) 10 20 30 40 50 60 pF1KB9 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL :..: ::. : : . ::.::.. : :..:. :. : :.: : NP_005 MTENSTSAPAAK-PKRAKASKKSTDH---------PKYSDMIVAAIQAEKNRAGS 10 20 30 40 70 80 90 100 110 pF1KB9 SLAALKKALAAGGYDVEKN-NSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEA : ...: . . : : .: .:.:::..: ::. :.: ::::.::::::.: : : : NP_005 SRQSIQKYIKSH-YKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAK---SDE- 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB9 KPKAKKAGAAKAKKPAG--ATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKA :: :... :.:: ::::::.: :::..:.: .::: :. :::. : NP_005 -PK-KSVAFKKTKKEIKKVATPKKASKP---KKAASKAP--TKKPKATPVKKAKK----- 110 120 130 140 180 190 200 210 220 pF1KB9 KAAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK : :: :::: :.: :: ::.::: ::: .:::: .. : :.::: NP_005 KLAATPKKA-KKPKTVKAKPVKASKPKKAKP--VKPKAKSSAKRAGKKK 150 160 170 180 190 >>NP_006017 (OMIM: 602785) histone H1x [Homo sapiens] (213 aa) initn: 438 init1: 181 opt: 319 Z-score: 232.4 bits: 50.1 E(85289): 3.3e-06 Smith-Waterman score: 319; 37.9% identity (63.5% similar) in 211 aa overlap (8-202:6-213) 10 20 30 40 50 pF1KB9 MSETAPAETATPAPVEKSPAKK--KATKKAAGAGAAKRKAT---GPP--VSELITKAVAA : : :. . .. ::: :: .:: . . ::: . . : :.:..... NP_006 MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRR 10 20 30 40 50 60 70 80 90 100 110 pF1KB9 SKERNGLSLAAL-KKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNK :::: ::: . .: . .: ... . .: ..:.::.. ::.:.:::::.::::::. NP_006 LGERNGSSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNR 60 70 80 90 100 110 120 130 140 150 160 pF1KB9 KAASGEAKPKAKKAGAAKAKKPAGATPKKAKK-AAGAKKAVKKTPKKAKKPA------AA : : .. .. : :: : :.. ::: :::...: :: : ...:: .: NP_006 KKLEGGGERRGAPA-AATAPAPTAHKAKKAAPGAAGSRRADKK-PARGQKPEQRSHKKGA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB9 GVKKVAKSPKKAKAAAKPKKATKSPAKPKAVK-PKAAKPKAAKPKAAKPKAAKAKKAAAK :.:: :. : :.:: : .:. :::.. : ::. : NP_006 GAKK-DKGGKAKKTAAAGGKKVKKAAKPSVPKVPKGRK 180 190 200 210 pF1KB9 KK >>NP_066554 (OMIM: 105400,162230,616924) neurofilament h (1020 aa) initn: 262 init1: 194 opt: 252 Z-score: 180.1 bits: 42.7 E(85289): 0.0027 Smith-Waterman score: 266; 31.2% identity (58.5% similar) in 224 aa overlap (5-222:540-756) 10 20 30 pF1KB9 MSETAPAETATPAPVEKSPAKKKATKKAAGAGAA .:::. .: . :::::..: . . . NP_066 ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA-KSPAKEEAKSPPEAKSPE 510 520 530 540 550 560 40 50 60 70 80 90 pF1KB9 KRKATGPPVSELITKAVAASKERNGLSLAALKKALAAGGYDVE-KNNSRIKLGLKSLVSK :..: .: . :: . .::. : . : . : :. .. : .: ... NP_066 KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 570 580 590 600 610 620 100 110 120 130 140 150 pF1KB9 GTLVQTKGTGASGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVK . :.. . : . . :. .... : . . :::.:. : :. .:: . :: NP_066 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA 630 640 650 660 670 680 160 170 180 190 200 pF1KB9 KTPKKAKKPAAAGVKKVAKSPKKAKAAAK-----PKKATKSPAKPKAVKPKAAKPKAAKP :.:.:::.: ::. ::::.:::. .: :.:: :::.: .: :. :: . .: NP_066 KSPEKAKSP----VKEEAKSPEKAKSPVKEEAKSPEKA-KSPVKEEAKTPEKAK-SPVKE 690 700 710 720 730 740 210 220 pF1KB9 KAAKPKAAKAKKAAAKKK .: .:. ::. . : NP_066 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSP 750 760 770 780 790 800 226 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 19:07:30 2016 done: Fri Nov 4 19:07:31 2016 Total Scan time: 7.060 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]